heme b biosynthesis I (aerobic)
Romero P, Wagg J, Green ML, Kaiser D, Krummenacker M, Karp PD. Computational prediction of human metabolic pathways from the complete human genome. Genome Biology. 2004 Dec 22;6(1):r2. doi: 10.1186/gb-2004-6-1-r2.; Yeh I, Hanekamp T, Tsoka S, Karp PD, Altman RB. Computational Analysis of Plasmodium falciparum Metabolism: Organizing Genomic Information to Facilitate Drug Discovery. Genome Res. 2004 Apr 12;14(5):917–24. doi: 10.1101/gr.2050304.; Christie KR, Weng S, Balakrishnan R, Costanzo MC, Dolinski K, Dwight SS, Engel SR, Feierbach B, Fisk DG, Hirschman JE, Hong EL, Issel-Tarver L, Nash R, Sethuraman A, Starr B, Theesfeld CL, Andrada R, Binkley G, Dong Q, Lane C, Schroeder M, Botstein D, Cherry JM. Saccharomyces Genome Database (SGD) provides tools to identify and analyze sequences from Saccharomyces cerevisiae and related sequences from other organisms. Nucleic Acids Res. 2004 Jan 01;32(Database issue):D311–4. PMID: 14681421; PMCID: PMC308767.; Frankenberg N, Moser J, Jahn D. Bacterial heme biosynthesis and its biotechnological application. Applied Microbiology and Biotechnology. 2003 Dec 01;63(2):115–27. doi: 10.1007/s00253-003-1432-2.; Panek H, O'Brian MR. A whole genome view of prokaryotic haem biosynthesis. Microbiology (Reading). 2002 Aug;148(Pt 8):2273–82. doi: 10.1099/00221287-148-8-2273. PMID: 12177321.
Metabolites
Enzyme
| EC Number | name | full name | note |
|---|---|---|---|
| 1.3.99.- | |||
| 1.3.3.3 | coproporphyrinogen oxidase | coproporphyrinogen:oxygen oxidoreductase (decarboxylating) | |
| 1.3.3.4 | protoporphyrinogen oxidase | protoporphyrinogen-IX:oxygen oxidoreductase | |
| 1.3.5.3 | protoporphyrinogen IX dehydrogenase (quinone) | protoporphyrinogen IX:quinone oxidoreductase | |
| 4.1.1.37 | uroporphyrinogen decarboxylase | uroporphyrinogen-III carboxy-lyase (coproporphyrinogen-III-forming) | |
| 4.98.1.1 | protoporphyrin ferrochelatase | protoheme ferro-lyase (protoporphyrin-forming) |
Pathway Source
| Organism | Taxonomy Group | Enzyme List | Source Ratio |
|---|---|---|---|
| Trichodesmium erythraeum IMS101 | MAGs | 1.3.3.3 / 1.3.3.4 / 1.3.99.- / 4.1.1.37 / 4.98.1.1 | 83.33% |
| Coccidioides posadasii C735 delta SOWgp | MAGs | 1.3.3.3 / 1.3.3.4 / 1.3.99.- / 4.1.1.37 / 4.98.1.1 | 83.33% |
| Homo sapiens | vertebrate_mammalian | 1.3.3.3 / 1.3.3.4 / 1.3.99.- / 4.1.1.37 / 4.98.1.1 | 83.33% |
| Proteus mirabilis HI4320 | MAGs | 1.3.3.3 / 1.3.3.4 / 1.3.99.- / 4.1.1.37 / 4.98.1.1 | 83.33% |
| Mus musculus | vertebrate_mammalian | 1.3.3.3 / 1.3.3.4 / 1.3.99.- / 4.1.1.37 / 4.98.1.1 | 83.33% |
| Escherichia coli K-12 | MAGs | 1.3.3.3 / 1.3.5.3 / 1.3.99.- / 4.1.1.37 / 4.98.1.1 | 83.33% |
| Aspergillus fumigatus Af293 | MAGs | 1.3.3.3 / 1.3.3.4 / 1.3.99.- / 4.1.1.37 / 4.98.1.1 | 83.33% |
| Aspergillus novofumigatus IBT 16806 | MAGs | 1.3.3.3 / 1.3.3.4 / 1.3.99.- / 4.1.1.37 / 4.98.1.1 | 83.33% |
| Aeromonas hydrophila subsp. hydrophila ATCC 7966 | MAGs | 1.3.3.3 / 1.3.3.4 / 1.3.99.- / 4.1.1.37 / 4.98.1.1 | 83.33% |
| Aspergillus tubingensis | fungi | 1.3.3.3 / 1.3.3.4 / 4.1.1.37 / 4.98.1.1 | 66.67% |
| Triticum aestivum | plant | 1.3.3.3 / 1.3.3.4 / 4.1.1.37 / 4.98.1.1 | 66.67% |
| Oryza nivara | MAGs | 1.3.3.3 / 1.3.3.4 / 4.1.1.37 / 4.98.1.1 | 66.67% |
| Streptomyces albogriseolus | bacteria | 1.3.3.4 / 1.3.5.3 / 4.1.1.37 / 4.98.1.1 | 66.67% |
| Aspergillus oryzae | fungi | 1.3.3.3 / 1.3.3.4 / 4.1.1.37 / 4.98.1.1 | 66.67% |
| Monascus purpureus | MAGs | 1.3.3.3 / 1.3.3.4 / 4.1.1.37 / 4.98.1.1 | 66.67% |
| Zygosaccharomyces rouxii | fungi | 1.3.3.3 / 1.3.3.4 / 4.1.1.37 / 4.98.1.1 | 66.67% |
| Penicillium canescens | fungi | 1.3.3.3 / 1.3.3.4 / 4.1.1.37 / 4.98.1.1 | 66.67% |
| Aspergillus parasiticus | MAGs | 1.3.3.3 / 1.3.3.4 / 4.1.1.37 / 4.98.1.1 | 66.67% |
| Pseudomonas syringae pv. syringae | MAGs | 1.3.3.3 / 1.3.99.- / 4.1.1.37 / 4.98.1.1 | 66.67% |
| Aspergillus niger | fungi | 1.3.3.3 / 1.3.3.4 / 4.1.1.37 / 4.98.1.1 | 66.67% |