EC: 1.2.1.88

L-glutamate gamma-semialdehyde dehydrogenase (L-glutamate gamma-semialdehyde:NAD+ oxidoreductase)

enzyme lambda metabolic reaction experiment
uniprot:P30038 [L-glutamate gamma-semialdehyde dehydrogenase(Enzyme) wildtype]

NAD+ + Acetaldehyde + H2O -> NADH + H+ + Acetate		 (( (Vmax * S) ) / (Km + S)) buffer: 0.1 M sodium pyrophosphate, 1 mM EDTA
PH: 8.5
Temperature: 25
uniprot:P30038 [L-glutamate gamma-semialdehyde dehydrogenase(Enzyme) wildtype]

Acetaldehyde + H2O + NAD+ -> Acetate + NADH + H+		 (( (Vmax * S) ) / (Km + S)) buffer: 0.1 M sodium phosphate, 1 mM EDTA
PH: 7
Temperature: 25
uniprot:P30038 [L-glutamate gamma-semialdehyde dehydrogenase(Enzyme) wildtype]

Succinate_semialdehyde + H2O + NAD+ -> NADH + Succinate + H+		 (( (Vmax * S) ) / (Km + S)) buffer: 0.1 M sodium pyrophosphate, 1 mM EDTA
PH: 8.5
Temperature: 25
uniprot:P30038 [L-glutamate gamma-semialdehyde dehydrogenase(Enzyme) wildtype]

Succinate_semialdehyde + H2O + NAD+ -> H+ + NADH + Succinate		 (( (Vmax * S) ) / (Km + S)) buffer: 0.1 M sodium pyrophosphate, 1 mM EDTA
PH: 8.5
Temperature: 25
uniprot:P30038 [L-glutamate gamma-semialdehyde dehydrogenase(Enzyme) wildtype]

NAD+ + 5_Oxopentanoate + H2O -> H+ + Glutarate + NADH		 (( (Vmax * S) ) / (Km + S)) buffer: 0.1 M sodium pyrophosphate, 1 mM EDTA
PH: 8.5
Temperature: 25
uniprot:P30038 [L-glutamate gamma-semialdehyde dehydrogenase(Enzyme) wildtype]

NAD+ + Propanal + H2O -> NADH + Propanoate + H+		 (( (Vmax * S) ) / (Km + S)) buffer: 0.1 M sodium pyrophosphate, 1 mM EDTA
PH: 8.5
Temperature: 25
uniprot:P30038 [L-glutamate gamma-semialdehyde dehydrogenase(Enzyme) wildtype]

H2O + NAD+ + 6_Oxohexanoate -> Adipate + NADH + H+		 (( (Vmax * S) ) / (Km + S)) buffer: 0.1 M sodium pyrophosphate, 1 mM EDTA
PH: 8.5
Temperature: 25
uniprot:P30038 [L-glutamate gamma-semialdehyde dehydrogenase(Enzyme) wildtype]

H2O + Glutamate_gamma_semialdehyde + NAD+ -> NADH + H+ + Glutamate		 (( (Vmax * S) ) / (Km + S)) buffer: 0.1 M sodium pyrophosphate, 1 mM EDTA
PH: 8.5
Temperature: 25
uniprot:P30038 [L-glutamate gamma-semialdehyde dehydrogenase(Enzyme) wildtype]

H2O + p_Nitrophenyl_acetate -> p_Nitrophenol + Acetate		 (( (Vmax * S) ) / (Km + S)) buffer: 0.1 M sodium phosphate, 1 mM EDTA
PH: 7
Temperature: 25
uniprot:P30038 [L-glutamate gamma-semialdehyde dehydrogenase(Enzyme) wildtype]

NAD+ + Acetaldehyde + H2O -> NADH + Acetate + H+		 (( (Vmax * S) ) / (Km + S)) buffer: 0.1 M sodium phosphate, 1 mM EDTA
PH: 7
Temperature: 25
uniprot:P30038 [L-glutamate gamma-semialdehyde dehydrogenase(Enzyme) wildtype]

Succinate_semialdehyde + H2O + NAD+ -> Succinate + H+ + NADH		 (( (Vmax * S) ) / (Km + S)) buffer: 0.1 M sodium phosphate, 1 mM EDTA
PH: 7
Temperature: 25
uniprot:P30038 [L-glutamate gamma-semialdehyde dehydrogenase(Enzyme) wildtype]

Succinate_semialdehyde + H2O + NAD+ -> NADH + H+ + Succinate		 (( (Vmax * S) ) / (Km + S)) buffer: 0.1 M sodium phosphate, 1 mM EDTA
PH: 7
Temperature: 25
uniprot:P30038 [L-glutamate gamma-semialdehyde dehydrogenase(Enzyme) wildtype]

5_Oxopentanoate + H2O + NAD+ -> H+ + Glutarate + NADH		 (( (Vmax * S) ) / (Km + S)) buffer: 0.1 M sodium phosphate, 1 mM EDTA
PH: 7
Temperature: 25
uniprot:P30038 [L-glutamate gamma-semialdehyde dehydrogenase(Enzyme) wildtype]

NAD+ + H2O + Propanal -> H+ + Propanoate + NADH		 (( (Vmax * S) ) / (Km + S)) buffer: 0.1 M sodium phosphate, 1 mM EDTA
PH: 7
Temperature: 25
uniprot:P30038 [L-glutamate gamma-semialdehyde dehydrogenase(Enzyme) wildtype]

NAD+ + H2O + 6_Oxohexanoate -> H+ + NADH + Adipate		 (( (Vmax * S) ) / (Km + S)) buffer: 0.1 M sodium phosphate, 1 mM EDTA
PH: 7
Temperature: 25
uniprot:P30038 [L-glutamate gamma-semialdehyde dehydrogenase(Enzyme) wildtype]

p_Nitrobenzaldehyde + H2O + NAD+ -> H+ + NADH + p_Nitrobenzoate		 (( (Vmax * S) ) / (Km + S)) buffer: 0.1 M sodium pyrophosphate, 1 mM EDTA
PH: 9
Temperature: 25
uniprot:P30038 [L-glutamate gamma-semialdehyde dehydrogenase(Enzyme) wildtype]

H2O + NAD+ + Glutamate_gamma_semialdehyde -> Glutamate + NADH + H+		 (( (Vmax * S) ) / (Km + S)) buffer: 0.1 M sodium phosphate, 1 mM EDTA
PH: 7
Temperature: 25
uniprot:P30038 [L-glutamate gamma-semialdehyde dehydrogenase(Enzyme) wildtype]

m_Nitrobenzaldehyde + NAD+ + H2O -> NADH + m_Nitrobenzoate + H+		 (( (Vmax * S) ) / (Km + S)) buffer: 0.1 M sodium pyrophosphate, 1 mM EDTA
PH: 9
Temperature: 25
uniprot:P30038 [L-glutamate gamma-semialdehyde dehydrogenase(Enzyme) wildtype]

H2O + NAD+ + Acetaldehyde -> NADH + Acetate + H+		 (( (Vmax * S) ) / (Km + S)) buffer: 0.1 M sodium pyrophosphate, 1 mM EDTA
PH: 8.5
Temperature: 25
uniprot:P30038 [L-glutamate gamma-semialdehyde dehydrogenase(Enzyme) wildtype]

H2O + Succinate_semialdehyde + NAD+ -> Succinate + H+ + NADH		 (( (Vmax * S) ) / (Km + S)) buffer: 0.1 M sodium phosphate, 1 mM EDTA
PH: 7
Temperature: 25
uniprot:P30038 [L-glutamate gamma-semialdehyde dehydrogenase(Enzyme) wildtype]

H2O + 5_Oxopentanoate + NAD+ -> NADH + H+ + Glutarate		 (( (Vmax * S) ) / (Km + S)) buffer: 0.1 M sodium phosphate, 1 mM EDTA
PH: 7
Temperature: 25
uniprot:P30038 [L-glutamate gamma-semialdehyde dehydrogenase(Enzyme) wildtype]

H2O + 5_Oxopentanoate + NAD+ -> NADH + Glutarate + H+		 (( (Vmax * S) ) / (Km + S)) buffer: 0.1 M sodium pyrophosphate, 1 mM EDTA
PH: 8.5
Temperature: 25
uniprot:P30038 [L-glutamate gamma-semialdehyde dehydrogenase(Enzyme) wildtype]

NADP+ + H2O + Acetaldehyde -> NADPH + Acetate + H+		 (( (Vmax * S) ) / (Km + S)) buffer: 0.1 M sodium pyrophosphate, 1 mM EDTA
PH: 8.5
Temperature: 25
uniprot:P30038 [L-glutamate gamma-semialdehyde dehydrogenase(Enzyme) wildtype]

H2O + Glutamate_gamma_semialdehyde + NAD+ -> NADH + Glutamate + H+		 (( (Vmax * S) ) / (Km + S)) buffer: 0.1 M sodium pyrophosphate, 1 mM EDTA
PH: 8.5
Temperature: 25
uniprot:P30038 [L-glutamate gamma-semialdehyde dehydrogenase(Enzyme) wildtype]

Glutamate_gamma_semialdehyde + H2O + NAD+ -> H+ + NADH + Glutamate		 (( (Vmax * S) ) / (Km + S)) buffer: 0.1 M sodium phosphate, 1 mM EDTA
PH: 7
Temperature: 25

Pathways

pathway id name
BioCyc:META_HYDROXYPRODEG-PWY trans-4-hydroxy-L-proline degradation I
BioCyc:ARA_PROUT-PWY L-proline degradation
BioCyc:ECOL316407_PROUT-PWY proline degradation
BioCyc:HUMAN_PROUT-PWY proline degradation
BioCyc:META_PROUT-PWY L-proline degradation
BioCyc:META_ARGASEDEG-PWY L-arginine degradation I (arginase pathway)
BioCyc:ECO_PWY0-1544 proline to cytochrome bo oxidase electron transfer
BioCyc:ARA_ARGASEDEG-PWY L-arginine degradation I (arginase pathway)
BioCyc:GCF_000013425_PROUT-PWY L-proline degradation
BioCyc:HUMAN_HYDROXYPRODEG-PWY 4-hydroxyproline degradation
BioCyc:MOUSE_ARGASEDEG-PWY arginine degradation I (arginase pathway)
BioCyc:GCF_000013425_ARGASEDEG-PWY L-arginine degradation I (arginase pathway)
BioCyc:META_PWY0-1544 proline to cytochrome bo oxidase electron transfer
BioCyc:ECO_PROUT-PWY-I proline degradation
BioCyc:YEAST_PROUT-PWY proline degradation
BioCyc:MOUSE_PROLINE-DEG2-PWY proline degradation III
BioCyc:ECOL316407_PWY0-1544 proline to cytochrome bo oxidase electron transfer
WikiPathways:WP2472 Escherichia coli K-12 peripherome
PathBank:SMP0000815 Proline Metabolism
PlantCyc:ARA_PROUT-PWY L-proline degradation
PlantCyc:ARA_ARGASEDEG-PWY L-arginine degradation I (arginase pathway)
PlantCyc:PLANT_ARGASEDEG-PWY L-arginine degradation I (arginase pathway)
Reactome:R-BTA-1430728 Metabolism
Reactome:R-BTA-71291 Amino acid and derivative metabolism
Reactome:R-DRE-71291 Amino acid and derivative metabolism
Reactome:R-HSA-389661 Glyoxylate metabolism and glycine degradation
Reactome:R-MMU-1430728 Metabolism
Reactome:R-MMU-389661 Glyoxylate metabolism and glycine degradation
Reactome:R-RNO-389661 Glyoxylate metabolism and glycine degradation
Reactome:R-BTA-389661 Glyoxylate metabolism and glycine degradation
Reactome:R-DRE-389661 Glyoxylate metabolism and glycine degradation
Reactome:R-BTA-70688 Proline catabolism
Reactome:R-DRE-1430728 Metabolism
Reactome:R-DRE-70688 Proline catabolism
Reactome:R-HSA-71291 Amino acid and derivative metabolism
Reactome:R-MMU-71291 Amino acid and derivative metabolism
Reactome:R-RNO-1430728 Metabolism
Reactome:R-RNO-71291 Amino acid and derivative metabolism
Reactome:R-HSA-1430728 Metabolism
Reactome:R-HSA-70688 Proline catabolism
Reactome:R-MMU-70688 Proline catabolism
Reactome:R-RNO-70688 Proline catabolism
WikiPathways:WP4595 Urea cycle and associated pathways
WikiPathways:WP5166 Glyoxylate metabolism
PathBank:SMP0120496 Hyperinsulinism-Hyperammonemia Syndrome
PathBank:SMP0120569 Creatine Deficiency, Guanidinoacetate Methyltransferase Deficiency
PathBank:SMP0000020 Arginine and Proline Metabolism
PathBank:SMP0000339 Hyperinsulinism-Hyperammonemia Syndrome
PathBank:SMP0000362 Arginine: Glycine Amidinotransferase Deficiency (AGAT Deficiency)
PathBank:SMP0000188 Guanidinoacetate Methyltransferase Deficiency (GAMT Deficiency)
PathBank:SMP0000504 Creatine Deficiency, Guanidinoacetate Methyltransferase Deficiency
PathBank:SMP0002308 4-Aminobutanoate Degradation
PathBank:SMP0002420 Proline Metabolism
PathBank:SMP0087169 Glutamate Metabolism
PathBank:SMP0063596 Arginine and Proline Metabolism
PathBank:SMP0120499 Hyperprolinemia Type I
PathBank:SMP0120539 Prolinemia Type II
PathBank:SMP0120572 L-Arginine:Glycine Amidinotransferase Deficiency
PathBank:SMP0000385 Homocarnosinosis
PathBank:SMP0000207 Prolidase Deficiency (PD)
PathBank:SMP0000208 Prolinemia Type II
PathBank:SMP0000136 2-Hydroxyglutric Aciduria (D and L Form)
PathBank:SMP0000507 L-Arginine:Glycine Amidinotransferase Deficiency
PathBank:SMP0000567 Succinic Semialdehyde Dehydrogenase Deficiency
PathBank:SMP0002416 Arginine Metabolism
PathBank:SMP0120445 4-Hydroxybutyric Aciduria/Succinic Semialdehyde Dehydrogenase Deficiency
PathBank:SMP0120501 Hyperprolinemia Type II
PathBank:SMP0120541 Prolidase Deficiency (PD)
PathBank:SMP0120570 Hyperornithinemia with Gyrate Atrophy (HOGA)
PathBank:SMP0000360 Hyperprolinemia Type II
PathBank:SMP0000363 Ornithine Aminotransferase Deficiency (OAT Deficiency)
PathBank:SMP0000505 Hyperornithinemia with Gyrate Atrophy (HOGA)
PathBank:SMP0063590 Glutamate Metabolism
PathBank:SMP0120438 2-Hydroxyglutric Aciduria (D and L Form)
PathBank:SMP0120454 Arginine: Glycine Amidinotransferase Deficiency (AGAT Deficiency)
PathBank:SMP0120490 Guanidinoacetate Methyltransferase Deficiency (GAMT Deficiency)
PathBank:SMP0120494 Homocarnosinosis
PathBank:SMP0120538 Ornithine Aminotransferase Deficiency (OAT Deficiency)
PathBank:SMP0120571 Hyperornithinemia-Hyperammonemia-Homocitrullinuria [HHH-syndrome]
PathBank:SMP0120631 Succinic Semialdehyde Dehydrogenase Deficiency
PathBank:SMP0000072 Glutamate Metabolism
PathBank:SMP0000243 4-Hydroxybutyric Aciduria/Succinic Semialdehyde Dehydrogenase Deficiency
PathBank:SMP0000361 Hyperprolinemia Type I
PathBank:SMP0000506 Hyperornithinemia-Hyperammonemia-Homocitrullinuria [HHH-syndrome]
PathBank:SMP0087178 Arginine and Proline Metabolism