1,4-dihydroxy-6-naphthoate biosynthesis II
Mahanta N, Fedoseyenko D, Dairi T, Begley TP. Menaquinone biosynthesis: formation of aminofutalosine requires a unique radical SAM enzyme. J Am Chem Soc. 2013 Oct 16;135(41):15318–21. PMID: 24083939; PMCID: PMC3855536.; Li X, Apel D, Gaynor EC, Tanner ME. 5'-Methylthioadenosine Nucleosidase Is Implicated in Playing a Key Role in a Modified Futalosine Pathway for Menaquinone Biosynthesis in Campylobacter jejuni. Journal of Biological Chemistry. 2011 Jun;286(22):19392–8. doi: 10.1074/jbc.m111.229781.; HIRATSUKA T, ITOH N, SETO H, DAIRI T. Enzymatic Properties of Futalosine Hydrolase, an Enzyme Essential to a Newly Identified Menaquinone Biosynthetic Pathway. Bioscience, Biotechnology, and Biochemistry. 2009 May 23;73(5):1137–41. doi: 10.1271/bbb.80906.; Hiratsuka T, Furihata K, Ishikawa J, Yamashita H, Itoh N, Seto H, Dairi T. An alternative menaquinone biosynthetic pathway operating in microorganisms. Science. 2008 Sep 19;321(5896):1670–3. doi: 10.1126/science.1160446. PMID: 18801996.
Metabolites
Enzyme
| EC Number | name | full name | note |
|---|---|---|---|
| 1.21.98.1 | cyclic dehypoxanthinyl futalosine synthase | dehypoxanthine futalosine:S-adenosyl-L-methionine oxidoreductase (cyclizing) | |
| 3.2.2.30 | aminodeoxyfutalosine nucleosidase | 6-amino-6-deoxyfutalosine ribohydrolase | |
| 3.2.2.9 | adenosylhomocysteine nucleosidase | S-adenosyl-L-homocysteine homocysteinylribohydrolase |
Pathway Source
| Organism | Taxonomy Group | Enzyme List | Source Ratio |
|---|---|---|---|
| Helicobacter pylori J99 | MAGs | 3.2.2.30 / 3.2.2.9 | 66.67% |
| Helicobacter pylori 26695 | MAGs | 3.2.2.30 / 3.2.2.9 | 66.67% |
| Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 | MAGs | 3.2.2.30 / 3.2.2.9 | 66.67% |
| Thermus thermophilus HB27 | MAGs | 1.21.98.1 / 3.2.2.9 | 66.67% |
| Streptomyces albogriseolus | bacteria | 1.21.98.1 / 3.2.2.9 | 66.67% |
| Halalkalibacterium halodurans C-125 | MAGs | 1.21.98.1 / 3.2.2.9 | 66.67% |
| Campylobacter lari RM2100 | MAGs | 1.21.98.1 / 3.2.2.9 | 66.67% |
| Shewanella sp. MR-4 | bacteria | 3.2.2.9 | 33.33% |
| Mycobacterium tuberculosis CDC1551 | MAGs | 3.2.2.9 | 33.33% |
| Haemophilus influenzae Rd KW20 | MAGs | 3.2.2.9 | 33.33% |
| Shouchella clausii KSM-K16 | MAGs | 3.2.2.9 | 33.33% |
| Paraburkholderia graminis | bacteria | 3.2.2.9 | 33.33% |
| Shewanella sp. MR-7 | MAGs | 3.2.2.9 | 33.33% |
| Vibrio campbellii ATCC BAA-1116 | MAGs | 3.2.2.9 | 33.33% |
| Aeromonas salmonicida subsp. salmonicida | MAGs | 3.2.2.9 | 33.33% |
| Oryza sativa | plant | 3.2.2.9 | 33.33% |
| Streptomyces halstedii | bacteria | 1.21.98.1 | 33.33% |
| Bacillus anthracis | bacteria | 3.2.2.9 | 33.33% |
| Aliivibrio fischeri | bacteria | 3.2.2.9 | 33.33% |
| Yersinia pestis | bacteria | 3.2.2.9 | 33.33% |