NAD phosphorylation and dephosphorylation

Kemmer G, Reilly TJ, Schmidt-Brauns J, Zlotnik GW, Green BA, Fiske MJ, Herbert M, Kraiß A, Schlo¨r S, Smith A, Reidl J. NadN and e (P4) Are Essential for Utilization of NAD and Nicotinamide Mononucleotide but Not Nicotinamide Riboside in Haemophilus influenzae. J Bacteriol. 2001 Jul;183(13):3974–81. doi: 10.1128/jb.183.13.3974-3981.2001.; Reidl J, Schlör S, Kraiss A, Schmidt-Brauns J, Kemmer G, Soleva E. NADP and NAD utilization in Haemophilus influenzae. Mol Microbiol. 2000 Mar;35(6):1573–81. doi: 10.1046/j.1365-2958.2000.01829.x. PMID: 10760156.

Metabolites

H+

Formula: H (1.0078246)

CAS ID: 12408-02-5

H2O

Formula: H2O (18.0105642)

CAS ID: 7732-18-5

Magnesium cation

Formula: Mg (23.98505)

CAS ID: 22537-22-0

4-Chloro-7-nitrobenzofurazan

Formula: C6H2ClN3O3 (198.9784692)

CAS ID: 10199-89-0

Dicyclohexylcarbodiimide

Formula: C13H22N2 (206.1782892)

CAS ID: 538-75-0

NADPH(4-)

Formula: C21H26N7O17P3 (741.0598016)

CAS ID: 53-57-6

ATP(4-)

Formula: C10H12N5O13P3 (502.9644492)

CAS ID:

NADH(2-)

Formula: C21H27N7O14P2 (663.1091182000001)

CAS ID:

NAD(1-)

Formula: C21H26N7O14P2 (662.1012936000001)

CAS ID: 53-84-9

ADP(3-)

Formula: C10H12N5O10P2 (424.0059412)

CAS ID:

NADP(3-)

Formula: C21H25N7O17P3 (740.051977)

CAS ID: 53-59-8



Enzyme

EC Number name full name note
2.7.1.23 NAD+ kinase ATP:NAD+ 2'-phosphotransferase
7.1.1.1 proton-translocating NAD(P)+ transhydrogenase NADPH:NAD+ oxidoreductase (H+-transporting)


Pathway Source

Organism Taxonomy Group Enzyme List Source Ratio
Pseudomonas aeruginosa PAO1 MAGs 2.7.1.23 / 7.1.1.1 100.00%
Exophiala dermatitidis fungi 2.7.1.23 / 7.1.1.1 100.00%
Homo sapiens vertebrate_mammalian 2.7.1.23 / 7.1.1.1 100.00%
Escherichia coli K-12 MAGs 2.7.1.23 / 7.1.1.1 100.00%
Escherichia coli O157:H7 MAGs 2.7.1.23 / 7.1.1.1 100.00%
Mus musculus vertebrate_mammalian 2.7.1.23 / 7.1.1.1 100.00%
Paraburkholderia graminis bacteria 2.7.1.23 / 7.1.1.1 100.00%
Haemophilus influenzae Rd KW20 MAGs 2.7.1.23 / 7.1.1.1 100.00%
Trichodesmium erythraeum IMS101 MAGs 2.7.1.23 / 7.1.1.1 100.00%
Rhodospirillum rubrum ATCC 11170 MAGs 2.7.1.23 / 7.1.1.1 100.00%
Pseudomonas syringae pv. syringae MAGs 2.7.1.23 / 7.1.1.1 100.00%
Rattus norvegicus vertebrate_mammalian 2.7.1.23 / 7.1.1.1 100.00%
Knufia fluminis MAGs 2.7.1.23 / 7.1.1.1 100.00%
Synechocystis sp. PCC 6803 bacteria 2.7.1.23 / 7.1.1.1 100.00%
Escherichia coli CFT073 MAGs 2.7.1.23 / 7.1.1.1 100.00%
Coccidioides posadasii C735 delta SOWgp MAGs 2.7.1.23 / 7.1.1.1 100.00%
Rickettsia prowazekii str. Madrid E MAGs 2.7.1.23 / 7.1.1.1 100.00%
Aeromonas salmonicida subsp. salmonicida MAGs 2.7.1.23 / 7.1.1.1 100.00%
Cupriavidus taiwanensis bacteria 2.7.1.23 / 7.1.1.1 100.00%
Shigella flexneri bacteria 2.7.1.23 / 7.1.1.1 100.00%