autoinducer AI-2 biosynthesis I

Schauder S, Shokat K, Surette MG, Bassler BL. The LuxS family of bacterial autoinducers: biosynthesis of a novel quorum-sensing signal molecule. Mol Microbiol. 2001 Jul;41(2):463–76. doi: 10.1046/j.1365-2958.2001.02532.x. PMID: 11489131.

Metabolites

(S)-4,5-Dihydroxypentane-2,3-dione

Formula: C5H8O4 (132.0422568)

CAS ID: 710324-30-4

Adenine

Formula: C5H5N5 (135.054493)

CAS ID: 73-24-5

H+

Formula: H (1.0078246)

CAS ID: 12408-02-5

H2O

Formula: H2O (18.0105642)

CAS ID: 7732-18-5

R-THMF

Formula: C5H10O5 (150.052821)

CAS ID: 791810-94-1

5'-ethylthioadenosine

Formula: C12H17N5O3S (311.1052052)

CAS ID:

5'-Methylthioformycin

Formula: C11H15N5O3S (297.089556)

CAS ID: 91255-90-2

5'-Deoxy-5'-(methylthio)-tubercidin

Formula: C12H16N4O3S (296.0943066)

CAS ID: 61893-98-9

5'-S-Propyl-5'-thioadenosine

Formula: C13H19N5O3S (325.1208544)

CAS ID: 5135-33-1



Enzyme

EC Number name full name note
3.2.2.9 adenosylhomocysteine nucleosidase S-adenosyl-L-homocysteine homocysteinylribohydrolase
4.4.1.21 S-ribosylhomocysteine lyase S-(5-deoxy-D-ribos-5-yl)-L-homocysteine L-homocysteine-lyase [(4S)-4,5-dihydroxypentan-2,3-dione-forming]


Pathway Source

Organism Taxonomy Group Enzyme List Source Ratio
Salmonella enterica subsp. enterica serovar Typhimurium str. LT2 MAGs 3.2.2.9 / 4.4.1.21 100.00%
Escherichia coli K-12 MAGs 3.2.2.9 / 4.4.1.21 100.00%
Escherichia coli O157:H7 MAGs 3.2.2.9 / 4.4.1.21 100.00%
Haemophilus influenzae Rd KW20 MAGs 3.2.2.9 / 4.4.1.21 100.00%
Shouchella clausii KSM-K16 MAGs 3.2.2.9 / 4.4.1.21 100.00%
Salmonella enterica subsp. enterica serovar Typhi MAGs 3.2.2.9 / 4.4.1.21 100.00%
Shewanella sp. MR-7 MAGs 3.2.2.9 / 4.4.1.21 100.00%
Shewanella sp. MR-4 bacteria 3.2.2.9 / 4.4.1.21 100.00%
Salmonella enterica subsp. arizonae serovar 62:z4,z23:- MAGs 3.2.2.9 / 4.4.1.21 100.00%
Aeromonas salmonicida subsp. salmonicida MAGs 3.2.2.9 / 4.4.1.21 100.00%
Staphylococcus aureus subsp. aureus NCTC 8325 MAGs 3.2.2.9 / 4.4.1.21 100.00%
Helicobacter pylori J99 MAGs 3.2.2.9 / 4.4.1.21 100.00%
Helicobacter pylori 26695 MAGs 3.2.2.9 / 4.4.1.21 100.00%
Bacillus anthracis bacteria 3.2.2.9 / 4.4.1.21 100.00%
Staphylococcus aureus subsp. aureus COL MAGs 3.2.2.9 / 4.4.1.21 100.00%
Shewanella sp. ANA-3 bacteria 3.2.2.9 / 4.4.1.21 100.00%
Neisseria meningitidis MC58 MAGs 3.2.2.9 / 4.4.1.21 100.00%
Yersinia pestis bacteria 3.2.2.9 / 4.4.1.21 100.00%
Shigella flexneri bacteria 3.2.2.9 / 4.4.1.21 100.00%
Vibrio campbellii ATCC BAA-1116 MAGs 3.2.2.9 / 4.4.1.21 100.00%