Pathways Knowlegdes

Biological pathway database

Pathway DOIs Note
Signaling by Nuclear Receptors

Accession ID: Reactome:R-SSC-9006931
  • 10.1016/0039-128x(96)00030-x
  • 10.1016/bs.ctdb.2017.02.003
  • 10.1016/j.bbamcr.2009.11.012
  • 10.1016/j.bbamcr.2016.06.004
  • 10.1016/j.mce.2013.06.021
  • 10.1038/nrm.2016.122
  • 10.1210/me.2013-1334
 Holzer G, Markov GV, Laudet V. Evolution of Nuclear Receptors and Ligand Signaling: Toward a Soft Key-Lock Model? Curr Top Dev Biol. 2017;125():1–38. doi: 10.1016/bs.ctdb.2017.02.003. PMID: 28527568.; Levin ER, Hammes SR. Nuclear receptors outside the nucleus: extranuclear signalling by steroid receptors. Nature Reviews Molecular Cell Biology. 2016 Oct 12;17(12):783–97. doi: 10.1038/nrm.2016.122.; Schwartz N, Verma A, Bivens CB, Schwartz Z, Boyan BD. Rapid steroid hormone actions via membrane receptors. Biochimica et Biophysica Acta (BBA) - Molecular Cell Research. 2016 Sep;1863(9):2289–98. doi: 10.1016/j.bbamcr.2016.06.004.; Simons SS, Edwards DP, Kumar R. Minireview: dynamic structures of nuclear hormone receptors: new promises and challenges. Mol Endocrinol. 2014 Feb;28(2):173–82. PMID: 24284822; PMCID: PMC3896641.; Hah N, Kraus WL. Hormone-regulated transcriptomes: Lessons learned from estrogen signaling pathways in breast cancer cells. Molecular and Cellular Endocrinology. 2014 Jan;382(1):652–64. doi: 10.1016/j.mce.2013.06.021.; Echeverria PC, Picard D. Molecular chaperones, essential partners of steroid hormone receptors for activity and mobility. Biochimica et Biophysica Acta (BBA) - Molecular Cell Research. 2010 Jun;1803(6):641–9. doi: 10.1016/j.bbamcr.2009.11.012.; Beato M, Chávez S, Truss M. Transcriptional regulation by steroid hormones. Steroids. 1996 Apr;61(4):240–51. doi: 10.1016/0039-128x(96)00030-x. PMID: 8733009.
Signaling Pathways

Accession ID: Reactome:R-XTR-162582
  • 10.1016/j.bbcan.2006.09.001
  • 10.1016/j.cell.2007.06.009
  • 10.1016/j.cell.2009.03.045
  • 10.1016/j.cytogfr.2004.04.003
  • 10.1016/j.cytogfr.2005.01.001
  • 10.1016/j.devcel.2009.06.016
  • 10.1016/j.tcb.2009.05.008
  • 10.1016/j.tibs.2005.10.005
  • 10.1038/414799a
  • 10.1038/nature08144
  • 10.1038/nrm1498
  • 10.1038/nrm2299
  • 10.1038/nrm2717
  • 10.1038/nrm2803
  • 10.1038/nrm3048
  • 10.1038/sj.onc.1210394
  • 10.1093/jb/mvp148
  • 10.1098/rstb.2006.1894
  • 10.1101/gad.1653708
  • 10.3109/09687688.2011.603101
 Avraham R, Yarden Y. Feedback regulation of EGFR signalling: decision making by early and delayed loops. Nature Reviews Molecular Cell Biology. 2011 Jan 21;12(2):104–17. doi: 10.1038/nrm3048.; Citi S, Spadaro D, Schneider Y, Stutz J, Pulimeno P. Regulation of small GTPases at epithelial cell-cell junctions. Mol Membr Biol. 2011 Oct;28(7-8):427–44. doi: 10.3109/09687688.2011.603101. PMID: 21781017.; Ritter SL, Hall RA. Fine-tuning of GPCR activity by receptor-interacting proteins. Nature Reviews Molecular Cell Biology. 2009 Dec;10(12):819–30. doi: 10.1038/nrm2803.; Miyazono K, Kamiya Y, Morikawa M. Bone morphogenetic protein receptors and signal transduction. Journal of Biochemistry. 2009 Sep 17;147(1):35–51. doi: 10.1093/jb/mvp148.; Kang JS, Liu C, Derynck R. New regulatory mechanisms of TGF-beta receptor function. Trends Cell Biol. 2009 Aug;19(8):385–94. doi: 10.1016/j.tcb.2009.05.008. PMID: 19648010.; MacDonald BT, Tamai K, He X. Wnt/ß-Catenin Signaling: Components, Mechanisms, and Diseases. Developmental Cell. 2009 Jul;17(1):9–26. doi: 10.1016/j.devcel.2009.06.016.; Angers S, Moon RT. Proximal events in Wnt signal transduction. Nature Reviews Molecular Cell Biology. 2009 Jun 17;10(7):468–77. doi: 10.1038/nrm2717.; Rosenbaum DM, Rasmussen SG, Kobilka BK. The structure and function of G-protein-coupled receptors. Nature. 2009 May 21;459(7245):356–63. PMID: 19458711; PMCID: PMC3967846.; Kopan R, Ilagan MX. The canonical Notch signaling pathway: unfolding the activation mechanism. Cell. 2009 Apr 17;137(2):216–33. PMID: 19379690; PMCID: PMC2827930.; Andrae J, Gallini R, Betsholtz C. Role of platelet-derived growth factors in physiology and medicine. Genes Dev. 2008 May 15;22(10):1276–312. PMID: 18483217; PMCID: PMC2732412.; Oldham WM, Hamm HE. Heterotrimeric G protein activation by G-protein-coupled receptors. Nature Reviews Molecular Cell Biology. 2008 Jan;9(1):60–71. doi: 10.1038/nrm2299.; Manning BD, Cantley LC. AKT/PKB signaling: navigating downstream. Cell. 2007 Jun 29;129(7):1261–74. PMID: 17604717; PMCID: PMC2756685.; McKay MM, Morrison DK. Integrating signals from RTKs to ERK/MAPK. Oncogene. 2007 May 14;26(22):3113–21. doi: 10.1038/sj.onc.1210394. PMID: 17496910.; Hehlgans S, Haase M, Cordes N. Signalling via integrins: Implications for cell survival and anticancer strategies. Biochimica et Biophysica Acta (BBA) - Reviews on Cancer. 2007 Jan;1775(1):163–80. doi: 10.1016/j.bbcan.2006.09.001.; Reichardt LF. Neurotrophin-regulated signalling pathways. Philos Trans R Soc Lond B Biol Sci. 2006 Sep 29;361(1473):1545–64. PMID: 16939974; PMCID: PMC1664664.; Patterson RL, van Rossum DB, Nikolaidis N, Gill DL, Snyder SH. Phospholipase C-gamma: diverse roles in receptor-mediated calcium signaling. Trends Biochem Sci. 2005 Dec;30(12):688–97. doi: 10.1016/j.tibs.2005.10.005. PMID: 16260143.; Eswarakumar VP, Lax I, Schlessinger J. Cellular signaling by fibroblast growth factor receptors. Cytokine Growth Factor Rev. 2005 Apr;16(2):139–49. doi: 10.1016/j.cytogfr.2005.01.001. PMID: 15863030.; Wellbrock C, Karasarides M, Marais R. The RAF proteins take centre stage. Nature Reviews Molecular Cell Biology. 2004 Nov;5(11):875–85. doi: 10.1038/nrm1498.; Xie K, Wei D, Shi Q, Huang S. Constitutive and inducible expression and regulation of vascular endothelial growth factor. Cytokine Growth Factor Rev. 2004 Oct;15(5):297–324. doi: 10.1016/j.cytogfr.2004.04.003. PMID: 15450248.; Saltiel AR, Kahn CR. Insulin signalling and the regulation of glucose and lipid metabolism. Nature. 2001 Dec 13;414(6865):799–806. doi: 10.1038/414799a. PMID: 11742412.
Retinol metabolism

Accession ID: WikiPathways:WP5188
  • 10.1016/0005-2760(84)90008-0
 Blaner WS, Prystowsky JH, Smith JE, Goodman DS. Rat liver retinyl palmitate hydrolase activity. Relationship to cholesteryl oleate and triolein hydrolase activities. Biochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism. 1984 Jul;794(3):419–27. doi: 10.1016/0005-2760(84)90008-0.
Vitamin A and carotenoid metabolism

Accession ID: WikiPathways:WP1038
  • 10.1111/j.1749-6632.1992.tb17085.x
 Sies H, Stahl W, Sundquist AR. Antioxidant functions of vitamins. Vitamins E and C, beta-carotene, and other carotenoids. Ann N Y Acad Sci. 1992 Sep 30;669():7–20. doi: 10.1111/j.1749-6632.1992.tb17085.x. PMID: 1444060.
Vitamin A and carotenoid metabolism

Accession ID: WikiPathways:WP716
  • 10.1089/omi.2009.0029
 Waagmeester A, Pezik P, Coort S, Tourniaire F, Evelo C, Rebholz-Schuhmann D. Pathway Enrichment Based on Text Mining and Its Validation on Carotenoid and Vitamin A Metabolism. OMICS: A Journal of Integrative Biology. 2009 Oct;13(5):367–79. doi: 10.1089/omi.2009.0029.
Vitamin A and carotenoid metabolism

Accession ID: WikiPathways:WP3843
  • 10.1093/ajcn/55.6.1120
 Micozzi M, Brown E, Edwards B, Bieri J, Taylor P, Khachik F, Beecher G, Smith J. Plasma carotenoid response to chronic intake of selected foods and ß-carotene supplements in men. The American Journal of Clinical Nutrition. 1992 Jun;55(6):1120–5. doi: 10.1093/ajcn/55.6.1120.
Vitamin A Deficiency

Accession ID: PathBank:SMP0120500		 -
Retinol Metabolism

Accession ID: PathBank:SMP0087510		 -
Retinol Metabolism

Accession ID: PathBank:SMP0087353		 -
Vitamin A Deficiency

Accession ID: PathBank:SMP0120720		 -
Retinol Metabolism

Accession ID: PathBank:SMP0000074		 -
Vitamin A Deficiency

Accession ID: PathBank:SMP0000336		 -
Retinol Metabolism

Accession ID: PathBank:SMP0087260		 -
Retinol Metabolism

Accession ID: PathBank:SMP0087412		 -
Retinol Metabolism

Accession ID: PathBank:SMP0063662		 -