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Pathways Knowlegdes

Biological pathway database

Pathway	DOIs	Note
Proton-coupled monocarboxylate transport Accession ID: Reactome:R-RNO-433692	`10.1074/jbc.m411950200` `10.1208/s12248-008-9035-6` `10.14670/hh-24.243`	Merezhinskaya N, Fishbein WN. Monocarboxylate transporters: past, present, and future. Histol Histopathol. 2009 Feb;24(2):243–64. doi: 10.14670/hh-24.243. PMID: 19085840.; Morris ME, Felmlee MA. Overview of the Proton-coupled MCT (SLC16A) Family of Transporters: Characterization, Function and Role in the Transport of the Drug of Abuse ?-Hydroxybutyric Acid. The AAPS Journal. 2008 Jun 04;10(2):311. doi: 10.1208/s12248-008-9035-6.; Wilson MC, Meredith D, Fox JE, Manoharan C, Davies AJ, Halestrap AP. Basigin (CD147) is the target for organomercurial inhibition of monocarboxylate transporter isoforms 1 and 4: the ancillary protein for the insensitive MCT2 is EMBIGIN (gp70). J Biol Chem. 2005 Jul 22;280(29):27213–21. doi: 10.1074/jbc.m411950200. PMID: 15917240.
Metabolism Accession ID: Reactome:R-XTR-1430728	-
Pyruvate metabolism Accession ID: Reactome:R-XTR-70268	`10.1016/s0021-9258(19)38795-2` `10.3390/cells10040762`	Prochownik EV, Wang H. The Metabolic Fates of Pyruvate in Normal and Neoplastic Cells. Cells. 2021 Mar 30;10(4). PMID: 33808495; PMCID: PMC8066905.; Reed LJ, Hackert ML. Structure-function relationships in dihydrolipoamide acyltransferases. Journal of Biological Chemistry. 1990 Jun;265(16):8971–4. doi: 10.1016/s0021-9258(19)38795-2.; Cori CF. The glucose-lactic acid cycle and gluconeogenesis. Curr Top Cell Regul. 1981;18():377–87. PMID: 7273846.
Transport of small molecules Accession ID: Reactome:R-XTR-382551	-
SLC-mediated transmembrane transport Accession ID: Reactome:R-XTR-425407	`10.1006/abbi.1999.1213` `10.1007/s00424-003-1064-5` `10.1007/s00424-003-1089-9` `10.1007/s00424-003-1168-y` `10.1007/s00424-003-1192-y` `10.1007/s00424-005-1487-2` `10.1016/j.febslet.2015.03.012` `10.1016/j.mam.2012.07.010` `10.1016/s0021-9258(18)31744-7` `10.1073/pnas.94.7.2897` `10.1079/bjn2002763` `10.1097/mnh.0b013e3282e7d7d0` `10.1111/j.1471-4159.2004.02962.x` `10.1152/physiol.00037.2007` `10.1152/physrev.00044.2006` `10.1177/0960327107070573` `10.1186/1479-7364-3-2-195` `10.1208/s12248-008-9035-6` `10.1590/s0100-879x2006000900002`	Schneider S. Inositol transport proteins. FEBS Lett. 2015 Apr 28;589(10):1049–58. doi: 10.1016/j.febslet.2015.03.012. PMID: 25819438.; Anderson CM, Stahl A. SLC27 fatty acid transport proteins. Molecular Aspects of Medicine. 2013 Apr;34(2-3):516–28. doi: 10.1016/j.mam.2012.07.010.; He L, Vasiliou K, Nebert DW. Analysis and update of the human solute carrier (SLC) gene superfamily. Hum Genomics. 2009 Jan;3(2):195–206. PMID: 19164095; PMCID: PMC2752037.; Morris ME, Felmlee MA. Overview of the Proton-coupled MCT (SLC16A) Family of Transporters: Characterization, Function and Role in the Transport of the Drug of Abuse ?-Hydroxybutyric Acid. The AAPS Journal. 2008 Jun 04;10(2):311. doi: 10.1208/s12248-008-9035-6.; Dorwart MR, Shcheynikov N, Yang D, Muallem S. The solute carrier 26 family of proteins in epithelial ion transport. Physiology (Bethesda). 2008 Apr;23():104–14. doi: 10.1152/physiol.00037.2007. PMID: 18400693.; Ashmore J. Cochlear outer hair cell motility. Physiol Rev. 2008 Jan;88(1):173–210. doi: 10.1152/physrev.00044.2006. PMID: 18195086.; Sindic A, Chang MH, Mount DB, Romero MF. Renal physiology of SLC26 anion exchangers. Curr Opin Nephrol Hypertens. 2007 Sep;16(5):484–90. doi: 10.1097/mnh.0b013e3282e7d7d0. PMID: 17693766.; Bressler JP, Olivi L, Cheong JH, Kim Y, Maerten A, Bannon D. Metal transporters in intestine and brain: their involvement in metal-associated neurotoxicities. Hum Exp Toxicol. 2007 Mar;26(3):221–9. doi: 10.1177/0960327107070573. PMID: 17439925.; Handford M, Rodriguez-Furlán C, Orellana A. Nucleotide-sugar transporters: structure, function and roles in vivo. Braz J Med Biol Res. 2006 Sep;39(9):1149–58. doi: 10.1590/s0100-879x2006000900002. PMID: 16981043.; Pajor AM. Molecular properties of the SLC13 family of dicarboxylate and sulfate transporters. Pflügers Archiv - European Journal of Physiology. 2005 Oct 07;451(5):597–605. doi: 10.1007/s00424-005-1487-2.; Traiffort E, Ruat M, O'Regan S, Meunier FM. Molecular characterization of the family of choline transporter-like proteins and their splice variants. Journal of Neurochemistry. 2005 Feb 04;92(5):1116–25. doi: 10.1111/j.1471-4159.2004.02962.x.; Koepsell H, Endou H. The SLC22 drug transporter family. Pflügers Archiv - European Journal of Physiology. 2003 Jul 19;447(5):666–76. doi: 10.1007/s00424-003-1089-9.; Hediger MA, Romero MF, Peng J, Rolfs A, Takanaga H, Bruford EA. The ABCs of solute carriers: physiological, pathological and therapeutic implications of human membrane transport proteins. Pflügers Archiv - European Journal of Physiology. 2003 Nov 18;447(5):465–8. doi: 10.1007/s00424-003-1192-y.; Hagenbuch B, Meier PJ. Organic anion transporting polypeptides of the OATP/ SLC21 family: phylogenetic classification as OATP/ SLCO superfamily, new nomenclature and molecular/functional properties. Pfl?gers Archiv European Journal of Physiology. 2004 Feb 01;447(5):653–65. doi: 10.1007/s00424-003-1168-y.; Chen N, Reith MEA, Quick MW. Synaptic uptake and beyond: the sodium- and chloride-dependent neurotransmitter transporter family SLC6. Pflügers Archiv - European Journal of Physiology. 2003 Apr 29;447(5):519–31. doi: 10.1007/s00424-003-1064-5.; Wood IS, Trayhurn P. Glucose transporters (GLUT and SGLT): expanded families of sugar transport proteins. Br J Nutr. 2003 Jan;89(1):3–9. doi: 10.1079/bjn2002763. PMID: 12568659.; Prasad PD, Wang H, Huang W, Fei YJ, Leibach FH, Devoe LD, Ganapathy V. Molecular and functional characterization of the intestinal Na+-dependent multivitamin transporter. Arch Biochem Biophys. 1999 Jun 01;366(1):95–106. doi: 10.1006/abbi.1999.1213. PMID: 10334869.; Kanamori A, Nakayama J, Fukuda MN, Stallcup WB, Sasaki K, Fukuda M, Hirabayashi Y. Expression cloning and characterization of a cDNA encoding a novel membrane protein required for the formation of O -acetylated ganglioside: A putative acetyl-CoA transporter. Proc. Natl. Acad. Sci. U.S.A. 1997 Apr;94(7):2897–902. doi: 10.1073/pnas.94.7.2897.; Olives B, Neau P, Bailly P, Hediger MA, Rousselet G, Cartron JP, Ripoche P. Cloning and functional expression of a urea transporter from human bone marrow cells. Journal of Biological Chemistry. 1994 Dec;269(50):31649–52. doi: 10.1016/s0021-9258(18)31744-7.
Metabolism Accession ID: Reactome:R-CEL-1430728	-
Signaling by GPCR Accession ID: Reactome:R-CFA-372790	`10.1002/cmdc.200600134` `10.1038/nrm2299` `10.1093/emboj/18.7.1723`	Oldham WM, Hamm HE. Heterotrimeric G protein activation by G-protein-coupled receptors. Nature Reviews Molecular Cell Biology. 2008 Jan;9(1):60–71. doi: 10.1038/nrm2299.; Jacoby E, Bouhelal R, Gerspacher M, Seuwen K. The 7 TM G-protein-coupled receptor target family. ChemMedChem. 2006 Aug;1(8):761–82. doi: 10.1002/cmdc.200600134. PMID: 16902930.; Bockaert J, Pin JP. Molecular tinkering of G protein-coupled receptors: an evolutionary success. EMBO J. 1999 Apr 01;18(7):1723–9. PMID: 10202136; PMCID: PMC1171258.
Pyruvate metabolism Accession ID: Reactome:R-CFA-70268	`10.1016/s0021-9258(19)38795-2` `10.3390/cells10040762`	Prochownik EV, Wang H. The Metabolic Fates of Pyruvate in Normal and Neoplastic Cells. Cells. 2021 Mar 30;10(4). PMID: 33808495; PMCID: PMC8066905.; Reed LJ, Hackert ML. Structure-function relationships in dihydrolipoamide acyltransferases. Journal of Biological Chemistry. 1990 Jun;265(16):8971–4. doi: 10.1016/s0021-9258(19)38795-2.; Cori CF. The glucose-lactic acid cycle and gluconeogenesis. Curr Top Cell Regul. 1981;18():377–87. PMID: 7273846.
Class A/1 (Rhodopsin-like receptors) Accession ID: Reactome:R-DRE-373076	`10.1002/cmdc.200600134` `10.1186/gb-2002-3-11-research0063`	Jacoby E, Bouhelal R, Gerspacher M, Seuwen K. The 7 TM G-protein-coupled receptor target family. ChemMedChem. 2006 Aug;1(8):761–82. doi: 10.1002/cmdc.200600134. PMID: 16902930.; Joost P, Methner A. Phylogenetic analysis of 277 human G-protein-coupled receptors as a tool for the prediction of orphan receptor ligands. Genome Biology. 2002 Oct 17;3(11):research0063.1. doi: 10.1186/gb-2002-3-11-research0063.
Organic anion transport by SLC22 transporters Accession ID: Reactome:R-DRE-561048	`10.1007/s00424-003-1089-9` `10.1007/s11095-006-9181-4` `10.1097/mnh.0b013e32830b5d5d`	Ahn S, Bhatnagar V. Update on the molecular physiology of organic anion transporters. Current Opinion in Nephrology and Hypertension. 2008 Sep;17(5):499–505. doi: 10.1097/mnh.0b013e32830b5d5d.; Rizwan AN, Burckhardt G. Organic Anion Transporters of the SLC22 Family: Biopharmaceutical, Physiological, and Pathological Roles. Pharmaceutical Research. 2007 Jan 24;24(3):450–70. doi: 10.1007/s11095-006-9181-4.; Koepsell H, Endou H. The SLC22 drug transporter family. Pflügers Archiv - European Journal of Physiology. 2003 Jul 19;447(5):666–76. doi: 10.1007/s00424-003-1089-9.
Pyruvate metabolism Accession ID: Reactome:R-DME-70268	`10.1016/s0021-9258(19)38795-2` `10.3390/cells10040762`	Prochownik EV, Wang H. The Metabolic Fates of Pyruvate in Normal and Neoplastic Cells. Cells. 2021 Mar 30;10(4). PMID: 33808495; PMCID: PMC8066905.; Reed LJ, Hackert ML. Structure-function relationships in dihydrolipoamide acyltransferases. Journal of Biological Chemistry. 1990 Jun;265(16):8971–4. doi: 10.1016/s0021-9258(19)38795-2.; Cori CF. The glucose-lactic acid cycle and gluconeogenesis. Curr Top Cell Regul. 1981;18():377–87. PMID: 7273846.
Proton-coupled monocarboxylate transport Accession ID: Reactome:R-GGA-433692	`10.1074/jbc.m411950200` `10.1208/s12248-008-9035-6` `10.14670/hh-24.243`	Merezhinskaya N, Fishbein WN. Monocarboxylate transporters: past, present, and future. Histol Histopathol. 2009 Feb;24(2):243–64. doi: 10.14670/hh-24.243. PMID: 19085840.; Morris ME, Felmlee MA. Overview of the Proton-coupled MCT (SLC16A) Family of Transporters: Characterization, Function and Role in the Transport of the Drug of Abuse ?-Hydroxybutyric Acid. The AAPS Journal. 2008 Jun 04;10(2):311. doi: 10.1208/s12248-008-9035-6.; Wilson MC, Meredith D, Fox JE, Manoharan C, Davies AJ, Halestrap AP. Basigin (CD147) is the target for organomercurial inhibition of monocarboxylate transporter isoforms 1 and 4: the ancillary protein for the insensitive MCT2 is EMBIGIN (gp70). J Biol Chem. 2005 Jul 22;280(29):27213–21. doi: 10.1074/jbc.m411950200. PMID: 15917240.
Transport of small molecules Accession ID: Reactome:R-HSA-382551	-
SLC-mediated transmembrane transport Accession ID: Reactome:R-HSA-425407	`10.1006/abbi.1999.1213` `10.1007/s00424-003-1064-5` `10.1007/s00424-003-1089-9` `10.1007/s00424-003-1168-y` `10.1007/s00424-003-1192-y` `10.1007/s00424-005-1487-2` `10.1016/j.febslet.2015.03.012` `10.1016/j.mam.2012.07.010` `10.1016/s0021-9258(18)31744-7` `10.1073/pnas.94.7.2897` `10.1079/bjn2002763` `10.1097/mnh.0b013e3282e7d7d0` `10.1111/j.1471-4159.2004.02962.x` `10.1152/physiol.00037.2007` `10.1152/physrev.00044.2006` `10.1177/0960327107070573` `10.1186/1479-7364-3-2-195` `10.1208/s12248-008-9035-6` `10.1590/s0100-879x2006000900002`	Schneider S. Inositol transport proteins. FEBS Lett. 2015 Apr 28;589(10):1049–58. doi: 10.1016/j.febslet.2015.03.012. PMID: 25819438.; Anderson CM, Stahl A. SLC27 fatty acid transport proteins. Molecular Aspects of Medicine. 2013 Apr;34(2-3):516–28. doi: 10.1016/j.mam.2012.07.010.; He L, Vasiliou K, Nebert DW. Analysis and update of the human solute carrier (SLC) gene superfamily. Hum Genomics. 2009 Jan;3(2):195–206. PMID: 19164095; PMCID: PMC2752037.; Morris ME, Felmlee MA. Overview of the Proton-coupled MCT (SLC16A) Family of Transporters: Characterization, Function and Role in the Transport of the Drug of Abuse ?-Hydroxybutyric Acid. The AAPS Journal. 2008 Jun 04;10(2):311. doi: 10.1208/s12248-008-9035-6.; Dorwart MR, Shcheynikov N, Yang D, Muallem S. The solute carrier 26 family of proteins in epithelial ion transport. Physiology (Bethesda). 2008 Apr;23():104–14. doi: 10.1152/physiol.00037.2007. PMID: 18400693.; Ashmore J. Cochlear outer hair cell motility. Physiol Rev. 2008 Jan;88(1):173–210. doi: 10.1152/physrev.00044.2006. PMID: 18195086.; Sindic A, Chang MH, Mount DB, Romero MF. Renal physiology of SLC26 anion exchangers. Curr Opin Nephrol Hypertens. 2007 Sep;16(5):484–90. doi: 10.1097/mnh.0b013e3282e7d7d0. PMID: 17693766.; Bressler JP, Olivi L, Cheong JH, Kim Y, Maerten A, Bannon D. Metal transporters in intestine and brain: their involvement in metal-associated neurotoxicities. Hum Exp Toxicol. 2007 Mar;26(3):221–9. doi: 10.1177/0960327107070573. PMID: 17439925.; Handford M, Rodriguez-Furlán C, Orellana A. Nucleotide-sugar transporters: structure, function and roles in vivo. Braz J Med Biol Res. 2006 Sep;39(9):1149–58. doi: 10.1590/s0100-879x2006000900002. PMID: 16981043.; Pajor AM. Molecular properties of the SLC13 family of dicarboxylate and sulfate transporters. Pflügers Archiv - European Journal of Physiology. 2005 Oct 07;451(5):597–605. doi: 10.1007/s00424-005-1487-2.; Traiffort E, Ruat M, O'Regan S, Meunier FM. Molecular characterization of the family of choline transporter-like proteins and their splice variants. Journal of Neurochemistry. 2005 Feb 04;92(5):1116–25. doi: 10.1111/j.1471-4159.2004.02962.x.; Koepsell H, Endou H. The SLC22 drug transporter family. Pflügers Archiv - European Journal of Physiology. 2003 Jul 19;447(5):666–76. doi: 10.1007/s00424-003-1089-9.; Hediger MA, Romero MF, Peng J, Rolfs A, Takanaga H, Bruford EA. The ABCs of solute carriers: physiological, pathological and therapeutic implications of human membrane transport proteins. Pflügers Archiv - European Journal of Physiology. 2003 Nov 18;447(5):465–8. doi: 10.1007/s00424-003-1192-y.; Hagenbuch B, Meier PJ. Organic anion transporting polypeptides of the OATP/ SLC21 family: phylogenetic classification as OATP/ SLCO superfamily, new nomenclature and molecular/functional properties. Pfl?gers Archiv European Journal of Physiology. 2004 Feb 01;447(5):653–65. doi: 10.1007/s00424-003-1168-y.; Chen N, Reith MEA, Quick MW. Synaptic uptake and beyond: the sodium- and chloride-dependent neurotransmitter transporter family SLC6. Pflügers Archiv - European Journal of Physiology. 2003 Apr 29;447(5):519–31. doi: 10.1007/s00424-003-1064-5.; Wood IS, Trayhurn P. Glucose transporters (GLUT and SGLT): expanded families of sugar transport proteins. Br J Nutr. 2003 Jan;89(1):3–9. doi: 10.1079/bjn2002763. PMID: 12568659.; Prasad PD, Wang H, Huang W, Fei YJ, Leibach FH, Devoe LD, Ganapathy V. Molecular and functional characterization of the intestinal Na+-dependent multivitamin transporter. Arch Biochem Biophys. 1999 Jun 01;366(1):95–106. doi: 10.1006/abbi.1999.1213. PMID: 10334869.; Kanamori A, Nakayama J, Fukuda MN, Stallcup WB, Sasaki K, Fukuda M, Hirabayashi Y. Expression cloning and characterization of a cDNA encoding a novel membrane protein required for the formation of O -acetylated ganglioside: A putative acetyl-CoA transporter. Proc. Natl. Acad. Sci. U.S.A. 1997 Apr;94(7):2897–902. doi: 10.1073/pnas.94.7.2897.; Olives B, Neau P, Bailly P, Hediger MA, Rousselet G, Cartron JP, Ripoche P. Cloning and functional expression of a urea transporter from human bone marrow cells. Journal of Biological Chemistry. 1994 Dec;269(50):31649–52. doi: 10.1016/s0021-9258(18)31744-7.
Metabolism Accession ID: Reactome:R-HSA-1430728	`10.1002/jcph.371` `10.1006/geno.1998.5606` `10.1006/jmbi.2001.4680` `10.1016/j.addr.2008.02.014` `10.1016/j.bbagen.2016.01.024` `10.1016/j.bbalip.2010.01.013` `10.1016/j.bbalip.2010.08.002` `10.1016/j.bbrc.2012.05.094` `10.1016/j.molcel.2021.06.027` `10.1016/j.pharmthera.2016.10.018` `10.1016/s0006-291x(02)00623-x` `10.1016/s0021-9258(18)90095-5` `10.1016/s0021-9258(19)36611-6` `10.1016/s0021-9258(19)77281-0` `10.1021/bi002249z` `10.1021/tx980144f` `10.1073/pnas.1607003113` `10.1073/pnas.79.2.325` `10.1073/pnas.92.21.9475` `10.1073/pnas.93.16.8612` `10.1074/jbc.273.40.26138` `10.1074/jbc.274.52.37125` `10.1074/jbc.m002863200` `10.1074/jbc.m112.355206` `10.1074/jbc.m700915200` `10.1083/jcb.201211110` `10.1084/jem.20081880` `10.1091/mbc.e03-06-0385` `10.1096/fj.14-268441` `10.1107/s2053230x13033591` `10.1111/j.1432-1033.1996.0132u.x` `10.1124/jpet.107.134593` `10.1124/jpet.110.173195` `10.1128/mcb.01636-07` `10.1152/physiolgenomics.90211.2008` `10.1159/000134427` `10.1172/jci117597` `10.1172/jci2890` `10.1177/0091270011405664` `10.1371/journal.pgen.1000133` `10.3109/03602539808996323` `10.3109/10409238909082552` `10.3389/fimmu.2015.00043` `10.3390/biology12050686`	Gao J, Shen W. Sirtuin-3-Mediated Cellular Metabolism Links Cardiovascular Remodeling with Hypertension. Biology (Basel). 2023 May 06;12(5). PMID: 37237500; PMCID: PMC10215109.; Chen D, Xia S, Zhang R, Li Y, Famulare CA, Fan H, Wu R, Wang M, Zhu AC, Elf SE, Su R, Dong L, Arellano M, Blum WG, Mao H, Lonial S, Stock W, Odenike O, Le Beau M, Boggon TJ, He C, Chen J, Gao X, Levine RL, Chen J. Lysine acetylation restricts mutant IDH2 activity to optimize transformation in AML cells. Molecular Cell. 2021 Sep;81(18):3833–3847.e11. doi: 10.1016/j.molcel.2021.06.027.; James MO, Jahn SC, Zhong G, Smeltz MG, Hu Z, Stacpoole PW. Therapeutic applications of dichloroacetate and the role of glutathione transferase zeta-1. Pharmacology & Therapeutics. 2017 Feb;170():166–80. doi: 10.1016/j.pharmthera.2016.10.018.; Dalli J, Vlasakov I, Riley IR, Rodriguez AR, Spur BW, Petasis NA, Chiang N, Serhan CN. Maresin conjugates in tissue regeneration biosynthesis enzymes in human macrophages. Proc Natl Acad Sci U S A. 2016 Oct 25;113(43):12232–7. PMID: 27791009; PMCID: PMC5087052.; Jahn SC, Solayman MHM, Lorenzo RJ, Langaee T, Stacpoole PW, James MO. GSTZ1 expression and chloride concentrations modulate sensitivity of cancer cells to dichloroacetate. Biochimica et Biophysica Acta (BBA) - General Subjects. 2016 Jun;1860(6):1202–10. doi: 10.1016/j.bbagen.2016.01.024.; Dalli J, Ramon S, Norris PC, Colas RA, Serhan CN. Novel proresolving and tissue-regenerative resolvin and protectin sulfido-conjugated pathways. The FASEB Journal. 2015 Feb 20;29(5):2120–36. doi: 10.1096/fj.14-268441.; Siiskonen H, Oikari S, Pasonen-SeppÃ¤nen S, Rilla K. Hyaluronan Synthase 1: A Mysterious Enzyme with Unexpected Functions. Front. Immunol. 2015 Feb 05;6(). doi: 10.3389/fimmu.2015.00043.; Shroads AL, Coats BS, McDonough CW, Langaee T, Stacpoole PW. Haplotype variations in glutathione transferase zeta 1 influence the kinetics and dynamics of chronic dichloroacetate in children. The Journal of Clinical Pharma. 2014 Aug 06;55(1):50–5. doi: 10.1002/jcph.371.; Boone CD, Zhong G, Smeltz M, James MO, McKenna R. Preliminary X-ray crystallographic analysis of glutathione transferase zeta 1 (GSTZ1a-1a). Acta Crystallogr F Struct Biol Commun. 2014 Feb;70(Pt 2):187–9. PMID: 24637752; PMCID: PMC3936459.; Shah M, Baterina OY, Taupin V, Farquhar MG. ARH directs megalin to the endocytic recycling compartment to regulate its proteolysis and gene expression. J Cell Biol. 2013 Jul 08;202(1):113–27. PMID: 23836931; PMCID: PMC3704979.; Harada N, Fujimoto E, Okuyama M, Sakaue H, Nakaya Y. Identification and functional characterization of human glycerol-3-phosphate acyltransferase 1 gene promoters. Biochemical and Biophysical Research Communications. 2012 Jun;423(1):128–33. doi: 10.1016/j.bbrc.2012.05.094.; Shroads AL, Langaee T, Coats BS, Kurtz TL, Bullock JR, Weithorn D, Gong Y, Wagner DA, Ostrov DA, Johnson JA, Stacpoole PW. Human Polymorphisms in the Glutathione Transferase Zeta 1/Maleylacetoacetate Isomerase Gene Influence the Toxicokinetics of Dichloroacetate. The Journal of Clinical Pharma. 2012 Jun;52(6):837–49. doi: 10.1177/0091270011405664.; Yu W, Dittenhafer-Reed KE, Denu JM. SIRT3 Protein Deacetylates Isocitrate Dehydrogenase 2 (IDH2) and Regulates Mitochondrial Redox Status. Journal of Biological Chemistry. 2012 Apr;287(17):14078–86. doi: 10.1074/jbc.m112.355206.; Li W, James MO, McKenzie SC, Calcutt NA, Liu C, Stacpoole PW. Mitochondrion as a Novel Site of Dichloroacetate Biotransformation by Glutathione Transferase ?1. The Journal of Pharmacology and Experimental Therapeutics. 2011 Jan;336(1):87–94. doi: 10.1124/jpet.110.173195.; Bannenberg G, Serhan CN. Specialized pro-resolving lipid mediators in the inflammatory response: An update. 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`10.1073/pnas.0901590106` `10.1073/pnas.0906944106` `10.1073/pnas.0908279106` `10.1073/pnas.0908444106` `10.1073/pnas.0909896107` `10.1073/pnas.0912008106` `10.1073/pnas.0912180106` `10.1073/pnas.0913986107` `10.1073/pnas.0914514107` `10.1073/pnas.1000975107` `10.1073/pnas.1003023107` `10.1073/pnas.1004602107` `10.1073/pnas.1005191107` `10.1073/pnas.1006437108` `10.1073/pnas.1008499107` `10.1073/pnas.1011410108` `10.1073/pnas.1016071107` `10.1073/pnas.1016147107` `10.1073/pnas.1100319108` `10.1073/pnas.1102554108` `10.1073/pnas.111114298` `10.1073/pnas.1114802109` `10.1073/pnas.112495999` `10.1073/pnas.1130513100` `10.1073/pnas.1135239100` `10.1073/pnas.1213773111` `10.1073/pnas.1219004110` `10.1073/pnas.1220341110` `10.1073/pnas.1301328110` `10.1073/pnas.1302725110` `10.1073/pnas.1304340110` `10.1073/pnas.1307218110` `10.1073/pnas.1309078110` `10.1073/pnas.1312791110` `10.1073/pnas.1322362111` `10.1073/pnas.1412009111` `10.1073/pnas.1432869100` `10.1073/pnas.151105198` 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`10.1073/pnas.88.24.11435` `10.1073/pnas.89.1.251` `10.1073/pnas.89.10.4285` `10.1073/pnas.89.23.11574` `10.1073/pnas.89.4.1281` `10.1073/pnas.89.5.1587` `10.1073/pnas.89.8.3630` `10.1073/pnas.89.9.3815` `10.1073/pnas.90.1.203` `10.1073/pnas.90.13.6120` `10.1073/pnas.90.15.7181` `10.1073/pnas.90.2.408` `10.1073/pnas.90.21.10365` `10.1073/pnas.90.22.10793` `10.1073/pnas.91.11.4731` `10.1073/pnas.91.21.10009` `10.1073/pnas.91.21.9780` `10.1073/pnas.91.21.9828` `10.1073/pnas.91.23.11089` `10.1073/pnas.91.26.12609` `10.1073/pnas.92.12.5734` `10.1073/pnas.92.15.6873` `10.1073/pnas.92.15.7006` `10.1073/pnas.92.17.7632` `10.1073/pnas.92.19.8601` `10.1073/pnas.92.19.8734` `10.1073/pnas.92.20.9284` `10.1073/pnas.92.22.10282` `10.1073/pnas.92.6.2179` `10.1073/pnas.92.7.2597` `10.1073/pnas.93.11.5466` `10.1073/pnas.93.16.8666` `10.1073/pnas.93.21.11540` `10.1073/pnas.93.21.11681` `10.1073/pnas.93.21.12002` `10.1073/pnas.93.5.1988` `10.1073/pnas.93.6.2576` `10.1073/pnas.93.9.4181` `10.1073/pnas.94.14.7192` `10.1073/pnas.94.17.9017` `10.1073/pnas.94.18.9562` `10.1073/pnas.94.18.9893` `10.1073/pnas.94.23.12419` `10.1073/pnas.94.25.13738` `10.1073/pnas.94.26.14671` `10.1073/pnas.94.9.4279` `10.1073/pnas.95.1.305` `10.1073/pnas.95.11.6061` `10.1073/pnas.95.11.6181` `10.1073/pnas.95.12.6941` `10.1073/pnas.95.14.8108` `10.1073/pnas.95.16.9214` `10.1073/pnas.95.19.11211` `10.1073/pnas.95.2.548` `10.1073/pnas.95.2.570` `10.1073/pnas.95.20.11590` `10.1073/pnas.95.21.12197` `10.1073/pnas.95.21.12202` `10.1073/pnas.95.25.14787` `10.1073/pnas.95.25.14991` `10.1073/pnas.95.3.1091` `10.1073/pnas.96.20.11217` `10.1073/pnas.96.22.12442` `10.1073/pnas.96.22.12548` `10.1073/pnas.96.25.14383` `10.1073/pnas.96.26.14911` `10.1073/pnas.96.4.1569` `10.1073/pnas.96.7.3546` `10.1073/pnas.97.1.185` `10.1073/pnas.97.13.7440` `10.1073/pnas.97.14.7732` `10.1073/pnas.97.2.817` `10.1073/pnas.97.26.14394` `10.1073/pnas.98.2.507` `10.1073/pnas.98.3.974` `10.1074/jbc.270.13.7587` 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`10.1074/jbc.272.23.14893` `10.1074/jbc.272.24.15442` `10.1074/jbc.272.27.16999` `10.1074/jbc.272.28.17251` `10.1074/jbc.272.28.17756` `10.1074/jbc.272.29.18382` `10.1074/jbc.272.33.20384` `10.1074/jbc.272.35.21999` `10.1074/jbc.272.38.23843` `10.1074/jbc.272.39.24333` `10.1074/jbc.272.44.27558` `10.1074/jbc.272.44.27949` `10.1074/jbc.272.44.28107` `10.1074/jbc.272.47.29579` `10.1074/jbc.272.50.31730` `10.1074/jbc.272.51.31969` `10.1074/jbc.272.51.32686` `10.1074/jbc.272.52.32830` `10.1074/jbc.272.6.3860` `10.1074/jbc.272.7.4065` `10.1074/jbc.272.7.4378` `10.1074/jbc.272.9.5915` `10.1074/jbc.273.1.577` `10.1074/jbc.273.10.5908` `10.1074/jbc.273.11.6019` `10.1074/jbc.273.12.7118` `10.1074/jbc.273.13.7717` `10.1074/jbc.273.14.7906` `10.1074/jbc.273.15.8616` `10.1074/jbc.273.15.8776` `10.1074/jbc.273.18.11288` `10.1074/jbc.273.19.11962` `10.1074/jbc.273.2.829` `10.1074/jbc.273.22.13950` `10.1074/jbc.273.22.14037` `10.1074/jbc.273.28.17469` `10.1074/jbc.273.29.17987` 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Transport of small molecules Accession ID: Reactome:R-MMU-382551	-
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