Pathways Knowlegdes
Biological pathway database
| Pathway | DOIs | Note |
|---|---|---|
| glycogen degradation I Accession ID: BioCyc:PCHR_GLYCOCAT-PWY |
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| pantothenate biosynthesis I Accession ID: BioCyc:PCHR_PANTO-PWY |
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| gluconeogenesis I Accession ID: BioCyc:PCHR_GLUCONEO-PWY |
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| purine nucleotides degradation IV (anaerobic) Accession ID: BioCyc:PCHR_PWY-5497 |
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| glycerol degradation IV Accession ID: BioCyc:PCHR_PWY-4261 |
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| superpathway of D-myo-inositol (1,4,5)-trisphosphate metabolism Accession ID: BioCyc:PCHR_PWY-6358 |
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| GDP-glucose biosynthesis Accession ID: BioCyc:PCHR_PWY-5661 |
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| histidine biosynthesis Accession ID: BioCyc:CALBI_HISTSYN-PWY |
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Pla J, Pérez-Díaz RM, Navarro-García F, Sánchez M, Nombela C. Cloning of the Candida albicans HIS1 gene by direct complementation of a C. albicans histidine auxotroph using an improved double-ARS shuttle vector. Gene. 1995 Nov 07;165(1):115–20. doi: 10.1016/0378-1119(95)00492-o. PMID: 7489899. |
| superpathway of phenylalanine, tyrosine and tryptophan biosynthesis Accession ID: BioCyc:CALBI_COMPLETE-ARO-PWY |
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| selenocysteine biosynthesis Accession ID: BioCyc:CALBI_PWY0-901 |
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Falcone G, Giambanco V. Synthesis of seleno-amino-acids in cell free extracts of Candida albicans. Nature. 1967 Jan 28;213(5074):396–8. doi: 10.1038/213396a0. PMID: 6029526.; HEDEGAARD J, FALCONE G, CALABRO S. [Incorporation of selenium into analogs of sulfurated amino acids in Candida albicans]. C R Seances Soc Biol Fil. 1963 Jun 10;157():280–4. PMID: 13963671.; FALCONE G, NICKERSON WJ, TABER WA. Physiological bases of morphogenesis in fungi. V. Effect of selenite and tellurite on cellular division of yeastlike fungi. Can J Microbiol. 1956 Oct;2(6):575–84. doi: 10.1139/m56-070. PMID: 13374604. |
| superpathway of histidine, purine and pyrimidine biosynthesis Accession ID: BioCyc:CALBI_PRPP-PWY |
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| trehalose degradation V Accession ID: BioCyc:CALBI_PWY-2723 |
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| tetrahydrofolate biosynthesis Accession ID: BioCyc:CALBI_PWY-3742 |
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Cossins EA, Chen L. Folates and one-carbon metabolism in plants and fungi. Phytochemistry. 1997 Jun;45(3):437–52. doi: 10.1016/s0031-9422(96)00833-3. PMID: 9190084.; Daly S, Mastromei G, Yacoub A, Lorenzetti R. Sequence of a dihydrofolate reductase-encoding gene from Candida albicans. Gene. 1994 Sep 15;147(1):115–8. doi: 10.1016/0378-1119(94)90049-3. PMID: 7916311. |
| TCA cycle, aerobic respiration Accession ID: BioCyc:CALBI_PWY3B3-100 |
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Yasutake Y, Watanabe S, Yao M, Takada Y, Fukunaga N, Tanaka I. Crystal Structure of the Monomeric Isocitrate Dehydrogenase in the Presence of NADP+. Journal of Biological Chemistry. 2003 Sep;278(38):36897–904. doi: 10.1074/jbc.m304091200.; Oyedotun KS, Lemire BD. The Carboxyl Terminus of the Saccharomyces cerevisiaeSuccinate Dehydrogenase Membrane Subunit, SDH4p, Is Necessary for Ubiquinone Reduction and Enzyme Stability. Journal of Biological Chemistry. 1997 Dec;272(50):31382–8. doi: 10.1074/jbc.272.50.31382.; Haselbeck RJ, McAlister-Henn L. Function and expression of yeast mitochondrial NAD- and NADP-specific isocitrate dehydrogenases. Journal of Biological Chemistry. 1993 Jun;268(16):12116–22. doi: 10.1016/s0021-9258(19)50315-5.; RAO GR, SIRSI M, RAMAKRISHNAN T. Enzymes in Candida albicans. II. Tricarboxylic acid cycle and related enzymes. J Bacteriol. 1962 Oct;84():778–83. PMID: 13973046; PMCID: PMC277958. |
| salvage pathways of pyrimidine deoxyribonucleotides Accession ID: BioCyc:CALBI_YEAST-SALV-PYRMID-DNTP |
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Kurtz JE, Exinger F, Erbs P, Jund R. The URH1 uridine ribohydrolase of Saccharomyces cerevisiae. Curr Genet. 2002 Jun;41(3):132–41. doi: 10.1007/s00294-002-0296-9. PMID: 12111094.; Kurtz JE, Exinger F, Erbs P, Jund R. New insights into the pyrimidine salvage pathway of Saccharomyces cerevisiae: requirement of six genes for cytidine metabolism. Curr Genet. 1999 Sep;36(3):130–6. doi: 10.1007/s002940050482. PMID: 10501935. |
| glutamine biosynthesis Accession ID: BioCyc:CALBI_GLNSYN-PWY |
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Holmes AR, McNaughton GS, More RD, Shepherd MG. Ammonium assimilation by Candida albicans and other yeasts: a 13N isotope study. Can. J. Microbiol. 1991 Mar 01;37(3):226–32. doi: 10.1139/m91-034.; Holmes AR, Collings A, Farnden KJ, Shepherd MG. Ammonium assimilation by Candida albicans and other yeasts: evidence for activity of glutamate synthase. J Gen Microbiol. 1989 Jun;135(6):1423–30. doi: 10.1099/00221287-135-6-1423. PMID: 2575653.; Benjamin PM, Wu J, Mitchell AP, Magasanik B. Three regulatory systems control expression of glutamine synthetase inSaccharomyces cerevisiae at the level of transcription. Molecular Genetics and Genomics. 1989 Jun;217(2-3):370–7. doi: 10.1007/bf02464906. |
| oxidative ethanol degradation Accession ID: BioCyc:CALBI_PWY66-21 |
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Kusch H, Engelmann S, Bode R, Albrecht D, Morschhäuser J, Hecker M. A proteomic view of Candida albicans yeast cell metabolism in exponential and stationary growth phases. International Journal of Medical Microbiology. 2008 Apr;298(3-4):291–318. doi: 10.1016/j.ijmm.2007.03.020. |
| homoserine biosynthesis Accession ID: BioCyc:CALBI_HOMOSERSYN-PWY |
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Schlösser T, Gätgens C, Weber U, Stahmann KP. Alanine : glyoxylate aminotransferase of Saccharomyces cerevisiae-encoding gene AGX1 and metabolic significance. Yeast. 2004 Jan 15;21(1):63–73. doi: 10.1002/yea.1058. PMID: 14745783.; Mountain HA, Byström AS, Larsen JT, Korch C. Four major transcriptional responses in the methionine/threonine biosynthetic pathway of Saccharomyces cerevisiae. Yeast. 1991 Nov;7(8):781–803. doi: 10.1002/yea.320070804. PMID: 1789001.; Yamagata S. O-Acetylhomoserine sulfhydrylase of the fission yeast Schizosaccharomyces pombe: partial purification, characterization, and its probable role in homocysteine biosynthesis. J Biochem. 1984 Nov;96(5):1511–23. doi: 10.1093/oxfordjournals.jbchem.a134980. PMID: 6526818. |
| threonine biosynthesis Accession ID: BioCyc:CALBI_HOMOSER-THRESYN-PWY |
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Kingsbury JM, Goldstein AL, McCusker JH. Role of Nitrogen and Carbon Transport, Regulation, and Metabolism Genes for Saccharomyces cerevisiae Survival In Vivo. Eukaryot Cell. 2006 May;5(5):816–24. doi: 10.1128/ec.5.5.816-824.2006.; Mountain HA, Byström AS, Larsen JT, Korch C. Four major transcriptional responses in the methionine/threonine biosynthetic pathway of Saccharomyces cerevisiae. Yeast. 1991 Nov;7(8):781–803. doi: 10.1002/yea.320070804. PMID: 1789001. |
| S-adenosylmethionine cycle Accession ID: BioCyc:CALBI_PWY-5041 |
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Nobile CJ, Mitchell AP. Genetics and genomics of Candida albicans biofilm formation. Cell Microbiol. 2006 Sep;8(9):1382–91. doi: 10.1111/j.1462-5822.2006.00761.x. PMID: 16848788.; Suliman HS, Sawyer GM, Appling DR, Robertus JD. Purification and properties of cobalamin-independent methionine synthase from Candida albicans and Saccharomyces cerevisiae. Archives of Biochemistry and Biophysics. 2005 Sep;441(1):56–63. doi: 10.1016/j.abb.2005.06.016.; Eschrich D, Buchhaupt M, Kötter P, Entian KD. Nep1p (Emg1p), a novel protein conserved in eukaryotes and archaea, is involved in ribosome biogenesis. Curr Genet. 2002 Feb;40(5):326–38. doi: 10.1007/s00294-001-0269-4. PMID: 11935223.; Thomas D, Surdin-Kerjan Y. Metabolism of sulfur amino acids in Saccharomyces cerevisiae. Microbiol Mol Biol Rev. 1997 Dec;61(4):503–32. doi: 10.1128/mmbr.61.4.503-532.1997.; Mountain HA, Byström AS, Larsen JT, Korch C. Four major transcriptional responses in the methionine/threonine biosynthetic pathway of Saccharomyces cerevisiae. Yeast. 1991 Nov;7(8):781–803. doi: 10.1002/yea.320070804. PMID: 1789001.; Shapiro SK, Schlenk F. Conversion of 5'-Methylthioadenosine into S-adenosylmethionine by yeast cells. Biochimica et Biophysica Acta (BBA) - General Subjects. 1980 Dec 01;633(2):176–80. doi: 10.1016/0304-4165(80)90403-1.; Schlenk F, Hannum CH, Ferro AJ. Biosynthesis of adenosyl-d-methionine and adenosyl-2-methylmethionine by Candida utilis. Archives of Biochemistry and Biophysics. 1978 Apr;187(1):191–6. doi: 10.1016/0003-9861(78)90022-x.; Holcomb ER, Shapiro SK. Assay and regulation of S-adenosylmethionine synthetase in Saccharomyces cerevisiae and Candida utilis. J Bacteriol. 1975 Jan;121(1):267–71. doi: 10.1128/jb.121.1.267-271.1975.; Nakamura KD, Schlenk F. Examination of Isolated Yeast Cell Vacuoles for Active Transport. J Bacteriol. 1974 Apr;118(1):314–6. doi: 10.1128/jb.118.1.314-316.1974.; Balish E. S-adenosylmethionine metabolism by members of the genus Candida. Can J Microbiol. 1973 Oct;19(10):1297–303. doi: 10.1139/m73-208. PMID: 4587092.; Schlenk F, Zydek-Cwick CR, Dainko JL. 5'-methylthioadenosine and related compounds as precursors of S-adenosylmethionine in yeast. Biochimica et Biophysica Acta (BBA) - General Subjects. 1973 Sep;320(2):357–62. doi: 10.1016/0304-4165(73)90316-4.; Balish E. Methionine biosynthesis and S-adenosylmethionine degradation during an induced morphogenesis of Candida albicans. Can J Microbiol. 1973 Jul;19(7):847–53. doi: 10.1139/m73-135. PMID: 4580452.; Mardon DN. In vivo synthesis of sulfur containing amino acids in Candida albicans. Can J Microbiol. 1973 Feb;19(2):155–61. doi: 10.1139/m73-024. PMID: 4572423.; Salem AR, Foster MA. The microbial biosynthesis of methionine. Biochem J. 1972 May;127(5):845–53. PMID: 4627687; PMCID: PMC1178794.; Mardon DN, Balish E. Methionine biosynthesis in Candida albicans. I. S-Adenosyl- |