secologanin and strictosidine biosynthesis
Miettinen K, Dong L, Navrot N, Schneider T, Burlat V, Pollier J, Woittiez L, van der Krol S, Lugan R, Ilc T, Verpoorte R, Oksman-Caldentey K, Martinoia E, Bouwmeester H, Goossens A, Memelink J, Werck-Reichhart D. Erratum: Corrigendum: The seco-iridoid pathway from Catharanthus roseus. Nature Communications. 2014 Jun 24;5(1):4175. doi: 10.1038/ncomms5175.; Geu-Flores F, Sherden NH, Courdavault V, Burlat V, Glenn WS, Wu C, Nims E, Cui Y, O’Connor SE. An alternative route to cyclic terpenes by reductive cyclization in iridoid biosynthesis. Nature. 2012 Nov 21;492(7427):138–42. doi: 10.1038/nature11692.
Metabolites
Enzyme
| EC Number | name | full name | note |
|---|---|---|---|
| 1.14.14.83 | geraniol 8-hydroxylase | geraniol,[reduced NADPH-hemoprotein reductase]:oxygen oxidoreductase (8-hydroxylating) | |
| 1.14.14.85 | 7-deoxyloganate 7-hydroxylase | 7-deoxyloganate,[reduced NADPH-hemoprotein reductase]:oxygen oxidoreductase (7alpha-hydroxylating) | |
| 1.3.1.122 | (S)-8-oxocitronellyl enol synthase | (S)-8-oxocitronellyl enol:NAD(P)+ oxidoreductase | |
| 2.1.1.50 | loganate O-methyltransferase | S-adenosyl-L-methionine:loganate 11-O-methyltransferase | |
| 2.4.1.323 | 7-deoxyloganetic acid glucosyltransferase | UDP-alpha-D-glucose:7-deoxyloganetate O-D-glucosyltransferase | |
| 3.5.99.13 | strictosidine synthase | 3-alpha(S)-strictosidine tryptamine-hydrolase (secologanin-forming) | |
| 4.1.1.105 | L-tryptophan decarboxylase | L-tryptophan carboxy-lyase | |
| 4.1.1.28 | aromatic-L-amino-acid decarboxylase | Aromatic-L-amino-acid carboxy-lyase |
Pathway Source
| Organism | Taxonomy Group | Enzyme List | Source Ratio |
|---|---|---|---|
| Pseudomonas putida KT2440 | MAGs | 4.1.1.28 | 12.50% |
| Citrus x changshan-huyou | MAGs | 2.4.1.323 | 12.50% |
| Mediterraneibacter gnavus ATCC 29149 | MAGs | 4.1.1.105 | 12.50% |
| Saccharopolyspora erythraea NRRL 2338 | MAGs | 4.1.1.28 | 12.50% |
| Pseudomonas entomophila L48 | MAGs | 4.1.1.28 | 12.50% |
| Teredinibacter turnerae T7901 | MAGs | 4.1.1.28 | 12.50% |
| Aspergillus fumigatus Af293 | MAGs | 4.1.1.28 | 12.50% |
| Chloroflexus aggregans DSM 9485 | MAGs | 4.1.1.28 | 12.50% |
| Sinorhizobium meliloti 1021 | MAGs | 4.1.1.28 | 12.50% |
| Coccidioides posadasii C735 delta SOWgp | MAGs | 4.1.1.28 | 12.50% |
| Psilocybe cubensis | fungi | 4.1.1.105 | 12.50% |
| Bacillus atrophaeus | bacteria | 4.1.1.28 | 12.50% |
| Diaphorina citri | invertebrate | 4.1.1.28 | 12.50% |
| Psilocybe cyanescens | MAGs | 4.1.1.105 | 12.50% |
| Citrus unshiu | MAGs | 2.4.1.323 | 12.50% |
| Oryza sativa Japonica Group | MAGs | 4.1.1.28 | 12.50% |
| Penicillium expansum | fungi | 4.1.1.105 | 12.50% |
| Rattus norvegicus | vertebrate_mammalian | 4.1.1.28 | 12.50% |
| Mus musculus | vertebrate_mammalian | 4.1.1.28 | 12.50% |
| Homo sapiens | vertebrate_mammalian | 4.1.1.28 | 12.50% |