2-Oxobutanoate
2-Ketobutyric acid, also known as alpha-ketobutyrate or 2-oxobutyrate, belongs to the class of organic compounds known as short-chain keto acids and derivatives. These are keto acids with an alkyl chain the contains less than 6 carbon atoms. 2-Ketobutyric acid is a substance that is involved in the metabolism of many amino acids (glycine, methionine, valine, leucine, serine, threonine, isoleucine) as well as propanoate metabolism and C-5 branched dibasic acid metabolism. It is also one of the degradation products of threonine. It can be converted into propionyl-CoA (and subsequently methylmalonyl CoA, which can be converted into succinyl CoA, a citric acid cycle intermediate), and thus enter the citric acid cycle. More specifically, 2-ketobutyric acid is a product of the lysis of cystathionine.
| ID | EC Number | Name |
|---|---|---|
| Rhea:RHEA:66116 | [66116] 2-oxobutanoate + L-glutamine = 2-oxoglutaramate + (2S)-2-aminobutanoate | |
| Rhea:RHEA:66112 | [66112] 2-oxobutanoate + L-tyrosine = (2S)-2-aminobutanoate + 3-(4-hydroxyphenyl)pyruvate | |
| Rhea:RHEA:70223 | [70223] (2S)-2-aminobutanoate + 2-oxoglutarate = 2-oxobutanoate + L-glutamate | |
| Rhea:RHEA:77339 | [77339] (2S)-2-aminobutanoate + glyoxylate = 2-oxobutanoate + glycine | |
| Rhea:RHEA:77351 | [77351] N(omega),N(omega)-dimethyl-L-arginine + 2-oxobutanoate = 5-(3,3-dimethylguanidino)-2-oxopentanoate + (2S)-2-aminobutanoate | |
| Rhea:RHEA:77355 | [77355] 2-oxobutanoate + L-alanine = (2S)-2-aminobutanoate + pyruvate | |
| Rhea:RHEA:82483 | [82483] (2R)-hydroxybutanoate + FAD + H(+) = 2-oxobutanoate + FADH2 | |
| Rhea:RHEA:82419 | [82419] 3-hydroxy-L-kynurenine + 2-oxobutanoate = 4-(2-amino-3-hydroxyphenyl)-2,4-dioxobutanoate + (2S)-2-aminobutanoate | |
| Rhea:RHEA:83043 | [83043] (2R)-hydroxybutanoate + NADP(+) = 2-oxobutanoate + NADPH + H(+) | |
| Rhea:RHEA:23800 | [23800] L-methionine + H2O = methanethiol + 2-oxobutanoate + NH4(+) | |
| Rhea:RHEA:51916 | [51916] (2S)-2-amino-3-butenoate + H2O = 2-oxobutanoate + NH4(+) |