chanoclavine I aldehyde biosynthesis

Unsöld IA, Li SM. Overproduction, purification and characterization of FgaPT2, a dimethylallyltryptophan synthase from Aspergillus fumigatus. Microbiology (Reading). 2005 May;151(Pt 5):1499–505. doi: 10.1099/mic.0.27759-0. PMID: 15870460.

Metabolites

CO2

Formula: CO2 (43.98983)

CAS ID: 124-38-9

Diphosphate

Formula: H4P2O7 (177.9432294)

CAS ID: 2466-09-3

H+

Formula: H (1.0078246)

CAS ID: 12408-02-5

H2O

Formula: H2O (18.0105642)

CAS ID: 7732-18-5

Magnesium cation

Formula: Mg (23.98505)

CAS ID: 22537-22-0

NADH(2-)

Formula: C21H27N7O14P2 (663.1091182000001)

CAS ID:

NAD(1-)

Formula: C21H26N7O14P2 (662.1012936000001)

CAS ID: 53-84-9

chanoclavine-I(1+)

Formula: C16H21N2O (257.1653796)

CAS ID:



Enzyme

EC Number name full name note
1.-.-.-
1.1.1.332 chanoclavine-I dehydrogenase chanoclavine-I:NAD+ oxidoreductase
2.1.1.261 4-dimethylallyltryptophan N-methyltransferase S-adenosyl-L-methionine:4-(3-methylbut-2-enyl)-L-tryptophan N-methyltransferase
2.5.1.34 4-dimethylallyltryptophan synthase dimethylallyl-diphosphate:L-tryptophan 4-dimethylallyltransferase


Pathway Source

Organism Taxonomy Group Enzyme List Source Ratio
Claviceps purpurea MAGs 1.-.-.- / 1.1.1.332 / 2.1.1.261 / 2.5.1.34 100.00%
Microsporum canis CBS 113480 MAGs 1.-.-.- / 1.1.1.332 / 2.1.1.261 / 2.5.1.34 100.00%
Claviceps fusiformis MAGs 1.-.-.- / 1.1.1.332 / 2.1.1.261 / 2.5.1.34 100.00%
Claviceps purpurea 20.1 MAGs 1.-.-.- / 1.1.1.332 / 2.1.1.261 / 2.5.1.34 100.00%
Trichophyton verrucosum HKI 0517 MAGs 1.-.-.- / 1.1.1.332 / 2.1.1.261 / 2.5.1.34 100.00%
Trichophyton benhamiae CBS 112371 MAGs 1.-.-.- / 1.1.1.332 / 2.1.1.261 / 2.5.1.34 100.00%
Aspergillus fumigatus A1163 MAGs 1.-.-.- / 1.1.1.332 / 2.1.1.261 / 2.5.1.34 100.00%
Aspergillus fumigatus Af293 MAGs 1.-.-.- / 1.1.1.332 / 2.1.1.261 / 2.5.1.34 100.00%
Aspergillus fumigatus fungi 1.-.-.- / 1.1.1.332 / 2.1.1.261 75.00%
Aspergillus leporis MAGs 1.-.-.- / 1.1.1.332 / 2.1.1.261 75.00%
Aspergillus nidulans FGSC A4 MAGs 1.-.-.- / 2.1.1.261 / 2.5.1.34 75.00%
Aspergillus viridinutans fungi 1.-.-.- / 1.1.1.332 / 2.1.1.261 75.00%
Aspergillus lentulus fungi 1.-.-.- / 1.1.1.332 / 2.5.1.34 75.00%
Penicillium roqueforti FM164 MAGs 1.-.-.- / 2.1.1.261 / 2.5.1.34 75.00%
Aspergillus bombycis fungi 1.-.-.- / 2.1.1.261 50.00%
Trichophyton interdigitale MAGs 1.-.-.- / 2.1.1.261 50.00%
Aspergillus alliaceus fungi 1.-.-.- / 2.1.1.261 50.00%
Penicillium olsonii MAGs 1.-.-.- / 2.1.1.261 50.00%
Phaeomoniella chlamydospora MAGs 1.-.-.- / 2.1.1.261 50.00%
Aspergillus coremiiformis MAGs 1.-.-.- / 2.1.1.261 50.00%