2-Oxobutanoate
2-Ketobutyric acid, also known as alpha-ketobutyrate or 2-oxobutyrate, belongs to the class of organic compounds known as short-chain keto acids and derivatives. These are keto acids with an alkyl chain the contains less than 6 carbon atoms. 2-Ketobutyric acid is a substance that is involved in the metabolism of many amino acids (glycine, methionine, valine, leucine, serine, threonine, isoleucine) as well as propanoate metabolism and C-5 branched dibasic acid metabolism. It is also one of the degradation products of threonine. It can be converted into propionyl-CoA (and subsequently methylmalonyl CoA, which can be converted into succinyl CoA, a citric acid cycle intermediate), and thus enter the citric acid cycle. More specifically, 2-ketobutyric acid is a product of the lysis of cystathionine.
| ID | EC Number | Name |
|---|---|---|
| BioCyc:RXN-22021 | ACETALD + 2-OXOBUTANOATE + PROTON --> CPD-23998 + WATER | |
| BioCyc:RXN-7790 | 1.2.1.25 | 2-OXOBUTANOATE + CO-A + NAD --> PROPIONYL-COA + CARBON-DIOXIDE + NADH |
| BioCyc:2-ETHYLMALATE-SYNTHASE-RXN | 2.3.3.6 | 2-OXOBUTANOATE + WATER + ACETYL-COA --> CPD-620 + CO-A + PROTON |
| BioCyc:RXN-13719 | 1.1.1.272 | (R)-2-hydroxybutanoate dehydrogenase (NADP+) |
| BioCyc:RXN-7745 | 1.1.1.- | CPD-7066 + NAD --> 2-OXOBUTANOATE + CARBON-DIOXIDE + NADH |
| Rhea:RHEA:14005 | [14005] L,L-cystathionine + H2O = 2-oxobutanoate + L-cysteine + NH4(+) | |
| Rhea:RHEA:16933 | [16933] 1-aminocyclopropane-1-carboxylate + H2O = 2-oxobutanoate + NH4(+) | |
| Rhea:RHEA:14501 | [14501] L-homocysteine + H2O = 2-oxobutanoate + hydrogen sulfide + NH4(+) + H(+) | |
| Rhea:RHEA:22108 | [22108] L-threonine = 2-oxobutanoate + NH4(+) | |
| Rhea:RHEA:23040 | [23040] 2-oxobutanoate + acetyl-CoA + H2O = (R)-2-ethylmalate + CoA + H(+) | |
| Rhea:RHEA:24923 | [24923] L-homoserine = 2-oxobutanoate + NH4(+) | |
| Rhea:RHEA:25767 | [25767] 3-carboxy-2-oxobutanoate + H(+) = 2-oxobutanoate + CO2 | |
| Rhea:RHEA:27654 | [27654] 2-oxobutanoate + pyruvate + H(+) = (S)-2-ethyl-2-hydroxy-3-oxobutanoate + CO2 | |
| Rhea:RHEA:28054 | [28054] 2-oxobutanoate + CoA = propanoyl-CoA + formate | |
| Rhea:RHEA:31151 | [31151] L-selenocystathionine + H2O = L-selenocysteine + 2-oxobutanoate + NH4(+) | |
| Rhea:RHEA:32135 | [32135] 2-oxobutanoate + 2 oxidized [2Fe-2S]-[ferredoxin] + CoA = propanoyl-CoA + 2 reduced [2Fe-2S]-[ferredoxin] + CO2 + H(+) | |
| Rhea:RHEA:32715 | [32715] (2R,3S)-3-methylmalate + NAD(+) = 2-oxobutanoate + CO2 + NADH | |
| Rhea:RHEA:33691 | [33691] 2-(1-hydroxyethyl)thiamine diphosphate + 2-oxobutanoate = (S)-2-ethyl-2-hydroxy-3-oxobutanoate + thiamine diphosphate | |
| Rhea:RHEA:33223 | [33223] 2-oxobutanoate + NAD(+) + CoA = propanoyl-CoA + CO2 + NADH | |
| Rhea:RHEA:36371 | [36371] (2S)-hydroxybutanoate + NAD(+) = 2-oxobutanoate + NADH + H(+) | |
| Rhea:RHEA:37259 | [37259] (2S)-2-aminobutanoate + NAD(+) + H2O = 2-oxobutanoate + NH4(+) + NADH + H(+) | |
| Rhea:RHEA:39975 | [39975] 2-iminobutanoate + H2O = 2-oxobutanoate + NH4(+) | |
| Rhea:RHEA:52608 | [52608] 2-hydroxybutanoate + NADP(+) = 2-oxobutanoate + NADPH + H(+) | |
| Rhea:RHEA:55072 | [55072] 2-oxobutanoate + H(+) = propanal + CO2 | |
| Rhea:RHEA:66048 | [66048] 2-oxobutanoate + L-kynurenine = 4-(2-aminophenyl)-2,4-dioxobutanoate + (2S)-2-aminobutanoate | |
| Rhea:RHEA:66044 | [66044] 2-oxobutanoate + L-kynurenine = (2S)-2-aminobutanoate + kynurenate + H2O | |
| Rhea:RHEA:66108 | [66108] 2-oxobutanoate + L-cysteine = 2-oxo-3-sulfanylpropanoate + (2S)-2-aminobutanoate | |
| Rhea:RHEA:66128 | [66128] 2-oxobutanoate + L-phenylalanine = (2S)-2-aminobutanoate + 3-phenylpyruvate | |
| Rhea:RHEA:66120 | [66120] 2-oxobutanoate + L-methionine = (2S)-2-aminobutanoate + 4-methylsulfanyl-2-oxobutanoate | |
| Rhea:RHEA:66124 | [66124] 2-oxobutanoate + L-histidine = 3-(imidazol-5-yl)pyruvate + (2S)-2-aminobutanoate |