L-Norleucine

L-Norleucine, also known as L-aminohexanoate or caprine, belongs to the class of organic compounds known as l-alpha-amino acids. These are alpha amino acids which have the L-configuration of the alpha-carbon atom. Thus, L-norleucine is considered to be a fatty acid lipid molecule. An unnatural amino acid that is used experimentally to study protein structure and function. L-Norleucine is a very hydrophobic molecule, practically insoluble in water, and relatively neutral. L-Norleucine exists in all eukaryotes, ranging from yeast to humans. Outside of the human body, L-Norleucine has been detected, but not quantified in cow milk. This could make L-norleucine a potential biomarker for the consumption of these foods. It binds reversibly to the kringle domain of plasminogen and blocks the binding of plasminogen to fibrin and its activation to plasmin.

ID EC Number Name
KEGG:R03053 2.6.1.67 L-2-aminohexanoate:2-oxoglutarate aminotransferase
BioCyc:2-AMINOHEXANOATE-AMINOTRANSFERASE-RXN 2.6.1.67 2-KETOGLUTARATE + L-2-AMINOHEXANOATE<=>GLT + 2-OXOHEXANOATE