- 数据之源，洞见之始

Pathways Knowlegdes

Biological pathway database

Pathway	DOIs	Note
SLC-mediated transmembrane transport Accession ID: Reactome:R-CFA-425407	`10.1006/abbi.1999.1213` `10.1007/s00424-003-1064-5` `10.1007/s00424-003-1089-9` `10.1007/s00424-003-1168-y` `10.1007/s00424-003-1192-y` `10.1007/s00424-005-1487-2` `10.1016/j.febslet.2015.03.012` `10.1016/j.mam.2012.07.010` `10.1016/s0021-9258(18)31744-7` `10.1073/pnas.94.7.2897` `10.1079/bjn2002763` `10.1097/mnh.0b013e3282e7d7d0` `10.1111/j.1471-4159.2004.02962.x` `10.1152/physiol.00037.2007` `10.1152/physrev.00044.2006` `10.1177/0960327107070573` `10.1186/1479-7364-3-2-195` `10.1208/s12248-008-9035-6` `10.1590/s0100-879x2006000900002`	Schneider S. Inositol transport proteins. FEBS Lett. 2015 Apr 28;589(10):1049–58. doi: 10.1016/j.febslet.2015.03.012. PMID: 25819438.; Anderson CM, Stahl A. SLC27 fatty acid transport proteins. Molecular Aspects of Medicine. 2013 Apr;34(2-3):516–28. doi: 10.1016/j.mam.2012.07.010.; He L, Vasiliou K, Nebert DW. Analysis and update of the human solute carrier (SLC) gene superfamily. Hum Genomics. 2009 Jan;3(2):195–206. PMID: 19164095; PMCID: PMC2752037.; Morris ME, Felmlee MA. Overview of the Proton-coupled MCT (SLC16A) Family of Transporters: Characterization, Function and Role in the Transport of the Drug of Abuse ?-Hydroxybutyric Acid. The AAPS Journal. 2008 Jun 04;10(2):311. doi: 10.1208/s12248-008-9035-6.; Dorwart MR, Shcheynikov N, Yang D, Muallem S. The solute carrier 26 family of proteins in epithelial ion transport. Physiology (Bethesda). 2008 Apr;23():104–14. doi: 10.1152/physiol.00037.2007. PMID: 18400693.; Ashmore J. Cochlear outer hair cell motility. Physiol Rev. 2008 Jan;88(1):173–210. doi: 10.1152/physrev.00044.2006. PMID: 18195086.; Sindic A, Chang MH, Mount DB, Romero MF. Renal physiology of SLC26 anion exchangers. Curr Opin Nephrol Hypertens. 2007 Sep;16(5):484–90. doi: 10.1097/mnh.0b013e3282e7d7d0. PMID: 17693766.; Bressler JP, Olivi L, Cheong JH, Kim Y, Maerten A, Bannon D. Metal transporters in intestine and brain: their involvement in metal-associated neurotoxicities. Hum Exp Toxicol. 2007 Mar;26(3):221–9. doi: 10.1177/0960327107070573. PMID: 17439925.; Handford M, Rodriguez-Furlán C, Orellana A. Nucleotide-sugar transporters: structure, function and roles in vivo. Braz J Med Biol Res. 2006 Sep;39(9):1149–58. doi: 10.1590/s0100-879x2006000900002. PMID: 16981043.; Pajor AM. Molecular properties of the SLC13 family of dicarboxylate and sulfate transporters. Pflügers Archiv - European Journal of Physiology. 2005 Oct 07;451(5):597–605. doi: 10.1007/s00424-005-1487-2.; Traiffort E, Ruat M, O'Regan S, Meunier FM. Molecular characterization of the family of choline transporter-like proteins and their splice variants. Journal of Neurochemistry. 2005 Feb 04;92(5):1116–25. doi: 10.1111/j.1471-4159.2004.02962.x.; Koepsell H, Endou H. The SLC22 drug transporter family. Pflügers Archiv - European Journal of Physiology. 2003 Jul 19;447(5):666–76. doi: 10.1007/s00424-003-1089-9.; Hediger MA, Romero MF, Peng J, Rolfs A, Takanaga H, Bruford EA. The ABCs of solute carriers: physiological, pathological and therapeutic implications of human membrane transport proteins. Pflügers Archiv - European Journal of Physiology. 2003 Nov 18;447(5):465–8. doi: 10.1007/s00424-003-1192-y.; Hagenbuch B, Meier PJ. Organic anion transporting polypeptides of the OATP/ SLC21 family: phylogenetic classification as OATP/ SLCO superfamily, new nomenclature and molecular/functional properties. Pfl?gers Archiv European Journal of Physiology. 2004 Feb 01;447(5):653–65. doi: 10.1007/s00424-003-1168-y.; Chen N, Reith MEA, Quick MW. Synaptic uptake and beyond: the sodium- and chloride-dependent neurotransmitter transporter family SLC6. Pflügers Archiv - European Journal of Physiology. 2003 Apr 29;447(5):519–31. doi: 10.1007/s00424-003-1064-5.; Wood IS, Trayhurn P. Glucose transporters (GLUT and SGLT): expanded families of sugar transport proteins. Br J Nutr. 2003 Jan;89(1):3–9. doi: 10.1079/bjn2002763. PMID: 12568659.; Prasad PD, Wang H, Huang W, Fei YJ, Leibach FH, Devoe LD, Ganapathy V. Molecular and functional characterization of the intestinal Na+-dependent multivitamin transporter. Arch Biochem Biophys. 1999 Jun 01;366(1):95–106. doi: 10.1006/abbi.1999.1213. PMID: 10334869.; Kanamori A, Nakayama J, Fukuda MN, Stallcup WB, Sasaki K, Fukuda M, Hirabayashi Y. Expression cloning and characterization of a cDNA encoding a novel membrane protein required for the formation of O -acetylated ganglioside: A putative acetyl-CoA transporter. Proc. Natl. Acad. Sci. U.S.A. 1997 Apr;94(7):2897–902. doi: 10.1073/pnas.94.7.2897.; Olives B, Neau P, Bailly P, Hediger MA, Rousselet G, Cartron JP, Ripoche P. Cloning and functional expression of a urea transporter from human bone marrow cells. Journal of Biological Chemistry. 1994 Dec;269(50):31649–52. doi: 10.1016/s0021-9258(18)31744-7.
Hydroxycarboxylic acid-binding receptors Accession ID: Reactome:R-CFA-3296197	`10.1124/pr.110.003301`	Offermanns S, Colletti SL, Lovenberg TW, Semple G, Wise A, IJzerman AP. International Union of Basic and Clinical Pharmacology. LXXXII: Nomenclature and Classification of Hydroxy-carboxylic Acid Receptors (GPR81, GPR109A, and GPR109B). Pharmacol Rev. 2011 Jun;63(2):269–90. doi: 10.1124/pr.110.003301. PMID: 21454438.
GPCR downstream signalling Accession ID: Reactome:R-CFA-388396	`10.1007/s00018-008-8006-5` `10.1007/s12033-008-9031-1` `10.1016/j.pharmthera.2004.05.002` `10.1038/nrm2803` `10.1073/pnas.0801508105` `10.1073/pnas.1936664100` `10.1074/jbc.m203962200` `10.1124/mol.108.049015` `10.1126/science.1071550` `10.1126/science.278.5345.1907`	Ritter SL, Hall RA. Fine-tuning of GPCR activity by receptor-interacting proteins. Nature Reviews Molecular Cell Biology. 2009 Dec;10(12):819–30. doi: 10.1038/nrm2803.; Gurevich VV, Gurevich EV. Rich Tapestry of G Protein-Coupled Receptor Signaling and Regulatory Mechanisms. Molecular Pharmacology. 2008 Aug;74(2):312–6. doi: 10.1124/mol.108.049015.; Smrcka AV. G protein ß? subunits: Central mediators of G protein-coupled receptor signaling. Cellular and Molecular Life Sciences. 2008 May 19;65(14):2191–214. doi: 10.1007/s00018-008-8006-5.; Soundararajan M, Willard FS, Kimple AJ, Turnbull AP, Ball LJ, Schoch GA, Gileadi C, Fedorov OY, Dowler EF, Higman VA, Hutsell SQ, Sundström M, Doyle DA, Siderovski DP. Structural diversity in the RGS domain and its interaction with heterotrimeric G protein alpha-subunits. Proc Natl Acad Sci U S A. 2008 Apr 29;105(17):6457–62. PMID: 18434541; PMCID: PMC2359823.; Luttrell LM. Reviews in molecular biology and biotechnology: transmembrane signaling by G protein-coupled receptors. Mol Biotechnol. 2008 Jul;39(3):239–64. doi: 10.1007/s12033-008-9031-1. PMID: 18240029.; Kristiansen K. Molecular mechanisms of ligand binding, signaling, and regulation within the superfamily of G-protein-coupled receptors: molecular modeling and mutagenesis approaches to receptor structure and function. Pharmacol Ther. 2004 Jul;103(1):21–80. doi: 10.1016/j.pharmthera.2004.05.002. PMID: 15251227.; Azzi M, Charest PG, Angers S, Rousseau G, Kohout T, Bouvier M, Piñeyro G. Beta-arrestin-mediated activation of MAPK by inverse agonists reveals distinct active conformations for G protein-coupled receptors. Proc Natl Acad Sci U S A. 2003 Sep 30;100(20):11406–11. PMID: 13679574; PMCID: PMC208770.; Dessauer CW, Chen-Goodspeed M, Chen J. Mechanism of Galpha i-mediated inhibition of type V adenylyl cyclase. J Biol Chem. 2002 Aug 09;277(32):28823–9. doi: 10.1074/jbc.m203962200. PMID: 12058044.; Neves SR, Ram PT, Iyengar R. G protein pathways. Science. 2002 May 31;296(5573):1636–9. doi: 10.1126/science.1071550. PMID: 12040175.; Tesmer JJ, Sunahara RK, Gilman AG, Sprang SR. Crystal structure of the catalytic domains of adenylyl cyclase in a complex with Gsalpha.GTPgammaS. Science. 1997 Dec 12;278(5345):1907–16. doi: 10.1126/science.278.5345.1907. PMID: 9417641.
GPCR ligand binding Accession ID: Reactome:R-DRE-500792	`10.1016/j.pharmthera.2004.05.002` `10.1034/j.1600-0773.2002.910607.x` `10.1124/mol.63.6.1256`	Kristiansen K. Molecular mechanisms of ligand binding, signaling, and regulation within the superfamily of G-protein-coupled receptors: molecular modeling and mutagenesis approaches to receptor structure and function. Pharmacol Ther. 2004 Jul;103(1):21–80. doi: 10.1016/j.pharmthera.2004.05.002. PMID: 15251227.; Fredriksson R, Lagerström MC, Lundin LG, Schiöth HB. The G-protein-coupled receptors in the human genome form five main families. Phylogenetic analysis, paralogon groups, and fingerprints. Mol Pharmacol. 2003 Jun;63(6):1256–72. doi: 10.1124/mol.63.6.1256. PMID: 12761335.; Gether U, Asmar F, Meinild AK, Rasmussen SG. Structural basis for activation of G-protein-coupled receptors. Pharmacol Toxicol. 2002 Dec;91(6):304–12. doi: 10.1034/j.1600-0773.2002.910607.x. PMID: 12688373.
Proton-coupled monocarboxylate transport Accession ID: Reactome:R-DRE-433692	`10.1074/jbc.m411950200` `10.1208/s12248-008-9035-6` `10.14670/hh-24.243`	Merezhinskaya N, Fishbein WN. Monocarboxylate transporters: past, present, and future. Histol Histopathol. 2009 Feb;24(2):243–64. doi: 10.14670/hh-24.243. PMID: 19085840.; Morris ME, Felmlee MA. Overview of the Proton-coupled MCT (SLC16A) Family of Transporters: Characterization, Function and Role in the Transport of the Drug of Abuse ?-Hydroxybutyric Acid. The AAPS Journal. 2008 Jun 04;10(2):311. doi: 10.1208/s12248-008-9035-6.; Wilson MC, Meredith D, Fox JE, Manoharan C, Davies AJ, Halestrap AP. Basigin (CD147) is the target for organomercurial inhibition of monocarboxylate transporter isoforms 1 and 4: the ancillary protein for the insensitive MCT2 is EMBIGIN (gp70). J Biol Chem. 2005 Jul 22;280(29):27213–21. doi: 10.1074/jbc.m411950200. PMID: 15917240.
Metabolism Accession ID: Reactome:R-DRE-1430728	-
Aerobic respiration and respiratory electron transport Accession ID: Reactome:R-DRE-1428517	-
Metabolism Accession ID: Reactome:R-GGA-1430728	-
Pyruvate metabolism Accession ID: Reactome:R-GGA-70268	`10.1016/s0021-9258(19)38795-2` `10.3390/cells10040762`	Prochownik EV, Wang H. The Metabolic Fates of Pyruvate in Normal and Neoplastic Cells. Cells. 2021 Mar 30;10(4). PMID: 33808495; PMCID: PMC8066905.; Reed LJ, Hackert ML. Structure-function relationships in dihydrolipoamide acyltransferases. Journal of Biological Chemistry. 1990 Jun;265(16):8971–4. doi: 10.1016/s0021-9258(19)38795-2.; Cori CF. The glucose-lactic acid cycle and gluconeogenesis. Curr Top Cell Regul. 1981;18():377–87. PMID: 7273846.
Pyruvate metabolism Accession ID: Reactome:R-GGA-373920	`10.1074/jbc.273.26.15920` `10.1152/ajpregu.1987.253.5.r679`	Wilson MC, Jackson VN, Heddle C, Price NT, Pilegaard H, Juel C, Bonen A, Montgomery I, Hutter OF, Halestrap AP. Lactic Acid Efflux from White Skeletal Muscle Is Catalyzed by the Monocarboxylate Transporter Isoform MCT3. Journal of Biological Chemistry. 1998 Jun;273(26):15920–6. doi: 10.1074/jbc.273.26.15920.; Yorita K, Yamano T, Ikeda K, Kobayashi T, Shiota M, Sugano T. Distribution of glycolysis and gluconeogenesis in perfused chicken kidney. American Journal of Physiology-Regulatory, Integrative and Comparative Physiology. 1987 Nov 01;253(5):R679–86. doi: 10.1152/ajpregu.1987.253.5.r679.; Watford M. Gluconeogenesis in the chicken: regulation of phosphoenolpyruvate carboxykinase gene expression. Fed Proc. 1985 May;44(8):2469–74. PMID: 2985455.
Transport of small molecules Accession ID: Reactome:R-GGA-382551	-
SLC-mediated transmembrane transport Accession ID: Reactome:R-GGA-425407	`10.1006/abbi.1999.1213` `10.1007/s00424-003-1064-5` `10.1007/s00424-003-1089-9` `10.1007/s00424-003-1168-y` `10.1007/s00424-003-1192-y` `10.1007/s00424-005-1487-2` `10.1016/j.febslet.2015.03.012` `10.1016/j.mam.2012.07.010` `10.1016/s0021-9258(18)31744-7` `10.1073/pnas.94.7.2897` `10.1079/bjn2002763` `10.1097/mnh.0b013e3282e7d7d0` `10.1111/j.1471-4159.2004.02962.x` `10.1152/physiol.00037.2007` `10.1152/physrev.00044.2006` `10.1177/0960327107070573` `10.1186/1479-7364-3-2-195` `10.1208/s12248-008-9035-6` `10.1590/s0100-879x2006000900002`	Schneider S. Inositol transport proteins. FEBS Lett. 2015 Apr 28;589(10):1049–58. doi: 10.1016/j.febslet.2015.03.012. PMID: 25819438.; Anderson CM, Stahl A. SLC27 fatty acid transport proteins. Molecular Aspects of Medicine. 2013 Apr;34(2-3):516–28. doi: 10.1016/j.mam.2012.07.010.; He L, Vasiliou K, Nebert DW. Analysis and update of the human solute carrier (SLC) gene superfamily. Hum Genomics. 2009 Jan;3(2):195–206. PMID: 19164095; PMCID: PMC2752037.; Morris ME, Felmlee MA. Overview of the Proton-coupled MCT (SLC16A) Family of Transporters: Characterization, Function and Role in the Transport of the Drug of Abuse ?-Hydroxybutyric Acid. The AAPS Journal. 2008 Jun 04;10(2):311. doi: 10.1208/s12248-008-9035-6.; Dorwart MR, Shcheynikov N, Yang D, Muallem S. The solute carrier 26 family of proteins in epithelial ion transport. Physiology (Bethesda). 2008 Apr;23():104–14. doi: 10.1152/physiol.00037.2007. PMID: 18400693.; Ashmore J. Cochlear outer hair cell motility. Physiol Rev. 2008 Jan;88(1):173–210. doi: 10.1152/physrev.00044.2006. PMID: 18195086.; Sindic A, Chang MH, Mount DB, Romero MF. Renal physiology of SLC26 anion exchangers. Curr Opin Nephrol Hypertens. 2007 Sep;16(5):484–90. doi: 10.1097/mnh.0b013e3282e7d7d0. PMID: 17693766.; Bressler JP, Olivi L, Cheong JH, Kim Y, Maerten A, Bannon D. Metal transporters in intestine and brain: their involvement in metal-associated neurotoxicities. Hum Exp Toxicol. 2007 Mar;26(3):221–9. doi: 10.1177/0960327107070573. PMID: 17439925.; Handford M, Rodriguez-Furlán C, Orellana A. Nucleotide-sugar transporters: structure, function and roles in vivo. Braz J Med Biol Res. 2006 Sep;39(9):1149–58. doi: 10.1590/s0100-879x2006000900002. PMID: 16981043.; Pajor AM. Molecular properties of the SLC13 family of dicarboxylate and sulfate transporters. Pflügers Archiv - European Journal of Physiology. 2005 Oct 07;451(5):597–605. doi: 10.1007/s00424-005-1487-2.; Traiffort E, Ruat M, O'Regan S, Meunier FM. Molecular characterization of the family of choline transporter-like proteins and their splice variants. Journal of Neurochemistry. 2005 Feb 04;92(5):1116–25. doi: 10.1111/j.1471-4159.2004.02962.x.; Koepsell H, Endou H. The SLC22 drug transporter family. Pflügers Archiv - European Journal of Physiology. 2003 Jul 19;447(5):666–76. doi: 10.1007/s00424-003-1089-9.; Hediger MA, Romero MF, Peng J, Rolfs A, Takanaga H, Bruford EA. The ABCs of solute carriers: physiological, pathological and therapeutic implications of human membrane transport proteins. Pflügers Archiv - European Journal of Physiology. 2003 Nov 18;447(5):465–8. doi: 10.1007/s00424-003-1192-y.; Hagenbuch B, Meier PJ. Organic anion transporting polypeptides of the OATP/ SLC21 family: phylogenetic classification as OATP/ SLCO superfamily, new nomenclature and molecular/functional properties. Pfl?gers Archiv European Journal of Physiology. 2004 Feb 01;447(5):653–65. doi: 10.1007/s00424-003-1168-y.; Chen N, Reith MEA, Quick MW. Synaptic uptake and beyond: the sodium- and chloride-dependent neurotransmitter transporter family SLC6. Pflügers Archiv - European Journal of Physiology. 2003 Apr 29;447(5):519–31. doi: 10.1007/s00424-003-1064-5.; Wood IS, Trayhurn P. Glucose transporters (GLUT and SGLT): expanded families of sugar transport proteins. Br J Nutr. 2003 Jan;89(1):3–9. doi: 10.1079/bjn2002763. PMID: 12568659.; Prasad PD, Wang H, Huang W, Fei YJ, Leibach FH, Devoe LD, Ganapathy V. Molecular and functional characterization of the intestinal Na+-dependent multivitamin transporter. Arch Biochem Biophys. 1999 Jun 01;366(1):95–106. doi: 10.1006/abbi.1999.1213. PMID: 10334869.; Kanamori A, Nakayama J, Fukuda MN, Stallcup WB, Sasaki K, Fukuda M, Hirabayashi Y. Expression cloning and characterization of a cDNA encoding a novel membrane protein required for the formation of O -acetylated ganglioside: A putative acetyl-CoA transporter. Proc. Natl. Acad. Sci. U.S.A. 1997 Apr;94(7):2897–902. doi: 10.1073/pnas.94.7.2897.; Olives B, Neau P, Bailly P, Hediger MA, Rousselet G, Cartron JP, Ripoche P. Cloning and functional expression of a urea transporter from human bone marrow cells. Journal of Biological Chemistry. 1994 Dec;269(50):31649–52. doi: 10.1016/s0021-9258(18)31744-7.
Aerobic respiration and respiratory electron transport Accession ID: Reactome:R-HSA-1428517	-
Class A/1 (Rhodopsin-like receptors) Accession ID: Reactome:R-HSA-373076	`10.1002/bip.20420` `10.1002/cmdc.200600134` `10.1002/eji.200323787` `10.1002/eji.200535716` `10.1002/hep.22293` `10.1002/j.1460-2075.1984.tb01904.x` `10.1002/j.1460-2075.1988.tb03042.x` `10.1002/jcp.31265` `10.1002/path.4123` `10.1002/psc.747` `10.1006/bbrc.1993.1403` `10.1006/bbrc.1993.1610` `10.1006/bbrc.1993.2027` `10.1006/bbrc.1993.2122` `10.1006/bbrc.1994.1613` `10.1006/bbrc.1994.2049` `10.1006/bbrc.1997.6161` `10.1006/bbrc.1998.9489` `10.1006/geno.1994.1553` `10.1006/geno.1995.1109` `10.1006/geno.1995.1180` `10.1006/geno.1995.9996` `10.1006/geno.1997.5069` `10.1006/geno.2002.6771` `10.1007/pl00005139` `10.1007/s40256-014-0081-4` `10.1016/0002-9378(94)90415-4` `10.1016/0006-291x(90)91143-g` `10.1016/0006-291x(91)91704-g` `10.1016/0006-291x(91)91944-8` `10.1016/0006-291x(92)90629-y` `10.1016/0006-291x(92)90685-e` `10.1016/0006-291x(92)91187-u` `10.1016/0006-291x(92)91557-7` `10.1016/0014-5793(81)80952-0` `10.1016/0014-5793(85)80069-7` `10.1016/0014-5793(86)81534-4` `10.1016/0014-5793(88)80427-7` `10.1016/0014-5793(91)80585-q` `10.1016/0014-5793(93)81509-x` `10.1016/0014-5793(94)80235-1` `10.1016/0014-5793(94)80368-4` `10.1016/0014-5793(95)00093-o` `10.1016/0014-5793(96)01004-6` `10.1016/0024-3205(82)90374-5` `10.1016/0024-3205(94)90138-4` `10.1016/0092-8674(93)90118-a` `10.1016/0092-8674(94)90425-1` `10.1016/0378-1119(93)90495-o` `10.1016/j.bbrc.2003.09.102` `10.1016/j.bcp.2024.116480` `10.1016/j.celrep.2024.114942` `10.1016/j.cytogfr.2006.09.009` `10.1016/j.mce.2010.02.003` `10.1016/j.molimm.2009.04.027` `10.1016/j.neuron.2004.08.005` `10.1016/j.placenta.2007.04.006` `10.1016/s0002-9149(99)80413-5` `10.1016/s0006-291x(02)00239-5` `10.1016/s0006-291x(05)80288-8` `10.1016/s0006-291x(05)81332-4` `10.1016/s0006-291x(88)80308-5` `10.1016/s0006-2952(97)00070-1` `10.1016/s0009-9236(96)90127-7` `10.1016/s0014-2999(98)00678-5` `10.1016/s0014-5793(97)00557-7` `10.1016/s0014-5793(99)00009-5` `10.1016/s0021-9258(17)30526-4` `10.1016/s0021-9258(17)31844-6` `10.1016/s0021-9258(17)35956-2` `10.1016/s0021-9258(17)38013-4` `10.1016/s0021-9258(17)39236-0` `10.1016/s0021-9258(17)40144-x` `10.1016/s0021-9258(17)41863-1` `10.1016/s0021-9258(17)45856-x` `10.1016/s0021-9258(18)37707-x` `10.1016/s0021-9258(18)47129-3` `10.1016/s0021-9258(18)53088-x` `10.1016/s0021-9258(18)53415-3` `10.1016/s0021-9258(18)53554-7` `10.1016/s0021-9258(18)55129-2` `10.1016/s0021-9258(19)49854-2` `10.1016/s0021-9258(19)76412-6` `10.1016/s0022-3476(83)80526-5` `10.1016/s0022-3565(25)22357-6` `10.1016/s0026-895x(24)09236-8` `10.1016/s0026-895x(24)12288-2` `10.1016/s0092-8674(00)80438-9` `10.1016/s0092-8674(00)80949-6` `10.1016/s0140-6736(09)61913-9` `10.1016/s0149-2918(03)90091-9` `10.1016/s0165-6147(00)88988-9` `10.1016/s0167-0115(99)00028-2` `10.1016/s0167-4781(01)00283-4` `10.1016/s0167-4781(02)00546-8` `10.1016/s0169-328x(98)00116-8` `10.1016/s0378-1119(01)00651-5` `10.1016/s1043-2760(00)00362-3` `10.1021/acs.jmedchem.0c01093` `10.1021/bi00356a023` `10.1021/bi026020q` `10.1021/bi952950g` `10.1021/jm031115r` `10.1021/jm9700068` `10.1021/jm980179c` `10.1038/22313` `10.1038/22321` `10.1038/295663a0` `10.1038/297431a0` `10.1038/30515` `10.1038/32660` `10.1038/349614a0` `10.1038/35015579` `10.1038/35079135` `10.1038/356526a0` `10.1038/385640a0` `10.1038/45230` `10.1038/45809` `10.1038/nm786` `10.1038/s41598-019-42181-2` `10.1038/s41598-020-72960-1` `10.1038/s42003-022-03668-3` `10.1038/sj.bjp.0702220` `10.1038/sj.bjp.0703617` `10.1038/sj.bjp.0705592` `10.1038/sj.bjp.0707140` `10.1038/sj.jhh.1000482` `10.1038/sj.jhh.1000991` `10.1038/sj.jhh.1001391` `10.1038/sj.ki.5000432` `10.1042/bj3141009` `10.1042/bj3280871` `10.1046/j.1365-2141.2003.04533.x` `10.1046/j.1432-1327.1999.00911.x` `10.1046/j.1471-4159.1998.71062239.x` `10.1046/j.1471-4159.1999.0730913.x` `10.1053/gast.2002.30329` `10.1056/nejmoa010713` `10.1056/nejmoa035322` `10.1056/nejmoa065181` `10.1073/pnas.0308250100` 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Metabolism Accession ID: Reactome:R-RNO-1430728	-
Aerobic respiration and respiratory electron transport Accession ID: Reactome:R-RNO-1428517	-
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