Pathways Knowlegdes

Biological pathway database

Pathway DOIs Note
Sensory perception of taste

Accession ID: Reactome:R-CFA-9717189
  • 10.1007/s00424-020-02464-4
  • 10.1016/j.neuron.2014.02.022
  • 10.1038/nature08783
  • 10.1038/nrn.2017.68
  • 10.12688/f1000research.21099.1
 Taruno A, Nomura K, Kusakizako T, Ma Z, Nureki O, Foskett JK. Taste transduction and channel synapses in taste buds. Pflügers Archiv - European Journal of Physiology. 2020 Sep 16;473(1):3–13. doi: 10.1007/s00424-020-02464-4.; Kinnamon SC, Finger TE. Recent advances in taste transduction and signaling. F1000Res. 2019 Dec 17;8():2117. doi: 10.12688/f1000research.21099.1.; Roper SD, Chaudhari N. Taste buds: cells, signals and synapses. Nature Reviews Neuroscience. 2017 Jun 29;18(8):485–97. doi: 10.1038/nrn.2017.68.; Liman ER, Zhang YV, Montell C. Peripheral coding of taste. Neuron. 2014 Mar 05;81(5):984–1000. PMID: 24607224; PMCID: PMC3994536.; Chandrashekar J, Kuhn C, Oka Y, Yarmolinsky DA, Hummler E, Ryba NJ, Zuker CS. The cells and peripheral representation of sodium taste in mice. Nature. 2010 Mar 11;464(7286):297–301. PMID: 20107438; PMCID: PMC2849629.
Azathioprine ADME

Accession ID: Reactome:R-CEL-9748787
  • 10.1016/s1542-3565(04)00344-1
  • 10.1136/gut.39.3.401
  • 10.3389/fphar.2020.582291
  • 10.3748/wjg.v22.i20.4794
 Tominaga K, Sugaya T, Tanaka T, Kanazawa M, Iijima M, Irisawa A. Thiopurines: Recent Topics and Their Role in the Treatment of Inflammatory Bowel Diseases. Front Pharmacol. 2020;11():582291. PMID: 33584261; PMCID: PMC7878672.; Axelrad JE, Lichtiger S, Yajnik V. Inflammatory bowel disease and cancer: The role of inflammation, immunosuppression, and cancer treatment. World J Gastroenterol. 2016 May 28;22(20):4794–801. PMID: 27239106; PMCID: PMC4873872.; Dubinsky MC. Azathioprine, 6-mercaptopurine in inflammatory bowel disease: pharmacology, efficacy, and safety. Clin Gastroenterol Hepatol. 2004 Sep;2(9):731–43. doi: 10.1016/s1542-3565(04)00344-1. PMID: 15354273.; Cuffari C, Théorêt Y, Latour S, Seidman G. 6-Mercaptopurine metabolism in Crohn's disease: correlation with efficacy and toxicity. Gut. 1996 Sep;39(3):401–6. PMID: 8949645; PMCID: PMC1383347.
Drug ADME

Accession ID: Reactome:R-DME-9748784
  • 10.1002/jps.21009
  • 10.2967/jnmt.117.199638
 Currie GM. Pharmacology, Part 2: Introduction to Pharmacokinetics. J Nucl Med Technol. 2018 Sep;46(3):221–30. doi: 10.2967/jnmt.117.199638. PMID: 29724803.; Ruiz-Garcia A, Bermejo M, Moss A, Casabo VG. Pharmacokinetics in Drug Discovery. Journal of Pharmaceutical Sciences. 2008 Feb;97(2):654–90. doi: 10.1002/jps.21009.; Pallasch TJ. Principles of pharmacotherapy: II. Pharmacokinetics. Anesth Prog. 1988 Jul;35(4):133–46. PMID: 3046441; PMCID: PMC2167950.
Azathioprine ADME

Accession ID: Reactome:R-GGA-9748787
  • 10.1016/s1542-3565(04)00344-1
  • 10.1136/gut.39.3.401
  • 10.3389/fphar.2020.582291
  • 10.3748/wjg.v22.i20.4794
 Tominaga K, Sugaya T, Tanaka T, Kanazawa M, Iijima M, Irisawa A. Thiopurines: Recent Topics and Their Role in the Treatment of Inflammatory Bowel Diseases. Front Pharmacol. 2020;11():582291. PMID: 33584261; PMCID: PMC7878672.; Axelrad JE, Lichtiger S, Yajnik V. Inflammatory bowel disease and cancer: The role of inflammation, immunosuppression, and cancer treatment. World J Gastroenterol. 2016 May 28;22(20):4794–801. PMID: 27239106; PMCID: PMC4873872.; Dubinsky MC. Azathioprine, 6-mercaptopurine in inflammatory bowel disease: pharmacology, efficacy, and safety. Clin Gastroenterol Hepatol. 2004 Sep;2(9):731–43. doi: 10.1016/s1542-3565(04)00344-1. PMID: 15354273.; Cuffari C, Théorêt Y, Latour S, Seidman G. 6-Mercaptopurine metabolism in Crohn's disease: correlation with efficacy and toxicity. Gut. 1996 Sep;39(3):401–6. PMID: 8949645; PMCID: PMC1383347.
Drug ADME

Accession ID: Reactome:R-HSA-9748784
  • 10.1002/jps.21009
  • 10.2967/jnmt.117.199638
 Currie GM. Pharmacology, Part 2: Introduction to Pharmacokinetics. J Nucl Med Technol. 2018 Sep;46(3):221–30. doi: 10.2967/jnmt.117.199638. PMID: 29724803.; Ruiz-Garcia A, Bermejo M, Moss A, Casabo VG. Pharmacokinetics in Drug Discovery. Journal of Pharmaceutical Sciences. 2008 Feb;97(2):654–90. doi: 10.1002/jps.21009.; Pallasch TJ. Principles of pharmacotherapy: II. Pharmacokinetics. Anesth Prog. 1988 Jul;35(4):133–46. PMID: 3046441; PMCID: PMC2167950.
Azathioprine ADME

Accession ID: Reactome:R-MMU-9748787
  • 10.1016/s1542-3565(04)00344-1
  • 10.1136/gut.39.3.401
  • 10.3389/fphar.2020.582291
  • 10.3748/wjg.v22.i20.4794
 Tominaga K, Sugaya T, Tanaka T, Kanazawa M, Iijima M, Irisawa A. Thiopurines: Recent Topics and Their Role in the Treatment of Inflammatory Bowel Diseases. Front Pharmacol. 2020;11():582291. PMID: 33584261; PMCID: PMC7878672.; Axelrad JE, Lichtiger S, Yajnik V. Inflammatory bowel disease and cancer: The role of inflammation, immunosuppression, and cancer treatment. World J Gastroenterol. 2016 May 28;22(20):4794–801. PMID: 27239106; PMCID: PMC4873872.; Dubinsky MC. Azathioprine, 6-mercaptopurine in inflammatory bowel disease: pharmacology, efficacy, and safety. Clin Gastroenterol Hepatol. 2004 Sep;2(9):731–43. doi: 10.1016/s1542-3565(04)00344-1. PMID: 15354273.; Cuffari C, Théorêt Y, Latour S, Seidman G. 6-Mercaptopurine metabolism in Crohn's disease: correlation with efficacy and toxicity. Gut. 1996 Sep;39(3):401–6. PMID: 8949645; PMCID: PMC1383347.
Sensory perception of salty taste

Accession ID: Reactome:R-BTA-9730628
  • 10.1002/ana.21895
  • 10.1007/s00424-014-1683-z
  • 10.1016/j.neuron.2020.03.006
  • 10.1093/chemse/bjaa004
  • 10.1093/chemse/bjh002
  • 10.3390/nu12041195
 Nomura K, Nakanishi M, Ishidate F, Iwata K, Taruno A. All-Electrical Ca2+-Independent Signal Transduction Mediates Attractive Sodium Taste in Taste Buds. Neuron. 2020 Jun 03;106(5):816–829.e6. doi: 10.1016/j.neuron.2020.03.006. PMID: 32229307.; Bigiani A. Does ENaC Work as Sodium Taste Receptor in Humans? Nutrients. 2020 Apr 24;12(4). PMID: 32344597; PMCID: PMC7230849.; Lossow K, Hermans-Borgmeyer I, Meyerhof W, Behrens M. Segregated Expression of ENaC Subunits in Taste Cells. Chem Senses. 2020 May 21;45(4):235–48. doi: 10.1093/chemse/bjaa004. PMID: 32006019.; Roper SD. The taste of table salt. Pflügers Archiv - European Journal of Physiology. 2015 Jan 07;467(3):457–63. doi: 10.1007/s00424-014-1683-z.; Estacion M, Harty TP, Choi JS, Tyrrell L, Dib-Hajj SD, Waxman SG. A sodium channel gene SCN9A polymorphism that increases nociceptor excitability. Ann Neurol. 2009 Dec;66(6):862–6. doi: 10.1002/ana.21895. PMID: 20033988.; Rossier O, Cao J, Huque T, Spielman AI, Feldman RS, Medrano JF, Brand JG, le Coutre J. Analysis of a human fungiform papillae cDNA library and identification of taste-related genes. Chem Senses. 2004 Jan;29(1):13–23. doi: 10.1093/chemse/bjh002. PMID: 14752036.
Ribavirin ADME

Accession ID: Reactome:R-HSA-9755088
  • 10.1007/s00018-005-5455-y
  • 10.1016/j.xphs.2016.01.017
 Goodarzi N, Barazesh Morgani A, Abrahamsson B, Cristofoletti R, Groot DW, Langguth P, Mehta MU, Polli JE, Shah VP, Dressman JB. Biowaiver Monographs for Immediate Release Solid Oral Dosage Forms: Ribavirin. Journal of Pharmaceutical Sciences. 2016 Apr;105(4):1362–9. doi: 10.1016/j.xphs.2016.01.017.; Dixit NM, Perelson AS. The metabolism, pharmacokinetics and mechanisms of antiviral activity of ribavirin against hepatitis C virus. Cellular and Molecular Life Sciences. 2006 Feb 23;63(7-8):832–42. doi: 10.1007/s00018-005-5455-y.
High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells

Accession ID: Reactome:R-HSA-9856530
  • 10.1002/cm.21652
  • 10.1016/j.ceb.2023.102216
  • 10.1038/nature13701
  • 10.1038/s41569-023-00883-1
  • 10.1073/pnas.1409233111
  • 10.1115/1.3138275
  • 10.1115/1.3138276
  • 10.1152/ajpcell.00083.2007
  • 10.1172/jci87343
  • 10.1186/s13578-020-00522-z
  • 10.2741/3000
  • 10.3109/07853890.2011.585658
  • 10.3390/ijms23115883
 Xiao R, Liu J, Shawn Xu XZ. Mechanosensitive GPCRs and ion channels in shear stress sensing. Current Opinion in Cell Biology. 2023 Oct;84():102216. doi: 10.1016/j.ceb.2023.102216.; Tamargo IA, Baek KI, Kim Y, Park C, Jo H. Flow-induced reprogramming of endothelial cells in atherosclerosis. Nat Rev Cardiol. 2023 May 24;20(11):738–53. doi: 10.1038/s41569-023-00883-1.; Cabou C, Martinez LO. The Interplay of Endothelial P2Y Receptors in Cardiovascular Health: From Vascular Physiology to Pathology. Int J Mol Sci. 2022 May 24;23(11). PMID: 35682562; PMCID: PMC9180512.; Tanaka K, Joshi D, Timalsina S, Schwartz MA. Early events in endothelial flow sensing. Cytoskeleton (Hoboken). 2021 Jun;78(6):217–31. doi: 10.1002/cm.21652. PMID: 33543538.; Fang XZ, Zhou T, Xu JQ, Wang YX, Sun MM, He YJ, Pan SW, Xiong W, Peng ZK, Gao XH, Shang Y. Structure, kinetic properties and biological function of mechanosensitive Piezo channels. Cell Biosci. 2021 Jan 09;11(1):13. PMID: 33422128; PMCID: PMC7796548.; Wang S, Chennupati R, Kaur H, Iring A, Wettschureck N, Offermanns S. Endothelial cation channel PIEZO1 controls blood pressure by mediating flow-induced ATP release. J Clin Invest. 2016 Dec 01;126(12):4527–36. PMID: 27797339; PMCID: PMC5127677.; Li J, Hou B, Tumova S, Muraki K, Bruns A, Ludlow MJ, Sedo A, Hyman AJ, McKeown L, Young RS, Yuldasheva NY, Majeed Y, Wilson LA, Rode B, Bailey MA, Kim HR, Fu Z, Carter DA, Bilton J, Imrie H, Ajuh P, Dear TN, Cubbon RM, Kearney MT, Prasad RK, Evans PC, Ainscough JF, Beech DJ. Piezo1 integration of vascular architecture with physiological force. Nature. 2014 Nov 13;515(7526):279–82. PMID: 25119035; PMCID: PMC4230887.; Ranade SS, Qiu Z, Woo SH, Hur SS, Murthy SE, Cahalan SM, Xu J, Mathur J, Bandell M, Coste B, Li YS, Chien S, Patapoutian A. Piezo1, a mechanically activated ion channel, is required for vascular development in mice. Proc Natl Acad Sci U S A. 2014 Jul 15;111(28):10347–52. PMID: 24958852; PMCID: PMC4104881.; Félétou M, Köhler R, Vanhoutte PM. Nitric oxide: orchestrator of endothelium-dependent responses. Ann Med. 2012 Nov;44(7):694–716. doi: 10.3109/07853890.2011.585658. PMID: 21895549.; Feletou M, Tang EH, Vanhoutte PM. Nitric oxide the gatekeeper of endothelial vasomotor control. Front Biosci. 2008 May 01;13():4198–217. doi: 10.2741/3000. PMID: 18508506.; Miyazaki T, Honda K, Ohata H. Requirement of Ca2+ influx- and phosphatidylinositol 3-kinase-mediated m-calpain activity for shear stress-induced endothelial cell polarity. American Journal of Physiology-Cell Physiology. 2007 Oct;293(4):C1216–25. doi: 10.1152/ajpcell.00083.2007.; Nerem RM, Levesque MJ, Cornhill JF. Vascular endothelial morphology as an indicator of the pattern of blood flow. J Biomech Eng. 1981 Aug;103(3):172–6. doi: 10.1115/1.3138275. PMID: 7278195.; Dewey CF, Bussolari SR, Gimbrone MA, Davies PF. The dynamic response of vascular endothelial cells to fluid shear stress. J Biomech Eng. 1981 Aug;103(3):177–85. doi: 10.1115/1.3138276. PMID: 7278196.
SLC-mediated bile acid transport

Accession ID: Reactome:R-BTA-9958517
  • 10.1016/s0014-5793(00)02134-7
  • 10.1111/j.1471-4159.2004.02962.x
 Traiffort E, Ruat M, O'Regan S, Meunier FM. Molecular characterization of the family of choline transporter-like proteins and their splice variants. Journal of Neurochemistry. 2005 Feb 04;92(5):1116–25. doi: 10.1111/j.1471-4159.2004.02962.x.; Okuda T, Haga T. Functional characterization of the human high-affinity choline transporter. FEBS Lett. 2000 Nov 03;484(2):92–7. doi: 10.1016/s0014-5793(00)02134-7. PMID: 11068039.
SLC-mediated transport of organic anions

Accession ID: Reactome:R-CEL-9955298		 -
SLC-mediated transport of organic anions

Accession ID: Reactome:R-CFA-9955298		 -
SLC-mediated transport of organic anions

Accession ID: Reactome:R-DRE-9955298		 -
SLC-mediated transport of amino acids

Accession ID: Reactome:R-DME-9958863		 -
SLC-mediated transport of amino acids

Accession ID: Reactome:R-GGA-9958863		 -
SLC-mediated transport of inorganic anions

Accession ID: Reactome:R-HSA-9958790
  • 10.1007/s00424-003-1066-3
  • 10.1007/s00424-003-1088-x
  • 10.1038/sj.ki.5001813
  • 10.1152/ajprenal.00228.2007
  • 10.1152/ajprenal.00252.2005
 Virkki LV, Biber J, Murer H, Forster IC. Phosphate transporters: a tale of two solute carrier families. American Journal of Physiology-Renal Physiology. 2007 Sep;293(3):F643–54. doi: 10.1152/ajprenal.00228.2007.; Forster IC, Hernando N, Biber J, Murer H. Proximal tubular handling of phosphate: A molecular perspective. Kidney Int. 2006 Nov;70(9):1548–59. doi: 10.1038/sj.ki.5001813. PMID: 16955105.; Pushkin A, Kurtz I. SLC4 base (HCO3-, CO32-) transporters: classification, function, structure, genetic diseases, and knockout models. American Journal of Physiology-Renal Physiology. 2006 Mar;290(3):F580–99. doi: 10.1152/ajprenal.00252.2005.; Hebert SC, Mount DB, Gamba G. Molecular physiology of cation-coupled Cl- cotransport: the SLC12 family. Pflügers Archiv - European Journal of Physiology. 2003 May 09;447(5):580–93. doi: 10.1007/s00424-003-1066-3.; Collins JF, Bai L, Ghishan FK. The SLC20 family of proteins: dual functions as sodium-phosphate cotransporters and viral receptors. Pflügers Archiv - European Journal of Physiology. 2003 May 21;447(5):647–52. doi: 10.1007/s00424-003-1088-x.
SLC-mediated transport of amino acids

Accession ID: Reactome:R-MMU-9958863		 -
SLC-mediated transport of amino acids

Accession ID: Reactome:R-PFA-9958863		 -
SLC-mediated transport of amino acids

Accession ID: Reactome:R-RNO-9958863		 -
SLC-mediated transport of inorganic anions

Accession ID: Reactome:R-SPO-9958790
  • 10.1007/s00424-003-1066-3
  • 10.1007/s00424-003-1088-x
  • 10.1038/sj.ki.5001813
  • 10.1152/ajprenal.00228.2007
  • 10.1152/ajprenal.00252.2005
 Virkki LV, Biber J, Murer H, Forster IC. Phosphate transporters: a tale of two solute carrier families. American Journal of Physiology-Renal Physiology. 2007 Sep;293(3):F643–54. doi: 10.1152/ajprenal.00228.2007.; Forster IC, Hernando N, Biber J, Murer H. Proximal tubular handling of phosphate: A molecular perspective. Kidney Int. 2006 Nov;70(9):1548–59. doi: 10.1038/sj.ki.5001813. PMID: 16955105.; Pushkin A, Kurtz I. SLC4 base (HCO3-, CO32-) transporters: classification, function, structure, genetic diseases, and knockout models. American Journal of Physiology-Renal Physiology. 2006 Mar;290(3):F580–99. doi: 10.1152/ajprenal.00252.2005.; Hebert SC, Mount DB, Gamba G. Molecular physiology of cation-coupled Cl- cotransport: the SLC12 family. Pflügers Archiv - European Journal of Physiology. 2003 May 09;447(5):580–93. doi: 10.1007/s00424-003-1066-3.; Collins JF, Bai L, Ghishan FK. The SLC20 family of proteins: dual functions as sodium-phosphate cotransporters and viral receptors. Pflügers Archiv - European Journal of Physiology. 2003 May 21;447(5):647–52. doi: 10.1007/s00424-003-1088-x.