Tetracycline
Tetracycline is a broad spectrum polyketide antibiotic produced by the Streptomyces genus of Actinobacteria. It exerts a bacteriostatic effect on bacteria by binding reversible to the bacterial 30S ribosomal subunit and blocking incoming aminoacyl tRNA from binding to the ribosome acceptor site. It also binds to some extent to the bacterial 50S ribosomal subunit and may alter the cytoplasmic membrane causing intracellular components to leak from bacterial cells.
| ID | EC Number | Name |
|---|---|---|
| KEGG:R05459 | 1.3.98.4 | tetracycline:coenzyme-F420 oxidoreductase |
| KEGG:R11449 | 1.14.13.231 | tetracycline,NADPH:oxygen oxidoreductase (11a-hydroxylating) |
| KEGG:R11478 | 1.14.19.49 | tetracycline:FADH2 oxidoreductase (7-halogenating) |
| BioCyc:RXN-17988 | 1.3.98.4 | 12-DEHYDROTETRACYCLINE + Reduced-Factor-F420 --> CPD0-1414 + Oxidized-Factor-F420 |
| BioCyc:RXN-17996 | 1.14.19.49 | CPD0-1414 + OXYGEN-MOLECULE + CL- + FADH2 --> CPD-19258 + 2 WATER + FAD + PROTON |
| BioCyc:RXN-17967 | 1.14.13.231 | CPD0-1414 + OXYGEN-MOLECULE + NADPH + PROTON --> CPD-19252 + WATER + NADP |
| BioCyc:TRANS-RXN-391 | CPD0-1414 --> CPD0-1414 | |
| BioCyc:RXN-17971 | CPD0-1414 + OXYGEN-MOLECULE + NADPH --> CPD-19263 + NADP + 2 WATER + 2 CARBON-MONOXIDE | |
| Manual Audit:BIOCAD_RXN-85566 | 7.6.2.- | ABC-type drug exporters[Tetracycline] |
| Manual Audit:BIOCAD_RXN-85572 | 1.14.13.- | 11a-Hydroxylation of Tetracyclines[Tetracycline] |