Manual Audit:BIOCAD_RXN-85573

Inferred initial enzymatic inactivation step where a flavin-dependent monooxygenase introduces a hydroxyl group at the 11a position of the naphthacene core, disrupting the molecule’s binding to the bacterial ribosome.

11a-Hydroxylation of Tetracyclines[Oxytetracycline]

Oxytetracycline[C22H24N2O9] + Oxygen[O2] + NADPH[C21H30N7O17P3] + H+[H] = 11a-Hydroxyoxytetracycline[C22H24N2O10] + NADP+[C21H29N7O17P3] + H2O[H2O]

DB Links

Alias

Metabolites

Substrates
metabolite compartment Structure
Oxytetracycline

Formula: C22H24N2O9 		Cytoplasm
Oxygen

Formula: O2 		Cytoplasm
NADPH

Formula: C21H30N7O17P3 		Cytoplasm
H+

Formula: H 		Cytoplasm
Products
metabolite compartment Structure
11a-Hydroxyoxytetracycline

Formula: C22H24N2O10		 Cytoplasm
NADP+

Formula: C21H29N7O17P3		 Cytoplasm
H2O

Formula: H2O		 Cytoplasm