CYP7B
K07430 CYP7B; 25/26-hydroxycholesterol 7alpha-hydroxylase [EC:1.14.14.29]
Protein Function: 25/26-hydroxycholesterol 7alpha-hydroxylase [EC:1.14.14.29]
DBLinks
- KEGG: K07430
- EC Number: 1.14.14.29
Proteins
| protein id | name | function | taxonomy source |
|---|---|---|---|
| O75881 | CYP7B1 | Cytochrome P450 7B1 | Homo sapiens |
| Q60991 | Cyp7b1 | Cytochrome P450 7B1 | Mus musculus |
| Q05C57 | CYP7B1 | 25/26-hydroxycholesterol 7alpha-hydroxylase | Homo sapiens |
| Q3USU4 | Cyp7b1 | 25/26-hydroxycholesterol 7alpha-hydroxylase | Mus musculus |
| Q8CHV7 | Cyp7b1 | 25/26-hydroxycholesterol 7alpha-hydroxylase | Mus musculus |
| Q3TA21 | Cyp7b1 | 25/26-hydroxycholesterol 7alpha-hydroxylase | Mus musculus |
| A0A0G2K4N5 | Cyp7b1 | 25/26-hydroxycholesterol 7alpha-hydroxylase | Rattus norvegicus |
| A6IHA6 | Cyp7b1 | 25/26-hydroxycholesterol 7alpha-hydroxylase | Rattus norvegicus |
| Q63688 | Cyp7b1 | 25-hydroxycholesterol 7-alpha-hydroxylase | Rattus norvegicus |
Reactions
| reaction id | name | note |
|---|---|---|
| KEGG:R07209 | cholest-5-ene-3beta,25-diol,[NADPH---hemoprotein reductase]:oxygen oxidoreductase (7alpha-hydroxylating) | 25-Hydroxycholesterol + [Reduced NADPH---hemoprotein reductase] + Oxygen <=> Cholest-5-ene-3beta,7alpha,25-triol + [Oxidized NADPH---hemoprotein reductase] + H2O |
| KEGG:R07372 | cholest-5-ene-3beta,26-diol,[NADPH---hemoprotein reductase]:oxygen oxidoreductase (7alpha-hydroxylating) | Cholest-5-ene-3beta,26-diol + [Reduced NADPH---hemoprotein reductase] + Oxygen <=> 7alpha,27-Dihydroxycholesterol + [Oxidized NADPH---hemoprotein reductase] + H2O |
| KEGG:R08727 | 3beta-hydroxy-5-cholestenoate,NADPH:oxygen oxidoreductase (7alpha-hydroxylating) | 3beta-Hydroxy-5-cholestenoate + Oxygen + NADPH + H+ <=> 3beta,7alpha-Dihydroxy-5-cholestenoate + NADP+ + H2O |
| KEGG:R08943 | pregnenolone,NADPH:oxygen oxidoreductase (7alpha-hydroxylating) | Pregnenolone + NADPH + H+ + Oxygen <=> 7alpha-Hydroxypregnenolone + NADP+ + H2O |
| Rhea:RHEA:19042 | (25R)-cholest-5-ene-3β,26-diol + reduced [NADPH—hemoprotein reductase] + O2 => (25R)-cholest-5-en-3β,7α,26-triol + oxidized [NADPH—hemoprotein reductase] + H2O + H+ | |
| Rhea:RHEA:19043 | (25R)-cholest-5-en-3β,7α,26-triol + oxidized [NADPH—hemoprotein reductase] + H2O + H+ => (25R)-cholest-5-ene-3β,26-diol + reduced [NADPH—hemoprotein reductase] + O2 | |
| Rhea:RHEA:19044 | (25R)-cholest-5-ene-3β,26-diol + reduced [NADPH—hemoprotein reductase] + O2 <=> (25R)-cholest-5-en-3β,7α,26-triol + oxidized [NADPH—hemoprotein reductase] + H2O + H+ | |
| Rhea:RHEA:24309 | 25-hydroxycholesterol + reduced [NADPH—hemoprotein reductase] + O2 => 7α,25-dihydroxycholesterol + oxidized [NADPH—hemoprotein reductase] + H2O + H+ | |
| Rhea:RHEA:24310 | 7α,25-dihydroxycholesterol + oxidized [NADPH—hemoprotein reductase] + H2O + H+ => 25-hydroxycholesterol + reduced [NADPH—hemoprotein reductase] + O2 | |
| Rhea:RHEA:24311 | 25-hydroxycholesterol + reduced [NADPH—hemoprotein reductase] + O2 <=> 7α,25-dihydroxycholesterol + oxidized [NADPH—hemoprotein reductase] + H2O + H+ |