Microbial Natural Product
Microbial natural products, primarily secondary metabolites produced by bacteria, fungi, and other microorganisms, remain a cornerstone of modern medicine and biotechnology. They form the foundation of numerous antibiotics (e.g., penicillin, streptomycin), anticancer agents, and immunosuppressants, addressing critical global health challenges like infectious diseases and cancer. Despite historical challenges such as compound rediscovery and complex biosynthesis, advances in genomics, metabolomics, and synthetic biology are unlocking novel chemical diversity from underexplored microbial sources. Consequently, microbial natural products continue to represent an unparalleled reservoir for discovering next-generation therapeutics, underscoring their enduring significance in drug development and sustainable bioprospecting. (98 words)
Mitomycin
Formula: C15H18N4O5 (334.1277)
Mitomycin is only found in individuals that have used or taken this drug. It is an antineoplastic antibiotic produced by Streptomyces caespitosus. It ...
Kidamycin
Formula: C39H48N2O9 (688.336)
13-Deoxycarminomycin
A cytotoxic anthracycline antibiotic that is produced by Streptomyces peucetius var. carminatus (a biochemical mutant of Streptomyces peucetius var. c...
migrastatin
A 14-membered macrolide which is isolated from Streptomyces sp.MK929-43F1 and inhibits cell migration of human esophageal cancer EC17 cells and mouse ...
Ikarugamycin
Formula: C29H38N2O4 (478.2831)
(3E,5R,7R,8R,10R,11R,12S,15R,16R,18Z,25S)-11-ethyl-2-hydroxy-10-methyl-21,26-diazapentacyclo[23.2.1.05,16.07,15.08,12]octacosa-1,3,13,18-tetraene-20,2...
Methyl (±)-2-methylpentanoate
Methyl (±)-2-methylpentanoate is a flavouring ingredien
Cucurbitacin B
Cucurbitacin B is found in bitter gourd. Together wth other cucurbitacins, is responsible for the bitter taste and toxic properties of spoilt cucumber
Muramic acid
Muramic acid is an amino sugar acid. In terms of chemical composition, it is the ether of lactic acid and glucosamine. It occurs naturally as N-acetyl...
Tetracycline
Formula: C22H24N2O8 (444.1533)
Tetracycline is a broad spectrum polyketide antibiotic produced by the Streptomyces genus of Actinobacteria. It exerts a bacteriostatic effect on bact...
Thienamycin
Formula: C11H16N2O4S (272.0831)
Thienamycin is a member of carbapenems. Thienamycin is a natural product found in Streptomyces cattleya with data available.
Lankacidin C
Lankacidin C is an organic molecular entity. Lankacidin C is a natural product found in Streptomyces rochei with data available.
UDP-4-dehydro-6-deoxy-D-glucose
Formula: C15H22N2O16P2 (548.0445)
UDP-4-dehydro-6-deoxy-D-glucose, also known as UDP-4-keto-6-deoxy-D-glucose, belongs to the class of organic compounds known as pyrimidine nucleotide ...
pimaricin
Formula: C33H47NO13 (665.3047)
Natamycin is a polyene amphoteric macrolide antibiotic with antifungal properties. Natamycin exerts its antifungal effects by binding to sterols in th...
Leptomycin B
Leptomycin B is a leptomycin having a (2E,10E,12E,16Z,18E)-double bond configuration as well as an ethyl substituent at position 17. It has a role as ...
Thiolactomycin
Thiolactomycin is a natural product found in Streptomyces and Nocardia with data available.
bafilomycin A1
The most used of the bafilomycins, a family of toxic macrolide antibiotics derived from Streptomyces griseus." []
Pentalenolactone
(1R,4aR,6aS,7R,9aR)-7,8-dimethyl-2-oxospiro[4,4a,6a,7-tetrahydropentaleno[1,6a-c]pyran-1,2'-oxirane]-5-carboxylic acid is a natural product found in S...
Streptolydigin
Formula: C32H44N2O9 (600.3047)
Streptolydigin is a monocarboxylic acid amide that is a broad-spectrum antibiotic produced by Streptomyces lydicus. It has a role as an antimicrobial ...
Tylosin
Formula: C46H77NO17 (915.5191)
Tylosin is used in treatment of cattle, swine and mycoplasmas in poultry Tylosin is a macrolide-class antibiotic used in veterinary medicine. It has a...
Streptothricin F
Formula: C19H34N8O8 (502.2499)
Streptothricin is an N-glycosyl compound consisting of 2-amino-4-O-carbamoyl-2-deoxy-N-[(3aS,7R,7aS)-7-hydroxy-4-oxooctahydro-2H-imidazo[4,5-c]pyridin...
5-Hydroxyectoine
A carboxamidine heterocycle which is obtained by formal condensation of 4-amino-L-allothreonine with acetic acid." []
7-Hydroxystaurosporine
Formula: C28H26N4O4 (482.1954)
UCN-01 is an indolocarbazole. Ucn-01 is a natural product found in Streptomyces with data available.
Antramycin
Formula: C16H17N3O4 (315.1219)
Anthramycin is a member of the class of pyrrolobenzodiazepines that is (11aS)-5,10,11,11a-tetrahydro-1H-pyrrolo[2,1-c][1,4]benzodiazepine substituted ...
beta-Caryophyllene alcohol
beta-Caryophyllene alcohol is found in citrus. beta-Caryophyllene alcohol is a constituent of grapefruit juice, pimento berry, Korean chamchwi and the...
Granaticin
Granaticin is a benzoisochromanequinone and a member of p-quinones. It has a role as an antineoplastic agent and a metabolite. Litomycin is a natural...
2,4.6-Trichloroanisole
1,3,5-Trichloro-2-methoxybenzene is found in alcoholic beverages. Off-odour component found in foods etc. Responsible for 'cork taint' in wine
Bohemamine B
Formula: C14H20N2O3 (264.1474)
Quinomycin A
Formula: C51H64N12O12S2 (1100.4208)
A cytotoxic polypeptide quinoxaline antibiotic isolated from Streptomyces echinatus that binds to DNA and inhibits RNA synthesis.
cytotrienin A
Formula: C37H48N2O8 (648.341)
A 21-membered macrocyclic lactam which contains three conjugated double bonds as part of the ring system. It acts as an apoptosis inducer in human leu...
Nebularine
Formula: C10H12N4O4 (252.0859)
Nebularine, also known as purine riboside is found in mushrooms. Nebularine can be isolated from the mushroom Clitocybe nebularis (clouded agaric). Ne...
Cinnabaramide A
Cinnabaramide A is a potent and selective inhibitor of the human 20S proteasome isolated from |FRAME: TAX-319633|, a soil bacterium isolated in Japan ...
Phospho gluconate
Phospho gluconate is a natural product found in Streptomyces with data available.
Hydroxyprolyl-Leucine
Formula: C11H20N2O4 (244.1423)
Hydroxyprolyl-Leucine is a dipeptide composed of hydroxyproline and leucine. It is an incomplete breakdown product of protein digestion or protein cat...
(+)-epi-Isozizaene
(+)-epi-isozizaene is a sesquiterpene. (+)-Epi-isozizaene has been reported in Streptomyces albidoflavus and Streptomyces coelicolor with data availa...
13-Desoxypaxilline
Dehydroxypaxilline is an organic heterotricyclic compound and an organooxygen compound. Dehydroxypaxilline has been reported in Claviceps paspali, Pe...
Furaquinocin D
Furaquinocin is a natural polyketide-isoprenoid hybrid (meroterpenoid) produced by |FRAME: TAX-285219| that exhibits antitumor activity |CITS: [209378...
Rabelomycin
Rabelomycin is an angucycline. Rabelomycin is a natural product found in Streptomyces, Micromonospora rosaria, and Streptomyces venezuelae with data ...
Dehydrorabelomycin
Dehydrorabelomycin is an angucycline. Dehydrorabelomycin is a natural product found in Streptomyces murayamaensis, Daphnia pulex, and other organisms...
Indigoidine
Indigoidine is a member of the class of pyridone that is a dimeric blue pigment biosynthesised from L-glutamine. It has a role as a bacterial metaboli...