Endoplasmic reticulum lumen

The endoplasmic reticulum (ER) lumen constitutes the aqueous, enclosed space within the ER membrane network, serving as a critical compartment for protein folding, post-translational modification (e.g., glycosylation, disulfide bond formation), and lipid synthesis. Its unique oxidizing environment facilitates proper protein maturation, while specialized chaperones (e.g., BiP) and quality control mechanisms ensure only correctly folded proteins proceed to the Golgi. Additionally, the lumen acts as a major intracellular calcium reservoir, essential for cellular signaling. Dysfunction in lumenal processes is linked to protein misfolding diseases and cellular stress. (Approx. 90 words)

View SubCellular Compartment Model

Protein List

ID name Taxonomy Function
A0AAV5QRU0 A0AAV5QRU0_9ASCO Saccharomycopsis crataegensis Endoplasmic reticulum chaperone BIP
A0AAV5S586 A0AAV5S586_MAUHU Maudiozyma humilis Endoplasmic reticulum chaperone BIP
A6ZPU2 KAR2 Saccharomyces cerevisiae YJM789 Endoplasmic reticulum chaperone BIP
A6ZTE9 PDI1 Saccharomyces cerevisiae YJM789 Protein disulfide-isomerase
A7TFB1 A7TFB1_VANPO Vanderwaltozyma polyspora DSM 70294 Protein disulfide-isomerase
B3LQ77 B3LQ77_YEAS1 Saccharomyces cerevisiae RM11-1a Endoplasmic reticulum chaperone BIP
B3LU41 B3LU41_YEAS1 Saccharomyces cerevisiae RM11-1a Protein disulfide-isomerase
C5DK19 C5DK19_LACTC Lachancea thermotolerans CBS 6340 Protein disulfide-isomerase
C5DMC8 C5DMC8_LACTC Lachancea thermotolerans CBS 6340 Endoplasmic reticulum chaperone BIP
C5DQE5 C5DQE5_ZYGRC Zygosaccharomyces rouxii CBS 732 Endoplasmic reticulum chaperone BIP
C7GSQ6 KAR2 Saccharomyces cerevisiae JAY291 Endoplasmic reticulum chaperone BIP
C7GSZ8 PDI1 Saccharomyces cerevisiae JAY291 Protein disulfide-isomerase
C8Z447 C8Z447_YEAS8 Saccharomyces cerevisiae EC1118 Protein disulfide-isomerase
C8ZBH9 C8ZBH9_YEAS8 Saccharomyces cerevisiae EC1118 Endoplasmic reticulum chaperone BIP
F2Z6F2 F2Z6F2_KLULA Kluyveromyces lactis NRRL Y-1140 Protein disulfide-isomerase
G0VAV1 NCAS0B08940 Naumovozyma castellii Protein disulfide-isomerase
G0W5H7 NDAI0A00310 Naumovozyma dairenensis CBS 421 Protein disulfide-isomerase
G2W9Y3 K7_PDI1 Saccharomyces cerevisiae Kyokai no. 7 Protein disulfide-isomerase
G2WD20 K7_SSA4 Saccharomyces cerevisiae Kyokai no. 7 Endoplasmic reticulum chaperone BIP
G2WGY4 K7_KAR2 Saccharomyces cerevisiae Kyokai no. 7 Endoplasmic reticulum chaperone BIP
G8BQ74 TPHA0B04860 Tetrapisispora phaffii CBS 4417 Protein disulfide-isomerase
G8ZQS4 TDEL0C06720 Torulaspora delbrueckii protein disulfide-isomerase
H0GD36 H0GD36_SACCK Saccharomyces cerevisiae x Saccharomyces kudriavzevii VIN7 Protein disulfide-isomerase
H0GIK3 H0GIK3_SACCK Saccharomyces cerevisiae x Saccharomyces kudriavzevii VIN7 Endoplasmic reticulum chaperone BIP
H0GRS5 H0GRS5_SACCK Saccharomyces cerevisiae x Saccharomyces kudriavzevii VIN7 Protein disulfide-isomerase
H2ATH7 KAFR0D00300 Kazachstania africana CBS 2517 Protein disulfide-isomerase
H2AVB9 KAFR0E01650 Kazachstania africana CBS 2517 Endoplasmic reticulum chaperone BIP
H2B0M3 KAFR0J01060 Kazachstania africana CBS 2517 Endoplasmic reticulum chaperone BIP
I2GVZ5 TBLA0A05040 Henningerozyma blattae CBS 6284 Protein disulfide-isomerase
J6EHM2 YCL043C Saccharomyces kudriavzevii IFO 1802 Protein disulfide-isomerase
J7RW07 KNAG0C00380 Huiozyma naganishii CBS 8797 Protein disulfide-isomerase
J8LM34 J8LM34_SACAR Saccharomyces arboricola H-6 Endoplasmic reticulum chaperone BIP
J8LQX0 J8LQX0_SACAR Saccharomyces arboricola H-6 Protein disulfide-isomerase
K0KHM2 KAR2 Wickerhamomyces ciferrii NRRL Y-1031 Endoplasmic reticulum chaperone BIP
N1P0X7 N1P0X7_YEASC Saccharomyces cerevisiae CEN.PK113-7D Endoplasmic reticulum chaperone BIP