BioCyc:TRANS-RXN0-623
This reaction models vectorial import of exogenous LCFA by membrane-associated acyl-CoA synthetases, as described in |CITS: [12034706]| and |CITS: [12966144]|. Fatty acids must partition into the membrane and flip prior to extraction by acyl-CoA synthetases, resulting in a requirement for an energized membrane |CITS: [10328825]|.
CPD66-39 + ATP + CO-A + PROTON --> Saturated-Fatty-Acyl-CoA + AMP + PPI + PROTON
2,3,4-saturated fatty acid(1-)[C4H6O2R] + ATP[C10H16N5O13P3] + CoA[C21H36N7O16P3S] + H+[H] = 2,3,4-saturated fatty acyl CoA(4-)[C25H37N7O17P3SR] + AMP[C10H14N5O7P] + diphosphate(3-)[HO7P2] + H+[H]
DB Links
- BioCyc: TRANS-RXN0-623
- EC Number: 6.2.1.3
Alias
Metabolites
Substrates
| metabolite | compartment | Structure |
|---|---|---|
| 2,3,4-saturated fatty acid(1-) Formula: C4H6O2R |
Extracellular | |
| ATP Formula: C10H16N5O13P3 |
Cytoplasm | |
| CoA Formula: C21H36N7O16P3S |
Cytoplasm | |
| H+ Formula: H |
Extracellular |
Products
| metabolite | compartment | Structure |
|---|---|---|
| 2,3,4-saturated fatty acyl CoA(4-) Formula: C25H37N7O17P3SR |
Cytoplasm | |
| AMP Formula: C10H14N5O7P |
Cytoplasm | |
| diphosphate(3-) Formula: HO7P2 |
Cytoplasm | |
| H+ Formula: H |
Cytoplasm |