Proline Metabolism

Metabolites

ADP

Formula: C10H15N5O10P2 (427.02941500000003)

CAS ID: 58-64-0

ATP

Formula: C10H16N5O13P3 (506.9957476)

CAS ID: 56-65-5

Delta1-Pyrroline-5-carboxylate

Formula: C5H7NO2 (113.0476762)

CAS ID: 2906-39-0

H+

Formula: H (1.0078246)

CAS ID: 12408-02-5

H2O

Formula: H2O (18.0105642)

CAS ID: 7732-18-5

L-Glutamate

Formula: C5H9NO4 (147.0531554)

CAS ID: 56-86-0

L-Glutamate 5-semialdehyde

Formula: C5H9NO3 (131.0582404)

CAS ID: 496-92-4

L-Glutamyl 5-phosphate

Formula: C5H10NO7P (227.019488)

CAS ID: 13254-53-0

L-Proline

Formula: C5H9NO2 (115.0633254)

CAS ID: 147-85-3

NAD+

Formula: C21H28N7O14P2 (664.1169428000001)

CAS ID: 53-84-9

NADH

Formula: C21H29N7O14P2 (665.1247674)

CAS ID: 58-68-4

NADP+

Formula: C21H29N7O17P3 (744.0832754)

CAS ID: 53-59-8

Ubiquinone-1

Formula: C14H18O4 (250.1205028)

CAS ID: 727-81-1

QH(2)

Formula: C14H20O4 (252.136152)

CAS ID: 52590-98-4

phosphate(3-)

Formula: O4P (94.953423)

CAS ID: 14265-44-2



Enzyme

EC Number name full name note
1.2.1.41 glutamate-5-semialdehyde dehydrogenase L-glutamate-5-semialdehyde:NADP+ 5-oxidoreductase (phosphorylating)
1.2.1.88 L-glutamate gamma-semialdehyde dehydrogenase L-glutamate gamma-semialdehyde:NAD+ oxidoreductase
1.5.1.2 pyrroline-5-carboxylate reductase L-proline:NAD(P)+ 5-oxidoreductase
1.5.5.2 proline dehydrogenase L-proline:quinone oxidoreductase
2.7.2.11 glutamate 5-kinase ATP:L-glutamate 5-phosphotransferase
7.4.2.1 ABC-type polar-amino-acid transporter ATP phosphohydrolase (ABC-type, polar-amino-acid-importing)


Pathway Source

Organism Taxonomy Group Enzyme List Source Ratio
Escherichia coli K-12 MAGs 1.2.1.41 / 1.2.1.88 / 1.5.1.2 / 1.5.5.2 / 2.7.2.11 / 7.4.2.1 100.00%
Actinacidiphila oryziradicis bacteria 1.2.1.41 / 1.2.1.88 / 1.5.1.2 / 1.5.5.2 / 2.7.2.11 / 7.4.2.1 100.00%
Streptomyces halstedii bacteria 1.2.1.41 / 1.2.1.88 / 1.5.1.2 / 1.5.5.2 / 2.7.2.11 / 7.4.2.1 100.00%
Humibacillus xanthopallidus bacteria 1.2.1.41 / 1.2.1.88 / 1.5.1.2 / 1.5.5.2 / 2.7.2.11 / 7.4.2.1 100.00%
Pseudomonas aeruginosa PAO1 MAGs 1.2.1.41 / 1.2.1.88 / 1.5.1.2 / 1.5.5.2 / 2.7.2.11 / 7.4.2.1 100.00%
Aeromonas salmonicida subsp. salmonicida MAGs 1.2.1.41 / 1.2.1.88 / 1.5.1.2 / 1.5.5.2 / 2.7.2.11 / 7.4.2.1 100.00%
Cupriavidus taiwanensis bacteria 1.2.1.41 / 1.2.1.88 / 1.5.1.2 / 1.5.5.2 / 2.7.2.11 / 7.4.2.1 100.00%
Rhodococcus erythropolis PR4 MAGs 1.2.1.41 / 1.2.1.88 / 1.5.1.2 / 1.5.5.2 / 2.7.2.11 83.33%
Homo sapiens vertebrate_mammalian 1.2.1.41 / 1.2.1.88 / 1.5.1.2 / 1.5.5.2 / 2.7.2.11 83.33%
Corynebacterium glutamicum ATCC 13032 MAGs 1.2.1.41 / 1.5.1.2 / 1.5.5.2 / 2.7.2.11 / 7.4.2.1 83.33%
Bacillus subtilis subsp. subtilis str. 168 MAGs 1.2.1.41 / 1.2.1.88 / 1.5.1.2 / 1.5.5.2 / 2.7.2.11 83.33%
Coccidioides posadasii C735 delta SOWgp MAGs 1.2.1.41 / 1.2.1.88 / 1.5.1.2 / 1.5.5.2 / 2.7.2.11 83.33%
Trichodesmium erythraeum IMS101 MAGs 1.2.1.41 / 1.2.1.88 / 1.5.1.2 / 1.5.5.2 / 2.7.2.11 83.33%
Exophiala dermatitidis fungi 1.2.1.41 / 1.2.1.88 / 1.5.1.2 / 1.5.5.2 / 2.7.2.11 83.33%
Streptomyces albogriseolus bacteria 1.2.1.41 / 1.2.1.88 / 1.5.1.2 / 1.5.5.2 / 2.7.2.11 83.33%
Mus musculus vertebrate_mammalian 1.2.1.41 / 1.2.1.88 / 1.5.1.2 / 1.5.5.2 / 2.7.2.11 83.33%
Salmonella enterica subsp. enterica serovar Typhimurium str. LT2 MAGs 1.2.1.41 / 1.2.1.88 / 1.5.5.2 / 2.7.2.11 / 7.4.2.1 83.33%
Paraburkholderia graminis bacteria 1.2.1.41 / 1.2.1.88 / 1.5.1.2 / 1.5.5.2 / 2.7.2.11 83.33%
Diaphorina citri invertebrate 1.2.1.41 / 1.2.1.88 / 1.5.1.2 / 1.5.5.2 / 2.7.2.11 83.33%
Pseudomonas syringae pv. syringae MAGs 1.2.1.41 / 1.2.1.88 / 1.5.1.2 / 1.5.5.2 / 2.7.2.11 83.33%