Microbial Natural Product
Microbial natural products, primarily secondary metabolites produced by bacteria, fungi, and other microorganisms, remain a cornerstone of modern medicine and biotechnology. They form the foundation of numerous antibiotics (e.g., penicillin, streptomycin), anticancer agents, and immunosuppressants, addressing critical global health challenges like infectious diseases and cancer. Despite historical challenges such as compound rediscovery and complex biosynthesis, advances in genomics, metabolomics, and synthetic biology are unlocking novel chemical diversity from underexplored microbial sources. Consequently, microbial natural products continue to represent an unparalleled reservoir for discovering next-generation therapeutics, underscoring their enduring significance in drug development and sustainable bioprospecting. (98 words)
Cyclooctatin
4-(Hydroxymethyl)-1,8-dimethyl-12-propan-2-yltricyclo[9.3.0.03,7]tetradec-10-ene-6,8-diol has been reported in Streptomyces albus with data available.
Euxanthone
Euxanthone is found in fruits. Euxanthone occurs in Mammea americana (mamey), Platonia insignis (bakuri) and Mangifera indica (mango
kinamycin C
Formula: C24H20N2O10 (496.1118)
Kinamycin C is a kinamycin. Kinamycin C has been reported in Streptomyces murayamaensis with data available.
Platenolide I
Platenolide A is a macrolide. Platenolide A has been reported in Streptomyces ambofaciens with data available.
Vidarabine
Formula: C10H13N5O4 (267.0967)
A nucleoside antibiotic isolated from Streptomyces antibioticus. It has some antineoplastic properties and has broad spectrum activity against DNA vir...
2-Hydroxyethylclavam
2-Hydroxyethylclavam is a member of penams. Hydroxyethylclavam has been reported in Streptomyces antibioticus with data available.
Oleandrose
2,6-Dideoxy-3-O-methyl-arabino-hexose has been reported in Streptomyces avermitilis and Streptomyces antibioticus with data available.
3-Hydroxyanthranilate
3-Hydroxyanthranilic acid, also known as 2-amino-3-hydroxy-benzoate or 3-ohaa, belongs to the class of organic compounds known as hydroxybenzoic acid ...
Deoxyguanosine
Formula: C10H13N5O4 (267.0967)
Deoxyguanosine, also known as dG, belongs to the class of organic compounds known as purine 2'-deoxyribonucleosides. Purine 2'-deoxyribonucleosides ar...
oviedomycin
A member of the class of tetraphenes that is 1,4,7,12-tetrahydrotetraphene substituted by oxo groups at positions 1, 4, 7, and 12, by hydroxy groups a...
Virginiae butanolide A
Virginiae butanolide A is an aliphatic alcohol. Virginiae butanolide A has been reported in Streptomyces antibioticus and Streptomyces virginiae with...
Prephenate
Prephenate (CAS: 126-49-8), also known as prephenic acid, belongs to the class of organic compounds known as gamma-keto acids and derivatives. These a...
Crataegolic acid
Maslinic acid is a pentacyclic triterpene, found in the non-glyceride fraction of olive pomace oil (Olive pomace oil, also known as "orujo" olive oil,...
5-Hydroxy-3,6,7,8-tetramethoxyflavone
5-Hydroxy-3,6,7,8-tetramethoxyflavone
Dihydrooroxylin
Dihydrooroxylin is found in fruits. Dihydrooroxylin is isolated from Prunus avium (wild cherry) and Piper sp.
7-epi-ent-Eudesmane-5,11-diol
7-epi-ent-eudesmane-5,11-diol is a carbobicyclic compound that is decahydronaphthalene substituted at positions 2, 4a, 8 and 8a by 2-hydroxypropan-2-y...
Cholesterol
Cholesterol is a sterol (a combination steroid and alcohol) and a lipid found in the cell membranes of all body tissues and transported in the blood p...
Dodecanoic acid
Dodecanoic acid, also known as dodecanoate or lauric acid, belongs to the class of organic compounds known as medium-chain fatty acids. These are fatt...
Pentadecanoic acid
Pentadecanoic acid, also known as pentadecylic acid or C15:0, belongs to the class of organic compounds known as long-chain fatty acids. These are fat...
Hypogeic acid
Hypogeic acid is a fatty acids found in human milk Approximately 50% of the dietary calories in human milk are supplied to new-borns as fat. More than...
Berkeleyacetal A
Berkeleyacetal A is a furopyran. berkeleyacetal A is a natural product found in Penicillium ubiquetum and Penicillium with data available.
Heptadecanoic acid
Heptadecanoic acid is a fatty acid of exogenous (primarily ruminant) origin. Many "odd" length long chain amino acids are derived from the consumption...
Nonadecanoic acid
Nonadecanoic acid, also known as n-nonadecanoic acid or nonadecylic acid or C19:0, belongs to the class of organic compounds known as long-chain fatty...
Kaur-16-en-18-ol
Kaur-16-en-18-ol is a kaurane diterpenoid. ent-Kaur-16-en-19-ol is a natural product found in Disynaphia multicrenulata, Smallanthus fruticosus, and ...
RES-1149-2
RES-1149-2 is a naphthofuran. (2E,4E)-2,4,6-Octatrienoic acid [(5R)-1,3,5,5aalpha,6,7,8,9,9a,9balpha-decahydro-9balpha-hydroxy-6,6,9abeta-trimethyl-1...
9Z-Heptadecenoic acid
9Z-Heptadecenoic acid, also known as margaroleic acid, belongs to the class of organic compounds known as long-chain fatty acids. These are fatty acid...
Ipecoside
Formula: C27H35NO12 (565.2159)
Tubulosine
Formula: C29H37N3O3 (475.2835)
A member of the class of beta-carbolines that is tubulosan bearing methoxy groups at positions 10 and 11 and a hydroxy group at the 8' position." []
Emetine
Formula: C29H40N2O4 (480.2988)
A pyridoisoquinoline comprising emetam having methoxy substituents at the 6'-, 7'-, 10- and 11-positions. It is an antiprotozoal agent and emetic. It ...
Emetamine
Formula: C29H36N2O4 (476.2675)
A pyridoisoquinoline consisting of emetine having a fully aromatised isoquinoline." []
Cephaeline
Formula: C28H38N2O4 (466.2831)
A pyridoisoquinoline comprising emetam having a hydroxy group at the 6'-position and methoxy substituents at the 7'-, 10- and 11-positions." []
Alangiside
Formula: C25H31NO10 (505.1948)
An organic heterotetracyclic compound that is an alkaloidal glycoside isolated from Alangium salviifolium." []
o-Methylpsychotrine
Formula: C29H38N2O4 (478.2831)
Emesis Inducement (vomiting promoter) Drug Dollery, Colin Therapeutic Drugs, 2nd Ed. 1999 p. I72
Demethylalangiside
Formula: C24H29NO10 (491.1791)
Demethylalangiside is a glycoside. Demethylalangiside is a natural product found in Alangium salviifolium, Alangium kurzii, and other organisms with ...
Progesterone
The major progestational steroid that is secreted primarily by the corpus luteum and the placenta. Progesterone acts on the uterus, the mammary glands...
Streptomycin 6-phosphate
Formula: C21H40N7O15P (661.232)
Streptomycin 6-phosphate is a streptomycin phosphate. It is a conjugate base of a streptomycin 6-phosphate(1+). Streptomycin 6-phosphate is a natural...
Dihydrostreptomycin 6-phosphate
Formula: C21H42N7O15P (663.2476)
The 6-O-phospho derivative of dihydrostreptomycin." []