Pathways Knowlegdes
Biological pathway database
| Pathway | DOIs | Note |
|---|---|---|
| Signaling Pathways Accession ID: Reactome:R-BTA-162582 |
|
Avraham R, Yarden Y. Feedback regulation of EGFR signalling: decision making by early and delayed loops. Nature Reviews Molecular Cell Biology. 2011 Jan 21;12(2):104–17. doi: 10.1038/nrm3048.; Citi S, Spadaro D, Schneider Y, Stutz J, Pulimeno P. Regulation of small GTPases at epithelial cell-cell junctions. Mol Membr Biol. 2011 Oct;28(7-8):427–44. doi: 10.3109/09687688.2011.603101. PMID: 21781017.; Ritter SL, Hall RA. Fine-tuning of GPCR activity by receptor-interacting proteins. Nature Reviews Molecular Cell Biology. 2009 Dec;10(12):819–30. doi: 10.1038/nrm2803.; Miyazono K, Kamiya Y, Morikawa M. Bone morphogenetic protein receptors and signal transduction. Journal of Biochemistry. 2009 Sep 17;147(1):35–51. doi: 10.1093/jb/mvp148.; Kang JS, Liu C, Derynck R. New regulatory mechanisms of TGF-beta receptor function. Trends Cell Biol. 2009 Aug;19(8):385–94. doi: 10.1016/j.tcb.2009.05.008. PMID: 19648010.; MacDonald BT, Tamai K, He X. Wnt/ß-Catenin Signaling: Components, Mechanisms, and Diseases. Developmental Cell. 2009 Jul;17(1):9–26. doi: 10.1016/j.devcel.2009.06.016.; Angers S, Moon RT. Proximal events in Wnt signal transduction. Nature Reviews Molecular Cell Biology. 2009 Jun 17;10(7):468–77. doi: 10.1038/nrm2717.; Rosenbaum DM, Rasmussen SG, Kobilka BK. The structure and function of G-protein-coupled receptors. Nature. 2009 May 21;459(7245):356–63. PMID: 19458711; PMCID: PMC3967846.; Kopan R, Ilagan MX. The canonical Notch signaling pathway: unfolding the activation mechanism. Cell. 2009 Apr 17;137(2):216–33. PMID: 19379690; PMCID: PMC2827930.; Andrae J, Gallini R, Betsholtz C. Role of platelet-derived growth factors in physiology and medicine. Genes Dev. 2008 May 15;22(10):1276–312. PMID: 18483217; PMCID: PMC2732412.; Oldham WM, Hamm HE. Heterotrimeric G protein activation by G-protein-coupled receptors. Nature Reviews Molecular Cell Biology. 2008 Jan;9(1):60–71. doi: 10.1038/nrm2299.; Manning BD, Cantley LC. AKT/PKB signaling: navigating downstream. Cell. 2007 Jun 29;129(7):1261–74. PMID: 17604717; PMCID: PMC2756685.; McKay MM, Morrison DK. Integrating signals from RTKs to ERK/MAPK. Oncogene. 2007 May 14;26(22):3113–21. doi: 10.1038/sj.onc.1210394. PMID: 17496910.; Hehlgans S, Haase M, Cordes N. Signalling via integrins: Implications for cell survival and anticancer strategies. Biochimica et Biophysica Acta (BBA) - Reviews on Cancer. 2007 Jan;1775(1):163–80. doi: 10.1016/j.bbcan.2006.09.001.; Reichardt LF. Neurotrophin-regulated signalling pathways. Philos Trans R Soc Lond B Biol Sci. 2006 Sep 29;361(1473):1545–64. PMID: 16939974; PMCID: PMC1664664.; Patterson RL, van Rossum DB, Nikolaidis N, Gill DL, Snyder SH. Phospholipase C-gamma: diverse roles in receptor-mediated calcium signaling. Trends Biochem Sci. 2005 Dec;30(12):688–97. doi: 10.1016/j.tibs.2005.10.005. PMID: 16260143.; Eswarakumar VP, Lax I, Schlessinger J. Cellular signaling by fibroblast growth factor receptors. Cytokine Growth Factor Rev. 2005 Apr;16(2):139–49. doi: 10.1016/j.cytogfr.2005.01.001. PMID: 15863030.; Wellbrock C, Karasarides M, Marais R. The RAF proteins take centre stage. Nature Reviews Molecular Cell Biology. 2004 Nov;5(11):875–85. doi: 10.1038/nrm1498.; Xie K, Wei D, Shi Q, Huang S. Constitutive and inducible expression and regulation of vascular endothelial growth factor. Cytokine Growth Factor Rev. 2004 Oct;15(5):297–324. doi: 10.1016/j.cytogfr.2004.04.003. PMID: 15450248.; Saltiel AR, Kahn CR. Insulin signalling and the regulation of glucose and lipid metabolism. Nature. 2001 Dec 13;414(6865):799–806. doi: 10.1038/414799a. PMID: 11742412. |
| Visual phototransduction Accession ID: Reactome:R-BTA-2187338 |
|
Korenbrot JI. Speed, sensitivity, and stability of the light response in rod and cone photoreceptors: Facts and models. Progress in Retinal and Eye Research. 2012 Sep;31(5):442–66. doi: 10.1016/j.preteyeres.2012.05.002.; von Lintig J. Metabolism of Carotenoids and Retinoids Related to Vision. Journal of Biological Chemistry. 2012 Jan;287(3):1627–34. doi: 10.1074/jbc.r111.303990.; Kefalov VJ. Rod and Cone Visual Pigments and Phototransduction through Pharmacological, Genetic, and Physiological Approaches. Journal of Biological Chemistry. 2012 Jan;287(3):1635–41. doi: 10.1074/jbc.r111.303008.; Wang J, Kefalov VJ. The Cone-specific visual cycle. Progress in Retinal and Eye Research. 2011 Mar;30(2):115–28. doi: 10.1016/j.preteyeres.2010.11.001.; D'Ambrosio DN, Clugston RD, Blaner WS. Vitamin A metabolism: an update. Nutrients. 2011 Jan;3(1):63–103. PMID: 21350678; PMCID: PMC3042718.; von Lintig J, Kiser PD, Golczak M, Palczewski K. The biochemical and structural basis for trans-to-cis isomerization of retinoids in the chemistry of vision. Trends in Biochemical Sciences. 2010 Jul;35(7):400–10. doi: 10.1016/j.tibs.2010.01.005.; Burns ME, Pugh EN. Lessons from photoreceptors: turning off g-protein signaling in living cells. Physiology (Bethesda). 2010 Apr;25(2):72–84. PMID: 20430952; PMCID: PMC2880230.; Blomhoff R, Blomhoff HK. Overview of retinoid metabolism and function. J Neurobiol. 2006 Jun;66(7):606–30. doi: 10.1002/neu.20242. PMID: 16688755.; Harrison EH. Mechanisms of digestion and absorption of dietary vitamin A. Annu Rev Nutr. 2005;25():87–103. doi: 10.1146/annurev.nutr.25.050304.092614. PMID: 16011460.; Wolf G. The visual cycle of the cone photoreceptors of the retina. Nutr Rev. 2004 Jul;62(7 Pt 1):283–6. doi: 10.1111/j.1753-4887.2004.tb00053.x. PMID: 15384919.; Harrison EH, Hussain MM. Mechanisms Involved in the Intestinal Digestion and Absorption of Dietary Vitamin A. The Journal of Nutrition. 2001 May;131(5):1405–8. doi: 10.1093/jn/131.5.1405.; Pugh EN, Lamb TD. Amplification and kinetics of the activation steps in phototransduction. Biochimica et Biophysica Acta (BBA) - Bioenergetics. 1993 Mar;1141(2-3):111–49. doi: 10.1016/0005-2728(93)90038-h. |
| RA biosynthesis pathway Accession ID: Reactome:R-BTA-5365859 |
|
Das BC, Thapa P, Karki R, Das S, Mahapatra S, Liu T, Torregroza I, Wallace DP, Kambhampati S, Van Veldhuizen P, Verma A, Ray SK, Evans T. Retinoic acid signaling pathways in development and diseases. Bioorganic & Medicinal Chemistry. 2014 Jan;22(2):673–83. doi: 10.1016/j.bmc.2013.11.025.; Napoli JL. Physiological insights into all-trans-retinoic acid biosynthesis. Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids. 2012 Jan;1821(1):152–67. doi: 10.1016/j.bbalip.2011.05.004. |
| Visual phototransduction Accession ID: Reactome:R-CEL-2187338 |
|
Korenbrot JI. Speed, sensitivity, and stability of the light response in rod and cone photoreceptors: Facts and models. Progress in Retinal and Eye Research. 2012 Sep;31(5):442–66. doi: 10.1016/j.preteyeres.2012.05.002.; von Lintig J. Metabolism of Carotenoids and Retinoids Related to Vision. Journal of Biological Chemistry. 2012 Jan;287(3):1627–34. doi: 10.1074/jbc.r111.303990.; Kefalov VJ. Rod and Cone Visual Pigments and Phototransduction through Pharmacological, Genetic, and Physiological Approaches. Journal of Biological Chemistry. 2012 Jan;287(3):1635–41. doi: 10.1074/jbc.r111.303008.; Wang J, Kefalov VJ. The Cone-specific visual cycle. Progress in Retinal and Eye Research. 2011 Mar;30(2):115–28. doi: 10.1016/j.preteyeres.2010.11.001.; D'Ambrosio DN, Clugston RD, Blaner WS. Vitamin A metabolism: an update. Nutrients. 2011 Jan;3(1):63–103. PMID: 21350678; PMCID: PMC3042718.; von Lintig J, Kiser PD, Golczak M, Palczewski K. The biochemical and structural basis for trans-to-cis isomerization of retinoids in the chemistry of vision. Trends in Biochemical Sciences. 2010 Jul;35(7):400–10. doi: 10.1016/j.tibs.2010.01.005.; Burns ME, Pugh EN. Lessons from photoreceptors: turning off g-protein signaling in living cells. Physiology (Bethesda). 2010 Apr;25(2):72–84. PMID: 20430952; PMCID: PMC2880230.; Blomhoff R, Blomhoff HK. Overview of retinoid metabolism and function. J Neurobiol. 2006 Jun;66(7):606–30. doi: 10.1002/neu.20242. PMID: 16688755.; Harrison EH. Mechanisms of digestion and absorption of dietary vitamin A. Annu Rev Nutr. 2005;25():87–103. doi: 10.1146/annurev.nutr.25.050304.092614. PMID: 16011460.; Wolf G. The visual cycle of the cone photoreceptors of the retina. Nutr Rev. 2004 Jul;62(7 Pt 1):283–6. doi: 10.1111/j.1753-4887.2004.tb00053.x. PMID: 15384919.; Harrison EH, Hussain MM. Mechanisms Involved in the Intestinal Digestion and Absorption of Dietary Vitamin A. The Journal of Nutrition. 2001 May;131(5):1405–8. doi: 10.1093/jn/131.5.1405.; Pugh EN, Lamb TD. Amplification and kinetics of the activation steps in phototransduction. Biochimica et Biophysica Acta (BBA) - Bioenergetics. 1993 Mar;1141(2-3):111–49. doi: 10.1016/0005-2728(93)90038-h. |
| The retinoid cycle in cones (daylight vision) Accession ID: Reactome:R-CFA-2187335 |
|
von Lintig J. Metabolism of Carotenoids and Retinoids Related to Vision. Journal of Biological Chemistry. 2012 Jan;287(3):1627–34. doi: 10.1074/jbc.r111.303990.; Kefalov VJ. Rod and Cone Visual Pigments and Phototransduction through Pharmacological, Genetic, and Physiological Approaches. Journal of Biological Chemistry. 2012 Jan;287(3):1635–41. doi: 10.1074/jbc.r111.303008.; Wang J, Kefalov VJ. The Cone-specific visual cycle. Progress in Retinal and Eye Research. 2011 Mar;30(2):115–28. doi: 10.1016/j.preteyeres.2010.11.001.; Wolf G. The visual cycle of the cone photoreceptors of the retina. Nutr Rev. 2004 Jul;62(7 Pt 1):283–6. doi: 10.1111/j.1753-4887.2004.tb00053.x. PMID: 15384919. |
| Signaling by Nuclear Receptors Accession ID: Reactome:R-CFA-9006931 |
|
Holzer G, Markov GV, Laudet V. Evolution of Nuclear Receptors and Ligand Signaling: Toward a Soft Key-Lock Model? Curr Top Dev Biol. 2017;125():1–38. doi: 10.1016/bs.ctdb.2017.02.003. PMID: 28527568.; Levin ER, Hammes SR. Nuclear receptors outside the nucleus: extranuclear signalling by steroid receptors. Nature Reviews Molecular Cell Biology. 2016 Oct 12;17(12):783–97. doi: 10.1038/nrm.2016.122.; Schwartz N, Verma A, Bivens CB, Schwartz Z, Boyan BD. Rapid steroid hormone actions via membrane receptors. Biochimica et Biophysica Acta (BBA) - Molecular Cell Research. 2016 Sep;1863(9):2289–98. doi: 10.1016/j.bbamcr.2016.06.004.; Simons SS, Edwards DP, Kumar R. Minireview: dynamic structures of nuclear hormone receptors: new promises and challenges. Mol Endocrinol. 2014 Feb;28(2):173–82. PMID: 24284822; PMCID: PMC3896641.; Hah N, Kraus WL. Hormone-regulated transcriptomes: Lessons learned from estrogen signaling pathways in breast cancer cells. Molecular and Cellular Endocrinology. 2014 Jan;382(1):652–64. doi: 10.1016/j.mce.2013.06.021.; Echeverria PC, Picard D. Molecular chaperones, essential partners of steroid hormone receptors for activity and mobility. Biochimica et Biophysica Acta (BBA) - Molecular Cell Research. 2010 Jun;1803(6):641–9. doi: 10.1016/j.bbamcr.2009.11.012.; Beato M, Chávez S, Truss M. Transcriptional regulation by steroid hormones. Steroids. 1996 Apr;61(4):240–51. doi: 10.1016/0039-128x(96)00030-x. PMID: 8733009. |
| Signaling Pathways Accession ID: Reactome:R-DRE-162582 |
|
Avraham R, Yarden Y. Feedback regulation of EGFR signalling: decision making by early and delayed loops. Nature Reviews Molecular Cell Biology. 2011 Jan 21;12(2):104–17. doi: 10.1038/nrm3048.; Citi S, Spadaro D, Schneider Y, Stutz J, Pulimeno P. Regulation of small GTPases at epithelial cell-cell junctions. Mol Membr Biol. 2011 Oct;28(7-8):427–44. doi: 10.3109/09687688.2011.603101. PMID: 21781017.; Ritter SL, Hall RA. Fine-tuning of GPCR activity by receptor-interacting proteins. Nature Reviews Molecular Cell Biology. 2009 Dec;10(12):819–30. doi: 10.1038/nrm2803.; Miyazono K, Kamiya Y, Morikawa M. Bone morphogenetic protein receptors and signal transduction. Journal of Biochemistry. 2009 Sep 17;147(1):35–51. doi: 10.1093/jb/mvp148.; Kang JS, Liu C, Derynck R. New regulatory mechanisms of TGF-beta receptor function. Trends Cell Biol. 2009 Aug;19(8):385–94. doi: 10.1016/j.tcb.2009.05.008. PMID: 19648010.; MacDonald BT, Tamai K, He X. Wnt/ß-Catenin Signaling: Components, Mechanisms, and Diseases. Developmental Cell. 2009 Jul;17(1):9–26. doi: 10.1016/j.devcel.2009.06.016.; Angers S, Moon RT. Proximal events in Wnt signal transduction. Nature Reviews Molecular Cell Biology. 2009 Jun 17;10(7):468–77. doi: 10.1038/nrm2717.; Rosenbaum DM, Rasmussen SG, Kobilka BK. The structure and function of G-protein-coupled receptors. Nature. 2009 May 21;459(7245):356–63. PMID: 19458711; PMCID: PMC3967846.; Kopan R, Ilagan MX. The canonical Notch signaling pathway: unfolding the activation mechanism. Cell. 2009 Apr 17;137(2):216–33. PMID: 19379690; PMCID: PMC2827930.; Andrae J, Gallini R, Betsholtz C. Role of platelet-derived growth factors in physiology and medicine. Genes Dev. 2008 May 15;22(10):1276–312. PMID: 18483217; PMCID: PMC2732412.; Oldham WM, Hamm HE. Heterotrimeric G protein activation by G-protein-coupled receptors. Nature Reviews Molecular Cell Biology. 2008 Jan;9(1):60–71. doi: 10.1038/nrm2299.; Manning BD, Cantley LC. AKT/PKB signaling: navigating downstream. Cell. 2007 Jun 29;129(7):1261–74. PMID: 17604717; PMCID: PMC2756685.; McKay MM, Morrison DK. Integrating signals from RTKs to ERK/MAPK. Oncogene. 2007 May 14;26(22):3113–21. doi: 10.1038/sj.onc.1210394. PMID: 17496910.; Hehlgans S, Haase M, Cordes N. Signalling via integrins: Implications for cell survival and anticancer strategies. Biochimica et Biophysica Acta (BBA) - Reviews on Cancer. 2007 Jan;1775(1):163–80. doi: 10.1016/j.bbcan.2006.09.001.; Reichardt LF. Neurotrophin-regulated signalling pathways. Philos Trans R Soc Lond B Biol Sci. 2006 Sep 29;361(1473):1545–64. PMID: 16939974; PMCID: PMC1664664.; Patterson RL, van Rossum DB, Nikolaidis N, Gill DL, Snyder SH. Phospholipase C-gamma: diverse roles in receptor-mediated calcium signaling. Trends Biochem Sci. 2005 Dec;30(12):688–97. doi: 10.1016/j.tibs.2005.10.005. PMID: 16260143.; Eswarakumar VP, Lax I, Schlessinger J. Cellular signaling by fibroblast growth factor receptors. Cytokine Growth Factor Rev. 2005 Apr;16(2):139–49. doi: 10.1016/j.cytogfr.2005.01.001. PMID: 15863030.; Wellbrock C, Karasarides M, Marais R. The RAF proteins take centre stage. Nature Reviews Molecular Cell Biology. 2004 Nov;5(11):875–85. doi: 10.1038/nrm1498.; Xie K, Wei D, Shi Q, Huang S. Constitutive and inducible expression and regulation of vascular endothelial growth factor. Cytokine Growth Factor Rev. 2004 Oct;15(5):297–324. doi: 10.1016/j.cytogfr.2004.04.003. PMID: 15450248.; Saltiel AR, Kahn CR. Insulin signalling and the regulation of glucose and lipid metabolism. Nature. 2001 Dec 13;414(6865):799–806. doi: 10.1038/414799a. PMID: 11742412. |
| The canonical retinoid cycle in rods (twilight vision) Accession ID: Reactome:R-DRE-2453902 |
|
von Lintig J. Metabolism of Carotenoids and Retinoids Related to Vision. Journal of Biological Chemistry. 2012 Jan;287(3):1627–34. doi: 10.1074/jbc.r111.303990.; D'Ambrosio DN, Clugston RD, Blaner WS. Vitamin A metabolism: an update. Nutrients. 2011 Jan;3(1):63–103. PMID: 21350678; PMCID: PMC3042718.; von Lintig J, Kiser PD, Golczak M, Palczewski K. The biochemical and structural basis for trans-to-cis isomerization of retinoids in the chemistry of vision. Trends in Biochemical Sciences. 2010 Jul;35(7):400–10. doi: 10.1016/j.tibs.2010.01.005.; Blomhoff R, Blomhoff HK. Overview of retinoid metabolism and function. J Neurobiol. 2006 Jun;66(7):606–30. doi: 10.1002/neu.20242. PMID: 16688755. |
| Signaling by Retinoic Acid Accession ID: Reactome:R-DRE-5362517 |
|
Das BC, Thapa P, Karki R, Das S, Mahapatra S, Liu T, Torregroza I, Wallace DP, Kambhampati S, Van Veldhuizen P, Verma A, Ray SK, Evans T. Retinoic acid signaling pathways in development and diseases. Bioorganic & Medicinal Chemistry. 2014 Jan;22(2):673–83. doi: 10.1016/j.bmc.2013.11.025.; Harrison EH. Mechanisms involved in the intestinal absorption of dietary vitamin A and provitamin A carotenoids. Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids. 2012 Jan;1821(1):70–7. doi: 10.1016/j.bbalip.2011.06.002.; Napoli JL. Physiological insights into all-trans-retinoic acid biosynthesis. Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids. 2012 Jan;1821(1):152–67. doi: 10.1016/j.bbalip.2011.05.004.; Catharine Ross A, Zolfaghari R. Cytochrome P450s in the Regulation of Cellular Retinoic Acid Metabolism. Annu. Rev. Nutr. 2011 Aug 21;31(1):65–87. doi: 10.1146/annurev-nutr-072610-145127. |
| Signaling by Retinoic Acid Accession ID: Reactome:R-DDI-5362517 |
|
Das BC, Thapa P, Karki R, Das S, Mahapatra S, Liu T, Torregroza I, Wallace DP, Kambhampati S, Van Veldhuizen P, Verma A, Ray SK, Evans T. Retinoic acid signaling pathways in development and diseases. Bioorganic & Medicinal Chemistry. 2014 Jan;22(2):673–83. doi: 10.1016/j.bmc.2013.11.025.; Harrison EH. Mechanisms involved in the intestinal absorption of dietary vitamin A and provitamin A carotenoids. Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids. 2012 Jan;1821(1):70–7. doi: 10.1016/j.bbalip.2011.06.002.; Napoli JL. Physiological insights into all-trans-retinoic acid biosynthesis. Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids. 2012 Jan;1821(1):152–67. doi: 10.1016/j.bbalip.2011.05.004.; Catharine Ross A, Zolfaghari R. Cytochrome P450s in the Regulation of Cellular Retinoic Acid Metabolism. Annu. Rev. Nutr. 2011 Aug 21;31(1):65–87. doi: 10.1146/annurev-nutr-072610-145127. |
| Signaling Pathways Accession ID: Reactome:R-DME-162582 |
|
Avraham R, Yarden Y. Feedback regulation of EGFR signalling: decision making by early and delayed loops. Nature Reviews Molecular Cell Biology. 2011 Jan 21;12(2):104–17. doi: 10.1038/nrm3048.; Citi S, Spadaro D, Schneider Y, Stutz J, Pulimeno P. Regulation of small GTPases at epithelial cell-cell junctions. Mol Membr Biol. 2011 Oct;28(7-8):427–44. doi: 10.3109/09687688.2011.603101. PMID: 21781017.; Ritter SL, Hall RA. Fine-tuning of GPCR activity by receptor-interacting proteins. Nature Reviews Molecular Cell Biology. 2009 Dec;10(12):819–30. doi: 10.1038/nrm2803.; Miyazono K, Kamiya Y, Morikawa M. Bone morphogenetic protein receptors and signal transduction. Journal of Biochemistry. 2009 Sep 17;147(1):35–51. doi: 10.1093/jb/mvp148.; Kang JS, Liu C, Derynck R. New regulatory mechanisms of TGF-beta receptor function. Trends Cell Biol. 2009 Aug;19(8):385–94. doi: 10.1016/j.tcb.2009.05.008. PMID: 19648010.; MacDonald BT, Tamai K, He X. Wnt/ß-Catenin Signaling: Components, Mechanisms, and Diseases. Developmental Cell. 2009 Jul;17(1):9–26. doi: 10.1016/j.devcel.2009.06.016.; Angers S, Moon RT. Proximal events in Wnt signal transduction. Nature Reviews Molecular Cell Biology. 2009 Jun 17;10(7):468–77. doi: 10.1038/nrm2717.; Rosenbaum DM, Rasmussen SG, Kobilka BK. The structure and function of G-protein-coupled receptors. Nature. 2009 May 21;459(7245):356–63. PMID: 19458711; PMCID: PMC3967846.; Kopan R, Ilagan MX. The canonical Notch signaling pathway: unfolding the activation mechanism. Cell. 2009 Apr 17;137(2):216–33. PMID: 19379690; PMCID: PMC2827930.; Andrae J, Gallini R, Betsholtz C. Role of platelet-derived growth factors in physiology and medicine. Genes Dev. 2008 May 15;22(10):1276–312. PMID: 18483217; PMCID: PMC2732412.; Oldham WM, Hamm HE. Heterotrimeric G protein activation by G-protein-coupled receptors. Nature Reviews Molecular Cell Biology. 2008 Jan;9(1):60–71. doi: 10.1038/nrm2299.; Manning BD, Cantley LC. AKT/PKB signaling: navigating downstream. Cell. 2007 Jun 29;129(7):1261–74. PMID: 17604717; PMCID: PMC2756685.; McKay MM, Morrison DK. Integrating signals from RTKs to ERK/MAPK. Oncogene. 2007 May 14;26(22):3113–21. doi: 10.1038/sj.onc.1210394. PMID: 17496910.; Hehlgans S, Haase M, Cordes N. Signalling via integrins: Implications for cell survival and anticancer strategies. Biochimica et Biophysica Acta (BBA) - Reviews on Cancer. 2007 Jan;1775(1):163–80. doi: 10.1016/j.bbcan.2006.09.001.; Reichardt LF. Neurotrophin-regulated signalling pathways. Philos Trans R Soc Lond B Biol Sci. 2006 Sep 29;361(1473):1545–64. PMID: 16939974; PMCID: PMC1664664.; Patterson RL, van Rossum DB, Nikolaidis N, Gill DL, Snyder SH. Phospholipase C-gamma: diverse roles in receptor-mediated calcium signaling. Trends Biochem Sci. 2005 Dec;30(12):688–97. doi: 10.1016/j.tibs.2005.10.005. PMID: 16260143.; Eswarakumar VP, Lax I, Schlessinger J. Cellular signaling by fibroblast growth factor receptors. Cytokine Growth Factor Rev. 2005 Apr;16(2):139–49. doi: 10.1016/j.cytogfr.2005.01.001. PMID: 15863030.; Wellbrock C, Karasarides M, Marais R. The RAF proteins take centre stage. Nature Reviews Molecular Cell Biology. 2004 Nov;5(11):875–85. doi: 10.1038/nrm1498.; Xie K, Wei D, Shi Q, Huang S. Constitutive and inducible expression and regulation of vascular endothelial growth factor. Cytokine Growth Factor Rev. 2004 Oct;15(5):297–324. doi: 10.1016/j.cytogfr.2004.04.003. PMID: 15450248.; Saltiel AR, Kahn CR. Insulin signalling and the regulation of glucose and lipid metabolism. Nature. 2001 Dec 13;414(6865):799–806. doi: 10.1038/414799a. PMID: 11742412. |
| Visual phototransduction Accession ID: Reactome:R-DME-2187338 |
|
Korenbrot JI. Speed, sensitivity, and stability of the light response in rod and cone photoreceptors: Facts and models. Progress in Retinal and Eye Research. 2012 Sep;31(5):442–66. doi: 10.1016/j.preteyeres.2012.05.002.; von Lintig J. Metabolism of Carotenoids and Retinoids Related to Vision. Journal of Biological Chemistry. 2012 Jan;287(3):1627–34. doi: 10.1074/jbc.r111.303990.; Kefalov VJ. Rod and Cone Visual Pigments and Phototransduction through Pharmacological, Genetic, and Physiological Approaches. Journal of Biological Chemistry. 2012 Jan;287(3):1635–41. doi: 10.1074/jbc.r111.303008.; Wang J, Kefalov VJ. The Cone-specific visual cycle. Progress in Retinal and Eye Research. 2011 Mar;30(2):115–28. doi: 10.1016/j.preteyeres.2010.11.001.; D'Ambrosio DN, Clugston RD, Blaner WS. Vitamin A metabolism: an update. Nutrients. 2011 Jan;3(1):63–103. PMID: 21350678; PMCID: PMC3042718.; von Lintig J, Kiser PD, Golczak M, Palczewski K. The biochemical and structural basis for trans-to-cis isomerization of retinoids in the chemistry of vision. Trends in Biochemical Sciences. 2010 Jul;35(7):400–10. doi: 10.1016/j.tibs.2010.01.005.; Burns ME, Pugh EN. Lessons from photoreceptors: turning off g-protein signaling in living cells. Physiology (Bethesda). 2010 Apr;25(2):72–84. PMID: 20430952; PMCID: PMC2880230.; Blomhoff R, Blomhoff HK. Overview of retinoid metabolism and function. J Neurobiol. 2006 Jun;66(7):606–30. doi: 10.1002/neu.20242. PMID: 16688755.; Harrison EH. Mechanisms of digestion and absorption of dietary vitamin A. Annu Rev Nutr. 2005;25():87–103. doi: 10.1146/annurev.nutr.25.050304.092614. PMID: 16011460.; Wolf G. The visual cycle of the cone photoreceptors of the retina. Nutr Rev. 2004 Jul;62(7 Pt 1):283–6. doi: 10.1111/j.1753-4887.2004.tb00053.x. PMID: 15384919.; Harrison EH, Hussain MM. Mechanisms Involved in the Intestinal Digestion and Absorption of Dietary Vitamin A. The Journal of Nutrition. 2001 May;131(5):1405–8. doi: 10.1093/jn/131.5.1405.; Pugh EN, Lamb TD. Amplification and kinetics of the activation steps in phototransduction. Biochimica et Biophysica Acta (BBA) - Bioenergetics. 1993 Mar;1141(2-3):111–49. doi: 10.1016/0005-2728(93)90038-h. |
| The canonical retinoid cycle in rods (twilight vision) Accession ID: Reactome:R-GGA-2453902 |
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von Lintig J. Metabolism of Carotenoids and Retinoids Related to Vision. Journal of Biological Chemistry. 2012 Jan;287(3):1627–34. doi: 10.1074/jbc.r111.303990.; D'Ambrosio DN, Clugston RD, Blaner WS. Vitamin A metabolism: an update. Nutrients. 2011 Jan;3(1):63–103. PMID: 21350678; PMCID: PMC3042718.; von Lintig J, Kiser PD, Golczak M, Palczewski K. The biochemical and structural basis for trans-to-cis isomerization of retinoids in the chemistry of vision. Trends in Biochemical Sciences. 2010 Jul;35(7):400–10. doi: 10.1016/j.tibs.2010.01.005.; Blomhoff R, Blomhoff HK. Overview of retinoid metabolism and function. J Neurobiol. 2006 Jun;66(7):606–30. doi: 10.1002/neu.20242. PMID: 16688755. |
| Signaling by Nuclear Receptors Accession ID: Reactome:R-GGA-9006931 |
|
Holzer G, Markov GV, Laudet V. Evolution of Nuclear Receptors and Ligand Signaling: Toward a Soft Key-Lock Model? Curr Top Dev Biol. 2017;125():1–38. doi: 10.1016/bs.ctdb.2017.02.003. PMID: 28527568.; Levin ER, Hammes SR. Nuclear receptors outside the nucleus: extranuclear signalling by steroid receptors. Nature Reviews Molecular Cell Biology. 2016 Oct 12;17(12):783–97. doi: 10.1038/nrm.2016.122.; Schwartz N, Verma A, Bivens CB, Schwartz Z, Boyan BD. Rapid steroid hormone actions via membrane receptors. Biochimica et Biophysica Acta (BBA) - Molecular Cell Research. 2016 Sep;1863(9):2289–98. doi: 10.1016/j.bbamcr.2016.06.004.; Simons SS, Edwards DP, Kumar R. Minireview: dynamic structures of nuclear hormone receptors: new promises and challenges. Mol Endocrinol. 2014 Feb;28(2):173–82. PMID: 24284822; PMCID: PMC3896641.; Hah N, Kraus WL. Hormone-regulated transcriptomes: Lessons learned from estrogen signaling pathways in breast cancer cells. Molecular and Cellular Endocrinology. 2014 Jan;382(1):652–64. doi: 10.1016/j.mce.2013.06.021.; Echeverria PC, Picard D. Molecular chaperones, essential partners of steroid hormone receptors for activity and mobility. Biochimica et Biophysica Acta (BBA) - Molecular Cell Research. 2010 Jun;1803(6):641–9. doi: 10.1016/j.bbamcr.2009.11.012.; Beato M, Chávez S, Truss M. Transcriptional regulation by steroid hormones. Steroids. 1996 Apr;61(4):240–51. doi: 10.1016/0039-128x(96)00030-x. PMID: 8733009. |
| Signaling by Nuclear Receptors Accession ID: Reactome:R-HSA-9006931 |
|
Arnal JF, Lenfant F, Metivier R, Flouriot G, Henrion D, Adlanmerini M, Fontaine C, Gourdy P, Chambon P, Katzenellenbogen B, Katzenellenbogen J. Membrane and Nuclear Estrogen Receptor Alpha Actions: From Tissue Specificity to Medical Implications. Physiol Rev. 2017 Jul 01;97(3):1045–87. doi: 10.1152/physrev.00024.2016. PMID: 28539435.; Endres K, Deller T. Regulation of Alpha-Secretase ADAM10 In vitro and In vivo: Genetic, Epigenetic, and Protein-Based Mechanisms. Front. Mol. Neurosci. 2017 Mar 17;10(). doi: 10.3389/fnmol.2017.00056.; Mockett BG, Richter M, Abraham WC, Müller UC. Therapeutic Potential of Secreted Amyloid Precursor Protein APPsa. Front. Mol. Neurosci. 2017 Feb 07;10(). doi: 10.3389/fnmol.2017.00030.; Holzer G, Markov GV, Laudet V. Evolution of Nuclear Receptors and Ligand Signaling: Toward a Soft Key-Lock Model? Curr Top Dev Biol. 2017;125():1–38. doi: 10.1016/bs.ctdb.2017.02.003. PMID: 28527568.; Yasar P, Ayaz G, Muyan M. Estradiol-Estrogen Receptor a Mediates the Expression of the CXXC5 Gene through the Estrogen Response Element-Dependent Signaling Pathway. Scientific Reports. 2016 Nov 25;6(1):37808. doi: 10.1038/srep37808.; Levin ER, Hammes SR. Nuclear receptors outside the nucleus: extranuclear signalling by steroid receptors. Nature Reviews Molecular Cell Biology. 2016 Oct 12;17(12):783–97. doi: 10.1038/nrm.2016.122.; Schwartz N, Verma A, Bivens CB, Schwartz Z, Boyan BD. Rapid steroid hormone actions via membrane receptors. Biochimica et Biophysica Acta (BBA) - Molecular Cell Research. 2016 Sep;1863(9):2289–98. doi: 10.1016/j.bbamcr.2016.06.004.; Swinstead EE, Miranda TB, Paakinaho V, Baek S, Goldstein I, Hawkins M, Karpova TS, Ball D, Mazza D, Lavis LD, Grimm JB, Morisaki T, Grøntved L, Presman DM, Hager GL. Steroid Receptors Reprogram FoxA1 Occupancy through Dynamic Chromatin Transitions. Cell. 2016 Apr 21;165(3):593–605. PMID: 27062924; PMCID: PMC4842147.; Busch M, Dünker N. Trefoil factor family peptides--friends or foes? Biomol Concepts. 2015 Dec;6(5-6):343–59. doi: 10.1515/bmc-2015-0020. PMID: 26479350.; Beckenbach L, Baron JM, Merk HF, Löffler H, Amann PM. Retinoid treatment of skin diseases. European Journal of Dermatology. 2015 Sep;25(5):384–91. doi: 10.1684/ejd.2015.2544.; Mohammed H, Russell IA, Stark R, Rueda OM, Hickey TE, Tarulli GA, Serandour AA, Serandour AA, Birrell SN, Bruna A, Saadi A, Menon S, Hadfield J, Pugh M, Raj GV, Brown GD, D'Santos C, Robinson JL, Silva G, Launchbury R, Perou CM, Stingl J, Caldas C, Tilley WD, Carroll JS. Progesterone receptor modulates ERa action in breast cancer. Nature. 2015 Jul 16;523(7560):313–7. PMID: 26153859; PMCID: PMC4650274.; Farooq A. Structural and Functional Diversity of Estrogen Receptor Ligands. Curr Top Med Chem. 2015;15(14):1372–84. PMID: 25866274; PMCID: PMC4604006.; Antony J, Dasgupta T, Rhodes JM, McEwan MV, Print CG, O’Sullivan JM, Horsfield JA. Cohesin modulates transcription of estrogen-responsive genes. Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms. 2015 Mar;1849(3):257–69. doi: 10.1016/j.bbagrm.2014.12.011.; Ikeda K, Horie-Inoue K, Inoue S. Identification of estrogen-responsive genes based on the DNA binding properties of estrogen receptors using high-throughput sequencing technology. Acta Pharmacologica Sinica. 2014 Dec 15;36(1):24–31. doi: 10.1038/aps.2014.123.; Liu Z, Merkurjev D, Yang F, Li W, Oh S, Friedman MJ, Song X, Zhang F, Ma Q, Ohgi KA, Krones A, Rosenfeld MG. Enhancer activation requires trans-recruitment of a mega transcription factor complex. Cell. 2014 Oct 09;159(2):358–73. PMID: 25303530; PMCID: PMC4465761.; Hodgkinson KM, Vanderhyden BC. Consideration of GREB1 as a potential therapeutic target for hormone-responsive or endocrine-resistant cancers. Expert Opinion on Therapeutic Targets. 2014 Jul 05;18(9):1065–76. doi: 10.1517/14728222.2014.936382.; Nguyen NT, Vendrell JA, Poulard C, Gyorffy B, Goddard-Léon S, Bièche I, Corbo L, Le Romancer M, Bachelot T, Treilleux I, Cohen PA. A functional interplay between ZNF217 and Estrogen Receptor alpha exists in luminal breast cancers. Molecular Oncology. 2014 Jun 10;8(8):1441–57. doi: 10.1016/j.molonc.2014.05.013.; Losada A. Cohesin in cancer: chromosome segregation and beyond. Nat Rev Cancer. 2014 Jun;14(6):389–93. doi: 10.1038/nrc3743. PMID: 24854081.; Tan S, Ding K, Li R, Zhang W, Li G, Kong X, Qian P, Lobie PE, Zhu T. Identification of miR-26 as a key mediator of estrogen stimulated cell proliferation by targeting CHD1, GREB1 and KPNA2. Breast Cancer Res. 2014 Apr 15;16(2):R40. PMID: 24735615; PMCID: PMC4053242.; Simons SS, Edwards DP, Kumar R. Minireview: dynamic structures of nuclear hormone receptors: new promises and challenges. Mol Endocrinol. 2014 Feb;28(2):173–82. PMID: 24284822; PMCID: PMC3896641.; Magnani L, Lupien M. Chromatin and epigenetic determinants of estrogen receptor alpha (ESR1) signaling. Mol Cell Endocrinol. 2014 Jan 25;382(1):633–41. doi: 10.1016/j.mce.2013.04.026. PMID: 23684889.; Hah N, Kraus WL. Hormone-regulated transcriptomes: Lessons learned from estrogen signaling pathways in breast cancer cells. Molecular and Cellular Endocrinology. 2014 Jan;382(1):652–64. doi: 10.1016/j.mce.2013.06.021.; Liu MH, Cheung E. Estrogen receptor-mediated long-range chromatin interactions and transcription in breast cancer. Mol Cell Endocrinol. 2014 Jan 25;382(1):624–32. doi: 10.1016/j.mce.2013.09.019. PMID: 24071518.; Foulds CE, Feng Q, Ding C, Bailey S, Hunsaker TL, Malovannaya A, Hamilton RA, Gates LA, Zhang Z, Li C, Chan D, Bajaj A, Callaway CG, Edwards DP, Lonard DM, Tsai SY, Tsai MJ, Qin J, O'Malley BW. Proteomic analysis of coregulators bound to ERa on DNA and nucleosomes reveals coregulator dynamics. Mol Cell. 2013 Jul 25;51(2):185–99. PMID: 23850489; PMCID: PMC3900250.; Noy N. The one-two punch: Retinoic acid suppresses obesity both by promoting energy expenditure and by inhibiting adipogenesis. Adipocyte. 2013 Jul 01;2(3):184–7. PMID: 23991366; PMCID: PMC3756108.; Gaughan L, Stockley J, Coffey K, O'Neill D, Jones DL, Wade M, Wright J, Moore M, Tse S, Rogerson L, Robson CN. KDM4B is a master regulator of the estrogen receptor signalling cascade. Nucleic Acids Res. 2013 Aug;41(14):6892–904. PMID: 23723241; PMCID: PMC3737554.; Christiansen A, Dyrskjøt L. The functional role of the novel biomarker karyopherin a 2 (KPNA2) in cancer. Cancer Letters. 2013 Apr;331(1):18–23. doi: 10.1016/j.canlet.2012.12.013.; Bchini R, Vasiliou V, Branlant G, Talfournier F, Rahuel-Clermont S. Retinoic acid biosynthesis catalyzed by retinal dehydrogenases relies on a rate-limiting conformational transition associated with substrate recognition. Chemico-Biological Interactions. 2013 Feb;202(1-3):78–84. doi: 10.1016/j.cbi.2012.11.019.; Coffey K, Rogerson L, Ryan-Munden C, Alkharaif D, Stockley J, Heer R, Sahadevan K, O'Neill D, Jones D, Darby S, Staller P, Mantilla A, Gaughan L, Robson CN. The lysine demethylase, KDM4B, is a key molecule in androgen receptor signalling and turnover. Nucleic Acids Res. 2013 Apr;41(8):4433–46. PMID: 23435229; PMCID: PMC3632104.; Kittler R, Zhou J, Hua S, Ma L, Liu Y, Pendleton E, Cheng C, Gerstein M, White KP. A comprehensive nuclear receptor network for breast cancer cells. Cell Rep. 2013 Feb 21;3(2):538–51. doi: 10.1016/j.celrep.2013.01.004. PMID: 23375374.; Mohammed H, D'Santos C, Serandour AA, Ali HR, Brown GD, Atkins A, Rueda OM, Holmes KA, Theodorou V, Robinson JL, Zwart W, Saadi A, Ross-Innes CS, Chin SF, Menon S, Stingl J, Palmieri C, Caldas C, Carroll JS. Endogenous purification reveals GREB1 as a key estrogen receptor regulatory factor. Cell Rep. 2013 Feb 21;3(2):342–9. PMID: 23403292; PMCID: PMC7116645.; Fiorito E, Katika MR, Hurtado A. Cooperating transcription factors mediate the function of estrogen receptor. Chromosoma. 2012 Nov 29;122(1-2):1–12. doi: 10.1007/s00412-012-0392-7.; Theodorou V, Stark R, Menon S, Carroll JS. GATA3 acts upstream of FOXA1 in mediating ESR1 binding by shaping enhancer accessibility. Genome Res. 2013 Jan;23(1):12–22. PMID: 23172872; PMCID: PMC3530671.; McEwan MV, Eccles MR, Horsfield JA. Cohesin Is Required for Activation of MYC by Estradiol. PLoS ONE. 2012 Nov 08;7(11):e49160. doi: 10.1371/journal.pone.0049160.; Amengual J, Petrov P, Bonet ML, Ribot J, Palou A. Induction of carnitine palmitoyl transferase 1 and fatty acid oxidation by retinoic acid in HepG2 cells. The International Journal of Biochemistry & Cell Biology. 2012 Nov;44(11):2019–27. doi: 10.1016/j.biocel.2012.07.026.; Mitra P, Pereira LA, Drabsch Y, Ramsay RG, Gonda TJ. Estrogen receptor-a recruits P-TEFb to overcome transcriptional pausing in intron 1 of the MYB gene. Nucleic Acids Res. 2012 Jul;40(13):5988–6000. PMID: 22492511; PMCID: PMC3401469.; Li G, Ruan X, Auerbach RK, Sandhu KS, Zheng M, Wang P, Poh HM, Goh Y, Lim J, Zhang J, Sim HS, Peh SQ, Mulawadi FH, Ong CT, Orlov YL, Hong S, Zhang Z, Landt S, Raha D, Euskirchen G, Wei CL, Ge W, Wang H, Davis C, Fisher-Aylor KI, Mortazavi A, Gerstein M, Gingeras T, Wold B, Sun Y, Fullwood MJ, Cheung E, Liu E, Sung WK, Snyder M, Ruan Y. Extensive promoter-centered chromatin interactions provide a topological basis for transcription regulation. Cell. 2012 Jan 20;148(1-2):84–98. PMID: 22265404; PMCID: PMC3339270.; Napoli JL. Physiological insights into all-trans-retinoic acid biosynthesis. Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids. 2012 Jan;1821(1):152–67. doi: 10.1016/j.bbalip.2011.05.004.; Majumdar A, Petrescu AD, Xiong Y, Noy N. Nuclear Translocation of Cellular Retinoic Acid-binding Protein II Is Regulated by Retinoic Acid-controlled SUMOylation. Journal of Biological Chemistry. 2011 Dec;286(49):42749–57. doi: 10.1074/jbc.m111.293464.; Rhodes JM, McEwan M, Horsfield JA. Gene regulation by cohesin in cancer: is the ring an unexpected party to proliferation? Mol Cancer Res. 2011 Dec;9(12):1587–607. doi: 10.1158/1541-7786.mcr-11-0382. PMID: 21940756.; Ruiz FX, Porté S, Gallego O, Moro A, Ardèvol A, Del Río-Espínola A, Rovira C, Farrés J, Parés X. Retinaldehyde is a substrate for human aldo-keto reductases of the 1C subfamily. Biochem J. 2011 Dec 15;440(3):335–44. doi: 10.1042/bj20111286. PMID: 21851338.; Zaret KS, Carroll JS. Pioneer transcription factors: establishing competence for gene expression. Genes Dev. 2011 Nov 01;25(21):2227–41. PMID: 22056668; PMCID: PMC3219227.; Augello MA, Hickey TE, Knudsen KE. FOXA1: master of steroid receptor function in cancer. EMBO J. 2011 Sep 20;30(19):3885–94. PMID: 21934649; PMCID: PMC3209791.; Wang C, Mayer JA, Mazumdar A, Fertuck K, Kim H, Brown M, Brown PH. Estrogen induces c-myc gene expression via an upstream enhancer activated by the estrogen receptor and the AP-1 transcription factor. Mol Endocrinol. 2011 Sep;25(9):1527–38. PMID: 21835891; PMCID: PMC3165912.; Kong SL, Li G, Loh SL, Sung WK, Liu ET. Cellular reprogramming by the conjoint action of ERa, FOXA1, and GATA3 to a ligand-inducible growth state. Mol Syst Biol. 2011 Aug 30;7():526. PMID: 21878914; PMCID: PMC3202798.; Kawazu M, Saso K, Tong KI, McQuire T, Goto K, Son DO, Wakeham A, Miyagishi M, Mak TW, Okada H. Histone demethylase JMJD2B functions as a co-factor of estrogen receptor in breast cancer proliferation and mammary gland development. PLoS One. 2011 Mar 18;6(3):e17830. PMID: 21445275; PMCID: PMC3060874.; Guo ZY, Hao XH, Tan FF, Pei X, Shang LM, Jiang XL, Yang F. The elements of human cyclin D1 promoter and regulation involved. Clin Epigenetics. 2011 Aug;2(2):63–76. PMID: 22704330; PMCID: PMC3365593.; Hurtado A, Holmes KA, Ross-Innes CS, Schmidt D, Carroll JS. FOXA1 is a key determinant of estrogen receptor function and endocrine response. Nat Genet. 2011 Jan;43(1):27–33. PMID: 21151129; PMCID: PMC3024537.; Parker RO, Crouch RK. Retinol dehydrogenases (RDHs) in the visual cycle. Experimental Eye Research. 2010 Dec;91(6):788–92. doi: 10.1016/j.exer.2010.08.013.; Creyghton MP, Cheng AW, Welstead GG, Kooistra T, Carey BW, Steine EJ, Hanna J, Lodato MA, Frampton GM, Sharp PA, Boyer LA, Young RA, Jaenisch R. Histone H3K27ac separates active from poised enhancers and predicts developmental state. Proc Natl Acad Sci U S A. 2010 Dec 14;107(50):21931–6. PMID: 21106759; PMCID: PMC3003124.; Yang J, Jubb AM, Pike L, Buffa FM, Turley H, Baban D, Leek R, Gatter KC, Ragoussis J, Harris AL. The histone demethylase JMJD2B is regulated by estrogen receptor alpha and hypoxia, and is a key mediator of estrogen induced growth. Cancer Res. 2010 Aug 15;70(16):6456–66. PMID: 20682797; PMCID: PMC4261152.; Kuhn PH, Wang H, Dislich B, Colombo A, Zeitschel U, Ellwart JW, Kremmer E, Rossner S, Lichtenthaler SF. ADAM10 is the physiologically relevant, constitutive alpha-secretase of the amyloid precursor protein in primary neurons. EMBO J. 2010 Sep 01;29(17):3020–32. PMID: 20676056; PMCID: PMC2944055.; Echeverria PC, Picard D. Molecular chaperones, essential partners of steroid hormone receptors for activity and mobility. Biochimica et Biophysica Acta (BBA) - Molecular Cell Research. 2010 Jun;1803(6):641–9. doi: 10.1016/j.bbamcr.2009.11.012.; Powell E, Wang Y, Shapiro DJ, Xu W. Differential Requirements of Hsp90 and DNA for the Formation of Estrogen Receptor Homodimers and Heterodimers. Journal of Biological Chemistry. 2010 May;285(21):16125–34. doi: 10.1074/jbc.m110.104356.; Schmidt D, Schwalie PC, Ross-Innes CS, Hurtado A, Brown GD, Carroll JS, Flicek P, Odom DT. A CTCF-independent role for cohesin in tissue-specific transcription. Genome Res. 2010 May;20(5):578–88. PMID: 20219941; PMCID: PMC2860160.; Santos NC, Kim KH. Activity of retinoic acid receptor-alpha is directly regulated at its protein kinase A sites in response to follicle-stimulating hormone signaling. Endocrinology. 2010 May;151(5):2361–72. PMID: 20215566; PMCID: PMC2869257.; Wolf G. Retinoic acid activation of peroxisome proliferation-activated receptor delta represses obesity and insulin resistance. Nutr Rev. 2010 Jan;68(1):67–70. doi: 10.1111/j.1753-4887.2009.00261.x. PMID: 20042001.; Zhu L, Santos NC, Kim KH. Small ubiquitin-like modifier-2 modification of retinoic acid receptor-alpha regulates its subcellular localization and transcriptional activity. Endocrinology. 2009 Dec;150(12):5586–95. PMID: 19850744; PMCID: PMC2795702.; Wortham NC, Ahamed E, Nicol SM, Thomas RS, Periyasamy M, Jiang J, Ochocka AM, Shousha S, Huson L, Bray SE, Coombes RC, Ali S, Fuller-Pace FV. The DEAD-box protein p72 regulates ERalpha-/oestrogen-dependent transcription and cell growth, and is associated with improved survival in ERalpha-positive breast cancer. Oncogene. 2009 Nov 19;28(46):4053–64. PMID: 19718048; PMCID: PMC2780396.; Nott SL, Huang Y, Li X, Fluharty BR, Qiu X, Welshons WV, Yeh S, Muyan M. Genomic Responses from the Estrogen-responsive Element-dependent Signaling Pathway Mediated by Estrogen Receptor a Are Required to Elicit Cellular Alterations. Journal of Biological Chemistry. 2009 May;284(22):15277–88. doi: 10.1074/jbc.m900365200.; Heintzman ND, Hon GC, Hawkins RD, Kheradpour P, Stark A, Harp LF, Ye Z, Lee LK, Stuart RK, Ching CW, Ching KA, Antosiewicz-Bourget JE, Liu H, Zhang X, Green RD, Lobanenkov VV, Stewart R, Thomson JA, Crawford GE, Kellis M, Ren B. Histone modifications at human enhancers reflect global cell-type-specific gene expression. Nature. 2009 May 07;459(7243):108–12. PMID: 19295514; PMCID: PMC2910248.; Bai Z, Gust R. Breast cancer, estrogen receptor and ligands. Arch Pharm (Weinheim). 2009 Mar;342(3):133–49. doi: 10.1002/ardp.200800174. PMID: 19274700.; Tippmann F, Hundt J, Schneider A, Endres K, Fahrenholz F: Up-regulation of the alpha-secretase ADAM10 by retinoic acid receptors and acitretin. FASEB J. 2009 Jun;23(6):1643-54. doi: 10.1096/fj.08-121392. Epub 2009 Jan 14.; Klein EA, Assoian RK. Transcriptional regulation of the cyclin D1 gene at a glance. J Cell Sci. 2008 Dec 01;121(Pt 23):3853–7. PMID: 19020303; PMCID: PMC4545630.; Smith DF, Toft DO. Minireview: the intersection of steroid receptors with molecular chaperones: observations and questions. Mol Endocrinol. 2008 Oct;22(10):2229–40. PMID: 18451092; PMCID: PMC2582531.; Duester G. Retinoic acid synthesis and signaling during early organogenesis. Cell. 2008 Sep 19;134(6):921–31. PMID: 18805086; PMCID: PMC2632951.; Niederreither K, Dollé P. Retinoic acid in development: towards an integrated view. Nat Rev Genet. 2008 Jul;9(7):541–53. doi: 10.1038/nrg2340. PMID: 18542081.; Wilson BJ, Giguère V. Meta-analysis of human cancer microarrays reveals GATA3 is integral to the estrogen receptor alpha pathway. Molecular Cancer. 2008 Jun 04;7(1):49. doi: 10.1186/1476-4598-7-49.; Gonda TJ, Leo P, Ramsay RG. Estrogen andMYBin breast cancer: potential for new therapies. Expert Opinion on Biological Therapy. 2008 May 14;8(6):713–7. doi: 10.1517/14712598.8.6.713.; Stedman W, Kang H, Lin S, Kissil JL, Bartolomei MS, Lieberman PM. Cohesins localize with CTCF at the KSHV latency control region and at cellular c-myc and H19/Igf2 insulators. EMBO J. 2008 Feb 20;27(4):654–66. PMID: 18219272; PMCID: PMC2262040.; Belyaeva OV, Korkina OV, Stetsenko AV, Kedishvili NY. Human retinol dehydrogenase 13 (RDH13) is a mitochondrial short-chain dehydrogenase/reductase with a retinaldehyde reductase activity. The FEBS Journal. 2007 Dec 06;275(1):138–47. doi: 10.1111/j.1742-4658.2007.06184.x.; Sun J, Nawaz Z, Slingerland JM. Long-range activation of GREB1 by estrogen receptor via three distal consensus estrogen-responsive elements in breast cancer cells. Mol Endocrinol. 2007 Nov;21(11):2651–62. doi: 10.1210/me.2007-0082. PMID: 17666587.; Drabsch Y, Hugo H, Zhang R, Dowhan DH, Miao YR, Gewirtz AM, Barry SC, Ramsay RG, Gonda TJ. Mechanism of and requirement for estrogen-regulated MYB expression in estrogen-receptor-positive breast cancer cells. Proc. Natl. Acad. Sci. U.S.A. 2007 Aug 21;104(34):13762–7. doi: 10.1073/pnas.0700104104.; Shen Q, Uray IP, Li Y, Krisko TI, Strecker TE, Kim HT, Brown PH. The AP-1 transcription factor regulates breast cancer cell growth via cyclins and E2F factors. Oncogene. 2008 Jan 10;27(3):366–77. doi: 10.1038/sj.onc.1210643. PMID: 17637753.; Deschênes J, Bourdeau V, White JH, Mader S. Regulation of GREB1 transcription by estrogen receptor alpha through a multipartite enhancer spread over 20 kb of upstream flanking sequences. J Biol Chem. 2007 Jun 15;282(24):17335–9. doi: 10.1074/jbc.c700030200. PMID: 17463000.; Caretti G, Lei EP, Sartorelli V. The DEAD-box p68/p72 proteins and the noncoding RNA steroid receptor activator SRA: eclectic regulators of disparate biological functions. Cell Cycle. 2007 May 15;6(10):1172–6. doi: 10.4161/cc.6.10.4228. PMID: 17495528.; Carroll JS, Meyer CA, Song J, Li W, Geistlinger TR, Eeckhoute J, Brodsky AS, Keeton EK, Fertuck KC, Hall GF, Wang Q, Bekiranov S, Sementchenko V, Fox EA, Silver PA, Gingeras TR, Liu XS, Brown M. Genome-wide analysis of estrogen receptor binding sites. Nat Genet. 2006 Nov;38(11):1289–97. doi: 10.1038/ng1901. PMID: 17013392.; Eeckhoute J, Carroll JS, Geistlinger TR, Torres-Arzayus MI, Brown M. A cell-type-specific transcriptional network required for estrogen regulation of cyclin D1 and cell cycle progression in breast cancer. Genes Dev. 2006 Sep 15;20(18):2513–26. PMID: 16980581; PMCID: PMC1578675.; Oxelmark E, Roth JM, Brooks PC, Braunstein SE, Schneider RJ, Garabedian MJ. The Cochaperone p23 Differentially Regulates Estrogen Receptor Target Genes and Promotes Tumor Cell Adhesion and Invasion. Molecular and Cellular Biology. 2006 Jul 01;26(14):5205–13. doi: 10.1128/mcb.00009-06.; Deroo BJ. Estrogen receptors and human disease. Journal of Clinical Investigation. 2006 Mar 01;116(3):561–70. doi: 10.1172/jci27987.; Laganière J, Deblois G, Lefebvre C, Bataille AR, Robert F, Giguère V. From the Cover: Location analysis of estrogen receptor alpha target promoters reveals that FOXA1 defines a domain of the estrogen response. Proc Natl Acad Sci U S A. 2005 Aug 16;102(33):11651–6. PMID: 16087863; PMCID: PMC1183449.; Carroll JS, Liu XS, Brodsky AS, Li W, Meyer CA, Szary AJ, Eeckhoute J, Shao W, Hestermann EV, Geistlinger TR, Fox EA, Silver PA, Brown M. Chromosome-wide mapping of estrogen receptor binding reveals long-range regulation requiring the forkhead protein FoxA1. Cell. 2005 Jul 15;122(1):33–43. doi: 10.1016/j.cell.2005.05.008. PMID: 16009131.; Rae JM, Johnson MD, Scheys JO, Cordero KE, Larios JM, Lippman ME. GREB 1 is a critical regulator of hormone dependent breast cancer growth. Breast Cancer Res Treat. 2005 Jul;92(2):141–9. doi: 10.1007/s10549-005-1483-4. PMID: 15986123.; Sessler RJ, Noy N. A ligand-activated nuclear localization signal in cellular retinoic acid binding protein-II. Mol Cell. 2005 Apr 29;18(3):343–53. doi: 10.1016/j.molcel.2005.03.026. PMID: 15866176.; DeNardo DG, Kim HT, Hilsenbeck S, Cuba V, Tsimelzon A, Brown PH. Global gene expression analysis of estrogen receptor transcription factor cross talk in breast cancer: identification of estrogen-induced/activator protein-1-dependent genes. Mol Endocrinol. 2005 Feb;19(2):362–78. doi: 10.1210/me.2004-0267. PMID: 15514030.; Howell A, Cuzick J, Baum M, Buzdar A, Dowsett M, Forbes JF, Hoctin-Boes G, Houghton J, Locker GY, Tobias JS; ATAC Trialists' Group. Results of the ATAC (Arimidex, Tamoxifen, Alone or in Combination) trial after completion of 5 years' adjuvant treatment for breast cancer. Lancet. 2005 Jan;365(9453):60–2. doi: 10.1016/s0140-6736(04)17666-6. PMID: 15639680.; Métivier R, Penot G, Carmouche RP, Hübner MR, Reid G, Denger S, Manu D, Brand H, Kos M, Benes V, Gannon F. Transcriptional complexes engaged by apo-estrogen receptor-alpha isoforms have divergent outcomes. EMBO J. 2004 Sep 15;23(18):3653–66. PMID: 15343269; PMCID: PMC517616.; Lin C, Ström A, Vega VB, Li Kong S, Li Yeo A, Thomsen JS, Chan WC, Doray B, Bangarusamy DK, Ramasamy A, Vergara LA, Tang S, Chong A, Bajic VB, Miller LD, Gustafsson J, Liu ET. Discovery of estrogen receptor a target genes and response elements in breast tumor cells. Genome Biology. 2004 Aug 12;5(9):r66. doi: 10.1186/gb-2004-5-9-r66.; Garriga J, Graña X. Cellular control of gene expression by T-type cyclin/CDK9 complexes. Gene. 2004 Aug 04;337():15–23. doi: 10.1016/j.gene.2004.05.007. PMID: 15276198.; Cicatiello L, Addeo R, Sasso A, Altucci L, Petrizzi VB, Borgo R, Cancemi M, Caporali S, Caristi S, Scafoglio C, Teti D, Bresciani F, Perillo B, Weisz A. Estrogens and Progesterone Promote Persistent CCND1 Gene Activation during G1 by Inducing Transcriptional Derepression via c-Jun/c-Fos/Estrogen Receptor (Progesterone Receptor) Complex Assembly to a Distal Regulatory Element and Recruitment of Cyclin D1 to Its Own Gene Promoter. Molecular and Cellular Biology. 2004 Aug 01;24(16):7260–74. doi: 10.1128/mcb.24.16.7260-7274.2004.; Pearce ST, Jordan VC. The biological role of estrogen receptors alpha and beta in cancer. Crit Rev Oncol Hematol. 2004 Apr;50(1):3–22. doi: 10.1016/j.critrevonc.2003.09.003. PMID: 15094156.; Métivier R, Penot G, Hübner MR, Reid G, Brand H, Kos M, Gannon F. Estrogen receptor-alpha directs ordered, cyclical, and combinatorial recruitment of cofactors on a natural target promoter. Cell. 2003 Dec 12;115(6):751–63. doi: 10.1016/s0092-8674(03)00934-6. PMID: 14675539.; Picozzi P, Marozzi A, Fornasari D, Benfante R, Barisani D, Meneveri R, Ginelli E. Genomic organization and transcription of the human retinol dehydrogenase 10 (RDH10) gene. FEBS Lett. 2003 Nov 06;554(1-2):59–66. doi: 10.1016/s0014-5793(03)01089-5. PMID: 14596915.; Frasor J, Danes JM, Komm B, Chang KC, Lyttle CR, Katzenellenbogen BS. Profiling of estrogen up- and down-regulated gene expression in human breast cancer cells: insights into gene networks and pathways underlying estrogenic control of proliferation and cell phenotype. Endocrinology. 2003 Oct;144(10):4562–74. doi: 10.1210/en.2003-0567. PMID: 12959972.; Harrington WR, Sheng S, Barnett DH, Petz LN, Katzenellenbogen JA, Katzenellenbogen BS. Activities of estrogen receptor alpha- and beta-selective ligands at diverse estrogen responsive gene sites mediating transactivation or transrepression. Mol Cell Endocrinol. 2003 Aug 29;206(1-2):13–22. doi: 10.1016/s0303-7207(03)00255-7. PMID: 12943986.; Xu W, Cho H, Evans RM. Acetylation and methylation in nuclear receptor gene activation. Methods Enzymol. 2003;364():205–23. doi: 10.1016/s0076-6879(03)64012-7. PMID: 14631847.; Daujat S, Bauer UM, Shah V, Turner B, Berger S, Kouzarides T. Crosstalk between CARM1 methylation and CBP acetylation on histone H3. Curr Biol. 2002 Dec 23;12(24):2090–7. doi: 10.1016/s0960-9822(02)01387-8. PMID: 12498683.; Budhu AS, Noy N. Direct Channeling of Retinoic Acid between Cellular Retinoic Acid-Binding Protein II and Retinoic Acid Receptor Sensitizes Mammary Carcinoma Cells to Retinoic Acid-Induced Growth Arrest. Molecular and Cellular Biology. 2002 Apr 01;22(8):2632–41. doi: 10.1128/mcb.22.8.2632-2641.2002.; Métivier R, Penot G, Flouriot G, Pakdel F. Synergism between ERalpha transactivation function 1 (AF-1) and AF-2 mediated by steroid receptor coactivator protein-1: requirement for the AF-1 alpha-helical core and for a direct interaction between the N- and C-terminal domains. Mol Endocrinol. 2001 Nov;15(11):1953–70. doi: 10.1210/mend.15.11.0727. PMID: 11682626.; Hall JM, Couse JF, Korach KS. The Multifaceted Mechanisms of Estradiol and Estrogen Receptor Signaling. Journal of Biological Chemistry. 2001 Oct;276(40):36869–72. doi: 10.1074/jbc.r100029200.; Yahata T, Shao W, Endoh H, Hur J, Coser KR, Sun H, Ueda Y, Kato S, Isselbacher KJ, Brown M, Shioda T. Selective coactivation of estrogen-dependent transcription by CITED1 CBP/p300-binding protein. Genes Dev. 2001 Oct 01;15(19):2598–612. PMID: 11581164; PMCID: PMC312794.; Bouhouche-Chatelier I, Chadli A, Catelli M. The N-terminal adenosine triphosphate binding domain of Hsp90 is necessary and sufficient for interaction with estrogen receptor. Cell Stress and Chaperones. 2001;6(4):297–305. doi: 10.1379/1466-1268(2001)006<0297:tntatb>2.0.co;2.; Castro-Rivera E, Samudio I, Safe S. Estrogen Regulation of Cyclin D1 Gene Expression in ZR-75 Breast Cancer Cells Involves Multiple Enhancer Elements. Journal of Biological Chemistry. 2001 Aug;276(33):30853–61. doi: 10.1074/jbc.m103339200.; Klinge CM. Estrogen receptor interaction with estrogen response elements. Nucleic Acids Res. 2001 Jul 15;29(14):2905–19. PMID: 11452016; PMCID: PMC55815.; Wood JR, Likhite VS, Loven MA, Nardulli AM. Allosteric modulation of estrogen receptor conformation by different estrogen response elements. Mol Endocrinol. 2001 Jul;15(7):1114–26. doi: 10.1210/mend.15.7.0671. PMID: 11435612.; Pfaffl MW, Lange IG, Daxenberger A, Meyer HH. Tissue-specific expression pattern of estrogen receptors (ER): quantification of ER alpha and ER beta mRNA with real-time RT-PCR. APMIS. 2001 May;109(5):345–55. doi: 10.1034/j.1600-0463.2001.090503.x. PMID: 11478682.; Chen D, Huang S, Stallcup MR. Synergistic, p160 Coactivator-dependent Enhancement of Estrogen Receptor Function by CARM1 and p300. Journal of Biological Chemistry. 2000 Dec;275(52):40810–6. doi: 10.1074/jbc.m005459200.; Lin M, Napoli JL. cDNA Cloning and Expression of a Human Aldehyde Dehydrogenase (ALDH) Active with 9-cis-Retinal and Identification of a Rat Ortholog, ALDH12. Journal of Biological Chemistry. 2000 Dec;275(51):40106–12. doi: 10.1074/jbc.m008027200.; Shang Y, Hu X, DiRenzo J, Lazar MA, Brown M. Cofactor dynamics and sufficiency in estrogen receptor-regulated transcription. Cell. 2000 Dec 08;103(6):843–52. doi: 10.1016/s0092-8674(00)00188-4. PMID: 11136970.; Katzenellenbogen BS, Choi I, Delage-Mourroux R, Ediger TR, Martini PGV, Montano M, Sun J, Weis K, Katzenellenbogen JA. Molecular mechanisms of estrogen action: selective ligands and receptor pharmacology. The Journal of Steroid Biochemistry and Molecular Biology. 2000 Nov;74(5):279–85. doi: 10.1016/s0960-0760(00)00104-7.; Stauffer SR, Coletta CJ, Tedesco R, Nishiguchi G, Carlson K, Sun J, Katzenellenbogen BS, Katzenellenbogen JA. Pyrazole ligands: structure-affinity/activity relationships and estrogen receptor-alpha-selective agonists. J Med Chem. 2000 Dec 28;43(26):4934–47. doi: 10.1021/jm000170m. PMID: 11150164.; Ghosh MG, Thompson DA, Weigel RJ. PDZK1 and GREB1 are estrogen-regulated genes expressed in hormone-responsive breast cancer. Cancer Res. 2000 Nov 15;60(22):6367–75. PMID: 11103799.; Ruff M, Gangloff M, Marie Wurtz J, Moras D. Estrogen receptor transcription and transactivation Structure-function relationship in DNA- and ligand-binding domains of estrogen receptors. Breast Cancer Research. 2000 Oct 01;2(5):353. doi: 10.1186/bcr80.; Kauraniemi P, Hedenfalk I, Persson K, Duggan DJ, Tanner M, Johannsson O, Olsson H, Trent JM, Isola J, Borg A. MYB oncogene amplification in hereditary BRCA1 breast cancer. Cancer Res. 2000 Oct 01;60(19):5323–8. PMID: 11034064.; Noy N. Retinoid-binding proteins: mediators of retinoid action. Biochem J. 2000 Jun 15;348 Pt 3():481–95. PMID: 10839978; PMCID: PMC1221089.; Vyhlidal C, Samudio I, Kladde MP, Safe S. Transcriptional activation of transforming growth factor alpha by estradiol: requirement for both a GC-rich site and an estrogen response element half-site. J Mol Endocrinol. 2000 Jun;24(3):329–38. doi: 10.1677/jme.0.0240329. PMID: 10828826.; Fliss AE, Benzeno S, Rao J, Caplan AJ. Control of estrogen receptor ligand binding by Hsp90. The Journal of Steroid Biochemistry and Molecular Biology. 2000 Apr;72(5):223–30. doi: 10.1016/s0960-0760(00)00037-6.; Gustafsson JA. Estrogen receptor beta--a new dimension in estrogen mechanism of action. J Endocrinol. 1999 Dec;163(3):379–83. doi: 10.1677/joe.0.1630379. PMID: 10588810.; Sabbah M, Courilleau D, Mester J, Redeuilh G. Estrogen induction of the cyclin D1 promoter: Involvement of a cAMP response-like element. Proc. Natl. Acad. Sci. U.S.A. 1999 Sep 28;96(20):11217–22. doi: 10.1073/pnas.96.20.11217.; Cosman F, Lindsay R. Selective estrogen receptor modulators: clinical spectrum. Endocr Rev. 1999 Jun;20(3):418–34. doi: 10.1210/edrv.20.3.0371. PMID: 10368777.; Yamamoto H, Simon A, Eriksson U, Harris E, Berson EL, Dryja TP. Mutations in the gene encoding 11-cis retinol dehydrogenase cause delayed dark adaptation and fundus albipunctatus. Nat Genet. 1999 Jun;22(2):188–91. doi: 10.1038/9707. PMID: 10369264.; Knoblauch R, Garabedian MJ. Role for Hsp90-Associated Cochaperone p23 in Estrogen Receptor Signal Transduction. Molecular and Cellular Biology. 1999 May 01;19(5):3748–59. doi: 10.1128/mcb.19.5.3748.; Jurukovski V, Markova NG, Karaman-Jurukovska N, Randolph RK, Su J, Napoli JL, Simon M. Cloning and Characterization of Retinol Dehydrogenase Transcripts Expressed in Human Epidermal Keratinocytes. Molecular Genetics and Metabolism. 1999 May;67(1):62–73. doi: 10.1006/mgme.1999.2840.; Obermann WM, Sondermann H, Russo AA, Pavletich NP, Hartl FU. In vivo function of Hsp90 is dependent on ATP binding and ATP hydrolysis. J Cell Biol. 1998 Nov 16;143(4):901–10. PMID: 9817749; PMCID: PMC2132952.; Panaretou B, Prodromou C, Roe SM, O'Brien R, Ladbury JE, Piper PW, Pearl LH. ATP binding and hydrolysis are essential to the function of the Hsp90 molecular chaperone in vivo. EMBO J. 1998 Aug 17;17(16):4829–36. PMID: 9707442; PMCID: PMC1170812.; Prall OWJ, Rogan EM, Musgrove EA, Watts CKW, Sutherland RL. c-Myc or Cyclin D1 Mimics Estrogen Effects on Cyclin E-Cdk2 Activation and Cell Cycle Reentry. Molecular and Cellular Biology. 1998 Aug 01;18(8):4499–508. doi: 10.1128/mcb.18.8.4499.; Gough WH, VanOoteghem S, Sint T, Kedishvili NY. cDNA cloning and characterization of a new human microsomal NAD+-dependent dehydrogenase that oxidizes all-trans-retinol and 3alpha-hydroxysteroids. J Biol Chem. 1998 Jul 31;273(31):19778–85. doi: 10.1074/jbc.273.31.19778. PMID: 9677409.; Kuntz MA, Shapiro DJ. Dimerizing the Estrogen Receptor DNA Binding Domain Enhances Binding to Estrogen Response Elements. Journal of Biological Chemistry. 1997 Oct;272(44):27949–56. doi: 10.1074/jbc.272.44.27949.; Grenert JP, Sullivan WP, Fadden P, Haystead TAJ, Clark J, Mimnaugh E, Krutzsch H, Ochel H, Schulte TW, Sausville E, Neckers LM, Toft DO. The Amino-terminal Domain of Heat Shock Protein 90 (hsp90) That Binds Geldanamycin Is an ATP/ADP Switch Domain That Regulates hsp90 Conformation. Journal of Biological Chemistry. 1997 Sep;272(38):23843–50. doi: 10.1074/jbc.272.38.23843.; Pratt WB, Toft DO. Steroid receptor interactions with heat shock protein and immunophilin chaperones. Endocr Rev. 1997 Jun;18(3):306–60. doi: 10.1210/edrv.18.3.0303. PMID: 9183567.; Kuiper GG, Carlsson B, Grandien K, Enmark E, Häggblad J, Nilsson S, Gustafsson JA. Comparison of the ligand binding specificity and transcript tissue distribution of estrogen receptors alpha and beta. Endocrinology. 1997 Mar;138(3):863–70. doi: 10.1210/endo.138.3.4979. PMID: 9048584.; Hanstein B, Eckner R, DiRenzo J, Halachmi S, Liu H, Searcy B, Kurokawa R, Brown M. p300 is a component of an estrogen receptor coactivator complex. Proc. Natl. Acad. Sci. U.S.A. 1996 Oct 15;93(21):11540–5. doi: 10.1073/pnas.93.21.11540.; Beato M, Chávez S, Truss M. Transcriptional regulation by steroid hormones. Steroids. 1996 Apr;61(4):240–51. doi: 10.1016/0039-128x(96)00030-x. PMID: 8733009.; Albanese C, Johnson J, Watanabe G, Eklund N, Vu D, Arnold A, Pestell RG. Transforming p21ras mutants and c-Ets-2 activate the cyclin D1 promoter through distinguishable regions. J Biol Chem. 1995 Oct 06;270(40):23589–97. doi: 10.1074/jbc.270.40.23589. PMID: 7559524.; Segnitz B, Gehring U. Subunit structure of the nonactivated human estrogen receptor. Proc. Natl. Acad. Sci. U.S.A. 1995 Mar 14;92(6):2179–83. doi: 10.1073/pnas.92.6.2179.; Kleywegt GJ, Bergfors T, Senn H, Le Motte P, Gsell B, Shudo K, Jones TA. Crystal structures of cellular retinoic acid binding proteins I and II in complex with all-trans-retinoic acid and a synthetic retinoid. Structure. 1994 Dec 15;2(12):1241–58. doi: 10.1016/s0969-2126(94)00125-1. PMID: 7704533.; Cavaillès V, Dauvois S, Danielian PS, Parker MG. Interaction of proteins with transcriptionally active estrogen receptors. Proc. Natl. Acad. Sci. U.S.A. 1994 Oct 11;91(21):10009–13. doi: 10.1073/pnas.91.21.10009.; Halachmi S, Marden E, Martin G, MacKay H, Abbondanza C, Brown M. Estrogen receptor-associated proteins: possible mediators of hormone-induced transcription. Science. 1994 Jun 03;264(5164):1455–8. doi: 10.1126/science.8197458. PMID: 8197458.; Schwabe JW, Chapman L, Finch JT, Rhodes D. The crystal structure of the estrogen receptor DNA-binding domain bound to DNA: how receptors discriminate between their response elements. Cell. 1993 Nov 05;75(3):567–78. doi: 10.1016/0092-8674(93)90390-c. PMID: 8221895.; Yoshida A, Hsu LC, Yanagawa Y. Biological role of human cytosolic aldehyde dehydrogenase 1: hormonal response, retinal oxidation and implication in testicular feminization. Adv Exp Med Biol. 1993;328():37–44. doi: 10.1007/978-1-4615-2904-0_5. PMID: 8493914.; Dubik D, Shiu RP. Mechanism of estrogen activation of c-myc oncogene expression. Oncogene. 1992 Aug;7(8):1587–94. PMID: 1630819.; White R, Fawell SE, Parker MG. Analysis of oestrogen receptor dimerisation using chimeric proteins. The Journal of Steroid Biochemistry and Molecular Biology. 1991;40(1-3):333–41. doi: 10.1016/0960-0760(91)90199-f.; Guérin M, Sheng ZM, Andrieu N, Riou G. Strong association between c-myb and oestrogen-receptor expression in human breast cancer. Oncogene. 1990 Jan;5(1):131–5. PMID: 2181374.; Berry M, Nunez AM, Chambon P. Estrogen-responsive element of the human pS2 gene is an imperfectly palindromic sequence. Proc. Natl. Acad. Sci. U.S.A. 1989 Feb;86(4):1218–22. doi: 10.1073/pnas.86.4.1218.; Kumar V, Chambon P. The estrogen receptor binds tightly to its responsive element as a ligand-induced homodimer. Cell. 1988 Oct 07;55(1):145–56. doi: 10.1016/0092-8674(88)90017-7. PMID: 3167974.; Dubik D, Shiu RP. Transcriptional regulation of c-myc oncogene expression by estrogen in hormone-responsive human breast cancer cells. Journal of Biological Chemistry. 1988 Sep;263(25):12705–8. doi: 10.1016/s0021-9258(18)37810-4.; Watson RJ. A transcriptional arrest mechanism involved in controlling constitutive levels of mouse c-myb mRNA. Oncogene. 1988 Mar;2(3):267–72. PMID: 3281094.; Dubik D, Dembinski TC, Shiu RP. Stimulation of c-myc oncogene expression associated with estrogen-induced proliferation of human breast cancer cells. Cancer Res. 1987 Dec 15;47(24 Pt 1):6517–21. PMID: 3677090.; Bender TP, Thompson CB, Kuehl WM. Differential expression of c-myb mRNA in murine B lymphomas by a block to transcription elongation. Science. 1987 Sep 18;237(4821):1473–6. doi: 10.1126/science.3498214. PMID: 3498214.; Joab I, Radanyi C, Renoir M, Buchou T, Catelli MG, Binart N, Mester J, Baulieu EE. Common non-hormone binding component in non-transformed chick oviduct receptors of four steroid hormones. Nature. 1984 Apr;308(5962):850–3. doi: 10.1038/308850a0. PMID: 6201744. |
| Visual phototransduction Accession ID: Reactome:R-MMU-2187338 |
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Korenbrot JI. Speed, sensitivity, and stability of the light response in rod and cone photoreceptors: Facts and models. Progress in Retinal and Eye Research. 2012 Sep;31(5):442–66. doi: 10.1016/j.preteyeres.2012.05.002.; von Lintig J. Metabolism of Carotenoids and Retinoids Related to Vision. Journal of Biological Chemistry. 2012 Jan;287(3):1627–34. doi: 10.1074/jbc.r111.303990.; Kefalov VJ. Rod and Cone Visual Pigments and Phototransduction through Pharmacological, Genetic, and Physiological Approaches. Journal of Biological Chemistry. 2012 Jan;287(3):1635–41. doi: 10.1074/jbc.r111.303008.; Wang J, Kefalov VJ. The Cone-specific visual cycle. Progress in Retinal and Eye Research. 2011 Mar;30(2):115–28. doi: 10.1016/j.preteyeres.2010.11.001.; D'Ambrosio DN, Clugston RD, Blaner WS. Vitamin A metabolism: an update. Nutrients. 2011 Jan;3(1):63–103. PMID: 21350678; PMCID: PMC3042718.; von Lintig J, Kiser PD, Golczak M, Palczewski K. The biochemical and structural basis for trans-to-cis isomerization of retinoids in the chemistry of vision. Trends in Biochemical Sciences. 2010 Jul;35(7):400–10. doi: 10.1016/j.tibs.2010.01.005.; Burns ME, Pugh EN. Lessons from photoreceptors: turning off g-protein signaling in living cells. Physiology (Bethesda). 2010 Apr;25(2):72–84. PMID: 20430952; PMCID: PMC2880230.; Blomhoff R, Blomhoff HK. Overview of retinoid metabolism and function. J Neurobiol. 2006 Jun;66(7):606–30. doi: 10.1002/neu.20242. PMID: 16688755.; Harrison EH. Mechanisms of digestion and absorption of dietary vitamin A. Annu Rev Nutr. 2005;25():87–103. doi: 10.1146/annurev.nutr.25.050304.092614. PMID: 16011460.; Wolf G. The visual cycle of the cone photoreceptors of the retina. Nutr Rev. 2004 Jul;62(7 Pt 1):283–6. doi: 10.1111/j.1753-4887.2004.tb00053.x. PMID: 15384919.; Harrison EH, Hussain MM. Mechanisms Involved in the Intestinal Digestion and Absorption of Dietary Vitamin A. The Journal of Nutrition. 2001 May;131(5):1405–8. doi: 10.1093/jn/131.5.1405.; Pugh EN, Lamb TD. Amplification and kinetics of the activation steps in phototransduction. Biochimica et Biophysica Acta (BBA) - Bioenergetics. 1993 Mar;1141(2-3):111–49. doi: 10.1016/0005-2728(93)90038-h. |
| RA biosynthesis pathway Accession ID: Reactome:R-MMU-5365859 |
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Das BC, Thapa P, Karki R, Das S, Mahapatra S, Liu T, Torregroza I, Wallace DP, Kambhampati S, Van Veldhuizen P, Verma A, Ray SK, Evans T. Retinoic acid signaling pathways in development and diseases. Bioorganic & Medicinal Chemistry. 2014 Jan;22(2):673–83. doi: 10.1016/j.bmc.2013.11.025.; Napoli JL. Physiological insights into all-trans-retinoic acid biosynthesis. Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids. 2012 Jan;1821(1):152–67. doi: 10.1016/j.bbalip.2011.05.004. |
| The retinoid cycle in cones (daylight vision) Accession ID: Reactome:R-RNO-2187335 |
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von Lintig J. Metabolism of Carotenoids and Retinoids Related to Vision. Journal of Biological Chemistry. 2012 Jan;287(3):1627–34. doi: 10.1074/jbc.r111.303990.; Kefalov VJ. Rod and Cone Visual Pigments and Phototransduction through Pharmacological, Genetic, and Physiological Approaches. Journal of Biological Chemistry. 2012 Jan;287(3):1635–41. doi: 10.1074/jbc.r111.303008.; Wang J, Kefalov VJ. The Cone-specific visual cycle. Progress in Retinal and Eye Research. 2011 Mar;30(2):115–28. doi: 10.1016/j.preteyeres.2010.11.001.; Wolf G. The visual cycle of the cone photoreceptors of the retina. Nutr Rev. 2004 Jul;62(7 Pt 1):283–6. doi: 10.1111/j.1753-4887.2004.tb00053.x. PMID: 15384919. |
| RA biosynthesis pathway Accession ID: Reactome:R-SPO-5365859 |
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Das BC, Thapa P, Karki R, Das S, Mahapatra S, Liu T, Torregroza I, Wallace DP, Kambhampati S, Van Veldhuizen P, Verma A, Ray SK, Evans T. Retinoic acid signaling pathways in development and diseases. Bioorganic & Medicinal Chemistry. 2014 Jan;22(2):673–83. doi: 10.1016/j.bmc.2013.11.025.; Napoli JL. Physiological insights into all-trans-retinoic acid biosynthesis. Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids. 2012 Jan;1821(1):152–67. doi: 10.1016/j.bbalip.2011.05.004. |
| Visual phototransduction Accession ID: Reactome:R-SSC-2187338 |
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Korenbrot JI. Speed, sensitivity, and stability of the light response in rod and cone photoreceptors: Facts and models. Progress in Retinal and Eye Research. 2012 Sep;31(5):442–66. doi: 10.1016/j.preteyeres.2012.05.002.; von Lintig J. Metabolism of Carotenoids and Retinoids Related to Vision. Journal of Biological Chemistry. 2012 Jan;287(3):1627–34. doi: 10.1074/jbc.r111.303990.; Kefalov VJ. Rod and Cone Visual Pigments and Phototransduction through Pharmacological, Genetic, and Physiological Approaches. Journal of Biological Chemistry. 2012 Jan;287(3):1635–41. doi: 10.1074/jbc.r111.303008.; Wang J, Kefalov VJ. The Cone-specific visual cycle. Progress in Retinal and Eye Research. 2011 Mar;30(2):115–28. doi: 10.1016/j.preteyeres.2010.11.001.; D'Ambrosio DN, Clugston RD, Blaner WS. Vitamin A metabolism: an update. Nutrients. 2011 Jan;3(1):63–103. PMID: 21350678; PMCID: PMC3042718.; von Lintig J, Kiser PD, Golczak M, Palczewski K. The biochemical and structural basis for trans-to-cis isomerization of retinoids in the chemistry of vision. Trends in Biochemical Sciences. 2010 Jul;35(7):400–10. doi: 10.1016/j.tibs.2010.01.005.; Burns ME, Pugh EN. Lessons from photoreceptors: turning off g-protein signaling in living cells. Physiology (Bethesda). 2010 Apr;25(2):72–84. PMID: 20430952; PMCID: PMC2880230.; Blomhoff R, Blomhoff HK. Overview of retinoid metabolism and function. J Neurobiol. 2006 Jun;66(7):606–30. doi: 10.1002/neu.20242. PMID: 16688755.; Harrison EH. Mechanisms of digestion and absorption of dietary vitamin A. Annu Rev Nutr. 2005;25():87–103. doi: 10.1146/annurev.nutr.25.050304.092614. PMID: 16011460.; Wolf G. The visual cycle of the cone photoreceptors of the retina. Nutr Rev. 2004 Jul;62(7 Pt 1):283–6. doi: 10.1111/j.1753-4887.2004.tb00053.x. PMID: 15384919.; Harrison EH, Hussain MM. Mechanisms Involved in the Intestinal Digestion and Absorption of Dietary Vitamin A. The Journal of Nutrition. 2001 May;131(5):1405–8. doi: 10.1093/jn/131.5.1405.; Pugh EN, Lamb TD. Amplification and kinetics of the activation steps in phototransduction. Biochimica et Biophysica Acta (BBA) - Bioenergetics. 1993 Mar;1141(2-3):111–49. doi: 10.1016/0005-2728(93)90038-h. |