Pathways Knowlegdes
Biological pathway database
| Pathway | DOIs | Note |
|---|---|---|
| Transport of small molecules Accession ID: Reactome:R-RNO-382551 |
- | |
| SLC-mediated transmembrane transport Accession ID: Reactome:R-RNO-425407 |
|
Schneider S. Inositol transport proteins. FEBS Lett. 2015 Apr 28;589(10):1049–58. doi: 10.1016/j.febslet.2015.03.012. PMID: 25819438.; Anderson CM, Stahl A. SLC27 fatty acid transport proteins. Molecular Aspects of Medicine. 2013 Apr;34(2-3):516–28. doi: 10.1016/j.mam.2012.07.010.; He L, Vasiliou K, Nebert DW. Analysis and update of the human solute carrier (SLC) gene superfamily. Hum Genomics. 2009 Jan;3(2):195–206. PMID: 19164095; PMCID: PMC2752037.; Morris ME, Felmlee MA. Overview of the Proton-coupled MCT (SLC16A) Family of Transporters: Characterization, Function and Role in the Transport of the Drug of Abuse ?-Hydroxybutyric Acid. The AAPS Journal. 2008 Jun 04;10(2):311. doi: 10.1208/s12248-008-9035-6.; Dorwart MR, Shcheynikov N, Yang D, Muallem S. The solute carrier 26 family of proteins in epithelial ion transport. Physiology (Bethesda). 2008 Apr;23():104–14. doi: 10.1152/physiol.00037.2007. PMID: 18400693.; Ashmore J. Cochlear outer hair cell motility. Physiol Rev. 2008 Jan;88(1):173–210. doi: 10.1152/physrev.00044.2006. PMID: 18195086.; Sindic A, Chang MH, Mount DB, Romero MF. Renal physiology of SLC26 anion exchangers. Curr Opin Nephrol Hypertens. 2007 Sep;16(5):484–90. doi: 10.1097/mnh.0b013e3282e7d7d0. PMID: 17693766.; Bressler JP, Olivi L, Cheong JH, Kim Y, Maerten A, Bannon D. Metal transporters in intestine and brain: their involvement in metal-associated neurotoxicities. Hum Exp Toxicol. 2007 Mar;26(3):221–9. doi: 10.1177/0960327107070573. PMID: 17439925.; Handford M, Rodriguez-Furlán C, Orellana A. Nucleotide-sugar transporters: structure, function and roles in vivo. Braz J Med Biol Res. 2006 Sep;39(9):1149–58. doi: 10.1590/s0100-879x2006000900002. PMID: 16981043.; Pajor AM. Molecular properties of the SLC13 family of dicarboxylate and sulfate transporters. Pflügers Archiv - European Journal of Physiology. 2005 Oct 07;451(5):597–605. doi: 10.1007/s00424-005-1487-2.; Traiffort E, Ruat M, O'Regan S, Meunier FM. Molecular characterization of the family of choline transporter-like proteins and their splice variants. Journal of Neurochemistry. 2005 Feb 04;92(5):1116–25. doi: 10.1111/j.1471-4159.2004.02962.x.; Koepsell H, Endou H. The SLC22 drug transporter family. Pflügers Archiv - European Journal of Physiology. 2003 Jul 19;447(5):666–76. doi: 10.1007/s00424-003-1089-9.; Hediger MA, Romero MF, Peng J, Rolfs A, Takanaga H, Bruford EA. The ABCs of solute carriers: physiological, pathological and therapeutic implications of human membrane transport proteins. Pflügers Archiv - European Journal of Physiology. 2003 Nov 18;447(5):465–8. doi: 10.1007/s00424-003-1192-y.; Hagenbuch B, Meier PJ. Organic anion transporting polypeptides of the OATP/ SLC21 family: phylogenetic classification as OATP/ SLCO superfamily, new nomenclature and molecular/functional properties. Pfl?gers Archiv European Journal of Physiology. 2004 Feb 01;447(5):653–65. doi: 10.1007/s00424-003-1168-y.; Chen N, Reith MEA, Quick MW. Synaptic uptake and beyond: the sodium- and chloride-dependent neurotransmitter transporter family SLC6. Pflügers Archiv - European Journal of Physiology. 2003 Apr 29;447(5):519–31. doi: 10.1007/s00424-003-1064-5.; Wood IS, Trayhurn P. Glucose transporters (GLUT and SGLT): expanded families of sugar transport proteins. Br J Nutr. 2003 Jan;89(1):3–9. doi: 10.1079/bjn2002763. PMID: 12568659.; Prasad PD, Wang H, Huang W, Fei YJ, Leibach FH, Devoe LD, Ganapathy V. Molecular and functional characterization of the intestinal Na+-dependent multivitamin transporter. Arch Biochem Biophys. 1999 Jun 01;366(1):95–106. doi: 10.1006/abbi.1999.1213. PMID: 10334869.; Kanamori A, Nakayama J, Fukuda MN, Stallcup WB, Sasaki K, Fukuda M, Hirabayashi Y. Expression cloning and characterization of a cDNA encoding a novel membrane protein required for the formation of O -acetylated ganglioside: A putative acetyl-CoA transporter. Proc. Natl. Acad. Sci. U.S.A. 1997 Apr;94(7):2897–902. doi: 10.1073/pnas.94.7.2897.; Olives B, Neau P, Bailly P, Hediger MA, Rousselet G, Cartron JP, Ripoche P. Cloning and functional expression of a urea transporter from human bone marrow cells. Journal of Biological Chemistry. 1994 Dec;269(50):31649–52. doi: 10.1016/s0021-9258(18)31744-7. |
| Organic anion transport by SLC22 transporters Accession ID: Reactome:R-SSC-561048 |
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Ahn S, Bhatnagar V. Update on the molecular physiology of organic anion transporters. Current Opinion in Nephrology and Hypertension. 2008 Sep;17(5):499–505. doi: 10.1097/mnh.0b013e32830b5d5d.; Rizwan AN, Burckhardt G. Organic Anion Transporters of the SLC22 Family: Biopharmaceutical, Physiological, and Pathological Roles. Pharmaceutical Research. 2007 Jan 24;24(3):450–70. doi: 10.1007/s11095-006-9181-4.; Koepsell H, Endou H. The SLC22 drug transporter family. Pflügers Archiv - European Journal of Physiology. 2003 Jul 19;447(5):666–76. doi: 10.1007/s00424-003-1089-9. |
| Class A/1 (Rhodopsin-like receptors) Accession ID: Reactome:R-SSC-373076 |
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Jacoby E, Bouhelal R, Gerspacher M, Seuwen K. The 7 TM G-protein-coupled receptor target family. ChemMedChem. 2006 Aug;1(8):761–82. doi: 10.1002/cmdc.200600134. PMID: 16902930.; Joost P, Methner A. Phylogenetic analysis of 277 human G-protein-coupled receptors as a tool for the prediction of orphan receptor ligands. Genome Biology. 2002 Oct 17;3(11):research0063.1. doi: 10.1186/gb-2002-3-11-research0063. |
| Hydroxycarboxylic acid-binding receptors Accession ID: Reactome:R-SSC-3296197 |
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Offermanns S, Colletti SL, Lovenberg TW, Semple G, Wise A, IJzerman AP. International Union of Basic and Clinical Pharmacology. LXXXII: Nomenclature and Classification of Hydroxy-carboxylic Acid Receptors (GPR81, GPR109A, and GPR109B). Pharmacol Rev. 2011 Jun;63(2):269–90. doi: 10.1124/pr.110.003301. PMID: 21454438. |
| Organic anion transport by SLC22 transporters Accession ID: Reactome:R-BTA-561048 |
|
Ahn S, Bhatnagar V. Update on the molecular physiology of organic anion transporters. Current Opinion in Nephrology and Hypertension. 2008 Sep;17(5):499–505. doi: 10.1097/mnh.0b013e32830b5d5d.; Rizwan AN, Burckhardt G. Organic Anion Transporters of the SLC22 Family: Biopharmaceutical, Physiological, and Pathological Roles. Pharmaceutical Research. 2007 Jan 24;24(3):450–70. doi: 10.1007/s11095-006-9181-4.; Koepsell H, Endou H. The SLC22 drug transporter family. Pflügers Archiv - European Journal of Physiology. 2003 Jul 19;447(5):666–76. doi: 10.1007/s00424-003-1089-9. |
| Signaling Pathways Accession ID: Reactome:R-BTA-162582 |
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Avraham R, Yarden Y. Feedback regulation of EGFR signalling: decision making by early and delayed loops. Nature Reviews Molecular Cell Biology. 2011 Jan 21;12(2):104–17. doi: 10.1038/nrm3048.; Citi S, Spadaro D, Schneider Y, Stutz J, Pulimeno P. Regulation of small GTPases at epithelial cell-cell junctions. Mol Membr Biol. 2011 Oct;28(7-8):427–44. doi: 10.3109/09687688.2011.603101. PMID: 21781017.; Ritter SL, Hall RA. Fine-tuning of GPCR activity by receptor-interacting proteins. Nature Reviews Molecular Cell Biology. 2009 Dec;10(12):819–30. doi: 10.1038/nrm2803.; Miyazono K, Kamiya Y, Morikawa M. Bone morphogenetic protein receptors and signal transduction. Journal of Biochemistry. 2009 Sep 17;147(1):35–51. doi: 10.1093/jb/mvp148.; Kang JS, Liu C, Derynck R. New regulatory mechanisms of TGF-beta receptor function. Trends Cell Biol. 2009 Aug;19(8):385–94. doi: 10.1016/j.tcb.2009.05.008. PMID: 19648010.; MacDonald BT, Tamai K, He X. Wnt/ß-Catenin Signaling: Components, Mechanisms, and Diseases. Developmental Cell. 2009 Jul;17(1):9–26. doi: 10.1016/j.devcel.2009.06.016.; Angers S, Moon RT. Proximal events in Wnt signal transduction. Nature Reviews Molecular Cell Biology. 2009 Jun 17;10(7):468–77. doi: 10.1038/nrm2717.; Rosenbaum DM, Rasmussen SG, Kobilka BK. The structure and function of G-protein-coupled receptors. Nature. 2009 May 21;459(7245):356–63. PMID: 19458711; PMCID: PMC3967846.; Kopan R, Ilagan MX. The canonical Notch signaling pathway: unfolding the activation mechanism. Cell. 2009 Apr 17;137(2):216–33. PMID: 19379690; PMCID: PMC2827930.; Andrae J, Gallini R, Betsholtz C. Role of platelet-derived growth factors in physiology and medicine. Genes Dev. 2008 May 15;22(10):1276–312. PMID: 18483217; PMCID: PMC2732412.; Oldham WM, Hamm HE. Heterotrimeric G protein activation by G-protein-coupled receptors. Nature Reviews Molecular Cell Biology. 2008 Jan;9(1):60–71. doi: 10.1038/nrm2299.; Manning BD, Cantley LC. AKT/PKB signaling: navigating downstream. Cell. 2007 Jun 29;129(7):1261–74. PMID: 17604717; PMCID: PMC2756685.; McKay MM, Morrison DK. Integrating signals from RTKs to ERK/MAPK. Oncogene. 2007 May 14;26(22):3113–21. doi: 10.1038/sj.onc.1210394. PMID: 17496910.; Hehlgans S, Haase M, Cordes N. Signalling via integrins: Implications for cell survival and anticancer strategies. Biochimica et Biophysica Acta (BBA) - Reviews on Cancer. 2007 Jan;1775(1):163–80. doi: 10.1016/j.bbcan.2006.09.001.; Reichardt LF. Neurotrophin-regulated signalling pathways. Philos Trans R Soc Lond B Biol Sci. 2006 Sep 29;361(1473):1545–64. PMID: 16939974; PMCID: PMC1664664.; Patterson RL, van Rossum DB, Nikolaidis N, Gill DL, Snyder SH. Phospholipase C-gamma: diverse roles in receptor-mediated calcium signaling. Trends Biochem Sci. 2005 Dec;30(12):688–97. doi: 10.1016/j.tibs.2005.10.005. PMID: 16260143.; Eswarakumar VP, Lax I, Schlessinger J. Cellular signaling by fibroblast growth factor receptors. Cytokine Growth Factor Rev. 2005 Apr;16(2):139–49. doi: 10.1016/j.cytogfr.2005.01.001. PMID: 15863030.; Wellbrock C, Karasarides M, Marais R. The RAF proteins take centre stage. Nature Reviews Molecular Cell Biology. 2004 Nov;5(11):875–85. doi: 10.1038/nrm1498.; Xie K, Wei D, Shi Q, Huang S. Constitutive and inducible expression and regulation of vascular endothelial growth factor. Cytokine Growth Factor Rev. 2004 Oct;15(5):297–324. doi: 10.1016/j.cytogfr.2004.04.003. PMID: 15450248.; Saltiel AR, Kahn CR. Insulin signalling and the regulation of glucose and lipid metabolism. Nature. 2001 Dec 13;414(6865):799–806. doi: 10.1038/414799a. PMID: 11742412. |
| Signaling by GPCR Accession ID: Reactome:R-BTA-372790 |
|
Oldham WM, Hamm HE. Heterotrimeric G protein activation by G-protein-coupled receptors. Nature Reviews Molecular Cell Biology. 2008 Jan;9(1):60–71. doi: 10.1038/nrm2299.; Jacoby E, Bouhelal R, Gerspacher M, Seuwen K. The 7 TM G-protein-coupled receptor target family. ChemMedChem. 2006 Aug;1(8):761–82. doi: 10.1002/cmdc.200600134. PMID: 16902930.; Bockaert J, Pin JP. Molecular tinkering of G protein-coupled receptors: an evolutionary success. EMBO J. 1999 Apr 01;18(7):1723–9. PMID: 10202136; PMCID: PMC1171258. |
| Pyruvate metabolism Accession ID: Reactome:R-CEL-70268 |
|
Prochownik EV, Wang H. The Metabolic Fates of Pyruvate in Normal and Neoplastic Cells. Cells. 2021 Mar 30;10(4). PMID: 33808495; PMCID: PMC8066905.; Reed LJ, Hackert ML. Structure-function relationships in dihydrolipoamide acyltransferases. Journal of Biological Chemistry. 1990 Jun;265(16):8971–4. doi: 10.1016/s0021-9258(19)38795-2.; Cori CF. The glucose-lactic acid cycle and gluconeogenesis. Curr Top Cell Regul. 1981;18():377–87. PMID: 7273846. |
| Transport of small molecules Accession ID: Reactome:R-CEL-382551 |
- | |
| SLC-mediated transmembrane transport Accession ID: Reactome:R-CEL-425407 |
|
Schneider S. Inositol transport proteins. FEBS Lett. 2015 Apr 28;589(10):1049–58. doi: 10.1016/j.febslet.2015.03.012. PMID: 25819438.; Anderson CM, Stahl A. SLC27 fatty acid transport proteins. Molecular Aspects of Medicine. 2013 Apr;34(2-3):516–28. doi: 10.1016/j.mam.2012.07.010.; He L, Vasiliou K, Nebert DW. Analysis and update of the human solute carrier (SLC) gene superfamily. Hum Genomics. 2009 Jan;3(2):195–206. PMID: 19164095; PMCID: PMC2752037.; Morris ME, Felmlee MA. Overview of the Proton-coupled MCT (SLC16A) Family of Transporters: Characterization, Function and Role in the Transport of the Drug of Abuse ?-Hydroxybutyric Acid. The AAPS Journal. 2008 Jun 04;10(2):311. doi: 10.1208/s12248-008-9035-6.; Dorwart MR, Shcheynikov N, Yang D, Muallem S. The solute carrier 26 family of proteins in epithelial ion transport. Physiology (Bethesda). 2008 Apr;23():104–14. doi: 10.1152/physiol.00037.2007. PMID: 18400693.; Ashmore J. Cochlear outer hair cell motility. Physiol Rev. 2008 Jan;88(1):173–210. doi: 10.1152/physrev.00044.2006. PMID: 18195086.; Sindic A, Chang MH, Mount DB, Romero MF. Renal physiology of SLC26 anion exchangers. Curr Opin Nephrol Hypertens. 2007 Sep;16(5):484–90. doi: 10.1097/mnh.0b013e3282e7d7d0. PMID: 17693766.; Bressler JP, Olivi L, Cheong JH, Kim Y, Maerten A, Bannon D. Metal transporters in intestine and brain: their involvement in metal-associated neurotoxicities. Hum Exp Toxicol. 2007 Mar;26(3):221–9. doi: 10.1177/0960327107070573. PMID: 17439925.; Handford M, Rodriguez-Furlán C, Orellana A. Nucleotide-sugar transporters: structure, function and roles in vivo. Braz J Med Biol Res. 2006 Sep;39(9):1149–58. doi: 10.1590/s0100-879x2006000900002. PMID: 16981043.; Pajor AM. Molecular properties of the SLC13 family of dicarboxylate and sulfate transporters. Pflügers Archiv - European Journal of Physiology. 2005 Oct 07;451(5):597–605. doi: 10.1007/s00424-005-1487-2.; Traiffort E, Ruat M, O'Regan S, Meunier FM. Molecular characterization of the family of choline transporter-like proteins and their splice variants. Journal of Neurochemistry. 2005 Feb 04;92(5):1116–25. doi: 10.1111/j.1471-4159.2004.02962.x.; Koepsell H, Endou H. The SLC22 drug transporter family. Pflügers Archiv - European Journal of Physiology. 2003 Jul 19;447(5):666–76. doi: 10.1007/s00424-003-1089-9.; Hediger MA, Romero MF, Peng J, Rolfs A, Takanaga H, Bruford EA. The ABCs of solute carriers: physiological, pathological and therapeutic implications of human membrane transport proteins. Pflügers Archiv - European Journal of Physiology. 2003 Nov 18;447(5):465–8. doi: 10.1007/s00424-003-1192-y.; Hagenbuch B, Meier PJ. Organic anion transporting polypeptides of the OATP/ SLC21 family: phylogenetic classification as OATP/ SLCO superfamily, new nomenclature and molecular/functional properties. Pfl?gers Archiv European Journal of Physiology. 2004 Feb 01;447(5):653–65. doi: 10.1007/s00424-003-1168-y.; Chen N, Reith MEA, Quick MW. Synaptic uptake and beyond: the sodium- and chloride-dependent neurotransmitter transporter family SLC6. Pflügers Archiv - European Journal of Physiology. 2003 Apr 29;447(5):519–31. doi: 10.1007/s00424-003-1064-5.; Wood IS, Trayhurn P. Glucose transporters (GLUT and SGLT): expanded families of sugar transport proteins. Br J Nutr. 2003 Jan;89(1):3–9. doi: 10.1079/bjn2002763. PMID: 12568659.; Prasad PD, Wang H, Huang W, Fei YJ, Leibach FH, Devoe LD, Ganapathy V. Molecular and functional characterization of the intestinal Na+-dependent multivitamin transporter. Arch Biochem Biophys. 1999 Jun 01;366(1):95–106. doi: 10.1006/abbi.1999.1213. PMID: 10334869.; Kanamori A, Nakayama J, Fukuda MN, Stallcup WB, Sasaki K, Fukuda M, Hirabayashi Y. Expression cloning and characterization of a cDNA encoding a novel membrane protein required for the formation of O -acetylated ganglioside: A putative acetyl-CoA transporter. Proc. Natl. Acad. Sci. U.S.A. 1997 Apr;94(7):2897–902. doi: 10.1073/pnas.94.7.2897.; Olives B, Neau P, Bailly P, Hediger MA, Rousselet G, Cartron JP, Ripoche P. Cloning and functional expression of a urea transporter from human bone marrow cells. Journal of Biological Chemistry. 1994 Dec;269(50):31649–52. doi: 10.1016/s0021-9258(18)31744-7. |
| Organic anion transport by SLC22 transporters Accession ID: Reactome:R-CFA-561048 |
|
Ahn S, Bhatnagar V. Update on the molecular physiology of organic anion transporters. Current Opinion in Nephrology and Hypertension. 2008 Sep;17(5):499–505. doi: 10.1097/mnh.0b013e32830b5d5d.; Rizwan AN, Burckhardt G. Organic Anion Transporters of the SLC22 Family: Biopharmaceutical, Physiological, and Pathological Roles. Pharmaceutical Research. 2007 Jan 24;24(3):450–70. doi: 10.1007/s11095-006-9181-4.; Koepsell H, Endou H. The SLC22 drug transporter family. Pflügers Archiv - European Journal of Physiology. 2003 Jul 19;447(5):666–76. doi: 10.1007/s00424-003-1089-9. |
| GPCR ligand binding Accession ID: Reactome:R-CFA-500792 |
|
Kristiansen K. Molecular mechanisms of ligand binding, signaling, and regulation within the superfamily of G-protein-coupled receptors: molecular modeling and mutagenesis approaches to receptor structure and function. Pharmacol Ther. 2004 Jul;103(1):21–80. doi: 10.1016/j.pharmthera.2004.05.002. PMID: 15251227.; Fredriksson R, Lagerström MC, Lundin LG, Schiöth HB. The G-protein-coupled receptors in the human genome form five main families. Phylogenetic analysis, paralogon groups, and fingerprints. Mol Pharmacol. 2003 Jun;63(6):1256–72. doi: 10.1124/mol.63.6.1256. PMID: 12761335.; Gether U, Asmar F, Meinild AK, Rasmussen SG. Structural basis for activation of G-protein-coupled receptors. Pharmacol Toxicol. 2002 Dec;91(6):304–12. doi: 10.1034/j.1600-0773.2002.910607.x. PMID: 12688373. |
| Signaling Pathways Accession ID: Reactome:R-DRE-162582 |
|
Avraham R, Yarden Y. Feedback regulation of EGFR signalling: decision making by early and delayed loops. Nature Reviews Molecular Cell Biology. 2011 Jan 21;12(2):104–17. doi: 10.1038/nrm3048.; Citi S, Spadaro D, Schneider Y, Stutz J, Pulimeno P. Regulation of small GTPases at epithelial cell-cell junctions. Mol Membr Biol. 2011 Oct;28(7-8):427–44. doi: 10.3109/09687688.2011.603101. PMID: 21781017.; Ritter SL, Hall RA. Fine-tuning of GPCR activity by receptor-interacting proteins. Nature Reviews Molecular Cell Biology. 2009 Dec;10(12):819–30. doi: 10.1038/nrm2803.; Miyazono K, Kamiya Y, Morikawa M. Bone morphogenetic protein receptors and signal transduction. Journal of Biochemistry. 2009 Sep 17;147(1):35–51. doi: 10.1093/jb/mvp148.; Kang JS, Liu C, Derynck R. New regulatory mechanisms of TGF-beta receptor function. Trends Cell Biol. 2009 Aug;19(8):385–94. doi: 10.1016/j.tcb.2009.05.008. PMID: 19648010.; MacDonald BT, Tamai K, He X. Wnt/ß-Catenin Signaling: Components, Mechanisms, and Diseases. Developmental Cell. 2009 Jul;17(1):9–26. doi: 10.1016/j.devcel.2009.06.016.; Angers S, Moon RT. Proximal events in Wnt signal transduction. Nature Reviews Molecular Cell Biology. 2009 Jun 17;10(7):468–77. doi: 10.1038/nrm2717.; Rosenbaum DM, Rasmussen SG, Kobilka BK. The structure and function of G-protein-coupled receptors. Nature. 2009 May 21;459(7245):356–63. PMID: 19458711; PMCID: PMC3967846.; Kopan R, Ilagan MX. The canonical Notch signaling pathway: unfolding the activation mechanism. Cell. 2009 Apr 17;137(2):216–33. PMID: 19379690; PMCID: PMC2827930.; Andrae J, Gallini R, Betsholtz C. Role of platelet-derived growth factors in physiology and medicine. Genes Dev. 2008 May 15;22(10):1276–312. PMID: 18483217; PMCID: PMC2732412.; Oldham WM, Hamm HE. Heterotrimeric G protein activation by G-protein-coupled receptors. Nature Reviews Molecular Cell Biology. 2008 Jan;9(1):60–71. doi: 10.1038/nrm2299.; Manning BD, Cantley LC. AKT/PKB signaling: navigating downstream. Cell. 2007 Jun 29;129(7):1261–74. PMID: 17604717; PMCID: PMC2756685.; McKay MM, Morrison DK. Integrating signals from RTKs to ERK/MAPK. Oncogene. 2007 May 14;26(22):3113–21. doi: 10.1038/sj.onc.1210394. PMID: 17496910.; Hehlgans S, Haase M, Cordes N. Signalling via integrins: Implications for cell survival and anticancer strategies. Biochimica et Biophysica Acta (BBA) - Reviews on Cancer. 2007 Jan;1775(1):163–80. doi: 10.1016/j.bbcan.2006.09.001.; Reichardt LF. Neurotrophin-regulated signalling pathways. Philos Trans R Soc Lond B Biol Sci. 2006 Sep 29;361(1473):1545–64. PMID: 16939974; PMCID: PMC1664664.; Patterson RL, van Rossum DB, Nikolaidis N, Gill DL, Snyder SH. Phospholipase C-gamma: diverse roles in receptor-mediated calcium signaling. Trends Biochem Sci. 2005 Dec;30(12):688–97. doi: 10.1016/j.tibs.2005.10.005. PMID: 16260143.; Eswarakumar VP, Lax I, Schlessinger J. Cellular signaling by fibroblast growth factor receptors. Cytokine Growth Factor Rev. 2005 Apr;16(2):139–49. doi: 10.1016/j.cytogfr.2005.01.001. PMID: 15863030.; Wellbrock C, Karasarides M, Marais R. The RAF proteins take centre stage. Nature Reviews Molecular Cell Biology. 2004 Nov;5(11):875–85. doi: 10.1038/nrm1498.; Xie K, Wei D, Shi Q, Huang S. Constitutive and inducible expression and regulation of vascular endothelial growth factor. Cytokine Growth Factor Rev. 2004 Oct;15(5):297–324. doi: 10.1016/j.cytogfr.2004.04.003. PMID: 15450248.; Saltiel AR, Kahn CR. Insulin signalling and the regulation of glucose and lipid metabolism. Nature. 2001 Dec 13;414(6865):799–806. doi: 10.1038/414799a. PMID: 11742412. |
| Pyruvate metabolism Accession ID: Reactome:R-DRE-70268 |
|
Prochownik EV, Wang H. The Metabolic Fates of Pyruvate in Normal and Neoplastic Cells. Cells. 2021 Mar 30;10(4). PMID: 33808495; PMCID: PMC8066905.; Reed LJ, Hackert ML. Structure-function relationships in dihydrolipoamide acyltransferases. Journal of Biological Chemistry. 1990 Jun;265(16):8971–4. doi: 10.1016/s0021-9258(19)38795-2.; Cori CF. The glucose-lactic acid cycle and gluconeogenesis. Curr Top Cell Regul. 1981;18():377–87. PMID: 7273846. |
| Transport of small molecules Accession ID: Reactome:R-DME-382551 |
- | |
| SLC-mediated transmembrane transport Accession ID: Reactome:R-DME-425407 |
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Schneider S. Inositol transport proteins. FEBS Lett. 2015 Apr 28;589(10):1049–58. doi: 10.1016/j.febslet.2015.03.012. PMID: 25819438.; Anderson CM, Stahl A. SLC27 fatty acid transport proteins. Molecular Aspects of Medicine. 2013 Apr;34(2-3):516–28. doi: 10.1016/j.mam.2012.07.010.; He L, Vasiliou K, Nebert DW. Analysis and update of the human solute carrier (SLC) gene superfamily. Hum Genomics. 2009 Jan;3(2):195–206. PMID: 19164095; PMCID: PMC2752037.; Morris ME, Felmlee MA. Overview of the Proton-coupled MCT (SLC16A) Family of Transporters: Characterization, Function and Role in the Transport of the Drug of Abuse ?-Hydroxybutyric Acid. The AAPS Journal. 2008 Jun 04;10(2):311. doi: 10.1208/s12248-008-9035-6.; Dorwart MR, Shcheynikov N, Yang D, Muallem S. The solute carrier 26 family of proteins in epithelial ion transport. Physiology (Bethesda). 2008 Apr;23():104–14. doi: 10.1152/physiol.00037.2007. PMID: 18400693.; Ashmore J. Cochlear outer hair cell motility. Physiol Rev. 2008 Jan;88(1):173–210. doi: 10.1152/physrev.00044.2006. PMID: 18195086.; Sindic A, Chang MH, Mount DB, Romero MF. Renal physiology of SLC26 anion exchangers. Curr Opin Nephrol Hypertens. 2007 Sep;16(5):484–90. doi: 10.1097/mnh.0b013e3282e7d7d0. PMID: 17693766.; Bressler JP, Olivi L, Cheong JH, Kim Y, Maerten A, Bannon D. Metal transporters in intestine and brain: their involvement in metal-associated neurotoxicities. Hum Exp Toxicol. 2007 Mar;26(3):221–9. doi: 10.1177/0960327107070573. PMID: 17439925.; Handford M, Rodriguez-Furlán C, Orellana A. Nucleotide-sugar transporters: structure, function and roles in vivo. Braz J Med Biol Res. 2006 Sep;39(9):1149–58. doi: 10.1590/s0100-879x2006000900002. PMID: 16981043.; Pajor AM. Molecular properties of the SLC13 family of dicarboxylate and sulfate transporters. Pflügers Archiv - European Journal of Physiology. 2005 Oct 07;451(5):597–605. doi: 10.1007/s00424-005-1487-2.; Traiffort E, Ruat M, O'Regan S, Meunier FM. Molecular characterization of the family of choline transporter-like proteins and their splice variants. Journal of Neurochemistry. 2005 Feb 04;92(5):1116–25. doi: 10.1111/j.1471-4159.2004.02962.x.; Koepsell H, Endou H. The SLC22 drug transporter family. Pflügers Archiv - European Journal of Physiology. 2003 Jul 19;447(5):666–76. doi: 10.1007/s00424-003-1089-9.; Hediger MA, Romero MF, Peng J, Rolfs A, Takanaga H, Bruford EA. The ABCs of solute carriers: physiological, pathological and therapeutic implications of human membrane transport proteins. Pflügers Archiv - European Journal of Physiology. 2003 Nov 18;447(5):465–8. doi: 10.1007/s00424-003-1192-y.; Hagenbuch B, Meier PJ. Organic anion transporting polypeptides of the OATP/ SLC21 family: phylogenetic classification as OATP/ SLCO superfamily, new nomenclature and molecular/functional properties. Pfl?gers Archiv European Journal of Physiology. 2004 Feb 01;447(5):653–65. doi: 10.1007/s00424-003-1168-y.; Chen N, Reith MEA, Quick MW. Synaptic uptake and beyond: the sodium- and chloride-dependent neurotransmitter transporter family SLC6. Pflügers Archiv - European Journal of Physiology. 2003 Apr 29;447(5):519–31. doi: 10.1007/s00424-003-1064-5.; Wood IS, Trayhurn P. Glucose transporters (GLUT and SGLT): expanded families of sugar transport proteins. Br J Nutr. 2003 Jan;89(1):3–9. doi: 10.1079/bjn2002763. PMID: 12568659.; Prasad PD, Wang H, Huang W, Fei YJ, Leibach FH, Devoe LD, Ganapathy V. Molecular and functional characterization of the intestinal Na+-dependent multivitamin transporter. Arch Biochem Biophys. 1999 Jun 01;366(1):95–106. doi: 10.1006/abbi.1999.1213. PMID: 10334869.; Kanamori A, Nakayama J, Fukuda MN, Stallcup WB, Sasaki K, Fukuda M, Hirabayashi Y. Expression cloning and characterization of a cDNA encoding a novel membrane protein required for the formation of O -acetylated ganglioside: A putative acetyl-CoA transporter. Proc. Natl. Acad. Sci. U.S.A. 1997 Apr;94(7):2897–902. doi: 10.1073/pnas.94.7.2897.; Olives B, Neau P, Bailly P, Hediger MA, Rousselet G, Cartron JP, Ripoche P. Cloning and functional expression of a urea transporter from human bone marrow cells. Journal of Biological Chemistry. 1994 Dec;269(50):31649–52. doi: 10.1016/s0021-9258(18)31744-7. |
| Organic anion transport by SLC22 transporters Accession ID: Reactome:R-DME-561048 |
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Ahn S, Bhatnagar V. Update on the molecular physiology of organic anion transporters. Current Opinion in Nephrology and Hypertension. 2008 Sep;17(5):499–505. doi: 10.1097/mnh.0b013e32830b5d5d.; Rizwan AN, Burckhardt G. Organic Anion Transporters of the SLC22 Family: Biopharmaceutical, Physiological, and Pathological Roles. Pharmaceutical Research. 2007 Jan 24;24(3):450–70. doi: 10.1007/s11095-006-9181-4.; Koepsell H, Endou H. The SLC22 drug transporter family. Pflügers Archiv - European Journal of Physiology. 2003 Jul 19;447(5):666–76. doi: 10.1007/s00424-003-1089-9. |
| Metabolism Accession ID: Reactome:R-DME-1430728 |
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| Aerobic respiration and respiratory electron transport Accession ID: Reactome:R-GGA-1428517 |
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