Pathways Knowlegdes

Biological pathway database

Pathway DOIs Note
SLC-mediated bile acid transport

Accession ID: Reactome:R-CFA-9958517
  • 10.1016/s0014-5793(00)02134-7
  • 10.1111/j.1471-4159.2004.02962.x
 Traiffort E, Ruat M, O'Regan S, Meunier FM. Molecular characterization of the family of choline transporter-like proteins and their splice variants. Journal of Neurochemistry. 2005 Feb 04;92(5):1116–25. doi: 10.1111/j.1471-4159.2004.02962.x.; Okuda T, Haga T. Functional characterization of the human high-affinity choline transporter. FEBS Lett. 2000 Nov 03;484(2):92–7. doi: 10.1016/s0014-5793(00)02134-7. PMID: 11068039.
SLC-mediated bile acid transport

Accession ID: Reactome:R-DRE-9958517
  • 10.1016/s0014-5793(00)02134-7
  • 10.1111/j.1471-4159.2004.02962.x
 Traiffort E, Ruat M, O'Regan S, Meunier FM. Molecular characterization of the family of choline transporter-like proteins and their splice variants. Journal of Neurochemistry. 2005 Feb 04;92(5):1116–25. doi: 10.1111/j.1471-4159.2004.02962.x.; Okuda T, Haga T. Functional characterization of the human high-affinity choline transporter. FEBS Lett. 2000 Nov 03;484(2):92–7. doi: 10.1016/s0014-5793(00)02134-7. PMID: 11068039.
SLC-mediated transport of inorganic anions

Accession ID: Reactome:R-DME-9958790
  • 10.1007/s00424-003-1066-3
  • 10.1007/s00424-003-1088-x
  • 10.1038/sj.ki.5001813
  • 10.1152/ajprenal.00228.2007
  • 10.1152/ajprenal.00252.2005
 Virkki LV, Biber J, Murer H, Forster IC. Phosphate transporters: a tale of two solute carrier families. American Journal of Physiology-Renal Physiology. 2007 Sep;293(3):F643–54. doi: 10.1152/ajprenal.00228.2007.; Forster IC, Hernando N, Biber J, Murer H. Proximal tubular handling of phosphate: A molecular perspective. Kidney Int. 2006 Nov;70(9):1548–59. doi: 10.1038/sj.ki.5001813. PMID: 16955105.; Pushkin A, Kurtz I. SLC4 base (HCO3-, CO32-) transporters: classification, function, structure, genetic diseases, and knockout models. American Journal of Physiology-Renal Physiology. 2006 Mar;290(3):F580–99. doi: 10.1152/ajprenal.00252.2005.; Hebert SC, Mount DB, Gamba G. Molecular physiology of cation-coupled Cl- cotransport: the SLC12 family. Pflügers Archiv - European Journal of Physiology. 2003 May 09;447(5):580–93. doi: 10.1007/s00424-003-1066-3.; Collins JF, Bai L, Ghishan FK. The SLC20 family of proteins: dual functions as sodium-phosphate cotransporters and viral receptors. Pflügers Archiv - European Journal of Physiology. 2003 May 21;447(5):647–52. doi: 10.1007/s00424-003-1088-x.
SLC-mediated transport of inorganic anions

Accession ID: Reactome:R-GGA-9958790
  • 10.1007/s00424-003-1066-3
  • 10.1007/s00424-003-1088-x
  • 10.1038/sj.ki.5001813
  • 10.1152/ajprenal.00228.2007
  • 10.1152/ajprenal.00252.2005
 Virkki LV, Biber J, Murer H, Forster IC. Phosphate transporters: a tale of two solute carrier families. American Journal of Physiology-Renal Physiology. 2007 Sep;293(3):F643–54. doi: 10.1152/ajprenal.00228.2007.; Forster IC, Hernando N, Biber J, Murer H. Proximal tubular handling of phosphate: A molecular perspective. Kidney Int. 2006 Nov;70(9):1548–59. doi: 10.1038/sj.ki.5001813. PMID: 16955105.; Pushkin A, Kurtz I. SLC4 base (HCO3-, CO32-) transporters: classification, function, structure, genetic diseases, and knockout models. American Journal of Physiology-Renal Physiology. 2006 Mar;290(3):F580–99. doi: 10.1152/ajprenal.00252.2005.; Hebert SC, Mount DB, Gamba G. Molecular physiology of cation-coupled Cl- cotransport: the SLC12 family. Pflügers Archiv - European Journal of Physiology. 2003 May 09;447(5):580–93. doi: 10.1007/s00424-003-1066-3.; Collins JF, Bai L, Ghishan FK. The SLC20 family of proteins: dual functions as sodium-phosphate cotransporters and viral receptors. Pflügers Archiv - European Journal of Physiology. 2003 May 21;447(5):647–52. doi: 10.1007/s00424-003-1088-x.
SLC-mediated transport of organic anions

Accession ID: Reactome:R-HSA-9955298		 -
SLC-mediated transport of inorganic anions

Accession ID: Reactome:R-MMU-9958790
  • 10.1007/s00424-003-1066-3
  • 10.1007/s00424-003-1088-x
  • 10.1038/sj.ki.5001813
  • 10.1152/ajprenal.00228.2007
  • 10.1152/ajprenal.00252.2005
 Virkki LV, Biber J, Murer H, Forster IC. Phosphate transporters: a tale of two solute carrier families. American Journal of Physiology-Renal Physiology. 2007 Sep;293(3):F643–54. doi: 10.1152/ajprenal.00228.2007.; Forster IC, Hernando N, Biber J, Murer H. Proximal tubular handling of phosphate: A molecular perspective. Kidney Int. 2006 Nov;70(9):1548–59. doi: 10.1038/sj.ki.5001813. PMID: 16955105.; Pushkin A, Kurtz I. SLC4 base (HCO3-, CO32-) transporters: classification, function, structure, genetic diseases, and knockout models. American Journal of Physiology-Renal Physiology. 2006 Mar;290(3):F580–99. doi: 10.1152/ajprenal.00252.2005.; Hebert SC, Mount DB, Gamba G. Molecular physiology of cation-coupled Cl- cotransport: the SLC12 family. Pflügers Archiv - European Journal of Physiology. 2003 May 09;447(5):580–93. doi: 10.1007/s00424-003-1066-3.; Collins JF, Bai L, Ghishan FK. The SLC20 family of proteins: dual functions as sodium-phosphate cotransporters and viral receptors. Pflügers Archiv - European Journal of Physiology. 2003 May 21;447(5):647–52. doi: 10.1007/s00424-003-1088-x.
SLC-mediated transport of inorganic anions

Accession ID: Reactome:R-PFA-9958790
  • 10.1007/s00424-003-1066-3
  • 10.1007/s00424-003-1088-x
  • 10.1038/sj.ki.5001813
  • 10.1152/ajprenal.00228.2007
  • 10.1152/ajprenal.00252.2005
 Virkki LV, Biber J, Murer H, Forster IC. Phosphate transporters: a tale of two solute carrier families. American Journal of Physiology-Renal Physiology. 2007 Sep;293(3):F643–54. doi: 10.1152/ajprenal.00228.2007.; Forster IC, Hernando N, Biber J, Murer H. Proximal tubular handling of phosphate: A molecular perspective. Kidney Int. 2006 Nov;70(9):1548–59. doi: 10.1038/sj.ki.5001813. PMID: 16955105.; Pushkin A, Kurtz I. SLC4 base (HCO3-, CO32-) transporters: classification, function, structure, genetic diseases, and knockout models. American Journal of Physiology-Renal Physiology. 2006 Mar;290(3):F580–99. doi: 10.1152/ajprenal.00252.2005.; Hebert SC, Mount DB, Gamba G. Molecular physiology of cation-coupled Cl- cotransport: the SLC12 family. Pflügers Archiv - European Journal of Physiology. 2003 May 09;447(5):580–93. doi: 10.1007/s00424-003-1066-3.; Collins JF, Bai L, Ghishan FK. The SLC20 family of proteins: dual functions as sodium-phosphate cotransporters and viral receptors. Pflügers Archiv - European Journal of Physiology. 2003 May 21;447(5):647–52. doi: 10.1007/s00424-003-1088-x.
SLC-mediated transport of inorganic anions

Accession ID: Reactome:R-RNO-9958790
  • 10.1007/s00424-003-1066-3
  • 10.1007/s00424-003-1088-x
  • 10.1038/sj.ki.5001813
  • 10.1152/ajprenal.00228.2007
  • 10.1152/ajprenal.00252.2005
 Virkki LV, Biber J, Murer H, Forster IC. Phosphate transporters: a tale of two solute carrier families. American Journal of Physiology-Renal Physiology. 2007 Sep;293(3):F643–54. doi: 10.1152/ajprenal.00228.2007.; Forster IC, Hernando N, Biber J, Murer H. Proximal tubular handling of phosphate: A molecular perspective. Kidney Int. 2006 Nov;70(9):1548–59. doi: 10.1038/sj.ki.5001813. PMID: 16955105.; Pushkin A, Kurtz I. SLC4 base (HCO3-, CO32-) transporters: classification, function, structure, genetic diseases, and knockout models. American Journal of Physiology-Renal Physiology. 2006 Mar;290(3):F580–99. doi: 10.1152/ajprenal.00252.2005.; Hebert SC, Mount DB, Gamba G. Molecular physiology of cation-coupled Cl- cotransport: the SLC12 family. Pflügers Archiv - European Journal of Physiology. 2003 May 09;447(5):580–93. doi: 10.1007/s00424-003-1066-3.; Collins JF, Bai L, Ghishan FK. The SLC20 family of proteins: dual functions as sodium-phosphate cotransporters and viral receptors. Pflügers Archiv - European Journal of Physiology. 2003 May 21;447(5):647–52. doi: 10.1007/s00424-003-1088-x.
SLC-mediated bile acid transport

Accession ID: Reactome:R-SSC-9958517
  • 10.1016/s0014-5793(00)02134-7
  • 10.1111/j.1471-4159.2004.02962.x
 Traiffort E, Ruat M, O'Regan S, Meunier FM. Molecular characterization of the family of choline transporter-like proteins and their splice variants. Journal of Neurochemistry. 2005 Feb 04;92(5):1116–25. doi: 10.1111/j.1471-4159.2004.02962.x.; Okuda T, Haga T. Functional characterization of the human high-affinity choline transporter. FEBS Lett. 2000 Nov 03;484(2):92–7. doi: 10.1016/s0014-5793(00)02134-7. PMID: 11068039.
SLC-mediated transport of amino acids

Accession ID: Reactome:R-XTR-9958863		 -
Cellular responses to mechanical stimuli

Accession ID: Reactome:R-HSA-9855142
  • 10.1007/s00424-014-1558-3
  • 10.1007/s11883-023-01139-6
  • 10.1016/j.bone.2021.116104
  • 10.1016/j.ceb.2023.102216
  • 10.1016/j.ydbio.2022.11.002
  • 10.1038/s41413-020-0099-y
  • 10.1038/s41583-021-00489-x
  • 10.1146/annurev-physiol-042022-030946
  • 10.1152/physrev.00053.2021
  • 10.1186/s13578-020-00522-z
  • 10.2147/jir.s355158
  • 10.3389/fncel.2024.1367476
  • 10.3389/fphys.2018.00824
 Logan DR, Hall J, Bianchi L. A helping hand: roles for accessory cells in the sense of touch across species. Front Cell Neurosci. 2024;18():1367476. PMID: 38433863; PMCID: PMC10904576.; Lim XR, Harraz OF. Mechanosensing by Vascular Endothelium. Annu. Rev. Physiol. 2024 Feb 12;86(1):71–97. doi: 10.1146/annurev-physiol-042022-030946.; Xiao R, Liu J, Shawn Xu XZ. Mechanosensitive GPCRs and ion channels in shear stress sensing. Current Opinion in Cell Biology. 2023 Oct;84():102216. doi: 10.1016/j.ceb.2023.102216.; Rahaman SG, Mahanty M, Mukherjee P, Dutta B, Rahaman SO. Mechanosensing and Mechanosignal Transduction in Atherosclerosis. Curr Atheroscler Rep. 2023 Oct;25(10):711–21. doi: 10.1007/s11883-023-01139-6. PMID: 37615786.; Davis MJ, Earley S, Li Y, Chien S. Vascular mechanotransduction. Physiological Reviews. 2023 Apr 01;103(2):1247–421. doi: 10.1152/physrev.00053.2021.; Wang J, Sun YX, Li J. The role of mechanosensor Piezo1 in bone homeostasis and mechanobiology. Dev Biol. 2023 Jan;493():80–8. doi: 10.1016/j.ydbio.2022.11.002. PMID: 36368521.; Li H, Zhou WY, Xia YY, Zhang JX. Endothelial Mechanosensors for Atheroprone and Atheroprotective Shear Stress Signals. J Inflamm Res. 2022;15():1771–83. PMID: 35300215; PMCID: PMC8923682.; Moharrer Y, Boerckel JD. Tunnels in the rock: Dynamics of osteocyte morphogenesis. Bone. 2021 Dec;153():116104. PMID: 34245936; PMCID: PMC8478866.; Handler A, Ginty DD. The mechanosensory neurons of touch and their mechanisms of activation. Nature Reviews Neuroscience. 2021 Jul 26;22(9):521–37. doi: 10.1038/s41583-021-00489-x.; Fang XZ, Zhou T, Xu JQ, Wang YX, Sun MM, He YJ, Pan SW, Xiong W, Peng ZK, Gao XH, Shang Y. Structure, kinetic properties and biological function of mechanosensitive Piezo channels. Cell Biosci. 2021 Jan 09;11(1):13. PMID: 33422128; PMCID: PMC7796548.; Qin L, Liu W, Cao H, Xiao G. Molecular mechanosensors in osteocytes. Bone Research. 2020 Jun 08;8(1):23. doi: 10.1038/s41413-020-0099-y.; Martino F, Perestrelo AR, Vinarský V, Pagliari S, Forte G. Cellular Mechanotransduction: From Tension to Function. Front. Physiol. 2018 Jul 05;9(). doi: 10.3389/fphys.2018.00824.; Hirata H, Tatsumi H, Hayakawa K, Sokabe M. Non-channel mechanosensors working at focal adhesion-stress fiber complex. Pflügers Archiv - European Journal of Physiology. 2014 Jun 26;467(1):141–55. doi: 10.1007/s00424-014-1558-3.
SLC-mediated transport of inorganic anions

Accession ID: Reactome:R-BTA-9958790
  • 10.1007/s00424-003-1066-3
  • 10.1007/s00424-003-1088-x
  • 10.1038/sj.ki.5001813
  • 10.1152/ajprenal.00228.2007
  • 10.1152/ajprenal.00252.2005
 Virkki LV, Biber J, Murer H, Forster IC. Phosphate transporters: a tale of two solute carrier families. American Journal of Physiology-Renal Physiology. 2007 Sep;293(3):F643–54. doi: 10.1152/ajprenal.00228.2007.; Forster IC, Hernando N, Biber J, Murer H. Proximal tubular handling of phosphate: A molecular perspective. Kidney Int. 2006 Nov;70(9):1548–59. doi: 10.1038/sj.ki.5001813. PMID: 16955105.; Pushkin A, Kurtz I. SLC4 base (HCO3-, CO32-) transporters: classification, function, structure, genetic diseases, and knockout models. American Journal of Physiology-Renal Physiology. 2006 Mar;290(3):F580–99. doi: 10.1152/ajprenal.00252.2005.; Hebert SC, Mount DB, Gamba G. Molecular physiology of cation-coupled Cl- cotransport: the SLC12 family. Pflügers Archiv - European Journal of Physiology. 2003 May 09;447(5):580–93. doi: 10.1007/s00424-003-1066-3.; Collins JF, Bai L, Ghishan FK. The SLC20 family of proteins: dual functions as sodium-phosphate cotransporters and viral receptors. Pflügers Archiv - European Journal of Physiology. 2003 May 21;447(5):647–52. doi: 10.1007/s00424-003-1088-x.
SLC-mediated transport of amino acids

Accession ID: Reactome:R-CEL-9958863		 -
SLC-mediated transport of amino acids

Accession ID: Reactome:R-CFA-9958863		 -
SLC-mediated transport of amino acids

Accession ID: Reactome:R-DRE-9958863		 -
SLC-mediated transport of inorganic anions

Accession ID: Reactome:R-DDI-9958790
  • 10.1007/s00424-003-1066-3
  • 10.1007/s00424-003-1088-x
  • 10.1038/sj.ki.5001813
  • 10.1152/ajprenal.00228.2007
  • 10.1152/ajprenal.00252.2005
 Virkki LV, Biber J, Murer H, Forster IC. Phosphate transporters: a tale of two solute carrier families. American Journal of Physiology-Renal Physiology. 2007 Sep;293(3):F643–54. doi: 10.1152/ajprenal.00228.2007.; Forster IC, Hernando N, Biber J, Murer H. Proximal tubular handling of phosphate: A molecular perspective. Kidney Int. 2006 Nov;70(9):1548–59. doi: 10.1038/sj.ki.5001813. PMID: 16955105.; Pushkin A, Kurtz I. SLC4 base (HCO3-, CO32-) transporters: classification, function, structure, genetic diseases, and knockout models. American Journal of Physiology-Renal Physiology. 2006 Mar;290(3):F580–99. doi: 10.1152/ajprenal.00252.2005.; Hebert SC, Mount DB, Gamba G. Molecular physiology of cation-coupled Cl- cotransport: the SLC12 family. Pflügers Archiv - European Journal of Physiology. 2003 May 09;447(5):580–93. doi: 10.1007/s00424-003-1066-3.; Collins JF, Bai L, Ghishan FK. The SLC20 family of proteins: dual functions as sodium-phosphate cotransporters and viral receptors. Pflügers Archiv - European Journal of Physiology. 2003 May 21;447(5):647–52. doi: 10.1007/s00424-003-1088-x.
SLC-mediated transport of organic anions

Accession ID: Reactome:R-DME-9955298		 -
SLC-mediated transport of organic anions

Accession ID: Reactome:R-GGA-9955298		 -
SLC-mediated bile acid transport

Accession ID: Reactome:R-HSA-9958517
  • 10.1016/s0014-5793(00)02134-7
  • 10.1111/j.1471-4159.2004.02962.x
 Traiffort E, Ruat M, O'Regan S, Meunier FM. Molecular characterization of the family of choline transporter-like proteins and their splice variants. Journal of Neurochemistry. 2005 Feb 04;92(5):1116–25. doi: 10.1111/j.1471-4159.2004.02962.x.; Okuda T, Haga T. Functional characterization of the human high-affinity choline transporter. FEBS Lett. 2000 Nov 03;484(2):92–7. doi: 10.1016/s0014-5793(00)02134-7. PMID: 11068039.
SLC-mediated transport of organic anions

Accession ID: Reactome:R-MMU-9955298		 -