fatty acid α-oxidation III

Foulon V, Sniekers M, Huysmans E, Asselberghs S, Mahieu V, Mannaerts GP, Van Veldhoven PP, Casteels M. Breakdown of 2-hydroxylated straight chain fatty acids via peroxisomal 2-hydroxyphytanoyl-CoA lyase: a revised pathway for the alpha-oxidation of straight chain fatty acids. J Biol Chem. 2005 Mar 18;280(11):9802–12. doi: 10.1074/jbc.m413362200. PMID: 15644336.

Metabolites

Diphosphate

Formula: H4P2O7 (177.9432294)

CAS ID: 2466-09-3

H+

Formula: H (1.0078246)

CAS ID: 12408-02-5

H2O

Formula: H2O (18.0105642)

CAS ID: 7732-18-5

Oxygen

Formula: O2 (31.98983)

CAS ID: 7782-44-7

formate

Formula: CHO2 (44.997654600000004)

CAS ID: 71-47-6

adenosine 5'-monophosphate(2-)

Formula: C10H12N5O7P (345.0474332)

CAS ID:

ATP(4-)

Formula: C10H12N5O13P3 (502.9644492)

CAS ID:

NADH(2-)

Formula: C21H27N7O14P2 (663.1091182000001)

CAS ID:

NAD(1-)

Formula: C21H26N7O14P2 (662.1012936000001)

CAS ID: 53-84-9



Enzyme

EC Number name full name note
1.14.18.-
1.2.1.3 aldehyde dehydrogenase (NAD+) aldehyde:NAD+ oxidoreductase
1.2.1.94 farnesal dehydrogenase farnesal:NAD+ oxidoreductase
3.5.1.23 ceramidase N-acylsphingosine amidohydrolase
4.1.2.63 2-hydroxyacyl-CoA lyase 2-hydroxy-3-methyl fatty-CoA formyl-CoA lyase (2-methyl branched fatty aldehyde-forming)


Pathway Source

Organism Taxonomy Group Enzyme List Source Ratio
Rattus norvegicus vertebrate_mammalian 1.14.18.- / 1.2.1.3 / 1.2.1.94 / 3.5.1.23 / 4.1.2.63 100.00%
Homo sapiens vertebrate_mammalian 1.14.18.- / 1.2.1.3 / 1.2.1.94 / 3.5.1.23 / 4.1.2.63 100.00%
Mus musculus vertebrate_mammalian 1.14.18.- / 1.2.1.3 / 1.2.1.94 / 3.5.1.23 / 4.1.2.63 100.00%
Aspergillus terreus NIH2624 MAGs 1.14.18.- / 1.2.1.3 / 3.5.1.23 / 4.1.2.63 80.00%
Aspergillus terreus fungi 1.14.18.- / 1.2.1.3 / 3.5.1.23 / 4.1.2.63 80.00%
Aspergillus fumigatus Af293 MAGs 1.14.18.- / 1.2.1.3 / 3.5.1.23 / 4.1.2.63 80.00%
Triticum aestivum plant 1.2.1.3 / 3.5.1.23 / 4.1.2.63 60.00%
Aspergillus parasiticus MAGs 1.2.1.3 / 3.5.1.23 / 4.1.2.63 60.00%
Aspergillus oryzae fungi 1.2.1.3 / 3.5.1.23 / 4.1.2.63 60.00%
Aspergillus niger fungi 1.2.1.3 / 3.5.1.23 / 4.1.2.63 60.00%
Aspergillus flavus fungi 1.2.1.3 / 3.5.1.23 / 4.1.2.63 60.00%
Histoplasma capsulatum fungi 1.2.1.3 / 3.5.1.23 / 4.1.2.63 60.00%
Monascus purpureus MAGs 1.2.1.3 / 3.5.1.23 / 4.1.2.63 60.00%
Aspergillus avenaceus MAGs 1.2.1.3 / 3.5.1.23 / 4.1.2.63 60.00%
Oryza nivara MAGs 1.2.1.3 / 3.5.1.23 / 4.1.2.63 60.00%
Citrus sinensis plant 1.2.1.3 / 3.5.1.23 / 4.1.2.63 60.00%
Oryza sativa Indica Group MAGs 1.2.1.3 / 3.5.1.23 / 4.1.2.63 60.00%
Trichophyton violaceum MAGs 1.2.1.3 / 3.5.1.23 / 4.1.2.63 60.00%
Penicillium canescens fungi 1.2.1.3 / 1.2.1.94 / 3.5.1.23 60.00%
Trichophyton rubrum fungi 1.2.1.3 / 3.5.1.23 / 4.1.2.63 60.00%