(R)-Lactate
Lactic acid is an organic acid. It is a chiral molecule, consisting of two optical isomers, L-lactic acid and D-lactic acid, with the L-isomer being the most common in living organisms. Lactic acid plays a role in several biochemical processes and is produced in the muscles during intense activity. D-Lactic acid is the end product of the enzyme glyoxalase II (or hydroxyacyl-glutathione hydrolase) (EC 3.1.2.6), which converts the intermediate substrate S-lactoyl-glutathione to reduced glutathione and D-lactate (OMIM: 138790). Lactic acid is a microbial metabolite found in Aerococcus, Bacillus, Carnobacterium, Corynebacterium, Enterococcus, Escherichia, Lactobacillus, Lactococcus, Leuconostoc, Oenococcus, Pediococcus, Rhizopus, Saccharomyces, Streptococcus, Tetragenococcus, Vagococcus and Weissella (PMID:26287368; PMID:26360870).
| ID | EC Number | Name |
|---|---|---|
| Rhea:RHEA:16465 | [16465] 2 Fe(III)-[cytochrome c553] + (R)-lactate = 2 Fe(II)-[cytochrome c553] + pyruvate + 2 H(+) | |
| Rhea:RHEA:20337 | [20337] (R)-2-O-sulfolactate + H2O = (R)-lactate + sulfate + H(+) | |
| Rhea:RHEA:25245 | [25245] (R)-S-lactoylglutathione + H2O = (R)-lactate + glutathione + H(+) | |
| Rhea:RHEA:24956 | [24956] N-acetyl-beta-D-muramate 6-phosphate + H2O = N-acetyl-beta-D-glucosamine 6-phosphate + (R)-lactate | |
| Rhea:RHEA:27754 | [27754] methylglyoxal + H2O = (R)-lactate + H(+) | |
| Rhea:RHEA:29079 | [29079] ubiquinone-8 + (R)-lactate = ubiquinol-8 + pyruvate | |
| Rhea:RHEA:37347 | [37347] (R)-lactate + D-alanine + ATP = D-alanyl-(R)-lactate + ADP + phosphate | |
| Rhea:RHEA:51468 | [51468] (R)-lactate + a quinone = a quinol + pyruvate | |
| Rhea:RHEA:62968 | [62968] (R)-lactate + NADP(+) = pyruvate + NADPH + H(+) | |
| Rhea:RHEA:68744 | [68744] 2 (R)-3-phenyllactate + 2 (R)-lactate + 4 L-leucine + 4 S-adenosyl-L-methionine + 8 ATP = PF1022A + 8 AMP + 4 S-adenosyl-L-homocysteine + 8 diphosphate + 8 H(+) | |
| Rhea:RHEA:68768 | [68768] 4 (R)-lactate + 4 L-leucine + 4 S-adenosyl-L-methionine + 8 ATP = PF1022F + 8 AMP + 4 S-adenosyl-L-homocysteine + 8 diphosphate + 8 H(+) | |
| Rhea:RHEA:68760 | [68760] 3 (R)-3-phenyllactate + (R)-lactate + 4 L-leucine + 4 S-adenosyl-L-methionine + 8 ATP = PF1022C + 8 AMP + 4 S-adenosyl-L-homocysteine + 8 diphosphate + 8 H(+) | |
| Rhea:RHEA:68764 | [68764] (R)-3-phenyllactate + 3 (R)-lactate + 4 L-leucine + 4 S-adenosyl-L-methionine + 8 ATP = PF1022D + 8 AMP + 4 S-adenosyl-L-homocysteine + 8 diphosphate + 8 H(+) | |
| Rhea:RHEA:82479 | [82479] (R)-lactate + FAD + H(+) = FADH2 + pyruvate | |
| Rhea:RHEA:26410 | [26410] N-acetyl-D-muramate 6-phosphate + H2O = N-acetyl-D-glucosamine 6-phosphate + (R)-lactate | |
| Rhea:RHEA:51608 | [51608] (R)-2-hydroxyglutarate + pyruvate = (R)-lactate + 2-oxoglutarate | |
| Rhea:RHEA:67956 | [67956] (S)-2-chloropropanoate + H2O = (R)-lactate + chloride + H(+) |