Pathways Knowlegdes

Biological pathway database

Pathway DOIs Note
SLC-mediated transport of organic anions

Accession ID: Reactome:R-SSC-9955298		 -
SLC-mediated bile acid transport

Accession ID: Reactome:R-XTR-9958517
  • 10.1016/s0014-5793(00)02134-7
  • 10.1111/j.1471-4159.2004.02962.x
 Traiffort E, Ruat M, O'Regan S, Meunier FM. Molecular characterization of the family of choline transporter-like proteins and their splice variants. Journal of Neurochemistry. 2005 Feb 04;92(5):1116–25. doi: 10.1111/j.1471-4159.2004.02962.x.; Okuda T, Haga T. Functional characterization of the human high-affinity choline transporter. FEBS Lett. 2000 Nov 03;484(2):92–7. doi: 10.1016/s0014-5793(00)02134-7. PMID: 11068039.
Response of endothelial cells to shear stress

Accession ID: Reactome:R-HSA-9860931
  • 10.1002/cm.21652
  • 10.1007/s11883-023-01139-6
  • 10.1016/j.ceb.2023.102216
  • 10.1038/21224
  • 10.1038/nature03952
  • 10.1038/nature13701
  • 10.1038/ncb3405
  • 10.1038/s41569-023-00883-1
  • 10.1084/jem.20180483
  • 10.1093/cvr/cvad076
  • 10.1146/annurev-physiol-042022-030946
  • 10.1152/ajpcell.00083.2007
  • 10.1152/physrev.00053.2021
  • 10.1172/jci123825
  • 10.1172/jci145734
  • 10.1172/jci81067
  • 10.1186/s13578-020-00522-z
  • 10.3389/fcell.2021.675562
 Lim XR, Harraz OF. Mechanosensing by Vascular Endothelium. Annu. Rev. Physiol. 2024 Feb 12;86(1):71–97. doi: 10.1146/annurev-physiol-042022-030946.; Xiao R, Liu J, Shawn Xu XZ. Mechanosensitive GPCRs and ion channels in shear stress sensing. Current Opinion in Cell Biology. 2023 Oct;84():102216. doi: 10.1016/j.ceb.2023.102216.; Rahaman SG, Mahanty M, Mukherjee P, Dutta B, Rahaman SO. Mechanosensing and Mechanosignal Transduction in Atherosclerosis. Curr Atheroscler Rep. 2023 Oct;25(10):711–21. doi: 10.1007/s11883-023-01139-6. PMID: 37615786.; Tamargo IA, Baek KI, Kim Y, Park C, Jo H. Flow-induced reprogramming of endothelial cells in atherosclerosis. Nat Rev Cardiol. 2023 May 24;20(11):738–53. doi: 10.1038/s41569-023-00883-1.; Wang X, Shen Y, Shang M, Liu X, Munn LL. Endothelial mechanobiology in atherosclerosis. Cardiovasc Res. 2023 Jul 06;119(8):1656–75. PMID: 37163659; PMCID: PMC10325702.; Davis MJ, Earley S, Li Y, Chien S. Vascular mechanotransduction. Physiological Reviews. 2023 Apr 01;103(2):1247–421. doi: 10.1152/physrev.00053.2021.; Jin YJ, Chennupati R, Li R, Liang G, Wang S, Iring A, Graumann J, Wettschureck N, Offermanns S. Protein kinase N2 mediates flow-induced endothelial NOS activation and vascular tone regulation. J Clin Invest. 2021 Nov 01;131(21). PMID: 34499618; PMCID: PMC8553558.; Jiang X, Hu J, Wu Z, Cafarello ST, Di Matteo M, Shen Y, Dong X, Adler H, Mazzone M, Ruiz de Almodovar C, Wang X. Protein Phosphatase 2A Mediates YAP Activation in Endothelial Cells Upon VEGF Stimulation and Matrix Stiffness. Front Cell Dev Biol. 2021;9():675562. PMID: 34055807; PMCID: PMC8158299.; Tanaka K, Joshi D, Timalsina S, Schwartz MA. Early events in endothelial flow sensing. Cytoskeleton (Hoboken). 2021 Jun;78(6):217–31. doi: 10.1002/cm.21652. PMID: 33543538.; Fang XZ, Zhou T, Xu JQ, Wang YX, Sun MM, He YJ, Pan SW, Xiong W, Peng ZK, Gao XH, Shang Y. Structure, kinetic properties and biological function of mechanosensitive Piezo channels. Cell Biosci. 2021 Jan 09;11(1):13. PMID: 33422128; PMCID: PMC7796548.; Iring A, Jin YJ, Albarrán-Juárez J, Siragusa M, Wang S, Dancs PT, Nakayama A, Tonack S, Chen M, Künne C, Sokol AM, Günther S, Martínez A, Fleming I, Wettschureck N, Graumann J, Weinstein LS, Offermanns S. Shear stress-induced endothelial adrenomedullin signaling regulates vascular tone and blood pressure. J Clin Invest. 2019 Jun 17;129(7):2775–91. PMID: 31205027; PMCID: PMC6597232.; Albarrán-Juárez J, Iring A, Wang S, Joseph S, Grimm M, Strilic B, Wettschureck N, Althoff TF, Offermanns S. Piezo1 and Gq/G11 promote endothelial inflammation depending on flow pattern and integrin activation. J Exp Med. 2018 Oct 01;215(10):2655–72. PMID: 30194266; PMCID: PMC6170174.; Yun S, Budatha M, Dahlman JE, Coon BG, Cameron RT, Langer R, Anderson DG, Baillie G, Schwartz MA. Interaction between integrin a5 and PDE4D regulates endothelial inflammatory signalling. Nat Cell Biol. 2016 Oct;18(10):1043–53. PMID: 27595237; PMCID: PMC5301150.; Wang S, Iring A, Strilic B, Albarrán Juárez J, Kaur H, Troidl K, Tonack S, Burbiel JC, Müller CE, Fleming I, Lundberg JO, Wettschureck N, Offermanns S. P2Y2 and Gq/G11 control blood pressure by mediating endothelial mechanotransduction. J Clin Invest. 2015 Aug 03;125(8):3077–86. PMID: 26168216; PMCID: PMC4563756.; Li J, Hou B, Tumova S, Muraki K, Bruns A, Ludlow MJ, Sedo A, Hyman AJ, McKeown L, Young RS, Yuldasheva NY, Majeed Y, Wilson LA, Rode B, Bailey MA, Kim HR, Fu Z, Carter DA, Bilton J, Imrie H, Ajuh P, Dear TN, Cubbon RM, Kearney MT, Prasad RK, Evans PC, Ainscough JF, Beech DJ. Piezo1 integration of vascular architecture with physiological force. Nature. 2014 Nov 13;515(7526):279–82. PMID: 25119035; PMCID: PMC4230887.; Miyazaki T, Honda K, Ohata H. Requirement of Ca2+ influx- and phosphatidylinositol 3-kinase-mediated m-calpain activity for shear stress-induced endothelial cell polarity. American Journal of Physiology-Cell Physiology. 2007 Oct;293(4):C1216–25. doi: 10.1152/ajpcell.00083.2007.; Tzima E, Irani-Tehrani M, Kiosses WB, Dejana E, Schultz DA, Engelhardt B, Cao G, DeLisser H, Schwartz MA. A mechanosensory complex that mediates the endothelial cell response to fluid shear stress. Nature. 2005 Sep 15;437(7057):426–31. doi: 10.1038/nature03952. PMID: 16163360.; Dimmeler S, Fleming I, Fisslthaler B, Hermann C, Busse R, Zeiher AM. Activation of nitric oxide synthase in endothelial cells by Akt-dependent phosphorylation. Nature. 1999 Jun 10;399(6736):601–5. doi: 10.1038/21224. PMID: 10376603.
SLC-mediated transport of organic anions

Accession ID: Reactome:R-BTA-9955298		 -
SLC-mediated transport of inorganic anions

Accession ID: Reactome:R-CEL-9958790
  • 10.1007/s00424-003-1066-3
  • 10.1007/s00424-003-1088-x
  • 10.1038/sj.ki.5001813
  • 10.1152/ajprenal.00228.2007
  • 10.1152/ajprenal.00252.2005
 Virkki LV, Biber J, Murer H, Forster IC. Phosphate transporters: a tale of two solute carrier families. American Journal of Physiology-Renal Physiology. 2007 Sep;293(3):F643–54. doi: 10.1152/ajprenal.00228.2007.; Forster IC, Hernando N, Biber J, Murer H. Proximal tubular handling of phosphate: A molecular perspective. Kidney Int. 2006 Nov;70(9):1548–59. doi: 10.1038/sj.ki.5001813. PMID: 16955105.; Pushkin A, Kurtz I. SLC4 base (HCO3-, CO32-) transporters: classification, function, structure, genetic diseases, and knockout models. American Journal of Physiology-Renal Physiology. 2006 Mar;290(3):F580–99. doi: 10.1152/ajprenal.00252.2005.; Hebert SC, Mount DB, Gamba G. Molecular physiology of cation-coupled Cl- cotransport: the SLC12 family. Pflügers Archiv - European Journal of Physiology. 2003 May 09;447(5):580–93. doi: 10.1007/s00424-003-1066-3.; Collins JF, Bai L, Ghishan FK. The SLC20 family of proteins: dual functions as sodium-phosphate cotransporters and viral receptors. Pflügers Archiv - European Journal of Physiology. 2003 May 21;447(5):647–52. doi: 10.1007/s00424-003-1088-x.
SLC-mediated transport of inorganic anions

Accession ID: Reactome:R-CFA-9958790
  • 10.1007/s00424-003-1066-3
  • 10.1007/s00424-003-1088-x
  • 10.1038/sj.ki.5001813
  • 10.1152/ajprenal.00228.2007
  • 10.1152/ajprenal.00252.2005
 Virkki LV, Biber J, Murer H, Forster IC. Phosphate transporters: a tale of two solute carrier families. American Journal of Physiology-Renal Physiology. 2007 Sep;293(3):F643–54. doi: 10.1152/ajprenal.00228.2007.; Forster IC, Hernando N, Biber J, Murer H. Proximal tubular handling of phosphate: A molecular perspective. Kidney Int. 2006 Nov;70(9):1548–59. doi: 10.1038/sj.ki.5001813. PMID: 16955105.; Pushkin A, Kurtz I. SLC4 base (HCO3-, CO32-) transporters: classification, function, structure, genetic diseases, and knockout models. American Journal of Physiology-Renal Physiology. 2006 Mar;290(3):F580–99. doi: 10.1152/ajprenal.00252.2005.; Hebert SC, Mount DB, Gamba G. Molecular physiology of cation-coupled Cl- cotransport: the SLC12 family. Pflügers Archiv - European Journal of Physiology. 2003 May 09;447(5):580–93. doi: 10.1007/s00424-003-1066-3.; Collins JF, Bai L, Ghishan FK. The SLC20 family of proteins: dual functions as sodium-phosphate cotransporters and viral receptors. Pflügers Archiv - European Journal of Physiology. 2003 May 21;447(5):647–52. doi: 10.1007/s00424-003-1088-x.
SLC-mediated transport of inorganic anions

Accession ID: Reactome:R-DRE-9958790
  • 10.1007/s00424-003-1066-3
  • 10.1007/s00424-003-1088-x
  • 10.1038/sj.ki.5001813
  • 10.1152/ajprenal.00228.2007
  • 10.1152/ajprenal.00252.2005
 Virkki LV, Biber J, Murer H, Forster IC. Phosphate transporters: a tale of two solute carrier families. American Journal of Physiology-Renal Physiology. 2007 Sep;293(3):F643–54. doi: 10.1152/ajprenal.00228.2007.; Forster IC, Hernando N, Biber J, Murer H. Proximal tubular handling of phosphate: A molecular perspective. Kidney Int. 2006 Nov;70(9):1548–59. doi: 10.1038/sj.ki.5001813. PMID: 16955105.; Pushkin A, Kurtz I. SLC4 base (HCO3-, CO32-) transporters: classification, function, structure, genetic diseases, and knockout models. American Journal of Physiology-Renal Physiology. 2006 Mar;290(3):F580–99. doi: 10.1152/ajprenal.00252.2005.; Hebert SC, Mount DB, Gamba G. Molecular physiology of cation-coupled Cl- cotransport: the SLC12 family. Pflügers Archiv - European Journal of Physiology. 2003 May 09;447(5):580–93. doi: 10.1007/s00424-003-1066-3.; Collins JF, Bai L, Ghishan FK. The SLC20 family of proteins: dual functions as sodium-phosphate cotransporters and viral receptors. Pflügers Archiv - European Journal of Physiology. 2003 May 21;447(5):647–52. doi: 10.1007/s00424-003-1088-x.
Sodium-coupled phosphate cotransporters

Accession ID: Reactome:R-DDI-427652
  • 10.1007/s00424-003-1072-5
  • 10.1007/s00424-003-1088-x
  • 10.1152/ajprenal.00228.2007
 Virkki LV, Biber J, Murer H, Forster IC. Phosphate transporters: a tale of two solute carrier families. American Journal of Physiology-Renal Physiology. 2007 Sep;293(3):F643–54. doi: 10.1152/ajprenal.00228.2007.; Collins JF, Bai L, Ghishan FK. The SLC20 family of proteins: dual functions as sodium-phosphate cotransporters and viral receptors. Pflügers Archiv - European Journal of Physiology. 2003 May 21;447(5):647–52. doi: 10.1007/s00424-003-1088-x.; Murer H, Forster I, Biber J. The sodium phosphate cotransporter family SLC34. Pflügers Archiv - European Journal of Physiology. 2003 May 16;447(5):763–7. doi: 10.1007/s00424-003-1072-5.
SLC-mediated bile acid transport

Accession ID: Reactome:R-DME-9958517
  • 10.1016/s0014-5793(00)02134-7
  • 10.1111/j.1471-4159.2004.02962.x
 Traiffort E, Ruat M, O'Regan S, Meunier FM. Molecular characterization of the family of choline transporter-like proteins and their splice variants. Journal of Neurochemistry. 2005 Feb 04;92(5):1116–25. doi: 10.1111/j.1471-4159.2004.02962.x.; Okuda T, Haga T. Functional characterization of the human high-affinity choline transporter. FEBS Lett. 2000 Nov 03;484(2):92–7. doi: 10.1016/s0014-5793(00)02134-7. PMID: 11068039.
SLC-mediated bile acid transport

Accession ID: Reactome:R-GGA-9958517
  • 10.1016/s0014-5793(00)02134-7
  • 10.1111/j.1471-4159.2004.02962.x
 Traiffort E, Ruat M, O'Regan S, Meunier FM. Molecular characterization of the family of choline transporter-like proteins and their splice variants. Journal of Neurochemistry. 2005 Feb 04;92(5):1116–25. doi: 10.1111/j.1471-4159.2004.02962.x.; Okuda T, Haga T. Functional characterization of the human high-affinity choline transporter. FEBS Lett. 2000 Nov 03;484(2):92–7. doi: 10.1016/s0014-5793(00)02134-7. PMID: 11068039.
SLC-mediated transport of amino acids

Accession ID: Reactome:R-HSA-9958863		 -
SLC-mediated bile acid transport

Accession ID: Reactome:R-MMU-9958517
  • 10.1016/s0014-5793(00)02134-7
  • 10.1111/j.1471-4159.2004.02962.x
 Traiffort E, Ruat M, O'Regan S, Meunier FM. Molecular characterization of the family of choline transporter-like proteins and their splice variants. Journal of Neurochemistry. 2005 Feb 04;92(5):1116–25. doi: 10.1111/j.1471-4159.2004.02962.x.; Okuda T, Haga T. Functional characterization of the human high-affinity choline transporter. FEBS Lett. 2000 Nov 03;484(2):92–7. doi: 10.1016/s0014-5793(00)02134-7. PMID: 11068039.
SLC-mediated bile acid transport

Accession ID: Reactome:R-RNO-9958517
  • 10.1016/s0014-5793(00)02134-7
  • 10.1111/j.1471-4159.2004.02962.x
 Traiffort E, Ruat M, O'Regan S, Meunier FM. Molecular characterization of the family of choline transporter-like proteins and their splice variants. Journal of Neurochemistry. 2005 Feb 04;92(5):1116–25. doi: 10.1111/j.1471-4159.2004.02962.x.; Okuda T, Haga T. Functional characterization of the human high-affinity choline transporter. FEBS Lett. 2000 Nov 03;484(2):92–7. doi: 10.1016/s0014-5793(00)02134-7. PMID: 11068039.
SLC-mediated transport of inorganic anions

Accession ID: Reactome:R-SCE-9958790
  • 10.1007/s00424-003-1066-3
  • 10.1007/s00424-003-1088-x
  • 10.1038/sj.ki.5001813
  • 10.1152/ajprenal.00228.2007
  • 10.1152/ajprenal.00252.2005
 Virkki LV, Biber J, Murer H, Forster IC. Phosphate transporters: a tale of two solute carrier families. American Journal of Physiology-Renal Physiology. 2007 Sep;293(3):F643–54. doi: 10.1152/ajprenal.00228.2007.; Forster IC, Hernando N, Biber J, Murer H. Proximal tubular handling of phosphate: A molecular perspective. Kidney Int. 2006 Nov;70(9):1548–59. doi: 10.1038/sj.ki.5001813. PMID: 16955105.; Pushkin A, Kurtz I. SLC4 base (HCO3-, CO32-) transporters: classification, function, structure, genetic diseases, and knockout models. American Journal of Physiology-Renal Physiology. 2006 Mar;290(3):F580–99. doi: 10.1152/ajprenal.00252.2005.; Hebert SC, Mount DB, Gamba G. Molecular physiology of cation-coupled Cl- cotransport: the SLC12 family. Pflügers Archiv - European Journal of Physiology. 2003 May 09;447(5):580–93. doi: 10.1007/s00424-003-1066-3.; Collins JF, Bai L, Ghishan FK. The SLC20 family of proteins: dual functions as sodium-phosphate cotransporters and viral receptors. Pflügers Archiv - European Journal of Physiology. 2003 May 21;447(5):647–52. doi: 10.1007/s00424-003-1088-x.
SLC-mediated transport of inorganic anions

Accession ID: Reactome:R-SSC-9958790
  • 10.1007/s00424-003-1066-3
  • 10.1007/s00424-003-1088-x
  • 10.1038/sj.ki.5001813
  • 10.1152/ajprenal.00228.2007
  • 10.1152/ajprenal.00252.2005
 Virkki LV, Biber J, Murer H, Forster IC. Phosphate transporters: a tale of two solute carrier families. American Journal of Physiology-Renal Physiology. 2007 Sep;293(3):F643–54. doi: 10.1152/ajprenal.00228.2007.; Forster IC, Hernando N, Biber J, Murer H. Proximal tubular handling of phosphate: A molecular perspective. Kidney Int. 2006 Nov;70(9):1548–59. doi: 10.1038/sj.ki.5001813. PMID: 16955105.; Pushkin A, Kurtz I. SLC4 base (HCO3-, CO32-) transporters: classification, function, structure, genetic diseases, and knockout models. American Journal of Physiology-Renal Physiology. 2006 Mar;290(3):F580–99. doi: 10.1152/ajprenal.00252.2005.; Hebert SC, Mount DB, Gamba G. Molecular physiology of cation-coupled Cl- cotransport: the SLC12 family. Pflügers Archiv - European Journal of Physiology. 2003 May 09;447(5):580–93. doi: 10.1007/s00424-003-1066-3.; Collins JF, Bai L, Ghishan FK. The SLC20 family of proteins: dual functions as sodium-phosphate cotransporters and viral receptors. Pflügers Archiv - European Journal of Physiology. 2003 May 21;447(5):647–52. doi: 10.1007/s00424-003-1088-x.
SLC-mediated transport of organic anions

Accession ID: Reactome:R-XTR-9955298		 -
Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells

Accession ID: Reactome:R-HSA-9860927
  • 10.1007/s10753-023-01960-w
  • 10.1007/s11883-023-01139-6
  • 10.1038/ncb3405
  • 10.1038/s41569-023-00883-1
  • 10.1084/jem.20180483
  • 10.1093/cvr/cvad076
  • 10.1093/cvr/cvp311
  • 10.1126/science.1193270
  • 10.1152/ajpcell.00083.2007
  • 10.1161/circresaha.120.316857
  • 10.1172/jci122440
  • 10.7150/ijbs.10273
 Lv Y, Jiang Z, Zhou W, Yang H, Jin G, Wang D, Kong C, Qian Z, Gu Y, Chen S, Zhu L. Low-Shear Stress Promotes Atherosclerosis via Inducing Endothelial Cell Pyroptosis Mediated by IKKe/STAT1/NLRP3 Pathway. Inflammation. 2024 Feb 05;47(3):1053–66. doi: 10.1007/s10753-023-01960-w.; Rahaman SG, Mahanty M, Mukherjee P, Dutta B, Rahaman SO. Mechanosensing and Mechanosignal Transduction in Atherosclerosis. Curr Atheroscler Rep. 2023 Oct;25(10):711–21. doi: 10.1007/s11883-023-01139-6. PMID: 37615786.; Tamargo IA, Baek KI, Kim Y, Park C, Jo H. Flow-induced reprogramming of endothelial cells in atherosclerosis. Nat Rev Cardiol. 2023 May 24;20(11):738–53. doi: 10.1038/s41569-023-00883-1.; Wang X, Shen Y, Shang M, Liu X, Munn LL. Endothelial mechanobiology in atherosclerosis. Cardiovasc Res. 2023 Jul 06;119(8):1656–75. PMID: 37163659; PMCID: PMC10325702.; Zhang C, Zhou T, Chen Z, Yan M, Li B, Lv H, Wang C, Xiang S, Shi L, Zhu Y, Ai D. Coupling of Integrin a5 to Annexin A2 by Flow Drives Endothelial Activation. Circ Res. 2020 Sep 25;127(8):1074–90. doi: 10.1161/circresaha.120.316857. PMID: 32673515.; Li B, He J, Lv H, Liu Y, Lv X, Zhang C, Zhu Y, Ai D. c-Abl regulates YAPY357 phosphorylation to activate endothelial atherogenic responses to disturbed flow. J Clin Invest. 2019 Mar 01;129(3):1167–79. PMID: 30629551; PMCID: PMC6391101.; Albarrán-Juárez J, Iring A, Wang S, Joseph S, Grimm M, Strilic B, Wettschureck N, Althoff TF, Offermanns S. Piezo1 and Gq/G11 promote endothelial inflammation depending on flow pattern and integrin activation. J Exp Med. 2018 Oct 01;215(10):2655–72. PMID: 30194266; PMCID: PMC6170174.; Yun S, Budatha M, Dahlman JE, Coon BG, Cameron RT, Langer R, Anderson DG, Baillie G, Schwartz MA. Interaction between integrin a5 and PDE4D regulates endothelial inflammatory signalling. Nat Cell Biol. 2016 Oct;18(10):1043–53. PMID: 27595237; PMCID: PMC5301150.; Dwyer SF, Gao L, Gelman IH. Identification of novel focal adhesion kinase substrates: role for FAK in NF?B signaling. Int J Biol Sci. 2015;11(4):404–10. PMID: 25798060; PMCID: PMC4366639.; Coste B, Mathur J, Schmidt M, Earley TJ, Ranade S, Petrus MJ, Dubin AE, Patapoutian A. Piezo1 and Piezo2 are essential components of distinct mechanically activated cation channels. Science. 2010 Oct 01;330(6000):55–60. PMID: 20813920; PMCID: PMC3062430.; Miyazaki T, Honda K, Ohata H. m-Calpain antagonizes RhoA overactivation and endothelial barrier dysfunction under disturbed shear conditions. Cardiovasc Res. 2010 Feb 01;85(3):530–41. doi: 10.1093/cvr/cvp311. PMID: 19752040.; Miyazaki T, Honda K, Ohata H. Requirement of Ca2+ influx- and phosphatidylinositol 3-kinase-mediated m-calpain activity for shear stress-induced endothelial cell polarity. American Journal of Physiology-Cell Physiology. 2007 Oct;293(4):C1216–25. doi: 10.1152/ajpcell.00083.2007.
Mechanical load activates signaling by PIEZO1 and integrins in osteocytes

Accession ID: Reactome:R-HSA-9856532
  • 10.1038/s41413-020-00126-w
  • 10.1073/pnas.1009382107
  • 10.1074/jbc.m803136200
  • 10.1523/jneurosci.5048-07.2008
  • 10.3389/fbioe.2024.1342149
  • 10.3389/fcell.2021.770143
  • 10.3389/fcell.2023.1151838
  • 10.3390/biom12121857
  • 10.3390/ijms21031146
  • 10.3390/ijms23031523
  • 10.3390/ijms23084373
 Du Y, Xu B, Li Q, Peng C, Yang K. The role of mechanically sensitive ion channel Piezo1 in bone remodeling. Front Bioeng Biotechnol. 2024;12():1342149. PMID: 38390363; PMCID: PMC10882629.; Zhao D, Wu J, Acosta FM, Xu H, Jiang JX. Connexin 43 hemichannels and prostaglandin E2 release in anabolic function of the skeletal tissue to mechanical stimulation. Front Cell Dev Biol. 2023;11():1151838. PMID: 37123401; PMCID: PMC10133519.; Reyes Fernandez PC, Wright CS, Masterson AN, Yi X, Tellman TV, Bonteanu A, Rust K, Noonan ML, White KE, Lewis KJ, Sankar U, Hum JM, Bix G, Wu D, Robling AG, Sardar R, Farach-Carson MC, Thompson WR. Gabapentin Disrupts Binding of Perlecan to the a2d1 Voltage Sensitive Calcium Channel Subunit and Impairs Skeletal Mechanosensation. Biomolecules. 2022 Dec 12;12(12). PMID: 36551284; PMCID: PMC9776037.; Moriishi T, Komori T. Osteocytes: Their Lacunocanalicular Structure and Mechanoresponses. Int J Mol Sci. 2022 Apr 15;23(8). PMID: 35457191; PMCID: PMC9032292.; Choi JUA, Kijas AW, Lauko J, Rowan AE. The Mechanosensory Role of Osteocytes and Implications for Bone Health and Disease States. Front Cell Dev Biol. 2021;9():770143. PMID: 35265628; PMCID: PMC8900535.; Yang K, Xiao Z, He X, Weng R, Zhao X, Sun T. Mechanisms of Pannexin 1 (PANX1) Channel Mechanosensitivity and Its Pathological Roles. Int J Mol Sci. 2022 Jan 28;23(3). PMID: 35163442; PMCID: PMC8836264.; Riquelme MA, Gu S, Hua R, Jiang JX. Mechanotransduction via the coordinated actions of integrins, PI3K signaling and Connexin hemichannels. Bone Research. 2021 Feb 02;9(1):8. doi: 10.1038/s41413-020-00126-w.; Riquelme MA, Cardenas ER, Xu H, Jiang JX. The Role of Connexin Channels in the Response of Mechanical Loading and Unloading of Bone. Int J Mol Sci. 2020 Feb 09;21(3). PMID: 32050469; PMCID: PMC7038207.; Burra S, Nicolella DP, Francis WL, Freitas CJ, Mueschke NJ, Poole K, Jiang JX. Dendritic processes of osteocytes are mechanotransducers that induce the opening of hemichannels. Proc Natl Acad Sci U S A. 2010 Aug 03;107(31):13648–53. PMID: 20643964; PMCID: PMC2922284.; Siller-Jackson AJ, Burra S, Gu S, Xia X, Bonewald LF, Sprague E, Jiang JX. Adaptation of Connexin 43-Hemichannel Prostaglandin Release to Mechanical Loading. Journal of Biological Chemistry. 2008 Sep;283(39):26374–82. doi: 10.1074/jbc.m803136200.; Kang J, Kang N, Lovatt D, Torres A, Zhao Z, Lin J, Nedergaard M. Connexin 43 Hemichannels Are Permeable to ATP. J. Neurosci. 2008 Apr 30;28(18):4702–11. doi: 10.1523/jneurosci.5048-07.2008.
SLC-mediated transport of amino acids

Accession ID: Reactome:R-BTA-9958863		 -
SLC-mediated bile acid transport

Accession ID: Reactome:R-CEL-9958517
  • 10.1016/s0014-5793(00)02134-7
  • 10.1111/j.1471-4159.2004.02962.x
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