CYP51
K05917 CYP51; sterol 14alpha-demethylase [EC:1.14.14.154 1.14.15.36]
Protein Function: sterol 14alpha-demethylase [EC:1.14.14.154 1.14.15.36]
DBLinks
- KEGG: K05917
- EC Number: 1.14.14.154
- EC Number: 1.14.15.36
Proteins
| protein id | name | function | taxonomy source |
|---|---|---|---|
| A0A017S8M2 | A0A017S8M2_ASPRC | sterol 14alpha-demethylase | Aspergillus ruber CBS 135680 |
| A0A017SGW5 | A0A017SGW5_ASPRC | sterol 14alpha-demethylase | Aspergillus ruber CBS 135680 |
| A0A022VVX6 | A0A022VVX6_TRIRU | sterol 14alpha-demethylase | Trichophyton rubrum CBS 288.86 |
| A0A022VZZ6 | A0A022VZZ6_TRIRU | sterol 14alpha-demethylase | Trichophyton rubrum CBS 288.86 |
| A0A022XM30 | A0A022XM30_TRISD | sterol 14alpha-demethylase | Trichophyton soudanense CBS 452.61 |
| A0A022XPR2 | A0A022XPR2_TRISD | sterol 14alpha-demethylase | Trichophyton soudanense CBS 452.61 |
| A0A059IZP5 | A0A059IZP5_TRIIM | sterol 14alpha-demethylase | Trichophyton interdigitale MR816 |
| A0A059J839 | A0A059J839_TRIIM | sterol 14alpha-demethylase | Trichophyton interdigitale MR816 |
| A0A061AQZ7 | A0A061AQZ7_CYBFA | sterol 14alpha-demethylase | Cyberlindnera fabianii |
| A0A067F3T9 | A0A067F3T9_CITSI | sterol 14alpha-demethylase | Citrus sinensis |
Reactions
| reaction id | name | note |
|---|---|---|
| KEGG:R05640 | lanosterol,[reduced NADPH---hemoprotein reductase]:oxygen oxidoreductase (14-methyl cleaving) | Lanosterol + 3 [Reduced NADPH---hemoprotein reductase] + 3 Oxygen <=> 4,4-Dimethyl-5alpha-cholesta-8,14,24-trien-3beta-ol + Formate + 3 [Oxidized NADPH---hemoprotein reductase] + 4 H2O |
| KEGG:R05731 | obtusifoliol,[reduced NADPH---hemoprotein reductase]:oxygen oxidoreductase (14-methyl cleaving) | Obtusifoliol + 3 [Reduced NADPH---hemoprotein reductase] + 3 Oxygen <=> 4alpha-Methyl-5alpha-ergosta-8,14,24(28)-trien-3beta-ol + Formate + 3 [Oxidized NADPH---hemoprotein reductase] + 4 H2O |
| KEGG:R12118 | sterol,[reduced NADPH---hemoprotein reductase]:oxygen oxidoreductase (14-methyl cleaving) | three-step reaction (see R12119+R12120+R12121) |
| KEGG:R12119 | C21918 + C03024 + C00007<=>C21920 + C03161 + C00001 | the first step of three-step reaction (see R12118, R12119+R12120+R12121) |
| KEGG:R12120 | C21920 + C03024 + C00007<=>C21921 + C03161 + 2 C00001 | the second step of three-step reaction (see R12118, R12119+R12120+R12121) |
| KEGG:R12121 | C21921 + C03024 + C00007<=>C21919 + C00058 + C03161 + C00001 | the last step of three-step reaction (see R12118, R12119+R12120+R12121) |
| Rhea:RHEA:14918 | obtusifoliol + 3 reduced [NADPH—hemoprotein reductase] + 3 O2 => 4α-methyl-5α-ergosta-8,14,24(28)-trien-3β-ol + formate + 3 oxidized [NADPH—hemoprotein reductase] + 4 H2O + 4 H+ | |
| Rhea:RHEA:14919 | 4α-methyl-5α-ergosta-8,14,24(28)-trien-3β-ol + formate + 3 oxidized [NADPH—hemoprotein reductase] + 4 H2O + 4 H+ => obtusifoliol + 3 reduced [NADPH—hemoprotein reductase] + 3 O2 | |
| Rhea:RHEA:14920 | obtusifoliol + 3 reduced [NADPH—hemoprotein reductase] + 3 O2 <=> 4α-methyl-5α-ergosta-8,14,24(28)-trien-3β-ol + formate + 3 oxidized [NADPH—hemoprotein reductase] + 4 H2O + 4 H+ | |
| Rhea:RHEA:25287 | lanosterol + 3 reduced [NADPH—hemoprotein reductase] + 3 O2 => 4,4-dimethyl-5α-cholesta-8,14,24-trien-3β-ol + formate + 3 oxidized [NADPH—hemoprotein reductase] + 4 H2O + 4 H+ | Multi-step reaction: RHEA:75103 + RHEA:75107 + RHEA:75111 |