CYP11B1
K00497 CYP11B1; steroid 11beta-monooxygenase [EC:1.14.15.4]
Protein Function: steroid 11beta-monooxygenase [EC:1.14.15.4]
DBLinks
Proteins
| protein id | name | function | taxonomy source |
|---|---|---|---|
| P15539 | Cyp11b2 | Cytochrome P450 11B2, mitochondrial | Mus musculus |
| P30099 | Cyp11b2 | Cytochrome P450 11B2, mitochondrial | Rattus norvegicus |
| P19099 | CYP11B2 | Cytochrome P450 11B2, mitochondrial | Homo sapiens |
| D3ZCW0 | Cyp11b2l1 | steroid 11beta-monooxygenase | Rattus norvegicus |
| Q64539 | Cyp11b3 | steroid 11beta-monooxygenase | Rattus norvegicus |
| Q64546 | Cyp11b3 | steroid 11beta-monooxygenase | Rattus norvegicus |
| Q64586 | Cyp11b3 | steroid 11beta-monooxygenase | Rattus norvegicus |
| P30100 | Cyp11b3 | Cytochrome P450 11B3, mitochondrial | Rattus norvegicus |
| Q8TDD0 | Q8TDD0_HUMAN | Mutated cytochrome P-450c11 protein | Homo sapiens |
Reactions
| reaction id | name | note |
|---|---|---|
| KEGG:R02218 | progesterone,reduced ferredoxin:oxygen oxidoreductase (11-hydroxylating) | Progesterone + 2 Reduced ferredoxin + Oxygen + 2 H+ <=> 11beta-Hydroxyprogesterone + 2 Oxidized ferredoxin + H2O |
| KEGG:R02725 | androstenedione,reduced-adrenal-ferredoxin:oxygen oxidoreductase (11-hydroxylating) | 2 Reduced adrenal ferredoxin + Androstenedione + Oxygen + 2 H+ <=> 11beta-Hydroxyandrost-4-ene-3,17-dione + 2 Oxidized adrenal ferredoxin + H2O |
| KEGG:R02726 | steroid,reduced-adrenal-ferredoxin:oxygen oxidoreductase (11-hydroxylating) | general reaction (see R02218, R02725, R02843, R03329, R03851 and R04850) |
| KEGG:R02843 | steroid,reduced ferredoxin:oxygen oxidoreductase (11-hydroxylating) | 11-Deoxycortisol + 2 Reduced ferredoxin + Oxygen + 2 H+ <=> Cortisol + 2 Oxidized ferredoxin + H2O |
| KEGG:R03262 | corticosterone,reduced-adrenal-ferredoxin:oxygen oxidoreductase (18-hydroxylating) | Corticosterone + 2 Reduced adrenal ferredoxin + Oxygen + 2 H+ <=> 18-Hydroxycorticosterone + 2 Oxidized adrenal ferredoxin + H2O |
| KEGG:R03263 | C01124 + C00662 + C00007<=>C01780 + C00667 + 2 C00001 | 18-Hydroxycorticosterone + Reduced adrenal ferredoxin + Oxygen <=> Aldosterone + Oxidized adrenal ferredoxin + 2 H2O |
| KEGG:R03329 | steroid,reduced-adrenal-ferredoxin:oxygen oxidoreductase (11-hydroxylating) | Oxidized ferredoxin is reduced by NADPH (see R01195) |
| KEGG:R03851 | 11-deoxycorticosterone,reduced ferredoxin:oxygen oxidoreductase (11-hydroxylating) | 11-Deoxycorticosterone + 2 Reduced ferredoxin + Oxygen + 2 H+ <=> Corticosterone + 2 Oxidized ferredoxin + H2O |
| KEGG:R04850 | 17alpha,21-dihydroxypregnenolone:oxygen oxidoreductase (11-hydroxylating) | Oxidized ferredoxin is reduced by NADPH (see R01195) |
| KEGG:R08949 | 11-deoxycorticosterone,reduced-adrenal-ferredoxin:oxygen oxidoreductase (11beta,18-hydroxylating) | three-step reaction (see R03851+R03262+R03263) |