Pathways Knowlegdes
Biological pathway database
| Pathway | DOIs | Note |
|---|---|---|
| Sensory perception of taste Accession ID: Reactome:R-RNO-9717189 |
|
Taruno A, Nomura K, Kusakizako T, Ma Z, Nureki O, Foskett JK. Taste transduction and channel synapses in taste buds. Pflügers Archiv - European Journal of Physiology. 2020 Sep 16;473(1):3–13. doi: 10.1007/s00424-020-02464-4.; Kinnamon SC, Finger TE. Recent advances in taste transduction and signaling. F1000Res. 2019 Dec 17;8():2117. doi: 10.12688/f1000research.21099.1.; Roper SD, Chaudhari N. Taste buds: cells, signals and synapses. Nature Reviews Neuroscience. 2017 Jun 29;18(8):485–97. doi: 10.1038/nrn.2017.68.; Liman ER, Zhang YV, Montell C. Peripheral coding of taste. Neuron. 2014 Mar 05;81(5):984–1000. PMID: 24607224; PMCID: PMC3994536.; Chandrashekar J, Kuhn C, Oka Y, Yarmolinsky DA, Hummler E, Ryba NJ, Zuker CS. The cells and peripheral representation of sodium taste in mice. Nature. 2010 Mar 11;464(7286):297–301. PMID: 20107438; PMCID: PMC2849629. |
| Sensory perception of taste Accession ID: Reactome:R-BTA-9717189 |
|
Taruno A, Nomura K, Kusakizako T, Ma Z, Nureki O, Foskett JK. Taste transduction and channel synapses in taste buds. Pflügers Archiv - European Journal of Physiology. 2020 Sep 16;473(1):3–13. doi: 10.1007/s00424-020-02464-4.; Kinnamon SC, Finger TE. Recent advances in taste transduction and signaling. F1000Res. 2019 Dec 17;8():2117. doi: 10.12688/f1000research.21099.1.; Roper SD, Chaudhari N. Taste buds: cells, signals and synapses. Nature Reviews Neuroscience. 2017 Jun 29;18(8):485–97. doi: 10.1038/nrn.2017.68.; Liman ER, Zhang YV, Montell C. Peripheral coding of taste. Neuron. 2014 Mar 05;81(5):984–1000. PMID: 24607224; PMCID: PMC3994536.; Chandrashekar J, Kuhn C, Oka Y, Yarmolinsky DA, Hummler E, Ryba NJ, Zuker CS. The cells and peripheral representation of sodium taste in mice. Nature. 2010 Mar 11;464(7286):297–301. PMID: 20107438; PMCID: PMC2849629. |
| Sensory perception of taste Accession ID: Reactome:R-MMU-9717189 |
|
Taruno A, Nomura K, Kusakizako T, Ma Z, Nureki O, Foskett JK. Taste transduction and channel synapses in taste buds. Pflügers Archiv - European Journal of Physiology. 2020 Sep 16;473(1):3–13. doi: 10.1007/s00424-020-02464-4.; Kinnamon SC, Finger TE. Recent advances in taste transduction and signaling. F1000Res. 2019 Dec 17;8():2117. doi: 10.12688/f1000research.21099.1.; Roper SD, Chaudhari N. Taste buds: cells, signals and synapses. Nature Reviews Neuroscience. 2017 Jun 29;18(8):485–97. doi: 10.1038/nrn.2017.68.; Liman ER, Zhang YV, Montell C. Peripheral coding of taste. Neuron. 2014 Mar 05;81(5):984–1000. PMID: 24607224; PMCID: PMC3994536.; Chandrashekar J, Kuhn C, Oka Y, Yarmolinsky DA, Hummler E, Ryba NJ, Zuker CS. The cells and peripheral representation of sodium taste in mice. Nature. 2010 Mar 11;464(7286):297–301. PMID: 20107438; PMCID: PMC2849629. |
| Sensory perception of sweet, bitter, and umami (glutamate) taste Accession ID: Reactome:R-HSA-9717207 |
|
von Molitor E, Riedel K, Krohn M, Rudolf R, Hafner M, Cesetti T. An alternative pathway for sweet sensation: possible mechanisms and physiological relevance. Pflügers Archiv - European Journal of Physiology. 2020 Oct 08;472(12):1667–91. doi: 10.1007/s00424-020-02467-1.; Aroke EN, Powell-Roach KL, Jaime-Lara RB, Tesfaye M, Roy A, Jackson P, Joseph PV. Taste the Pain: The Role of TRP Channels in Pain and Taste Perception. Int J Mol Sci. 2020 Aug 18;21(16). PMID: 32824721; PMCID: PMC7460556.; Yang L, Cui M, Liu B. Current Progress in Understanding the Structure and Function of Sweet Taste Receptor. Journal of Molecular Neuroscience. 2020 Jun 30;71(2):234–44. doi: 10.1007/s12031-020-01642-4.; Governini L, Semplici B, Pavone V, Crifasi L, Marrocco C, De Leo V, Arlt E, Gudermann T, Boekhoff I, Luddi A, Piomboni P. Expression of Taste Receptor 2 Subtypes in Human Testis and Sperm. J Clin Med. 2020 Jan 18;9(1). PMID: 31963712; PMCID: PMC7019805.; Servant G, Kenakin T, Zhang L, Williams M, Servant N. The function and allosteric control of the human sweet taste receptor. Adv Pharmacol. 2020;88():59–82. doi: 10.1016/bs.apha.2020.01.002. PMID: 32416872.; Kinnamon SC, Finger TE. Recent advances in taste transduction and signaling. F1000Res. 2019 Dec 17;8():2117. doi: 10.12688/f1000research.21099.1.; Roper SD, Chaudhari N. Taste buds: cells, signals and synapses. Nature Reviews Neuroscience. 2017 Jun 29;18(8):485–97. doi: 10.1038/nrn.2017.68.; Malki A, Fiedler J, Fricke K, Ballweg I, Pfaffl MW, Krautwurst D. Class I odorant receptors, TAS1R and TAS2R taste receptors, are markers for subpopulations of circulating leukocytes. J Leukoc Biol. 2015 Mar;97(3):533–45. PMID: 25624459; PMCID: PMC5477889.; Kurihara K. Umami the Fifth Basic Taste: History of Studies on Receptor Mechanisms and Role as a Food Flavor. BioMed Research International. 2015;2015():1–10. doi: 10.1155/2015/189402.; Barham HP, Cooper SE, Anderson CB, Tizzano M, Kingdom TT, Finger TE, Kinnamon SC, Ramakrishnan VR. Solitary chemosensory cells and bitter taste receptor signaling in human sinonasal mucosa. Int Forum Allergy Rhinol. 2013 Jun;3(6):450–7. PMID: 23404938; PMCID: PMC3655139.; Tizzano M, Cristofoletti M, Sbarbati A, Finger TE. Expression of taste receptors in Solitary Chemosensory Cells of rodent airways. BMC Pulmonary Medicine. 2011 Jan 13;11(1):3. doi: 10.1186/1471-2466-11-3.; Kinnamon SC. Umami taste transduction mechanisms. The American Journal of Clinical Nutrition. 2009 Sep;90(3):753S–755S. doi: 10.3945/ajcn.2009.27462k.; Chaudhari N, Pereira E, Roper SD. Taste receptors for umami: the case for multiple receptors. The American Journal of Clinical Nutrition. 2009 Sep;90(3):738S–742S. doi: 10.3945/ajcn.2009.27462h.; Wu SV, Rozengurt N, Yang M, Young SH, Sinnett-Smith J, Rozengurt E. Expression of bitter taste receptors of the T2R family in the gastrointestinal tract and enteroendocrine STC-1 cells. Proc Natl Acad Sci U S A. 2002 Feb 19;99(4):2392–7. PMID: 11854532; PMCID: PMC122375.; Margolskee RF. Molecular Mechanisms of Bitter and Sweet Taste Transduction. Journal of Biological Chemistry. 2002 Jan;277(1):1–4. doi: 10.1074/jbc.r100054200. |
| Azathioprine ADME Accession ID: Reactome:R-BTA-9748787 |
|
Tominaga K, Sugaya T, Tanaka T, Kanazawa M, Iijima M, Irisawa A. Thiopurines: Recent Topics and Their Role in the Treatment of Inflammatory Bowel Diseases. Front Pharmacol. 2020;11():582291. PMID: 33584261; PMCID: PMC7878672.; Axelrad JE, Lichtiger S, Yajnik V. Inflammatory bowel disease and cancer: The role of inflammation, immunosuppression, and cancer treatment. World J Gastroenterol. 2016 May 28;22(20):4794–801. PMID: 27239106; PMCID: PMC4873872.; Dubinsky MC. Azathioprine, 6-mercaptopurine in inflammatory bowel disease: pharmacology, efficacy, and safety. Clin Gastroenterol Hepatol. 2004 Sep;2(9):731–43. doi: 10.1016/s1542-3565(04)00344-1. PMID: 15354273.; Cuffari C, Théorêt Y, Latour S, Seidman G. 6-Mercaptopurine metabolism in Crohn's disease: correlation with efficacy and toxicity. Gut. 1996 Sep;39(3):401–6. PMID: 8949645; PMCID: PMC1383347. |
| Drug ADME Accession ID: Reactome:R-CEL-9748784 |
|
Currie GM. Pharmacology, Part 2: Introduction to Pharmacokinetics. J Nucl Med Technol. 2018 Sep;46(3):221–30. doi: 10.2967/jnmt.117.199638. PMID: 29724803.; Ruiz-Garcia A, Bermejo M, Moss A, Casabo VG. Pharmacokinetics in Drug Discovery. Journal of Pharmaceutical Sciences. 2008 Feb;97(2):654–90. doi: 10.1002/jps.21009.; Pallasch TJ. Principles of pharmacotherapy: II. Pharmacokinetics. Anesth Prog. 1988 Jul;35(4):133–46. PMID: 3046441; PMCID: PMC2167950. |
| Drug ADME Accession ID: Reactome:R-GGA-9748784 |
|
Currie GM. Pharmacology, Part 2: Introduction to Pharmacokinetics. J Nucl Med Technol. 2018 Sep;46(3):221–30. doi: 10.2967/jnmt.117.199638. PMID: 29724803.; Ruiz-Garcia A, Bermejo M, Moss A, Casabo VG. Pharmacokinetics in Drug Discovery. Journal of Pharmaceutical Sciences. 2008 Feb;97(2):654–90. doi: 10.1002/jps.21009.; Pallasch TJ. Principles of pharmacotherapy: II. Pharmacokinetics. Anesth Prog. 1988 Jul;35(4):133–46. PMID: 3046441; PMCID: PMC2167950. |
| Drug ADME Accession ID: Reactome:R-MMU-9748784 |
|
Currie GM. Pharmacology, Part 2: Introduction to Pharmacokinetics. J Nucl Med Technol. 2018 Sep;46(3):221–30. doi: 10.2967/jnmt.117.199638. PMID: 29724803.; Ruiz-Garcia A, Bermejo M, Moss A, Casabo VG. Pharmacokinetics in Drug Discovery. Journal of Pharmaceutical Sciences. 2008 Feb;97(2):654–90. doi: 10.1002/jps.21009.; Pallasch TJ. Principles of pharmacotherapy: II. Pharmacokinetics. Anesth Prog. 1988 Jul;35(4):133–46. PMID: 3046441; PMCID: PMC2167950. |
| Azathioprine ADME Accession ID: Reactome:R-RNO-9748787 |
|
Tominaga K, Sugaya T, Tanaka T, Kanazawa M, Iijima M, Irisawa A. Thiopurines: Recent Topics and Their Role in the Treatment of Inflammatory Bowel Diseases. Front Pharmacol. 2020;11():582291. PMID: 33584261; PMCID: PMC7878672.; Axelrad JE, Lichtiger S, Yajnik V. Inflammatory bowel disease and cancer: The role of inflammation, immunosuppression, and cancer treatment. World J Gastroenterol. 2016 May 28;22(20):4794–801. PMID: 27239106; PMCID: PMC4873872.; Dubinsky MC. Azathioprine, 6-mercaptopurine in inflammatory bowel disease: pharmacology, efficacy, and safety. Clin Gastroenterol Hepatol. 2004 Sep;2(9):731–43. doi: 10.1016/s1542-3565(04)00344-1. PMID: 15354273.; Cuffari C, Théorêt Y, Latour S, Seidman G. 6-Mercaptopurine metabolism in Crohn's disease: correlation with efficacy and toxicity. Gut. 1996 Sep;39(3):401–6. PMID: 8949645; PMCID: PMC1383347. |
| Azathioprine ADME Accession ID: Reactome:R-SSC-9748787 |
|
Tominaga K, Sugaya T, Tanaka T, Kanazawa M, Iijima M, Irisawa A. Thiopurines: Recent Topics and Their Role in the Treatment of Inflammatory Bowel Diseases. Front Pharmacol. 2020;11():582291. PMID: 33584261; PMCID: PMC7878672.; Axelrad JE, Lichtiger S, Yajnik V. Inflammatory bowel disease and cancer: The role of inflammation, immunosuppression, and cancer treatment. World J Gastroenterol. 2016 May 28;22(20):4794–801. PMID: 27239106; PMCID: PMC4873872.; Dubinsky MC. Azathioprine, 6-mercaptopurine in inflammatory bowel disease: pharmacology, efficacy, and safety. Clin Gastroenterol Hepatol. 2004 Sep;2(9):731–43. doi: 10.1016/s1542-3565(04)00344-1. PMID: 15354273.; Cuffari C, Théorêt Y, Latour S, Seidman G. 6-Mercaptopurine metabolism in Crohn's disease: correlation with efficacy and toxicity. Gut. 1996 Sep;39(3):401–6. PMID: 8949645; PMCID: PMC1383347. |
| Sensory perception of salty taste Accession ID: Reactome:R-DME-9730628 |
|
Nomura K, Nakanishi M, Ishidate F, Iwata K, Taruno A. All-Electrical Ca2+-Independent Signal Transduction Mediates Attractive Sodium Taste in Taste Buds. Neuron. 2020 Jun 03;106(5):816–829.e6. doi: 10.1016/j.neuron.2020.03.006. PMID: 32229307.; Bigiani A. Does ENaC Work as Sodium Taste Receptor in Humans? Nutrients. 2020 Apr 24;12(4). PMID: 32344597; PMCID: PMC7230849.; Lossow K, Hermans-Borgmeyer I, Meyerhof W, Behrens M. Segregated Expression of ENaC Subunits in Taste Cells. Chem Senses. 2020 May 21;45(4):235–48. doi: 10.1093/chemse/bjaa004. PMID: 32006019.; Roper SD. The taste of table salt. Pflügers Archiv - European Journal of Physiology. 2015 Jan 07;467(3):457–63. doi: 10.1007/s00424-014-1683-z.; Estacion M, Harty TP, Choi JS, Tyrrell L, Dib-Hajj SD, Waxman SG. A sodium channel gene SCN9A polymorphism that increases nociceptor excitability. Ann Neurol. 2009 Dec;66(6):862–6. doi: 10.1002/ana.21895. PMID: 20033988.; Rossier O, Cao J, Huque T, Spielman AI, Feldman RS, Medrano JF, Brand JG, le Coutre J. Analysis of a human fungiform papillae cDNA library and identification of taste-related genes. Chem Senses. 2004 Jan;29(1):13–23. doi: 10.1093/chemse/bjh002. PMID: 14752036. |
| Ribavirin ADME Accession ID: Reactome:R-BTA-9755088 |
|
Goodarzi N, Barazesh Morgani A, Abrahamsson B, Cristofoletti R, Groot DW, Langguth P, Mehta MU, Polli JE, Shah VP, Dressman JB. Biowaiver Monographs for Immediate Release Solid Oral Dosage Forms: Ribavirin. Journal of Pharmaceutical Sciences. 2016 Apr;105(4):1362–9. doi: 10.1016/j.xphs.2016.01.017.; Dixit NM, Perelson AS. The metabolism, pharmacokinetics and mechanisms of antiviral activity of ribavirin against hepatitis C virus. Cellular and Molecular Life Sciences. 2006 Feb 23;63(7-8):832–42. doi: 10.1007/s00018-005-5455-y. |
| Ribavirin ADME Accession ID: Reactome:R-CEL-9755088 |
|
Goodarzi N, Barazesh Morgani A, Abrahamsson B, Cristofoletti R, Groot DW, Langguth P, Mehta MU, Polli JE, Shah VP, Dressman JB. Biowaiver Monographs for Immediate Release Solid Oral Dosage Forms: Ribavirin. Journal of Pharmaceutical Sciences. 2016 Apr;105(4):1362–9. doi: 10.1016/j.xphs.2016.01.017.; Dixit NM, Perelson AS. The metabolism, pharmacokinetics and mechanisms of antiviral activity of ribavirin against hepatitis C virus. Cellular and Molecular Life Sciences. 2006 Feb 23;63(7-8):832–42. doi: 10.1007/s00018-005-5455-y. |
| Ribavirin ADME Accession ID: Reactome:R-CFA-9755088 |
|
Goodarzi N, Barazesh Morgani A, Abrahamsson B, Cristofoletti R, Groot DW, Langguth P, Mehta MU, Polli JE, Shah VP, Dressman JB. Biowaiver Monographs for Immediate Release Solid Oral Dosage Forms: Ribavirin. Journal of Pharmaceutical Sciences. 2016 Apr;105(4):1362–9. doi: 10.1016/j.xphs.2016.01.017.; Dixit NM, Perelson AS. The metabolism, pharmacokinetics and mechanisms of antiviral activity of ribavirin against hepatitis C virus. Cellular and Molecular Life Sciences. 2006 Feb 23;63(7-8):832–42. doi: 10.1007/s00018-005-5455-y. |
| Ribavirin ADME Accession ID: Reactome:R-DME-9755088 |
|
Goodarzi N, Barazesh Morgani A, Abrahamsson B, Cristofoletti R, Groot DW, Langguth P, Mehta MU, Polli JE, Shah VP, Dressman JB. Biowaiver Monographs for Immediate Release Solid Oral Dosage Forms: Ribavirin. Journal of Pharmaceutical Sciences. 2016 Apr;105(4):1362–9. doi: 10.1016/j.xphs.2016.01.017.; Dixit NM, Perelson AS. The metabolism, pharmacokinetics and mechanisms of antiviral activity of ribavirin against hepatitis C virus. Cellular and Molecular Life Sciences. 2006 Feb 23;63(7-8):832–42. doi: 10.1007/s00018-005-5455-y. |
| Ribavirin ADME Accession ID: Reactome:R-RNO-9755088 |
|
Goodarzi N, Barazesh Morgani A, Abrahamsson B, Cristofoletti R, Groot DW, Langguth P, Mehta MU, Polli JE, Shah VP, Dressman JB. Biowaiver Monographs for Immediate Release Solid Oral Dosage Forms: Ribavirin. Journal of Pharmaceutical Sciences. 2016 Apr;105(4):1362–9. doi: 10.1016/j.xphs.2016.01.017.; Dixit NM, Perelson AS. The metabolism, pharmacokinetics and mechanisms of antiviral activity of ribavirin against hepatitis C virus. Cellular and Molecular Life Sciences. 2006 Feb 23;63(7-8):832–42. doi: 10.1007/s00018-005-5455-y. |
| Ribavirin ADME Accession ID: Reactome:R-SSC-9755088 |
|
Goodarzi N, Barazesh Morgani A, Abrahamsson B, Cristofoletti R, Groot DW, Langguth P, Mehta MU, Polli JE, Shah VP, Dressman JB. Biowaiver Monographs for Immediate Release Solid Oral Dosage Forms: Ribavirin. Journal of Pharmaceutical Sciences. 2016 Apr;105(4):1362–9. doi: 10.1016/j.xphs.2016.01.017.; Dixit NM, Perelson AS. The metabolism, pharmacokinetics and mechanisms of antiviral activity of ribavirin against hepatitis C virus. Cellular and Molecular Life Sciences. 2006 Feb 23;63(7-8):832–42. doi: 10.1007/s00018-005-5455-y. |
| Sensory Perception Accession ID: Reactome:R-RNO-9709957 |
|
Lankford CK, Laird JG, Inamdar SM, Baker SA. A Comparison of the Primary Sensory Neurons Used in Olfaction and Vision. Front Cell Neurosci. 2020;14():595523. PMID: 33250719; PMCID: PMC7676898.; Glezer I, Malnic B. Olfactory receptor function. Handb Clin Neurol. 2019;164():67–78. doi: 10.1016/b978-0-444-63855-7.00005-8. PMID: 31604564.; Fettiplace R. Hair Cell Transduction, Tuning, and Synaptic Transmission in the Mammalian Cochlea. Comprehensive Physiology. 2017 Oct;7(4):1197–227. doi: 10.1002/j.2040-4603.2017.tb00783.x.; Roper SD, Chaudhari N. Taste buds: cells, signals and synapses. Nature Reviews Neuroscience. 2017 Jun 29;18(8):485–97. doi: 10.1038/nrn.2017.68.; Molday RS, Moritz OL. Photoreceptors at a glance. J Cell Sci. 2015 Nov 15;128(22):4039–45. PMID: 26574505; PMCID: PMC4712787.; Grossniklaus HE, Geisert EE, Nickerson JM. Introduction to the Retina. Prog Mol Biol Transl Sci. 2015;134():383–96. doi: 10.1016/bs.pmbts.2015.06.001. PMID: 26310166. |
| Sensory perception of taste Accession ID: Reactome:R-XTR-9717189 |
|
Taruno A, Nomura K, Kusakizako T, Ma Z, Nureki O, Foskett JK. Taste transduction and channel synapses in taste buds. Pflügers Archiv - European Journal of Physiology. 2020 Sep 16;473(1):3–13. doi: 10.1007/s00424-020-02464-4.; Kinnamon SC, Finger TE. Recent advances in taste transduction and signaling. F1000Res. 2019 Dec 17;8():2117. doi: 10.12688/f1000research.21099.1.; Roper SD, Chaudhari N. Taste buds: cells, signals and synapses. Nature Reviews Neuroscience. 2017 Jun 29;18(8):485–97. doi: 10.1038/nrn.2017.68.; Liman ER, Zhang YV, Montell C. Peripheral coding of taste. Neuron. 2014 Mar 05;81(5):984–1000. PMID: 24607224; PMCID: PMC3994536.; Chandrashekar J, Kuhn C, Oka Y, Yarmolinsky DA, Hummler E, Ryba NJ, Zuker CS. The cells and peripheral representation of sodium taste in mice. Nature. 2010 Mar 11;464(7286):297–301. PMID: 20107438; PMCID: PMC2849629. |
| Sensory perception of taste Accession ID: Reactome:R-SSC-9717189 |
|
Taruno A, Nomura K, Kusakizako T, Ma Z, Nureki O, Foskett JK. Taste transduction and channel synapses in taste buds. Pflügers Archiv - European Journal of Physiology. 2020 Sep 16;473(1):3–13. doi: 10.1007/s00424-020-02464-4.; Kinnamon SC, Finger TE. Recent advances in taste transduction and signaling. F1000Res. 2019 Dec 17;8():2117. doi: 10.12688/f1000research.21099.1.; Roper SD, Chaudhari N. Taste buds: cells, signals and synapses. Nature Reviews Neuroscience. 2017 Jun 29;18(8):485–97. doi: 10.1038/nrn.2017.68.; Liman ER, Zhang YV, Montell C. Peripheral coding of taste. Neuron. 2014 Mar 05;81(5):984–1000. PMID: 24607224; PMCID: PMC3994536.; Chandrashekar J, Kuhn C, Oka Y, Yarmolinsky DA, Hummler E, Ryba NJ, Zuker CS. The cells and peripheral representation of sodium taste in mice. Nature. 2010 Mar 11;464(7286):297–301. PMID: 20107438; PMCID: PMC2849629. |