D-Glutamine and D-Glutamate Metabolism

Metabolites

Adenosine tetraphosphate

Formula: C10H17N5O16P4 (586.9620802)

CAS ID: 58337-43-2

ADP

Formula: C10H15N5O10P2 (427.02941500000003)

CAS ID: 58-64-0

Ammonia

Formula: NH3 (17.0265478)

CAS ID: 7664-41-7

ATP

Formula: C10H16N5O13P3 (506.9957476)

CAS ID: 56-65-5

D-Glutamate

Formula: C5H9NO4 (147.0531554)

CAS ID: 6893-26-1

H+

Formula: H (1.0078246)

CAS ID: 12408-02-5

H2O

Formula: H2O (18.0105642)

CAS ID: 7732-18-5

L-Alanine

Formula: C3H7NO2 (89.0476762)

CAS ID: 56-41-7

L-Glutamate

Formula: C5H9NO4 (147.0531554)

CAS ID: 56-86-0

L-Glutamine

Formula: C5H10N2O3 (146.069139)

CAS ID: 56-85-9

NH4+

Formula: NH4 (18.0343724)

CAS ID: 14798-03-9

Sodium cation

Formula: Na (22.98977)

CAS ID: 17341-25-2

UDP-N-acetylmuramoyl-L-alanine

Formula: C23H36N4O20P2 (750.1398076)

CAS ID:

UDP-N-acetylmuraminate

Formula: C20H31N3O19P2 (679.1026956000001)

CAS ID: 18867-75-9

Lorglumide

Formula: C22H32Cl2N2O4 (458.1739012)

CAS ID: 97964-56-2

phosphate(3-)

Formula: O4P (94.953423)

CAS ID: 14265-44-2



Enzyme

EC Number name full name note
3.5.1.2 glutaminase L-glutamine amidohydrolase
5.1.1.3 glutamate racemase glutamate racemase
6.3.1.2 glutamine synthetase L-glutamate:ammonia ligase (ADP-forming)
6.3.2.8 UDP-N-acetylmuramate-L-alanine ligase UDP-N-acetylmuramate:L-alanine ligase (ADP-forming)
6.3.2.9 UDP-N-acetylmuramoyl-L-alanine-D-glutamate ligase UDP-N-acetylmuramoyl-L-alanine:D-glutamate ligase (ADP-forming)
7.4.2.1 ABC-type polar-amino-acid transporter ATP phosphohydrolase (ABC-type, polar-amino-acid-importing)


Pathway Source

Organism Taxonomy Group Enzyme List Source Ratio
Aeromonas salmonicida subsp. salmonicida MAGs 3.5.1.2 / 5.1.1.3 / 6.3.1.2 / 6.3.2.8 / 6.3.2.9 / 7.4.2.1 100.00%
Pseudomonas aeruginosa PAO1 MAGs 3.5.1.2 / 5.1.1.3 / 6.3.1.2 / 6.3.2.8 / 6.3.2.9 / 7.4.2.1 100.00%
Escherichia coli CFT073 MAGs 3.5.1.2 / 5.1.1.3 / 6.3.1.2 / 6.3.2.8 / 6.3.2.9 / 7.4.2.1 100.00%
Salmonella enterica subsp. enterica serovar Typhimurium str. LT2 MAGs 3.5.1.2 / 5.1.1.3 / 6.3.1.2 / 6.3.2.8 / 6.3.2.9 / 7.4.2.1 100.00%
Haemophilus influenzae Rd KW20 MAGs 3.5.1.2 / 5.1.1.3 / 6.3.1.2 / 6.3.2.8 / 6.3.2.9 / 7.4.2.1 100.00%
Escherichia coli K-12 MAGs 3.5.1.2 / 5.1.1.3 / 6.3.1.2 / 6.3.2.8 / 6.3.2.9 / 7.4.2.1 100.00%
Escherichia coli O157:H7 MAGs 3.5.1.2 / 5.1.1.3 / 6.3.1.2 / 6.3.2.8 / 6.3.2.9 / 7.4.2.1 100.00%
Shigella flexneri bacteria 3.5.1.2 / 5.1.1.3 / 6.3.1.2 / 6.3.2.8 / 6.3.2.9 / 7.4.2.1 100.00%
Corynebacterium glutamicum ATCC 13032 MAGs 3.5.1.2 / 5.1.1.3 / 6.3.1.2 / 6.3.2.8 / 6.3.2.9 / 7.4.2.1 100.00%
Prochlorococcus marinus str. MIT 9313 MAGs 3.5.1.2 / 5.1.1.3 / 6.3.1.2 / 6.3.2.8 / 6.3.2.9 83.33%
Mycobacterium tuberculosis CDC1551 MAGs 3.5.1.2 / 5.1.1.3 / 6.3.1.2 / 6.3.2.8 / 6.3.2.9 83.33%
Synechocystis sp. PCC 6803 bacteria 3.5.1.2 / 5.1.1.3 / 6.3.1.2 / 6.3.2.8 / 6.3.2.9 83.33%
Staphylococcus aureus subsp. aureus Mu50 MAGs 3.5.1.2 / 5.1.1.3 / 6.3.1.2 / 6.3.2.8 / 6.3.2.9 83.33%
Prochlorococcus marinus str. MIT 9312 MAGs 3.5.1.2 / 5.1.1.3 / 6.3.1.2 / 6.3.2.8 / 6.3.2.9 83.33%
Staphylococcus aureus subsp. aureus COL MAGs 3.5.1.2 / 5.1.1.3 / 6.3.1.2 / 6.3.2.8 / 6.3.2.9 83.33%
Paraburkholderia graminis bacteria 3.5.1.2 / 5.1.1.3 / 6.3.1.2 / 6.3.2.8 / 6.3.2.9 83.33%
Nostoc sp. PCC 7120 = FACHB-418 bacteria 3.5.1.2 / 5.1.1.3 / 6.3.1.2 / 6.3.2.8 / 6.3.2.9 83.33%
Streptomyces albogriseolus bacteria 3.5.1.2 / 5.1.1.3 / 6.3.1.2 / 6.3.2.8 / 6.3.2.9 83.33%
Mycobacterium tuberculosis H37Rv MAGs 3.5.1.2 / 5.1.1.3 / 6.3.1.2 / 6.3.2.8 / 6.3.2.9 83.33%
Streptomyces halstedii bacteria 3.5.1.2 / 6.3.1.2 / 6.3.2.8 / 6.3.2.9 / 7.4.2.1 83.33%