Pathways Knowlegdes

Biological pathway database

Pathway DOIs Note
Azathioprine ADME

Accession ID: Reactome:R-XTR-9748787
  • 10.1016/s1542-3565(04)00344-1
  • 10.1136/gut.39.3.401
  • 10.3389/fphar.2020.582291
  • 10.3748/wjg.v22.i20.4794
 Tominaga K, Sugaya T, Tanaka T, Kanazawa M, Iijima M, Irisawa A. Thiopurines: Recent Topics and Their Role in the Treatment of Inflammatory Bowel Diseases. Front Pharmacol. 2020;11():582291. PMID: 33584261; PMCID: PMC7878672.; Axelrad JE, Lichtiger S, Yajnik V. Inflammatory bowel disease and cancer: The role of inflammation, immunosuppression, and cancer treatment. World J Gastroenterol. 2016 May 28;22(20):4794–801. PMID: 27239106; PMCID: PMC4873872.; Dubinsky MC. Azathioprine, 6-mercaptopurine in inflammatory bowel disease: pharmacology, efficacy, and safety. Clin Gastroenterol Hepatol. 2004 Sep;2(9):731–43. doi: 10.1016/s1542-3565(04)00344-1. PMID: 15354273.; Cuffari C, Théorêt Y, Latour S, Seidman G. 6-Mercaptopurine metabolism in Crohn's disease: correlation with efficacy and toxicity. Gut. 1996 Sep;39(3):401–6. PMID: 8949645; PMCID: PMC1383347.
Ribavirin ADME

Accession ID: Reactome:R-GGA-9755088
  • 10.1007/s00018-005-5455-y
  • 10.1016/j.xphs.2016.01.017
 Goodarzi N, Barazesh Morgani A, Abrahamsson B, Cristofoletti R, Groot DW, Langguth P, Mehta MU, Polli JE, Shah VP, Dressman JB. Biowaiver Monographs for Immediate Release Solid Oral Dosage Forms: Ribavirin. Journal of Pharmaceutical Sciences. 2016 Apr;105(4):1362–9. doi: 10.1016/j.xphs.2016.01.017.; Dixit NM, Perelson AS. The metabolism, pharmacokinetics and mechanisms of antiviral activity of ribavirin against hepatitis C virus. Cellular and Molecular Life Sciences. 2006 Feb 23;63(7-8):832–42. doi: 10.1007/s00018-005-5455-y.
Sensory Perception

Accession ID: Reactome:R-BTA-9709957
  • 10.1002/cphy.c160049
  • 10.1016/b978-0-444-63855-7.00005-8
  • 10.1016/bs.pmbts.2015.06.001
  • 10.1038/nrn.2017.68
  • 10.1242/jcs.175687
  • 10.3389/fncel.2020.595523
 Lankford CK, Laird JG, Inamdar SM, Baker SA. A Comparison of the Primary Sensory Neurons Used in Olfaction and Vision. Front Cell Neurosci. 2020;14():595523. PMID: 33250719; PMCID: PMC7676898.; Glezer I, Malnic B. Olfactory receptor function. Handb Clin Neurol. 2019;164():67–78. doi: 10.1016/b978-0-444-63855-7.00005-8. PMID: 31604564.; Fettiplace R. Hair Cell Transduction, Tuning, and Synaptic Transmission in the Mammalian Cochlea. Comprehensive Physiology. 2017 Oct;7(4):1197–227. doi: 10.1002/j.2040-4603.2017.tb00783.x.; Roper SD, Chaudhari N. Taste buds: cells, signals and synapses. Nature Reviews Neuroscience. 2017 Jun 29;18(8):485–97. doi: 10.1038/nrn.2017.68.; Molday RS, Moritz OL. Photoreceptors at a glance. J Cell Sci. 2015 Nov 15;128(22):4039–45. PMID: 26574505; PMCID: PMC4712787.; Grossniklaus HE, Geisert EE, Nickerson JM. Introduction to the Retina. Prog Mol Biol Transl Sci. 2015;134():383–96. doi: 10.1016/bs.pmbts.2015.06.001. PMID: 26310166.
Sensory Perception

Accession ID: Reactome:R-HSA-9709957
  • 10.1002/cphy.c160049
  • 10.1016/b978-0-444-63855-7.00005-8
  • 10.1016/bs.pmbts.2015.06.001
  • 10.1038/nrn.2017.68
  • 10.1242/jcs.175687
  • 10.3389/fncel.2020.595523
 Lankford CK, Laird JG, Inamdar SM, Baker SA. A Comparison of the Primary Sensory Neurons Used in Olfaction and Vision. Front Cell Neurosci. 2020;14():595523. PMID: 33250719; PMCID: PMC7676898.; Glezer I, Malnic B. Olfactory receptor function. Handb Clin Neurol. 2019;164():67–78. doi: 10.1016/b978-0-444-63855-7.00005-8. PMID: 31604564.; Fettiplace R. Hair Cell Transduction, Tuning, and Synaptic Transmission in the Mammalian Cochlea. Comprehensive Physiology. 2017 Oct;7(4):1197–227. doi: 10.1002/j.2040-4603.2017.tb00783.x.; Roper SD, Chaudhari N. Taste buds: cells, signals and synapses. Nature Reviews Neuroscience. 2017 Jun 29;18(8):485–97. doi: 10.1038/nrn.2017.68.; Molday RS, Moritz OL. Photoreceptors at a glance. J Cell Sci. 2015 Nov 15;128(22):4039–45. PMID: 26574505; PMCID: PMC4712787.; Grossniklaus HE, Geisert EE, Nickerson JM. Introduction to the Retina. Prog Mol Biol Transl Sci. 2015;134():383–96. doi: 10.1016/bs.pmbts.2015.06.001. PMID: 26310166.
Sensory perception of taste

Accession ID: Reactome:R-CEL-9717189
  • 10.1007/s00424-020-02464-4
  • 10.1016/j.neuron.2014.02.022
  • 10.1038/nature08783
  • 10.1038/nrn.2017.68
  • 10.12688/f1000research.21099.1
 Taruno A, Nomura K, Kusakizako T, Ma Z, Nureki O, Foskett JK. Taste transduction and channel synapses in taste buds. Pflügers Archiv - European Journal of Physiology. 2020 Sep 16;473(1):3–13. doi: 10.1007/s00424-020-02464-4.; Kinnamon SC, Finger TE. Recent advances in taste transduction and signaling. F1000Res. 2019 Dec 17;8():2117. doi: 10.12688/f1000research.21099.1.; Roper SD, Chaudhari N. Taste buds: cells, signals and synapses. Nature Reviews Neuroscience. 2017 Jun 29;18(8):485–97. doi: 10.1038/nrn.2017.68.; Liman ER, Zhang YV, Montell C. Peripheral coding of taste. Neuron. 2014 Mar 05;81(5):984–1000. PMID: 24607224; PMCID: PMC3994536.; Chandrashekar J, Kuhn C, Oka Y, Yarmolinsky DA, Hummler E, Ryba NJ, Zuker CS. The cells and peripheral representation of sodium taste in mice. Nature. 2010 Mar 11;464(7286):297–301. PMID: 20107438; PMCID: PMC2849629.
Sensory perception of salty taste

Accession ID: Reactome:R-GGA-9730628
  • 10.1002/ana.21895
  • 10.1007/s00424-014-1683-z
  • 10.1016/j.neuron.2020.03.006
  • 10.1093/chemse/bjaa004
  • 10.1093/chemse/bjh002
  • 10.3390/nu12041195
 Nomura K, Nakanishi M, Ishidate F, Iwata K, Taruno A. All-Electrical Ca2+-Independent Signal Transduction Mediates Attractive Sodium Taste in Taste Buds. Neuron. 2020 Jun 03;106(5):816–829.e6. doi: 10.1016/j.neuron.2020.03.006. PMID: 32229307.; Bigiani A. Does ENaC Work as Sodium Taste Receptor in Humans? Nutrients. 2020 Apr 24;12(4). PMID: 32344597; PMCID: PMC7230849.; Lossow K, Hermans-Borgmeyer I, Meyerhof W, Behrens M. Segregated Expression of ENaC Subunits in Taste Cells. Chem Senses. 2020 May 21;45(4):235–48. doi: 10.1093/chemse/bjaa004. PMID: 32006019.; Roper SD. The taste of table salt. Pflügers Archiv - European Journal of Physiology. 2015 Jan 07;467(3):457–63. doi: 10.1007/s00424-014-1683-z.; Estacion M, Harty TP, Choi JS, Tyrrell L, Dib-Hajj SD, Waxman SG. A sodium channel gene SCN9A polymorphism that increases nociceptor excitability. Ann Neurol. 2009 Dec;66(6):862–6. doi: 10.1002/ana.21895. PMID: 20033988.; Rossier O, Cao J, Huque T, Spielman AI, Feldman RS, Medrano JF, Brand JG, le Coutre J. Analysis of a human fungiform papillae cDNA library and identification of taste-related genes. Chem Senses. 2004 Jan;29(1):13–23. doi: 10.1093/chemse/bjh002. PMID: 14752036.
Sensory perception of salty taste

Accession ID: Reactome:R-RNO-9730628
  • 10.1002/ana.21895
  • 10.1007/s00424-014-1683-z
  • 10.1016/j.neuron.2020.03.006
  • 10.1093/chemse/bjaa004
  • 10.1093/chemse/bjh002
  • 10.3390/nu12041195
 Nomura K, Nakanishi M, Ishidate F, Iwata K, Taruno A. All-Electrical Ca2+-Independent Signal Transduction Mediates Attractive Sodium Taste in Taste Buds. Neuron. 2020 Jun 03;106(5):816–829.e6. doi: 10.1016/j.neuron.2020.03.006. PMID: 32229307.; Bigiani A. Does ENaC Work as Sodium Taste Receptor in Humans? Nutrients. 2020 Apr 24;12(4). PMID: 32344597; PMCID: PMC7230849.; Lossow K, Hermans-Borgmeyer I, Meyerhof W, Behrens M. Segregated Expression of ENaC Subunits in Taste Cells. Chem Senses. 2020 May 21;45(4):235–48. doi: 10.1093/chemse/bjaa004. PMID: 32006019.; Roper SD. The taste of table salt. Pflügers Archiv - European Journal of Physiology. 2015 Jan 07;467(3):457–63. doi: 10.1007/s00424-014-1683-z.; Estacion M, Harty TP, Choi JS, Tyrrell L, Dib-Hajj SD, Waxman SG. A sodium channel gene SCN9A polymorphism that increases nociceptor excitability. Ann Neurol. 2009 Dec;66(6):862–6. doi: 10.1002/ana.21895. PMID: 20033988.; Rossier O, Cao J, Huque T, Spielman AI, Feldman RS, Medrano JF, Brand JG, le Coutre J. Analysis of a human fungiform papillae cDNA library and identification of taste-related genes. Chem Senses. 2004 Jan;29(1):13–23. doi: 10.1093/chemse/bjh002. PMID: 14752036.
Sensory perception of taste

Accession ID: Reactome:R-DME-9717189
  • 10.1007/s00424-020-02464-4
  • 10.1016/j.neuron.2014.02.022
  • 10.1038/nature08783
  • 10.1038/nrn.2017.68
  • 10.12688/f1000research.21099.1
 Taruno A, Nomura K, Kusakizako T, Ma Z, Nureki O, Foskett JK. Taste transduction and channel synapses in taste buds. Pflügers Archiv - European Journal of Physiology. 2020 Sep 16;473(1):3–13. doi: 10.1007/s00424-020-02464-4.; Kinnamon SC, Finger TE. Recent advances in taste transduction and signaling. F1000Res. 2019 Dec 17;8():2117. doi: 10.12688/f1000research.21099.1.; Roper SD, Chaudhari N. Taste buds: cells, signals and synapses. Nature Reviews Neuroscience. 2017 Jun 29;18(8):485–97. doi: 10.1038/nrn.2017.68.; Liman ER, Zhang YV, Montell C. Peripheral coding of taste. Neuron. 2014 Mar 05;81(5):984–1000. PMID: 24607224; PMCID: PMC3994536.; Chandrashekar J, Kuhn C, Oka Y, Yarmolinsky DA, Hummler E, Ryba NJ, Zuker CS. The cells and peripheral representation of sodium taste in mice. Nature. 2010 Mar 11;464(7286):297–301. PMID: 20107438; PMCID: PMC2849629.
Sensory perception of salty taste

Accession ID: Reactome:R-MMU-9730628
  • 10.1002/ana.21895
  • 10.1007/s00424-014-1683-z
  • 10.1016/j.neuron.2020.03.006
  • 10.1093/chemse/bjaa004
  • 10.1093/chemse/bjh002
  • 10.3390/nu12041195
 Nomura K, Nakanishi M, Ishidate F, Iwata K, Taruno A. All-Electrical Ca2+-Independent Signal Transduction Mediates Attractive Sodium Taste in Taste Buds. Neuron. 2020 Jun 03;106(5):816–829.e6. doi: 10.1016/j.neuron.2020.03.006. PMID: 32229307.; Bigiani A. Does ENaC Work as Sodium Taste Receptor in Humans? Nutrients. 2020 Apr 24;12(4). PMID: 32344597; PMCID: PMC7230849.; Lossow K, Hermans-Borgmeyer I, Meyerhof W, Behrens M. Segregated Expression of ENaC Subunits in Taste Cells. Chem Senses. 2020 May 21;45(4):235–48. doi: 10.1093/chemse/bjaa004. PMID: 32006019.; Roper SD. The taste of table salt. Pflügers Archiv - European Journal of Physiology. 2015 Jan 07;467(3):457–63. doi: 10.1007/s00424-014-1683-z.; Estacion M, Harty TP, Choi JS, Tyrrell L, Dib-Hajj SD, Waxman SG. A sodium channel gene SCN9A polymorphism that increases nociceptor excitability. Ann Neurol. 2009 Dec;66(6):862–6. doi: 10.1002/ana.21895. PMID: 20033988.; Rossier O, Cao J, Huque T, Spielman AI, Feldman RS, Medrano JF, Brand JG, le Coutre J. Analysis of a human fungiform papillae cDNA library and identification of taste-related genes. Chem Senses. 2004 Jan;29(1):13–23. doi: 10.1093/chemse/bjh002. PMID: 14752036.
Sensory perception of salty taste

Accession ID: Reactome:R-HSA-9730628
  • 10.1002/ana.21895
  • 10.1007/s00424-014-1683-z
  • 10.1016/j.neuron.2020.03.006
  • 10.1093/chemse/bjaa004
  • 10.1093/chemse/bjh002
  • 10.3390/nu12041195
 Nomura K, Nakanishi M, Ishidate F, Iwata K, Taruno A. All-Electrical Ca2+-Independent Signal Transduction Mediates Attractive Sodium Taste in Taste Buds. Neuron. 2020 Jun 03;106(5):816–829.e6. doi: 10.1016/j.neuron.2020.03.006. PMID: 32229307.; Bigiani A. Does ENaC Work as Sodium Taste Receptor in Humans? Nutrients. 2020 Apr 24;12(4). PMID: 32344597; PMCID: PMC7230849.; Lossow K, Hermans-Borgmeyer I, Meyerhof W, Behrens M. Segregated Expression of ENaC Subunits in Taste Cells. Chem Senses. 2020 May 21;45(4):235–48. doi: 10.1093/chemse/bjaa004. PMID: 32006019.; Roper SD. The taste of table salt. Pflügers Archiv - European Journal of Physiology. 2015 Jan 07;467(3):457–63. doi: 10.1007/s00424-014-1683-z.; Estacion M, Harty TP, Choi JS, Tyrrell L, Dib-Hajj SD, Waxman SG. A sodium channel gene SCN9A polymorphism that increases nociceptor excitability. Ann Neurol. 2009 Dec;66(6):862–6. doi: 10.1002/ana.21895. PMID: 20033988.; Rossier O, Cao J, Huque T, Spielman AI, Feldman RS, Medrano JF, Brand JG, le Coutre J. Analysis of a human fungiform papillae cDNA library and identification of taste-related genes. Chem Senses. 2004 Jan;29(1):13–23. doi: 10.1093/chemse/bjh002. PMID: 14752036.
Drug ADME

Accession ID: Reactome:R-CFA-9748784
  • 10.1002/jps.21009
  • 10.2967/jnmt.117.199638
 Currie GM. Pharmacology, Part 2: Introduction to Pharmacokinetics. J Nucl Med Technol. 2018 Sep;46(3):221–30. doi: 10.2967/jnmt.117.199638. PMID: 29724803.; Ruiz-Garcia A, Bermejo M, Moss A, Casabo VG. Pharmacokinetics in Drug Discovery. Journal of Pharmaceutical Sciences. 2008 Feb;97(2):654–90. doi: 10.1002/jps.21009.; Pallasch TJ. Principles of pharmacotherapy: II. Pharmacokinetics. Anesth Prog. 1988 Jul;35(4):133–46. PMID: 3046441; PMCID: PMC2167950.
Azathioprine ADME

Accession ID: Reactome:R-DME-9748787
  • 10.1016/s1542-3565(04)00344-1
  • 10.1136/gut.39.3.401
  • 10.3389/fphar.2020.582291
  • 10.3748/wjg.v22.i20.4794
 Tominaga K, Sugaya T, Tanaka T, Kanazawa M, Iijima M, Irisawa A. Thiopurines: Recent Topics and Their Role in the Treatment of Inflammatory Bowel Diseases. Front Pharmacol. 2020;11():582291. PMID: 33584261; PMCID: PMC7878672.; Axelrad JE, Lichtiger S, Yajnik V. Inflammatory bowel disease and cancer: The role of inflammation, immunosuppression, and cancer treatment. World J Gastroenterol. 2016 May 28;22(20):4794–801. PMID: 27239106; PMCID: PMC4873872.; Dubinsky MC. Azathioprine, 6-mercaptopurine in inflammatory bowel disease: pharmacology, efficacy, and safety. Clin Gastroenterol Hepatol. 2004 Sep;2(9):731–43. doi: 10.1016/s1542-3565(04)00344-1. PMID: 15354273.; Cuffari C, Théorêt Y, Latour S, Seidman G. 6-Mercaptopurine metabolism in Crohn's disease: correlation with efficacy and toxicity. Gut. 1996 Sep;39(3):401–6. PMID: 8949645; PMCID: PMC1383347.
Azathioprine ADME

Accession ID: Reactome:R-HSA-9748787
  • 10.1016/s1542-3565(04)00344-1
  • 10.1136/gut.39.3.401
  • 10.3389/fphar.2020.582291
  • 10.3748/wjg.v22.i20.4794
 Tominaga K, Sugaya T, Tanaka T, Kanazawa M, Iijima M, Irisawa A. Thiopurines: Recent Topics and Their Role in the Treatment of Inflammatory Bowel Diseases. Front Pharmacol. 2020;11():582291. PMID: 33584261; PMCID: PMC7878672.; Axelrad JE, Lichtiger S, Yajnik V. Inflammatory bowel disease and cancer: The role of inflammation, immunosuppression, and cancer treatment. World J Gastroenterol. 2016 May 28;22(20):4794–801. PMID: 27239106; PMCID: PMC4873872.; Dubinsky MC. Azathioprine, 6-mercaptopurine in inflammatory bowel disease: pharmacology, efficacy, and safety. Clin Gastroenterol Hepatol. 2004 Sep;2(9):731–43. doi: 10.1016/s1542-3565(04)00344-1. PMID: 15354273.; Cuffari C, Théorêt Y, Latour S, Seidman G. 6-Mercaptopurine metabolism in Crohn's disease: correlation with efficacy and toxicity. Gut. 1996 Sep;39(3):401–6. PMID: 8949645; PMCID: PMC1383347.
Drug ADME

Accession ID: Reactome:R-XTR-9748784
  • 10.1002/jps.21009
  • 10.2967/jnmt.117.199638
 Currie GM. Pharmacology, Part 2: Introduction to Pharmacokinetics. J Nucl Med Technol. 2018 Sep;46(3):221–30. doi: 10.2967/jnmt.117.199638. PMID: 29724803.; Ruiz-Garcia A, Bermejo M, Moss A, Casabo VG. Pharmacokinetics in Drug Discovery. Journal of Pharmaceutical Sciences. 2008 Feb;97(2):654–90. doi: 10.1002/jps.21009.; Pallasch TJ. Principles of pharmacotherapy: II. Pharmacokinetics. Anesth Prog. 1988 Jul;35(4):133–46. PMID: 3046441; PMCID: PMC2167950.
Ribavirin ADME

Accession ID: Reactome:R-MMU-9755088
  • 10.1007/s00018-005-5455-y
  • 10.1016/j.xphs.2016.01.017
 Goodarzi N, Barazesh Morgani A, Abrahamsson B, Cristofoletti R, Groot DW, Langguth P, Mehta MU, Polli JE, Shah VP, Dressman JB. Biowaiver Monographs for Immediate Release Solid Oral Dosage Forms: Ribavirin. Journal of Pharmaceutical Sciences. 2016 Apr;105(4):1362–9. doi: 10.1016/j.xphs.2016.01.017.; Dixit NM, Perelson AS. The metabolism, pharmacokinetics and mechanisms of antiviral activity of ribavirin against hepatitis C virus. Cellular and Molecular Life Sciences. 2006 Feb 23;63(7-8):832–42. doi: 10.1007/s00018-005-5455-y.
Ribavirin ADME

Accession ID: Reactome:R-XTR-9755088
  • 10.1007/s00018-005-5455-y
  • 10.1016/j.xphs.2016.01.017
 Goodarzi N, Barazesh Morgani A, Abrahamsson B, Cristofoletti R, Groot DW, Langguth P, Mehta MU, Polli JE, Shah VP, Dressman JB. Biowaiver Monographs for Immediate Release Solid Oral Dosage Forms: Ribavirin. Journal of Pharmaceutical Sciences. 2016 Apr;105(4):1362–9. doi: 10.1016/j.xphs.2016.01.017.; Dixit NM, Perelson AS. The metabolism, pharmacokinetics and mechanisms of antiviral activity of ribavirin against hepatitis C virus. Cellular and Molecular Life Sciences. 2006 Feb 23;63(7-8):832–42. doi: 10.1007/s00018-005-5455-y.
Sensory Perception

Accession ID: Reactome:R-CFA-9709957
  • 10.1002/cphy.c160049
  • 10.1016/b978-0-444-63855-7.00005-8
  • 10.1016/bs.pmbts.2015.06.001
  • 10.1038/nrn.2017.68
  • 10.1242/jcs.175687
  • 10.3389/fncel.2020.595523
 Lankford CK, Laird JG, Inamdar SM, Baker SA. A Comparison of the Primary Sensory Neurons Used in Olfaction and Vision. Front Cell Neurosci. 2020;14():595523. PMID: 33250719; PMCID: PMC7676898.; Glezer I, Malnic B. Olfactory receptor function. Handb Clin Neurol. 2019;164():67–78. doi: 10.1016/b978-0-444-63855-7.00005-8. PMID: 31604564.; Fettiplace R. Hair Cell Transduction, Tuning, and Synaptic Transmission in the Mammalian Cochlea. Comprehensive Physiology. 2017 Oct;7(4):1197–227. doi: 10.1002/j.2040-4603.2017.tb00783.x.; Roper SD, Chaudhari N. Taste buds: cells, signals and synapses. Nature Reviews Neuroscience. 2017 Jun 29;18(8):485–97. doi: 10.1038/nrn.2017.68.; Molday RS, Moritz OL. Photoreceptors at a glance. J Cell Sci. 2015 Nov 15;128(22):4039–45. PMID: 26574505; PMCID: PMC4712787.; Grossniklaus HE, Geisert EE, Nickerson JM. Introduction to the Retina. Prog Mol Biol Transl Sci. 2015;134():383–96. doi: 10.1016/bs.pmbts.2015.06.001. PMID: 26310166.
Sensory Perception

Accession ID: Reactome:R-MMU-9709957
  • 10.1002/cphy.c160049
  • 10.1016/b978-0-444-63855-7.00005-8
  • 10.1016/bs.pmbts.2015.06.001
  • 10.1038/nrn.2017.68
  • 10.1242/jcs.175687
  • 10.3389/fncel.2020.595523
 Lankford CK, Laird JG, Inamdar SM, Baker SA. A Comparison of the Primary Sensory Neurons Used in Olfaction and Vision. Front Cell Neurosci. 2020;14():595523. PMID: 33250719; PMCID: PMC7676898.; Glezer I, Malnic B. Olfactory receptor function. Handb Clin Neurol. 2019;164():67–78. doi: 10.1016/b978-0-444-63855-7.00005-8. PMID: 31604564.; Fettiplace R. Hair Cell Transduction, Tuning, and Synaptic Transmission in the Mammalian Cochlea. Comprehensive Physiology. 2017 Oct;7(4):1197–227. doi: 10.1002/j.2040-4603.2017.tb00783.x.; Roper SD, Chaudhari N. Taste buds: cells, signals and synapses. Nature Reviews Neuroscience. 2017 Jun 29;18(8):485–97. doi: 10.1038/nrn.2017.68.; Molday RS, Moritz OL. Photoreceptors at a glance. J Cell Sci. 2015 Nov 15;128(22):4039–45. PMID: 26574505; PMCID: PMC4712787.; Grossniklaus HE, Geisert EE, Nickerson JM. Introduction to the Retina. Prog Mol Biol Transl Sci. 2015;134():383–96. doi: 10.1016/bs.pmbts.2015.06.001. PMID: 26310166.
Sensory perception of salty taste

Accession ID: Reactome:R-CEL-9730628
  • 10.1002/ana.21895
  • 10.1007/s00424-014-1683-z
  • 10.1016/j.neuron.2020.03.006
  • 10.1093/chemse/bjaa004
  • 10.1093/chemse/bjh002
  • 10.3390/nu12041195
 Nomura K, Nakanishi M, Ishidate F, Iwata K, Taruno A. All-Electrical Ca2+-Independent Signal Transduction Mediates Attractive Sodium Taste in Taste Buds. Neuron. 2020 Jun 03;106(5):816–829.e6. doi: 10.1016/j.neuron.2020.03.006. PMID: 32229307.; Bigiani A. Does ENaC Work as Sodium Taste Receptor in Humans? Nutrients. 2020 Apr 24;12(4). PMID: 32344597; PMCID: PMC7230849.; Lossow K, Hermans-Borgmeyer I, Meyerhof W, Behrens M. Segregated Expression of ENaC Subunits in Taste Cells. Chem Senses. 2020 May 21;45(4):235–48. doi: 10.1093/chemse/bjaa004. PMID: 32006019.; Roper SD. The taste of table salt. Pflügers Archiv - European Journal of Physiology. 2015 Jan 07;467(3):457–63. doi: 10.1007/s00424-014-1683-z.; Estacion M, Harty TP, Choi JS, Tyrrell L, Dib-Hajj SD, Waxman SG. A sodium channel gene SCN9A polymorphism that increases nociceptor excitability. Ann Neurol. 2009 Dec;66(6):862–6. doi: 10.1002/ana.21895. PMID: 20033988.; Rossier O, Cao J, Huque T, Spielman AI, Feldman RS, Medrano JF, Brand JG, le Coutre J. Analysis of a human fungiform papillae cDNA library and identification of taste-related genes. Chem Senses. 2004 Jan;29(1):13–23. doi: 10.1093/chemse/bjh002. PMID: 14752036.
Sensory perception of taste

Accession ID: Reactome:R-GGA-9717189
  • 10.1007/s00424-020-02464-4
  • 10.1016/j.neuron.2014.02.022
  • 10.1038/nature08783
  • 10.1038/nrn.2017.68
  • 10.12688/f1000research.21099.1
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