Microbial Natural Product
Microbial natural products, primarily secondary metabolites produced by bacteria, fungi, and other microorganisms, remain a cornerstone of modern medicine and biotechnology. They form the foundation of numerous antibiotics (e.g., penicillin, streptomycin), anticancer agents, and immunosuppressants, addressing critical global health challenges like infectious diseases and cancer. Despite historical challenges such as compound rediscovery and complex biosynthesis, advances in genomics, metabolomics, and synthetic biology are unlocking novel chemical diversity from underexplored microbial sources. Consequently, microbial natural products continue to represent an unparalleled reservoir for discovering next-generation therapeutics, underscoring their enduring significance in drug development and sustainable bioprospecting. (98 words)
Clorobiocin
Formula: C35H37ClN2O11 (696.2086)
Clorobiocin is an aminocoumarin antibiotic, similar to [novobiocin] and coumermycin A1. Clorobiocin is a natural product found in Streptomyces with d...
Thiolutin
Formula: C8H8N2O2S2 (228.0027)
Thiolutin is found in alcoholic beverages. Thiolutin is isolated from several strains of Streptomyces albus and Streptomyces pimprina. Antibiotic whic...
8-O-Methyltetrangulol
8-O-methyltetrangulol is a member of tetraphenes. It is functionally related to a tetrangulol. 8-O-Methyltetrangulol is a natural product found in Ac...
Azatyrosine
Azatyrosine is a L-alpha-amino acid. Azatyrosine is a natural product found in Streptomyces corchorusii and Streptomyces olivaceoviridis with data av...
Dehydroxynocardamine
Formula: C27H48N6O8 (584.3533)
Dehydroxynocardamine is a keratan 6'-sulfate and an azamacrocycle. Dehydroxynocardamine has been reported in Streptomyces anthocyanicus and Streptomy...
Albaflavenone
A carbotricyclic compound that is (+)-epi-isozizaene in which the hydrogens at position 5 have been replaced by an oxo group." []
Albocycline
Albocycline is a macrolide. Albocycline has been reported in Streptomyces and Streptomyces sparsus with data available.
Aklavinone
Aklavinone is an anthracycline, a member of tetracenequinones, a methyl ester and a tertiary alcohol. It has a role as an antineoplastic agent. Aklav...
Gilvocarcin E
Gilvocarcin E is a glycoside. 4-[(2R,3R,4R,5S)-3,4-dihydroxy-5-[(1R)-1-hydroxyethyl]oxolan-2-yl]-8-ethyl-1-hydroxy-10,12-dimethoxynaphtho[1,2-c]isoch...
Lavendustin A
5-[(2,5-dihydroxyphenyl)methyl-[(2-hydroxyphenyl)methyl]amino]-2-hydroxybenzoic acid is an aromatic amine. Lavendustin A is a natural product found i...
Indolepyruvate
The thiamin diphosphate (ThDP)-dependent enzyme indolepyruvate decarboxylase (IPDC) is involved in the biosynthetic pathway of the phytohormone 3-indo...
Aldohexose 6-phosphate
The open-chain form of D-glucose 6-phosphate." []
Anisomycin
An antibiotic isolated from various Streptomyces species. It interferes with protein and DNA synthesis by inhibiting peptidyl transferase or the 80S r...
toyocamycin
Formula: C12H13N5O4 (291.0967)
An N-glycosylpyrrolopyrimidine that is tubercidin in which the hydrogen at position 5 of the pyrrolopyrimidine moiety has been replaced by a cyano gro...
6,7,3'-Trihydroxy-2',4'-dimethoxyisoflavene
6,7,3'-Trihydroxy-2',4'-dimethoxyisoflavene
Actiphenol
Actiphenol is an aromatic ketone. Actiphenol has been reported in Streptomyces albulus, Streptomyces pratensis, and other organisms with data availab...
beta-Carboline
beta-Carboline, also known as norharmane, is an organic amine and is the prototype of a class of compounds known as beta-carbolines. beta-Carbolines a...
5-Ethyl-2,3-dimethylpyrazine
5-Ethyl-2,3-dimethylpyrazine is found in herbs and spices. 5-Ethyl-2,3-dimethylpyrazine is a constituent of Galbanum oil
2-Ethyl-3,(5 or 6)-dimethylpyrazine
3-Ethyl-2,5-dimethylpyrazine is found in coffee and coffee products. 3-Ethyl-2,5-dimethylpyrazine is isolated from coffee. 2-Ethyl-3,(5 or 6)-dimethyl...
2,2'-Methylenebis(4-methyl-6-tert-butylphenol)
2,2'-Methylenebis(4-methyl-6-tert-butylphenol) is a diarylmethane. 2,2'-Methylenebis(4-methyl-6-tert-butylphenol) has been reported in Streptomyces a...
Undecylprodigiosin
A member of the class of tripyrroles that is 1H-pyrrole substituted by (4'-methoxy-1H,5'H-[2,2'-bipyrrol]-5'-ylidene)methyl and undecyl groups at posi...
beta-Nitropropanoate
Bovinocidin is isolated from Aspergillus sp. and moulds contaminating foo
Medermycin
Medermycin is a benzoisochromanequinone and a member of p-quinones. Lactoquinomycin is a natural product found in Streptomyces rosa, Streptomyces, an...
sibiromycin
Formula: C24H33N3O7 (475.2318)
An aminoglycoside antibiotic produced by Streptosporangium sibiricum that also exhibits antitumour properties." []
(S)-Hexahydropyrrolo[1,2-a]pyrazine-1,4-dione
(S)-Hexahydropyrrolo[1,2-a]pyrazine-1,4-dione is a natural product found in Suberites domuncula, Aspergillus fumigatus, and other organisms with data ...
2-Piperidinone
2-Piperidinone is a derivative of piperidine which is an organic compound. Piperidine is a colorless fuming liquid with an odor described as ammoniaca...
6-Diazo-5-oxo-L-norleucine
A non-proteinogenic L-alpha-amino acid that is L-norleucine which is substituted at position 5 by an oxo group and at position 6 by a diazo group. It ...
Thaxtomin A
Formula: C22H22N4O6 (438.1539)
Thaxtomin A is an organooxygen compound and an organonitrogen compound. It is functionally related to an alpha-amino acid. Thaxtomin A is a natural p...
Cyclo(4-hydroxy-R-Pro-S-Leu)
Formula: C11H18N2O3 (226.1317)
UK-1
Formula: C22H14N2O5 (386.0903)
UK-1 is a member of 1,3-oxazoles. Methyl 2-[2-(2-hydroxyphenyl)-1,3-benzoxazol-4-yl]-1,3-benzoxazole-4-carboxylate has been reported in Streptomyces ...
Nojirimycin
Nojirimycin is a hydroxypiperidine and an amino monosaccharide. Nojirimycin is a natural product found in Streptomyces ficellus with data available.
Frenolicin
Frenolicin is a natural product found in Streptomyces roseofulvus with data available.
Candicidin D
Formula: C59H84N2O18 (1108.5719)
Candicidin is only found in individuals that have used or taken this drug. It is an antibiotic obtained from a streptomyces (Streptomyces griseus) and...
trichostatin A
Formula: C17H22N2O3 (302.163)
Bafilomycin B1
Formula: C44H65NO13 (815.4456)
Bafilomycin B1 is a macrolide. Setamycin; Bafilomycin B1; KM-6054 is a natural product found in Streptomyces lohii and Streptomyces griseus with data...
Borrelidin
A macrolide that is isolated from several Streptomyces species and displays antibiotic, antineoplastic and antimalarial properties." []
virginiamycin m1
Formula: C28H35N3O7 (525.2475)
Pristinamycin IIA is a macrolide antibiotic, a member of the streptogramin A group of antibiotics, and one component of pristinamycin. It is produced ...
tunicamycin C1
Formula: C39H64N4O16 (844.4317)
A nucleoside that is one of the homologues in the mixture that is tunicamycin, characterised by a 14-methylpentadec-2-enoyl fatty acyl substituent on ...
Streptorubin B
|FRAME: CPD1A0-6177 "Streptorubin B"| is a red pigmented antibiotic of the prodiginines family that is produced by some actinomycetes. The first descr...