11-cis-Retinol
Cis-11-retinol is produce from vitamin A cycle driven by interphotoreceptor retinoid binding protein(IRBP). cis-11-retinol is released from retinal pigment epithelium(RPE) membranes. (PMID: 10655150). Retinoid metabolism of RPE cells freshly isolated by trypsinization showed no 11- cis -retinal and little 11- cis -retinol formation. Nondamaged cells cultured on thermally responsive surfaces detached in sheets upon temperature change. They showed metabolism similar to that of cells freshly isolated by nonenzymatic means. After trypsinization, confluent cultures dissociated into individual cells, but these cells showed poor retinoid metabolism, including no detectable retinyl esters or 11- cis -retinoid isomers. (PMID: 10375454).
| ID | EC Number | Name |
|---|---|---|
| Rhea:RHEA:55327 | 11-cis-retinol + hexadecanoyl-CoA <=> 11-cis-retinyl hexadecanoate + CoA | |
| Rhea:RHEA:55357 | 11-cis-retinol => 13-cis-retinol | |
| Rhea:RHEA:55358 | 13-cis-retinol => 11-cis-retinol | |
| Rhea:RHEA:55359 | 11-cis-retinol <=> 13-cis-retinol | |
| Rhea:RHEA:55361 | 11-cis-retinol => 9-cis-retinol | |
| Rhea:RHEA:55362 | 9-cis-retinol => 11-cis-retinol | |
| Rhea:RHEA:55363 | 11-cis-retinol <=> 9-cis-retinol | |
| Rhea:RHEA:77768 | 11-cis-retinol + a fatty acyl-CoA => 11-cis-retinyl ester + CoA | |
| Rhea:RHEA:77769 | 11-cis-retinyl ester + CoA => 11-cis-retinol + a fatty acyl-CoA | |
| Rhea:RHEA:77770 | 11-cis-retinol + a fatty acyl-CoA <=> 11-cis-retinyl ester + CoA | |
| Rhea:RHEA:19141 | [19141] all-trans-retinol = 11-cis-retinol | |
| Rhea:RHEA:19697 | [19697] 11-cis-retinyl hexadecanoate + H2O = 11-cis-retinol + hexadecanoate + H(+) | |
| Rhea:RHEA:31775 | [31775] all-trans-retinyl hexadecanoate + H2O = 11-cis-retinol + hexadecanoate + H(+) | |
| Rhea:RHEA:31771 | [31771] an all-trans-retinyl ester + H2O = 11-cis-retinol + a fatty acid + H(+) | |
| Rhea:RHEA:42060 | [42060] 11-cis-retinol + NAD(+) = 11-cis-retinal + NADH + H(+) | |
| Rhea:RHEA:54912 | [54912] 11-cis-retinol + NADP(+) = 11-cis-retinal + NADPH + H(+) | |
| Rhea:RHEA:55272 | [55272] 11-cis-retinol + tetradecanoyl-CoA = 11-cis-retinyl tetradecanoate + CoA | |
| Rhea:RHEA:55324 | [55324] 11-cis-retinol + hexadecanoyl-CoA = 11-cis-retinyl hexadecanoate + CoA | |
| Rhea:RHEA:55356 | [55356] 11-cis-retinol = 13-cis-retinol | |
| Rhea:RHEA:55360 | [55360] 11-cis-retinol = 9-cis-retinol | |
| Rhea:RHEA:77767 | [77767] 11-cis-retinol + a fatty acyl-CoA = 11-cis-retinyl ester + CoA |