Pathways Knowlegdes

Biological pathway database

Pathway DOIs Note
superpathway of central carbon metabolism

Accession ID: BioCyc:LEISH_PWY3IU-99
  • 10.1073/pnas.0603539103
 Sernee MF, Ralton JE, Dinev Z, Khairallah GN, O’Hair RA, Williams SJ, McConville MJ. Leishmania ß-1,2-mannan is assembled on a mannose-cyclic phosphate primer. Proc. Natl. Acad. Sci. U.S.A. 2006 Jun 20;103(25):9458–63. doi: 10.1073/pnas.0603539103.
TCA cycle

Accession ID: BioCyc:LEISH_TCA
  • 10.1016/j.molbiopara.2006.04.010
  • 10.2307/3285729
 Leroux A, Fleming-Canepa X, Aranda A, Maugeri D, Cazzulo JJ, Sánchez MA, Nowicki C. Functional characterization and subcellular localization of the three malate dehydrogenase isozymes in Leishmania spp. Molecular and Biochemical Parasitology. 2006 Sep;149(1):74–85. doi: 10.1016/j.molbiopara.2006.04.010.; Louassini M, Foulquie M, Benitez R, Adroher J. Citric-Acid Cycle Key Enzyme Activities during In vitro Growth and Metacyclogenesis of Leishmania infantum Promastigotes. The Journal of Parasitology. 1999 Aug;85(4):595. doi: 10.2307/3285729.
glycolysis I

Accession ID: BioCyc:LEISH_GLYCOLYSIS
  • 10.1016/j.bbamcr.2006.08.019
 Michels PAM, Bringaud F, Herman M, Hannaert V. Metabolic functions of glycosomes in trypanosomatids. Biochimica et Biophysica Acta (BBA) - Molecular Cell Research. 2006 Dec;1763(12):1463–77. doi: 10.1016/j.bbamcr.2006.08.019.
UDP-galactose biosynthesis

Accession ID: BioCyc:LEISH_PWY3IU-258
  • 10.1128/ec.00175-07
 Turnock DC, Ferguson MAJ. Sugar Nucleotide Pools of Trypanosoma brucei , Trypanosoma cruzi , and Leishmania major. Eukaryot Cell. 2007 Aug;6(8):1450–63. doi: 10.1128/ec.00175-07.
gluconeogenesis I

Accession ID: BioCyc:LEISH_GLUCONEO-PWY
  • 10.1073/pnas.0509196103
  • 10.1074/jbc.m603265200
 Rodríguez-Contreras D, Landfear SM. Metabolic Changes in Glucose Transporter-deficient Leishmania mexicana and Parasite Virulence. Journal of Biological Chemistry. 2006 Jul;281(29):20068–76. doi: 10.1074/jbc.m603265200.; Naderer T, Ellis MA, Sernee MF, De Souza DP, Curtis J, Handman E, McConville MJ. Virulence of Leishmania major in macrophages and mice requires the gluconeogenic enzyme fructose-1,6-bisphosphatase. Proc. Natl. Acad. Sci. U.S.A. 2006 Apr 04;103(14):5502–7. doi: 10.1073/pnas.0509196103.
S-adenosyl-L-methionine biosynthesis

Accession ID: BioCyc:LEISH_PWY3IU-113		 -
folate metabolism

Accession ID: BioCyc:LEISH_PWY3IU-235
  • 10.1016/j.pt.2007.02.004
  • 10.1016/s0020-7519(01)00346-0
  • 10.1111/j.1365-2958.2009.06610.x
 Murta SMF, Vickers TJ, Scott DA, Beverley SM. Methylene tetrahydrofolate dehydrogenase/cyclohydrolase and the synthesis of 10-CHO-THF are essential inLeishmania major. Molecular Microbiology. 2009 Mar;71(6):1386–401. doi: 10.1111/j.1365-2958.2009.06610.x.; Opperdoes FR, Coombs GH. Metabolism of Leishmania: proven and predicted. Trends Parasitol. 2007 Apr;23(4):149–58. doi: 10.1016/j.pt.2007.02.004. PMID: 17320480.; Ouellette M, Drummelsmith J, El Fadili A, Kündig C, Richard D, Roy G. Pterin transport and metabolism in Leishmania and related trypanosomatid parasites. International Journal for Parasitology. 2002 Apr;32(4):385–98. doi: 10.1016/s0020-7519(01)00346-0.
pyridine nucleotide cycling (plants)

Accession ID: BioCyc:LEISH_PWY-5381		 -
pyrimidine deoxyribonucleotides de novo biosynthesis I

Accession ID: BioCyc:LEISH_PWY0-166		 -
salvage pathways of pyrimidine ribonucleotides

Accession ID: BioCyc:LEISH_PWY0-163		 -
purine nucleotide metabolism (phosphotransfer and nucleotide modification)

Accession ID: BioCyc:LEISH_PWY3IU-445		 -
selenocysteine biosynthesis I (bacteria)

Accession ID: BioCyc:LEISH_PWY0-901		 -
methionine biosynthesis

Accession ID: BioCyc:LEISH_PWY3IU-196
  • 10.1016/j.pt.2007.02.004
 Opperdoes FR, Coombs GH. Metabolism of Leishmania: proven and predicted. Trends Parasitol. 2007 Apr;23(4):149–58. doi: 10.1016/j.pt.2007.02.004. PMID: 17320480.
trypanothione biosynthesis

Accession ID: BioCyc:LEISH_TRYPANOSYN-PWY
  • 10.1016/j.molbiopara.2004.10.004
 Oza SL, Shaw MP, Wyllie S, Fairlamb AH. Trypanothione biosynthesis in Leishmania major. Molecular and Biochemical Parasitology. 2005 Jan;139(1):107–16. doi: 10.1016/j.molbiopara.2004.10.004.
sphingolipid metabolism

Accession ID: BioCyc:LEISH_SPHINGOLIPID-SYN-PWY
  • 10.1038/sj.emboj.7601565
  • 10.1111/j.1365-2958.2004.04208.x
 Zhang K, Pompey JM, Hsu FF, Key P, Bandhuvula P, Saba JD, Turk J, Beverley SM. Redirection of sphingolipid metabolism toward de novo synthesis of ethanolamine in Leishmania. EMBO J. 2007 Feb 21;26(4):1094–104. PMID: 17290222; PMCID: PMC1852826.; Denny PW, Smith DF. Rafts and sphingolipid biosynthesis in the kinetoplastid parasitic protozoa. Mol Microbiol. 2004 Aug;53(3):725–33. doi: 10.1111/j.1365-2958.2004.04208.x. PMID: 15255887.
galactitol degradation

Accession ID: BioCyc:LEISH_GALACTITOLCAT-PWY		 -
methylmalonyl pathway

Accession ID: BioCyc:LEISH_PROPIONMET-PWY		 -
ribose degradation

Accession ID: BioCyc:LEISH_RIBOKIN-PWY
  • 10.1016/s0166-6851(03)00173-7
 Maugeri DA, Cazzulo JJ, Burchmore RJS, Barrett MP, Ogbunude POJ. Pentose phosphate metabolism in Leishmania mexicana. Molecular and Biochemical Parasitology. 2003 Aug;130(2):117–25. doi: 10.1016/s0166-6851(03)00173-7.
lactose and galactose degradation I

Accession ID: BioCyc:LEISH_LACTOSECAT-PWY		 -
glycerol metabolism

Accession ID: BioCyc:LEISH_PWY3IU-106
  • 10.1016/j.molbiopara.2006.05.006
 Guerra DG, Decottignies A, Bakker BM, Michels PAM. The mitochondrial FAD-dependent glycerol-3-phosphate dehydrogenase of Trypanosomatidae and the glycosomal redox balance of insect stages of Trypanosoma brucei and Leishmania spp. Molecular and Biochemical Parasitology. 2006 Oct;149(2):155–69. doi: 10.1016/j.molbiopara.2006.05.006.