Pathways Knowlegdes
Biological pathway database
| Pathway | DOIs | Note |
|---|---|---|
| urate biosynthesis/inosine 5'-phosphate degradation Accession ID: BioCyc:HUMAN_PWY-5695 |
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| theobromine biosynthesis II (via xanthine) Accession ID: BioCyc:META_PWY-5040 |
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| adenosine nucleotides degradation II Accession ID: BioCyc:META_SALVADEHYPOX-PWY |
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Bzowska A, Kulikowska E, Shugar D. Purine nucleoside phosphorylases: properties, functions, and clinical aspects. Pharmacol Ther. 2000 Dec;88(3):349–425. doi: 10.1016/s0163-7258(00)00097-8. PMID: 11337031.; Elshafei AM, Abu-Shady MR, el-Beih FM, Mohamed LA. Mode and extent of degradation of adenosine and guanosine by extracts of Aspergillus terricola. Microbiol Res. 1995 Sep;150(3):291–5. doi: 10.1016/s0944-5013(11)80008-x. PMID: 7551735. |
| purine nucleotides degradation I (plants) Accession ID: BioCyc:META_PWY-5044 |
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Hesberg C, Hänsch R, Mendel RR, Bittner F. Tandem orientation of duplicated xanthine dehydrogenase genes from Arabidopsis thaliana: differential gene expression and enzyme activities. J Biol Chem. 2004 Apr 02;279(14):13547–54. doi: 10.1074/jbc.m312929200. PMID: 14726515.; Capote-Maínez N, Sánchez F. Characterization of the common bean uricase II and its expression in organs other than nodules. Plant Physiol. 1997 Dec;115(4):1307–17. PMID: 9414545; PMCID: PMC158596. |
| inosine 5'-phosphate degradation Accession ID: BioCyc:META_PWY-5695 |
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Stoychev G, Kierdaszuk B, Shugar D. Xanthosine and xanthine. Substrate properties with purine nucleoside phosphorylases, and relevance to other enzyme systems. Eur J Biochem. 2002 Aug;269(16):4048–57. doi: 10.1046/j.1432-1033.2002.03097.x. PMID: 12180982.; Bzowska A, Kulikowska E, Shugar D. Purine nucleoside phosphorylases: properties, functions, and clinical aspects. Pharmacol Ther. 2000 Dec;88(3):349–425. doi: 10.1016/s0163-7258(00)00097-8. PMID: 11337031.; Xi H, Schneider BL, Reitzer L. Purine Catabolism in Escherichia coli and Function of Xanthine Dehydrogenase in Purine Salvage. J Bacteriol. 2000 Oct;182(19):5332–41. doi: 10.1128/jb.182.19.5332-5341.2000. |
| purine nucleobases degradation II (anaerobic) Accession ID: BioCyc:META_PWY-5497 |
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Vogels GD, Van der Drift C. Degradation of purines and pyrimidines by microorganisms. Bacteriol Rev. 1976 Jun;40(2):403–68. doi: 10.1128/br.40.2.403-468.1976. |
| urate conversion to allantoin I Accession ID: BioCyc:META_PWY-5691 |
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Raychaudhuri A, Tipton PA. Cloning and expression of the gene for soybean hydroxyisourate hydrolase. Localization and implications for function and mechanism. Plant Physiol. 2002 Dec;130(4):2061–8. PMID: 12481089; PMCID: PMC166717. |
| guanosine nucleotides degradation I Accession ID: BioCyc:META_PWY-6607 |
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Hesberg C, Hänsch R, Mendel RR, Bittner F. Tandem orientation of duplicated xanthine dehydrogenase genes from Arabidopsis thaliana: differential gene expression and enzyme activities. J Biol Chem. 2004 Apr 02;279(14):13547–54. doi: 10.1074/jbc.m312929200. PMID: 14726515. |
| xanthine and xanthosine salvage Accession ID: BioCyc:ECO_SALVPURINE2-PWY |
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Dandanell G, Szczepanowski RH, Kierdaszuk B, Shugar D, Bochtler M. Escherichia coli Purine Nucleoside Phosphorylase II, the Product of the xapA Gene. Journal of Molecular Biology. 2005 Apr;348(1):113–25. doi: 10.1016/j.jmb.2005.02.019.; Guddat LW, Vos S, Martin JL, Keough DT, de Jersey J. Crystal structures of free, IMP-, and GMP-bound Escherichia coli hypoxanthine phosphoribosyltransferase. Protein Science. 2002 Jul;11(7):1626–38. doi: 10.1110/ps.0201002.; Maynes JT, Yuan RG, Snyder FF. Identification, Expression, and Characterization of Escherichia coli Guanine Deaminase. J Bacteriol. 2000 Aug 15;182(16):4658–60. doi: 10.1128/jb.182.16.4658-4660.2000.; Vos S, de Jersey J, Martin JL. Crystal structure of Escherichia coli xanthine phosphoribosyltransferase. Biochemistry. 1997 Apr 08;36(14):4125–34. doi: 10.1021/bi962640d. PMID: 9100006.; Koszalka GW, Vanhooke J, Short SA, Hall WW. Purification and properties of inosine-guanosine phosphorylase from Escherichia coli K-12. J Bacteriol. 1988 Aug;170(8):3493–8. doi: 10.1128/jb.170.8.3493-3498.1988.; Bzowska A, Kulikowska E, Darzynkiewicz E, Shugar D. Purine nucleoside phosphorylase. Structure-activity relationships for substrate and inhibitor properties of N-1-, N-7-, and C-8-substituted analogues; differentiation of mammalian and bacterial enzymes with N-1-methylinosine and guanosine. Journal of Biological Chemistry. 1988 Jul;263(19):9212–7. doi: 10.1016/s0021-9258(19)76527-2.; Deo SS, Wen Chen Tseng, Saini R, Coles RS, Athwal RS. Purification and characterization of Escherichia coli xanthine-guanine phosphoribosyltransferase produced by plasmid pSV2gpt. Biochimica et Biophysica Acta (BBA) - General Subjects. 1985 May;839(3):233–9. doi: 10.1016/0304-4165(85)90003-0.; Liu SW, Milman G. Purification and characterization of Escherichia coli guanine-xanthine phosphoribosyltransferase produced by a high efficiency expression plasmid utilizing a lambda PL promoter and CI857 temperature-sensitive repressor. Journal of Biological Chemistry. 1983 Jun;258(12):7469–75. doi: 10.1016/s0021-9258(18)32201-4.; Hochstadt J. Hypoxanthine phosphoribosyltransferase and guanine phosphoribosyltransferase from enteric bacteria. Methods Enzymol. 1978;51():549–58. doi: 10.1016/s0076-6879(78)51077-x. PMID: 692401.; Holden JA, Harriman PD, Wall JD. Escherichia coli mutants deficient in guanine-xanthine phosphoribosyltransferase. J Bacteriol. 1976 Jun;126(3):1141–8. doi: 10.1128/jb.126.3.1141-1148.1976.; Jensen KF, Nygaard P. Purine nucleoside phosphorylase from Escherichia coli and Salmonella typhimurium. Purification and some properties. Eur J Biochem. 1975 Feb 03;51(1):253–65. doi: 10.1111/j.1432-1033.1975.tb03925.x. PMID: 235429. |
| purine ribonucleosides degradation Accession ID: BioCyc:SHIGELLA_PWY0-1296 |
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| urate biosynthesis/inosine 5'-phosphate degradation Accession ID: BioCyc:SHIGELLA_PWY-5695 |
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| guanosine nucleotides degradation I Accession ID: BioCyc:PLASMO_PWY-6607 |
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| inosine 5'-phosphate degradation Accession ID: BioCyc:MTBH37RV_PWY-5695 |
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| xanthine and xanthosine salvage Accession ID: BioCyc:MTBCDC1551_SALVPURINE2-PWY |
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| adenosine nucleotides degradation II Accession ID: BioCyc:ECOO157_SALVADEHYPOX-PWY |
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| purine ribonucleosides degradation Accession ID: BioCyc:ECOO157_PWY0-1296 |
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| xanthine and xanthosine salvage Accession ID: BioCyc:ECOO157_SALVPURINE2-PWY |
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| adenosine nucleotides degradation II Accession ID: BioCyc:CAULO_SALVADEHYPOX-PWY |
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| xanthine and xanthosine salvage Accession ID: BioCyc:ANTHRA_SALVPURINE2-PWY |
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| guanosine nucleotides degradation III Accession ID: BioCyc:ANTHRA_PWY-6608 |
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