EC: 4.1.1.28

aromatic-L-amino-acid decarboxylase (Aromatic-L-amino-acid carboxy-lyase)

enzyme lambda metabolic reaction experiment
uniprot:C0LIF1 [aromatic-L-amino-acid decarboxylase(Enzyme) wildtype His-tagged]

L_Tryptophan -> CO2 + Tryptamine		 (( (Vmax * S) ) / (Km + S)) buffer: 10 mM TrisHCl, 0.1 mM pyridoxal-5'-phosphate
PH: 7.5
Temperature: 37
uniprot:P20711 [Pyridoxal phosphate]

L_Dopa -> Dopamine + CO2		 (( (( (E * kcat) ) * S) ) / (Km + S)) buffer: 100 mM potassium phosphate
PH: 7.4
Temperature: 25
uniprot:P20711 [Pyridoxal phosphate]

L_Dopa -> CO2 + Dopamine		 (( (( (E * kcat) ) * S) ) / (Km + S)) buffer: 100 mM potassium phosphate
PH: 7.4
Temperature: 25
uniprot:P20711 [Pyridoxal phosphate]

L_Dopa -> Dopamine + CO2		 (( (( (E * kcat) ) * S) ) / (Km + S)) buffer: 100 mM potassium phosphate
PH: 7.4
Temperature: 25
uniprot:P20711 [Pyridoxal phosphate]

L_Dopa -> Dopamine + CO2		 (( (( (E * kcat) ) * S) ) / (Km + S)) buffer: 100 mM potassium phosphate
PH: 7.4
Temperature: 25
uniprot:P20711 [Pyridoxal phosphate]

L_Dopa -> CO2 + Dopamine		 (( (( (E * kcat) ) * S) ) / (Km + S)) buffer: 100 mM potassium phosphate
PH: 7.4
Temperature: 25
uniprot:P80041 [Pyridoxal phosphate]

5_Hydroxy_L_tryptophan -> Serotonin + CO2		 (( (( (kcat * E) ) * S) ) / (Km + S)) buffer: 50 mM Hepes
PH: 7.5
Temperature: 25
uniprot:P80041 [Pyridoxal phosphate]

L_Dopa -> Dopamine + CO2		 (( (( (kcat * E) ) * S) ) / (Km + S)) buffer: 50 mM Hepes
PH: 7.5
Temperature: 25
uniprot:P80041 [Pyridoxal phosphate]

L_Dopa -> Dopamine + CO2		 (( (( (kcat * E) ) * S) ) / (Km + S)) buffer: 50 mM Hepes
PH: 7.5
Temperature: 25
uniprot:P80041 [Pyridoxal phosphate]

5_Hydroxy_L_tryptophan -> CO2 + Serotonin		 (( (( (kcat * E) ) * S) ) / (Km + S)) buffer: 50 mM Hepes
PH: 7.5
Temperature: 25
uniprot:P20711 [Pyridoxal phosphate]

L_Dopa -> CO2 + Dopamine		 (( (Vmax * S) ) / (Km + S)) buffer: 100 mM potassium phosphate
PH: 7.4
Temperature: 36
uniprot:I0DFJ0 [Pyridoxal phosphate]

L_Tryptophan -> Tryptamine + CO2		 (( (( (E * kcat) ) * S) ) / (Km + S)) buffer: 50 mM potassium phosphate
PH: 7
Temperature: 37
uniprot:I0DFJ0 [Pyridoxal phosphate]

L_Phenylalanine -> CO2 + 2_Phenylethylamine		 (( (( (E * kcat) ) * S) ) / (Km + S)) buffer: 50 mM potassium phosphate
PH: 7
Temperature: 55
uniprot:I0DFJ0 [Pyridoxal phosphate]

L_Phenylalanine -> CO2 + 2_Phenylethylamine		 (( (( (E * kcat) ) * S) ) / (Km + S)) buffer: 50 mM potassium phosphate
PH: 7
Temperature: 45
uniprot:I0DFJ0 [Pyridoxal phosphate]

L_Phenylalanine -> CO2 + 2_Phenylethylamine		 (( (( (E * kcat) ) * S) ) / (Km + S)) buffer: 50 mM potassium phosphate
PH: 7
Temperature: 37
uniprot:I0DFJ0 [Pyridoxal phosphate]

L_Phenylalanine -> CO2 + 2_Phenylethylamine		 (( (( (E * kcat) ) * S) ) / (Km + S)) buffer: 50 mM potassium phosphate
PH: 7
Temperature: 30

Pathways

pathway id name
BioCyc:HUMAN_PWY-6307 tryptophan degradation via tryptamine
BioCyc:HUMAN_PWY66-401 superpathway of tryptophan utilization
BioCyc:META_PWY-5290 secologanin and strictosidine biosynthesis
BioCyc:META_PWY-6307 L-tryptophan degradation X (mammalian, via tryptamine)
BioCyc:META_PWY-3181 L-tryptophan degradation VI (via tryptamine)
BioCyc:META_PWY66-301 catecholamine biosynthesis
BioCyc:MOUSE_PWY3DJ-5 biosynthesis of serotonin and melatonin
BioCyc:MOUSE_PWY66-301 catecholamine biosynthesis
BioCyc:HUMAN_PWY66-301 catecholamine biosynthesis
BioCyc:HUMAN_PWY-6030 serotonin and melatonin biosynthesis
BioCyc:META_PWY-6030 serotonin and melatonin biosynthesis
BioCyc:META_PWY-6318 L-phenylalanine degradation IV (mammalian, via side chain)
BioCyc:MOUSE_PWY-6030 serotonin and melatonin biosynthesis
PlantCyc:CROSEUS_PWY-5290 secologanin and strictosidine biosynthesis
PlantCyc:PLANT_PWY-5290 secologanin and strictosidine biosynthesis
PlantCyc:CROSEUS_PWY-3181 L-tryptophan degradation VI (via tryptamine)
PlantCyc:PLANT_PWY-3181 L-tryptophan degradation VI (via tryptamine)
PlantCyc:CROSEUS_PWY-8475 serotonin and melatonin biosynthesis II
Reactome:R-DME-209776 Metabolism of amine-derived hormones
Reactome:R-HSA-209905 Catecholamine biosynthesis
Reactome:R-MMU-1430728 Metabolism
Reactome:R-MMU-209905 Catecholamine biosynthesis
Reactome:R-RNO-209905 Catecholamine biosynthesis
Reactome:R-DME-1430728 Metabolism
Reactome:R-DME-71291 Amino acid and derivative metabolism
Reactome:R-DME-209931 Serotonin and melatonin biosynthesis
Reactome:R-HSA-209776 Metabolism of amine-derived hormones
Reactome:R-HSA-209931 Serotonin and melatonin biosynthesis
Reactome:R-MMU-209776 Metabolism of amine-derived hormones
Reactome:R-MMU-209931 Serotonin and melatonin biosynthesis
Reactome:R-RNO-209776 Metabolism of amine-derived hormones
Reactome:R-RNO-209931 Serotonin and melatonin biosynthesis
Reactome:R-DME-209905 Catecholamine biosynthesis
Reactome:R-HSA-71291 Amino acid and derivative metabolism
Reactome:R-MMU-71291 Amino acid and derivative metabolism
Reactome:R-RNO-1430728 Metabolism
Reactome:R-RNO-71291 Amino acid and derivative metabolism
Reactome:R-HSA-1430728 Metabolism
WikiPathways:WP4220 Neurotransmitter disorders
WikiPathways:WP5376 17p13.3 (YWHAE) copy number variation
PathBank:SMP0000190 Hawkinsinuria
PathBank:SMP0000169 Alkaptonuria
PathBank:SMP0000429 Disulfiram Action Pathway
PathBank:SMP0000063 Tryptophan Metabolism
PathBank:SMP0000218 Tyrosinemia Type I
PathBank:SMP0000497 Tyrosine Hydroxylase Deficiency
PathBank:SMP0000533 Monoamine Oxidase-A Deficiency (MAO-A)
PathBank:SMP0000006 Tyrosine Metabolism
PathBank:SMP0000012 Catecholamine Biosynthesis
PathBank:SMP0000170 Aromatic L-Aminoacid Decarboxylase Deficiency
PathBank:SMP0000494 Tyrosinemia, Transient, of the Newborn
PathBank:SMP0000498 Dopamine beta-Hydroxylase Deficiency