Oxytetracycline (BioCAD00000015744)
Metabolite Card
Chinese Name: 土霉素
Formula: C22H24N2O9 (460.1482)
SMILES:
[H][C@@]12[C@@H](O)[C@@]3([H])C(=C(O)C4=C(O)C=CC=C4[C@@]3(C)O)C(=O)[C@]1(O)C(=O)C(C(N)=O)=C(O)[C@H]2N(C)CSynonyms [en]
Oxytetracycline; 5-Hydroxytetracycline; Oxytetracycline amphoteric; Oxytetracyclin; Oxytetracycline Anhydrous; Oxitetraciclina
Last reviewed on 2026-04-16.
Cite this Page
Oxytetracycline. 数据之源，洞见之始. SMRUCC genomics institute, a synthetic life researcher from China.
https://biocad_registry.innovation.ac.cn/s/Oxytetracycline
(retrieved
2026-08-20) (CAD Registry RN: BioCAD00000015744). Licensed
under the Attribution-Noncommercial 4.0 International License (CC BY-NC 4.0).
Note
Oxytetracycline is a tetracycline analog isolated from the actinomycete streptomyces rimosus and used in a wide variety of clinical conditions. [PubChem]Oxytetracycline inhibits cell growth by inhibiting translation. It binds to the 30S ribosomal subunit and prevents the amino-acyl tRNA from binding to the A site of the ribosome. The binding is reversible in nature. Oxytetracycline is lipophilic and can easily pass through the cell membrane or passively diffuses through porin channels in the bacterial membrane. Oxytetracycline is a clinically used broad-spectrum antibacterial antibiotic. It is approved by FDA for use in fish and animal feeds. Oxytetracycline is known as a broad-spectrum antibiotic due to its activity against such a wide range of infections. It was the second of the tetracyclines to be discovered. Oxytetracycline, like other tetracyclines, is used to treat many infections common and rare. Its better absorption profile makes it preferable to tetracycline for moderately severe acne, but alternatives sould be sought if no improvement occurs by 3 months
DBLinks
- CAS Registry Number: 79-57-2
- PubChem CID: 54715139
- ChEBI: 27701
- HMDB: HMDB0014733
- LipidMaps: LMPK07000005
- KEGG: C06624
- BioCyc:
- NCBI MeSH: Oxytetracycline
- Wikipedia: Oxytetracycline
Other DBLinks
- CAS Registry Number: di-hydrate)
- CAS Registry Number: 15251-48-6
- CAS Registry Number: 2058-46-0
- CAS Registry Number: 2058-46-0 (mono-hydrochloride)
- CAS Registry Number: 6153-64-6
- CAS Registry Number: 6153-64-6 (di-hydrate)
- CAS Registry Number: 6153-65-7 (di-hydrochloride salt
- CAS Registry Number: 7179-50-2
- CAS Registry Number: 7179-50-2 (calcium (1:1) salt)
- CAS Registry Number: 79-57-2
- CAS Registry Number: 79-57-2 (ANHYDROUS)
- PubChem: 121596244
- PubChem: 4645
- PubChem: 5280972
- PubChem: 54675779
- PubChem: 54686003
- PubChem: 54715139
- ChEBI: ChEBI:133011
- ChEBI: ChEBI:27701
- HMDB: HMDB0014733
- LipidMaps: LMPK07000005
- KEGG: C06624
- NCBI MeSH: Oxytetracycline
- Wikipedia: Oxytetracycline
- DrugBank: DB00595
- RefMet: RM0135172
- MoNA: BML81880
- MoNA: BML81881
- MoNA: Bruker_HCD_library000448
- MoNA: Bruker_HCD_library001415
- MoNA: CCMSLIB00000077020
- MoNA: CO000331
- MoNA: CO000332
- MoNA: CO000333
- MoNA: CO000334
- MoNA: CO000335
- MoNA: EQ361001
- MoNA: EQ361002
- MoNA: EQ361003
- MoNA: EQ361004
- MoNA: EQ361005
- MoNA: EQ361006
- MoNA: EQ361007
- MoNA: EQ361008
- MoNA: EQ361009
- MoNA: EQ361051
- MoNA: EQ361052
- MoNA: EQ361053
- MoNA: EQ361054
- MoNA: EQ361055
- MoNA: EQ361056
- MoNA: EQ361057
- MoNA: EQ361058
- MoNA: EQ361059
- MoNA: FiehnHILIC000649
- MoNA: FiehnHILIC001423
- MoNA: FiehnHILIC002214
- MoNA: VF-NPL-LTQ000099
- MoNA: VF-NPL-LTQ000100
- MoNA: VF-NPL-LTQ000101
- MoNA: VF-NPL-LTQ000102
- MoNA: VF-NPL-QEHF000001
- MoNA: VF-NPL-QEHF000002
- MoNA: VF-NPL-QEHF000003
- MoNA: VF-NPL-QEHF000004
- MoNA: VF-NPL-QEHF000005
- MoNA: VF-NPL-QEHF000006
- Metlin: METLIN_1690
- Coconut NaturalProduct: CNP0145232.1
- Coconut NaturalProduct: CNP0145232.3
- Coconut NaturalProduct: CNP0169100.1
- Coconut NaturalProduct: CNP0258086.0
- Coconut NaturalProduct: CNP0309543.1
- Coconut NaturalProduct: CNP0309543.2
- Coconut NaturalProduct: CNP0435069.1
- PMHub: MS000000886
- PMHub: MS000008637
- PMHub: MS000010137
- metaboanalyst: d5f770133ef028a6f296c8f597ed2fae
Class / Ontology
- WishartLab ClassyFire: [Tetracyclines] Tetracyclines
- RefMet: [Tetracyclines] Tetracyclines
- LipidMaps: [Linear tetracyclines [PK07]] Linear tetracyclines [PK07]
- ChEBI: [CHEBI:27701] oxytetracycline
- Coconut NaturalProduct: [Cholestane steroids] Cholestane steroids
- Coconut NaturalProduct: [Tetracyclines] Tetracyclines
- Coconut NaturalProduct: [Cyclic peptides] Cyclic peptides
- Coconut NaturalProduct: [Germacrane sesquiterpenoids] Germacrane sesquiterpenoids
| ID | EC Number | Name |
|---|---|---|
| KEGG:R09192 | 1.3.98.4 | oxytetracycline:coenzyme-F420 oxidoreductase |
| KEGG:R11525 | 1.14.13.231 | oxytetracycline,NADPH:oxygen oxidoreductase (11a-hydroxylating) |
| Manual Audit:BIOCAD_RXN-85567 | 7.6.2.- | ABC-type drug exporters[Oxytetracycline] |
| Manual Audit:BIOCAD_RXN-85573 | 1.14.13.- | 11a-Hydroxylation of Tetracyclines[Oxytetracycline] |
Taxonomy Source
- Microporus sp. [ncbi taxid: ]
- Streptomyces rimosus [ncbi taxid: 1927]
- Streptomyces [ncbi taxid: 1883]
- Streptomyces aureofaciens [ncbi taxid: ]
- Streptomyces bingchenggensis BC04 [ncbi taxid: ]
- Streptomyces coelicolor CH999 [ncbi taxid: ]
- Streptomyces coelicolor M146 [ncbi taxid: ]
- Streptomyces diastaticus 108 [ncbi taxid: ]
- Streptomyces lividans [ncbi taxid: 1916]
- Streptomyces lividans K4-114 [ncbi taxid: ]
- Streptomyces rimosus [ncbi taxid: 1927]
- Streptomyces rimosus 1 [ncbi taxid: ]
- Streptomyces rimosus 12907 [ncbi taxid: ]
- Streptomyces rimosus ATCC 10970 [ncbi taxid: ]
- Streptomyces rimosus CN08 [ncbi taxid: ]
- Streptomyces rimosus M4018 [ncbi taxid: ]
- Streptomyces rimosus R6 [ncbi taxid: ]
- Streptomyces rimosus R6-500 [ncbi taxid: 1421017]
- Streptomyces rimosus R6-65 [ncbi taxid: ]
- Streptomyces rimosus R7 [ncbi taxid: ]
- Streptomyces rimosus rimosus ATCC 10970 [ncbi taxid: ]
- Streptomyces rimosus TM-55 [ncbi taxid: ]
- Streptomyces varsoviensis MTCC 1537 [ncbi taxid: ]
- Streptomyces venezuelae [ncbi taxid: 54571]
- Haliclona sp. [ncbi taxid: 34490]
- Aspilia pluriseta [ncbi taxid: 1670834]
- Streptomyces anandii H41-59 [ncbi taxid: ]
Pathway Synthetic
| pathway id | name |
|---|---|
| PathBank:SMP0000293 | Oxytetracycline Action Pathway |