(R)-Lactate

Lactic acid is an organic acid. It is a chiral molecule, consisting of two optical isomers, L-lactic acid and D-lactic acid, with the L-isomer being the most common in living organisms. Lactic acid plays a role in several biochemical processes and is produced in the muscles during intense activity. D-Lactic acid is the end product of the enzyme glyoxalase II (or hydroxyacyl-glutathione hydrolase) (EC 3.1.2.6), which converts the intermediate substrate S-lactoyl-glutathione to reduced glutathione and D-lactate (OMIM: 138790). Lactic acid is a microbial metabolite found in Aerococcus, Bacillus, Carnobacterium, Corynebacterium, Enterococcus, Escherichia, Lactobacillus, Lactococcus, Leuconostoc, Oenococcus, Pediococcus, Rhizopus, Saccharomyces, Streptococcus, Tetragenococcus, Vagococcus and Weissella (PMID:26287368; PMID:26360870).

ID EC Number Name
Rhea:RHEA:67958 (R)-lactate + chloride + H+ => (S)-2-chloropropanoate + H2O
Rhea:RHEA:67959 (S)-2-chloropropanoate + H2O <=> (R)-lactate + chloride + H+
Rhea:RHEA:68745 2 (R)-3-phenyllactate + 2 (R)-lactate + 4 L-leucine + 4 S-adenosyl-L-methionine + 8 ATP => PF1022A + 8 AMP + 4 S-adenosyl-L-homocysteine + 8 diphosphate + 8 H+
Rhea:RHEA:68746 PF1022A + 8 AMP + 4 S-adenosyl-L-homocysteine + 8 diphosphate + 8 H+ => 2 (R)-3-phenyllactate + 2 (R)-lactate + 4 L-leucine + 4 S-adenosyl-L-methionine + 8 ATP
Rhea:RHEA:68747 2 (R)-3-phenyllactate + 2 (R)-lactate + 4 L-leucine + 4 S-adenosyl-L-methionine + 8 ATP <=> PF1022A + 8 AMP + 4 S-adenosyl-L-homocysteine + 8 diphosphate + 8 H+
Rhea:RHEA:68761 3 (R)-3-phenyllactate + (R)-lactate + 4 L-leucine + 4 S-adenosyl-L-methionine + 8 ATP => PF1022C + 8 AMP + 4 S-adenosyl-L-homocysteine + 8 diphosphate + 8 H+
Rhea:RHEA:68762 PF1022C + 8 AMP + 4 S-adenosyl-L-homocysteine + 8 diphosphate + 8 H+ => 3 (R)-3-phenyllactate + (R)-lactate + 4 L-leucine + 4 S-adenosyl-L-methionine + 8 ATP
Rhea:RHEA:68763 3 (R)-3-phenyllactate + (R)-lactate + 4 L-leucine + 4 S-adenosyl-L-methionine + 8 ATP <=> PF1022C + 8 AMP + 4 S-adenosyl-L-homocysteine + 8 diphosphate + 8 H+
Rhea:RHEA:68765 (R)-3-phenyllactate + 3 (R)-lactate + 4 L-leucine + 4 S-adenosyl-L-methionine + 8 ATP => PF1022D + 8 AMP + 4 S-adenosyl-L-homocysteine + 8 diphosphate + 8 H+
Rhea:RHEA:68766 PF1022D + 8 AMP + 4 S-adenosyl-L-homocysteine + 8 diphosphate + 8 H+ => (R)-3-phenyllactate + 3 (R)-lactate + 4 L-leucine + 4 S-adenosyl-L-methionine + 8 ATP
Rhea:RHEA:68767 (R)-3-phenyllactate + 3 (R)-lactate + 4 L-leucine + 4 S-adenosyl-L-methionine + 8 ATP <=> PF1022D + 8 AMP + 4 S-adenosyl-L-homocysteine + 8 diphosphate + 8 H+
Rhea:RHEA:68769 4 (R)-lactate + 4 L-leucine + 4 S-adenosyl-L-methionine + 8 ATP => PF1022F + 8 AMP + 4 S-adenosyl-L-homocysteine + 8 diphosphate + 8 H+
Rhea:RHEA:68770 PF1022F + 8 AMP + 4 S-adenosyl-L-homocysteine + 8 diphosphate + 8 H+ => 4 (R)-lactate + 4 L-leucine + 4 S-adenosyl-L-methionine + 8 ATP
Rhea:RHEA:68771 4 (R)-lactate + 4 L-leucine + 4 S-adenosyl-L-methionine + 8 ATP <=> PF1022F + 8 AMP + 4 S-adenosyl-L-homocysteine + 8 diphosphate + 8 H+
Rhea:RHEA:71792 (R)-lactate(in) + H+(in) => (R)-lactate(out) + H+(out)
Rhea:RHEA:71793 (R)-lactate(out) + H+(out) => (R)-lactate(in) + H+(in)
Rhea:RHEA:71794 (R)-lactate(in) + H+(in) <=> (R)-lactate(out) + H+(out)
Rhea:RHEA:79480 (R)-lactate(in) + (S)-malate(out) => (R)-lactate(out) + (S)-malate(in)
Rhea:RHEA:79481 (R)-lactate(out) + (S)-malate(in) => (R)-lactate(in) + (S)-malate(out)
Rhea:RHEA:79482 (R)-lactate(in) + (S)-malate(out) <=> (R)-lactate(out) + (S)-malate(in)
Rhea:RHEA:79492 (R)-lactate(in) + citrate(out) => (R)-lactate(out) + citrate(in)
Rhea:RHEA:79493 (R)-lactate(out) + citrate(in) => (R)-lactate(in) + citrate(out)
Rhea:RHEA:79494 (R)-lactate(in) + citrate(out) <=> (R)-lactate(out) + citrate(in)
Rhea:RHEA:82480 (R)-lactate + FAD + H+ => FADH2 + pyruvate
Rhea:RHEA:82481 FADH2 + pyruvate => (R)-lactate + FAD + H+
Rhea:RHEA:82482 (R)-lactate + FAD + H+ <=> FADH2 + pyruvate
Rhea:RHEA:10960 [10960] (S)-lactate = (R)-lactate
Rhea:RHEA:13521 [13521] (R)-lactate + 2 Fe(III)-[cytochrome c] = 2 Fe(II)-[cytochrome c] + pyruvate + 2 H(+)
Rhea:RHEA:16369 [16369] (R)-lactate + NAD(+) = pyruvate + NADH + H(+)
Rhea:RHEA:15089 [15089] (R)-lactate + A = pyruvate + AH2