Tetracycline (BioCAD00000018373)
Metabolite Card
Chinese Name: 四环素
Formula: C22H24N2O8 (444.1533)
SMILES:
[H][C@@]12C[C@@]3([H])C(=C(O)[C@]1(O)C(=O)C(C(N)=O)=C(O)[C@H]2N(C)C)C(=O)C1=C(O)C=CC=C1[C@@]3(C)OSynonyms [en]
tetracycline; Tetracyclinum; Tetrazyklin; Abramycin; Achromycin; Liquamycin
Last reviewed on 2026-04-16.
Cite this Page
Tetracycline. 数据之源，洞见之始. SMRUCC genomics institute, a synthetic life researcher from China.
https://biocad_registry.innovation.ac.cn/s/Tetracycline
(retrieved
2026-08-20) (CAD Registry RN: BioCAD00000018373). Licensed
under the Attribution-Noncommercial 4.0 International License (CC BY-NC 4.0).
Note
Tetracycline is a broad spectrum polyketide antibiotic produced by the Streptomyces genus of Actinobacteria. It exerts a bacteriostatic effect on bacteria by binding reversible to the bacterial 30S ribosomal subunit and blocking incoming aminoacyl tRNA from binding to the ribosome acceptor site. It also binds to some extent to the bacterial 50S ribosomal subunit and may alter the cytoplasmic membrane causing intracellular components to leak from bacterial cells.
DBLinks
- CAS Registry Number: 60-54-8
- PubChem CID: 54675776
- ChEBI: 27902
- HMDB: HMDB0014897
- LipidMaps:
- KEGG: C06570
- BioCyc: CPD0-1414
- NCBI MeSH: Tetracycline
- Wikipedia: Tetracycline
Other DBLinks
- CAS Registry Number: 21204-32-0
- CAS Registry Number: 60-54-8
- CAS Registry Number: 60-54-8 (FREE BASE)
- CAS Registry Number: 64-75-5
- CAS Registry Number: 6416-04-2 (3H2O)
- CAS Registry Number: 6543-77-7
- CAS Registry Number: 79-85-6
- PubChem: 5353990
- PubChem: 5412
- PubChem: 54675776
- PubChem: 54681536
- PubChem: 54682506
- PubChem: 54699147
- ChEBI: ChEBI:27902
- HMDB: HMDB0014897
- KEGG: C06570
- KEGG: C06973
- BioCyc: CPD0-1414
- NCBI MeSH: Tetracycline
- Wikipedia: Tetracycline
- DrugBank: DB00759
- RefMet: RM0136872
- MoNA: CCMSLIB00003739945
- MoNA: CO000466
- MoNA: CO000467
- MoNA: CO000468
- MoNA: CO000469
- MoNA: CO000470
- MoNA: EQ323501
- MoNA: EQ323502
- MoNA: EQ323552
- MoNA: EQ323553
- MoNA: EQ323555
- MoNA: HB001901
- MoNA: HB001902
- MoNA: HB001903
- MoNA: HB001904
- MoNA: HB001905
- MoNA: HB001906
- MoNA: HB001907
- MoNA: HB001908
- MoNA: HB001909
- MoNA: HB001910
- MoNA: HB001911
- MoNA: HB001912
- MoNA: HB001913
- MoNA: HB001914
- MoNA: HB001915
- MoNA: HB001916
- MoNA: HB001917
- MoNA: HB001918
- MoNA: HB001919
- MoNA: HB001920
- MoNA: HB001921
- MoNA: HB001922
- MoNA: HB001923
- MoNA: HB001924
- MoNA: HB001925
- MoNA: HB001926
- MoNA: HB001927
- MoNA: HB001928
- MoNA: HB001929
- MoNA: HB001930
- MoNA: HB001931
- MoNA: HB001932
- MoNA: HB001933
- MoNA: HB001934
- MoNA: HB001935
- MoNA: HB001936
- MoNA: HB001937
- MoNA: HB001938
- MoNA: HB001939
- MoNA: HB001940
- MoNA: HB001941
- MoNA: HB001942
- MoNA: HB001943
- MoNA: HB001944
- MoNA: HB001945
- MoNA: HB001946
- MoNA: HB001947
- MoNA: HB001948
- MoNA: HB001949
- MoNA: HB001950
- MoNA: HB001951
- MoNA: HB001952
- MoNA: HB001953
- MoNA: HB001954
- MoNA: HB001955
- MoNA: HB001956
- MoNA: HB001957
- MoNA: HB001958
- MoNA: HB001959
- MoNA: HB001960
- Metlin: METLIN_2811
- Coconut NaturalProduct: CNP0204626.1
- Coconut NaturalProduct: CNP0295709.1
- Coconut NaturalProduct: CNP0295709.2
- Coconut NaturalProduct: CNP0308106.1
- Coconut NaturalProduct: CNP0326169.1
- Coconut NaturalProduct: CNP0326169.2
- PMHub: MS000002119
- metaboanalyst: a096ecb6e5a92b2f886bc57e859e00ba
Class / Ontology
- WishartLab ClassyFire: [Tetracyclines] Tetracyclines
- RefMet: [Tetracyclines] Tetracyclines
- ChEBI: [CHEBI:27902] tetracycline
- Coconut NaturalProduct: [Anthracyclines] Anthracyclines
- Coconut NaturalProduct: [Tetracyclines] Tetracyclines
- Coconut NaturalProduct: [Eremophilane sesquiterpenoids] Eremophilane sesquiterpenoids
| ID | EC Number | Name |
|---|---|---|
| KEGG:R05459 | 1.3.98.4 | tetracycline:coenzyme-F420 oxidoreductase |
| KEGG:R11449 | 1.14.13.231 | tetracycline,NADPH:oxygen oxidoreductase (11a-hydroxylating) |
| KEGG:R11478 | 1.14.19.49 | tetracycline:FADH2 oxidoreductase (7-halogenating) |
| BioCyc:RXN-17988 | 1.3.98.4 | 12-DEHYDROTETRACYCLINE + Reduced-Factor-F420 --> CPD0-1414 + Oxidized-Factor-F420 |
| BioCyc:RXN-17996 | 1.14.19.49 | CPD0-1414 + OXYGEN-MOLECULE + CL- + FADH2 --> CPD-19258 + 2 WATER + FAD + PROTON |
| BioCyc:RXN-17967 | 1.14.13.231 | CPD0-1414 + OXYGEN-MOLECULE + NADPH + PROTON --> CPD-19252 + WATER + NADP |
| BioCyc:TRANS-RXN-391 | CPD0-1414 --> CPD0-1414 | |
| BioCyc:RXN-17971 | CPD0-1414 + OXYGEN-MOLECULE + NADPH --> CPD-19263 + NADP + 2 WATER + 2 CARBON-MONOXIDE | |
| Manual Audit:BIOCAD_RXN-85566 | 7.6.2.- | ABC-type drug exporters[Tetracycline] |
| Manual Audit:BIOCAD_RXN-85572 | 1.14.13.- | 11a-Hydroxylation of Tetracyclines[Tetracycline] |
Taxonomy Source
- Othonna spp. [ncbi taxid: ]
- Streptomyces coeruleorubidus [ncbi taxid: 116188]
- Streptomyces [ncbi taxid: 1883]
- Streptomyces albus DSM 41398 [ncbi taxid: ]
- Streptomyces aureofaciens [ncbi taxid: ]
- Streptomyces aureofaciens 84/25 [ncbi taxid: ]
- Streptomyces aureofaciens ATCC 10762 [ncbi taxid: ]
- Streptomyces aureofaciens BMK [ncbi taxid: ]
- Streptomyces aureofaciens CG-1 [ncbi taxid: ]
- Streptomyces aureofaciens LMG 5968 [ncbi taxid: ]
- Streptomyces aureofaciens NRRL 3203 [ncbi taxid: ]
- Streptomyces rimosus [ncbi taxid: 1927]
Pathway Synthetic
| pathway id | name |
|---|---|
| PathBank:SMP0000294 | Tetracycline Action Pathway |