ABH and Lewis epitopes biosynthesis from type 2 precursor disaccharide

Marsolais F, Boyd J, Paredes Y, Schinas AM, Garcia M, Elzein S, Varin L. Molecular and biochemical characterization of two brassinosteroid sulfotransferases from Arabidopsis, AtST4a (At2g14920) and AtST1 (At2g03760). Planta. 2007 Apr;225(5):1233–44. doi: 10.1007/s00425-006-0413-y. PMID: 17039368.

Metabolites

H+

Formula: H (1.0078246)

CAS ID: 12408-02-5

UDP(3-)

Formula: C9H11N2O12P2 (400.9787246)

CAS ID: 86527-70-0



Enzyme

EC Number name full name note
2.4.1.-
2.4.1.152 4-galactosyl-N-acetylglucosaminide 3-alpha-L-fucosyltransferase GDP-beta-L-fucose:beta-D-galactosyl-(1->4)-N-acetyl-D-glucosaminyl-R 3-alpha-L-fucosyltransferase (configuration-inverting)
2.4.1.22 lactose synthase UDP-galactose:D-glucose 4-beta-D-galactosyltransferase
2.4.1.275 neolactotriaosylceramide beta-1,4-galactosyltransferase UDP-alpha-D-galactose:N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1beta4)-beta-D-glucosyl-(1<->1)-ceramide 4-beta-D-galactosyltransferase
2.4.1.344 type 2 galactoside alpha-(1,2)-fucosyltransferase GDP-beta-L-fucose:beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-R alpha-(1,2)-L-fucosyltransferase (configuration-inverting)
2.4.1.37 fucosylgalactoside 3-alpha-galactosyltransferase UDP-galactose:alpha-L-fucosyl-(1->2)-D-galactoside 3-alpha-D-galactosyltransferase
2.4.1.38 beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase UDP-galactose:N-acetyl-beta-D-glucosaminylglycopeptide 4-beta-galactosyltransferase
2.4.1.40 glycoprotein-fucosylgalactoside alpha-N-acetylgalactosaminyltransferase UDP-N-acetyl-D-galactosamine:glycoprotein-alpha-L-fucosyl-(1->2)-D-galactose 3-N-acetyl-D-galactosaminyltransferase
2.4.1.65 3-galactosyl-N-acetylglucosaminide 4-alpha-L-fucosyltransferase GDP-beta-L-fucose:beta-D-galactosyl-(1->3)-N-acetyl-D-glucosaminyl-R 4I-alpha-L-fucosyltransferase
2.4.1.69 type 1 galactoside alpha-(1,2)-fucosyltransferase GDP-beta-L-fucose:beta-D-galactosyl-(1->3)-N-acetyl-beta-D-glucosaminyl-R alpha-(1,2)-L-fucosyltransferase (configuration-inverting)
2.4.1.90 N-acetyllactosamine synthase UDP-galactose:N-acetyl-D-glucosamine 4-beta-D-galactosyltransferase
2.4.3.2 beta-D-galactosyl-(1->3)-N-acetyl-beta-D-galactosaminide alpha-2,3-sialyltransferase CMP-N-acetyl-beta-neuraminate:a beta-D-galactosyl-(1->3)-N-acetyl-beta-D-galactosaminyl-R alpha-(2->3)-N-acetylneuraminyltransferase (configuration-inverting)
2.4.3.4 beta-galactoside alpha-2,3-sialyltransferase CMP-N-acetylneuraminate:beta-D-galactoside alpha-(2->3)-N-acetylneuraminyl-transferase
2.4.3.6 N-acetyllactosaminide alpha-2,3-sialyltransferase CMP-N-acetyl-beta-neuraminate:beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-R (2->3)-N-acetyl-alpha-neuraminyltransferase (configuration-inverting)
2.8.2.21 keratan sulfotransferase 3'-phosphoadenylyl-sulfate:keratan 6'-sulfotransferase


Pathway Source

Organism Taxonomy Group Enzyme List Source Ratio
Homo sapiens vertebrate_mammalian 2.4.1.- / 2.4.1.152 / 2.4.1.22 / 2.4.1.275 / 2.4.1.344 / 2.4.1.37 / 2.4.1.38 / 2.4.1.40 / 2.4.1.65 / 2.4.1.69 / 2.4.1.90 / 2.4.3.2 / 2.4.3.4 / 2.4.3.6 / 2.8.2.21 100.00%
Mus musculus vertebrate_mammalian 2.4.1.- / 2.4.1.152 / 2.4.1.22 / 2.4.1.275 / 2.4.1.344 / 2.4.1.37 / 2.4.1.38 / 2.4.1.40 / 2.4.1.69 / 2.4.1.90 / 2.4.3.2 / 2.4.3.4 / 2.4.3.6 / 2.8.2.21 93.33%
Rattus norvegicus vertebrate_mammalian 2.4.1.- / 2.4.1.152 / 2.4.1.22 / 2.4.1.275 / 2.4.1.344 / 2.4.1.37 / 2.4.1.38 / 2.4.1.40 / 2.4.1.69 / 2.4.1.90 / 2.4.3.2 / 2.4.3.4 / 2.4.3.6 / 2.8.2.21 93.33%
Neisseria meningitidis MC58 MAGs 2.4.1.- / 2.4.3.6 13.33%
Enterococcus faecium DO MAGs 2.4.1.- / 2.4.1.69 13.33%
Neisseria gonorrhoeae bacteria 2.4.3.6 6.67%
Streptococcus agalactiae bacteria 2.4.1.- 6.67%
Streptococcus gordonii bacteria 2.4.1.- 6.67%
Synechocystis sp. PCC 6803 bacteria 2.4.1.- 6.67%
Dichelobacter nodosus bacteria 2.4.1.- 6.67%
Shigella flexneri bacteria 2.4.1.- 6.67%
Escherichia coli bacteria 2.4.1.- 6.67%
Neisseria meningitidis bacteria 2.4.1.- 6.67%
Rhizobium tropici bacteria 2.4.1.- 6.67%
Sinorhizobium fredii NGR234 MAGs 2.4.1.- 6.67%
Penicillium cf. griseofulvum MAGs 2.4.1.- 6.67%
Rhizobium leguminosarum bv. viciae MAGs 2.4.1.- 6.67%
Rhizobium leguminosarum bv. trifolii MAGs 2.4.1.- 6.67%
Rhizobium leguminosarum bv. phaseoli MAGs 2.4.1.- 6.67%
Pseudomonas syringae pv. syringae MAGs 2.4.1.- 6.67%