Microbial Natural Product
Microbial natural products, primarily secondary metabolites produced by bacteria, fungi, and other microorganisms, remain a cornerstone of modern medicine and biotechnology. They form the foundation of numerous antibiotics (e.g., penicillin, streptomycin), anticancer agents, and immunosuppressants, addressing critical global health challenges like infectious diseases and cancer. Despite historical challenges such as compound rediscovery and complex biosynthesis, advances in genomics, metabolomics, and synthetic biology are unlocking novel chemical diversity from underexplored microbial sources. Consequently, microbial natural products continue to represent an unparalleled reservoir for discovering next-generation therapeutics, underscoring their enduring significance in drug development and sustainable bioprospecting. (98 words)
Micropeptin DR1006
Formula: C51H74N8O13 (1006.5375)
Microcystin LR
Formula: C49H74N10O12 (994.5487)
A microcystin consisting of D-alanyl, L-leucyl, (3S)-3-methyl-D-beta-aspartyl,L-arginyl, 2S,3S,4E,6E,8S,9S)-3-amino-4,5,6,7-tetradehydro-9-methoxy-2,6...
Crocetin dialdehyde
Crocetin dialdehyde is an apo carotenoid diterpenoid compound arising from oxidative degradation of the beta,beta-carotene skeleton at the 8- and 8'-p...
Aeruginopeptin 917S-C
Formula: C51H74N8O14 (1022.5324)
Microcystin RA
Formula: C46H68N10O12 (952.5018)
Cyanopeptolin S
Formula: C40H63N9O14S (925.4215)
Micropeptin MZ939A
Formula: C41H65N9O14S (939.4371)
Micropeptin MZ939B
Formula: C41H65N9O14S (939.4371)
Microcyclamide GL628
Formula: C27H32N8O6S2 (628.1886)
(3R,2'S)-Myxol 2'-(2,4-di-O-methylαL-fucoside)
Myxol 2'-dimethyl fucoside
venturamide B
Formula: C22H26N6O5S2 (518.1406)
An eighteen-membered homodetic cyclic peptide which is isolated from Oscillatoria sp. and exhibits antimalarial activity against the W2 chloroquine-r...
aldehydo-D-arabinose
Aldehydo-D-arabinose is an aldehydo-arabinose and a D-arabinose. It is an enantiomer of an aldehydo-L-arabinose. (2S,3R,4R)-2,3,4,5-tetrahydroxypenta...
schizokinen
Formula: C16H27N4O9 (419.1778)
|FRAME: CPD-12313 "Schizokinen"| is a siderophore originally discovered in the bacterium |FRAME: TAX-1404| but later reported from multiple other bact...
samaderine C
A quassinoid isolated from Quassia indica and has been shown to exhibit antineoplastic activity." []
Imipenem
Formula: C12H17N3O4S (299.094)
Semisynthetic thienamycin that has a wide spectrum of antibacterial activity against gram-negative and gram-positive aerobic and anaerobic bacteria, i...
Tenuecyclamide C
Formula: C20H22N6O4S3 (506.0865)
Prenostodione
Prenostodione is a cinnamate ester. Prenostodione has been reported in Nostoc with data available.
Cylindrocyclophane C3
Formula: C36H53Cl3O5 (670.2958)
beta-N-Methylamino-L-alanine
2-Amino-3-(methylamino)propanoic acid is a natural product found in Cycas circinalis with data available.
Mytilin B
Formula: C14H22N2O8 (346.1376)
Mytilin B is found in mollusks. Mytilin B is isolated from the edible mussel Mytilus galloprovincialis as a 1:3 inseparable mixture with Mytilin A
ambiguine I
Formula: C26H30N2O2 (402.2307)
An ambiguine that consists of a 5,5,7,10,10-pentamethyl-4,5,5a,6a,6b,7,8,9,9a,10-decahydro-10dH-6-oxa-4-azacyclopropa[6,7]cyclohepta[1,2,3,4-mno]acean...
Ambiguine H
This compound was observed experimentally in |FRAME: TAX-853| (unpublished data, X. Feng, University Medical Center Groningen).
Oxidized Latia luciferin
4-(2,6,6-Trimethyl-1-cyclohexen-1-yl)-2-butanone is found in fruits. 4-(2,6,6-Trimethyl-1-cyclohexen-1-yl)-2-butanone is a component of peach aroma.
Scytophycin E
Formula: C45H75NO12 (821.5289)
Scytophycin E is a diterpene lactone. Scytophycin E has been reported in Cylindrospermum muscicola with data available.
scytonemin
Formula: C36H20N2O4 (544.1423)
A ring assembly obtained by 1,1'-coupling of two molecules of (3E)-3-[(4-hydroxyphenyl)methylidene]cyclopenta[b]indol-2(3H)-one. A UV-screening molecu...
Deoxylapachol
2-demethylmenaquinone is a naphthoquinone and a member of p-quinones. It has a role as an Escherichia coli metabolite. Deoxylapachol is a natural pro...
Debromoaplysiatoxin
A member of the class of aplysiatoxins that has the structure of the parent aplysiatoxin, but is lacking the bromo substituent on the benzene ring at ...
Kaempferitrin
Kaempferitrin is found in linden. Kaempferitrin is a chemical compound. It can be isolated from the leaves of Hedyotis verticillata.
Tricin 7-glucoside
Tricin 7-glucoside is found in barley. Tricin 7-glucoside is isolated from rice leaves (Oryza sativa
D-Fructose
Fructose is a levorotatory monosaccharide and an isomer of glucose. Although fructose is a hexose (6 carbon sugar), it generally exists as a 5-member...
Tetraphyllin B
Tetraphyllin B is found in papaya. Tetraphyllin B is isolated from dried damiana leaves (Turnera diffusa
Vitexin 2'-OβL-rhamnoside
A derivative of vitexin having an alpha-L-rhamnosyl residue attached at the 2''-position of the glucitol moiety." []
Quercetin 3-O-diglucoside
Quercetin 3-gentiobioside is a member of the class of compounds known as flavonoid-3-o-glycosides. Flavonoid-3-o-glycosides are phenolic compounds con...
Apigenin 7-(4'-Z-p-coumarylglucoside)
Apigenin 7-(4''-Z-p-coumarylglucoside)
Atraric acid
Methyl beta-orcinolcarboxylate is a 4-hydroxybenzoate ester. Methyl 2,4-dihydroxy-3,6-dimethylbenzoate has been reported in Usnea undulata, Stereocau...