phenylalanine degradation/tyrosine biosynthesis

Fitzpatrick PF. Mechanism of aromatic amino acid hydroxylation. Biochemistry. 2003 Dec 09;42(48):14083–91. PMID: 14640675; PMCID: PMC1635487.

Metabolites

7,8-Dihydrobiopterin

Formula: C9H13N5O3 (239.1018348)

CAS ID: 6779-87-9

Cobalt ion

Formula: Co (58.933198)

CAS ID: 22541-53-3

H+

Formula: H (1.0078246)

CAS ID: 12408-02-5

H2O

Formula: H2O (18.0105642)

CAS ID: 7732-18-5

Mercury(2+)

Formula: Hg (201.970632)

CAS ID: 14302-87-5

Oxygen

Formula: O2 (31.98983)

CAS ID: 7782-44-7

Tetrahydrobiopterin

Formula: C9H15N5O3 (241.11748400000002)

CAS ID: 17528-72-2

NADH(2-)

Formula: C21H27N7O14P2 (663.1091182000001)

CAS ID:

NAD(1-)

Formula: C21H26N7O14P2 (662.1012936000001)

CAS ID: 53-84-9

Dithionitrobenzoic acid

Formula: C14H6N2O8S2-2 (393.9565596)

CAS ID:



Enzyme

EC Number name full name note
1.14.16.1 phenylalanine 4-monooxygenase L-phenylalanine,tetrahydrobiopterin:oxygen oxidoreductase (4-hydroxylating)
1.5.1.34 6,7-dihydropteridine reductase 5,6,7,8-tetrahydropteridine:NAD(P)+ oxidoreductase
4.2.1.96 4a-hydroxytetrahydrobiopterin dehydratase 4a-hydroxytetrahydrobiopterin hydro-lyase (6,7-dihydrobiopterin-forming)


Pathway Source

Organism Taxonomy Group Enzyme List Source Ratio
Burkholderia mallei ATCC 23344 MAGs 1.14.16.1 / 1.5.1.34 / 4.2.1.96 100.00%
Homo sapiens vertebrate_mammalian 1.14.16.1 / 1.5.1.34 / 4.2.1.96 100.00%
Mus musculus vertebrate_mammalian 1.14.16.1 / 1.5.1.34 / 4.2.1.96 100.00%
Rattus norvegicus vertebrate_mammalian 1.14.16.1 / 1.5.1.34 / 4.2.1.96 100.00%
Pseudomonas putida KT2440 MAGs 1.14.16.1 / 1.5.1.34 / 4.2.1.96 100.00%
Colwellia psychrerythraea 34H MAGs 1.14.16.1 / 1.5.1.34 / 4.2.1.96 100.00%
Chromobacterium violaceum ATCC 12472 MAGs 1.14.16.1 / 1.5.1.34 / 4.2.1.96 100.00%
Shewanella baltica OS155 MAGs 1.14.16.1 / 1.5.1.34 / 4.2.1.96 100.00%
Shewanella amazonensis SB2B MAGs 1.14.16.1 / 1.5.1.34 / 4.2.1.96 100.00%
Shewanella piezotolerans WP3 MAGs 1.14.16.1 / 1.5.1.34 / 4.2.1.96 100.00%
Diaphorina citri invertebrate 1.14.16.1 / 1.5.1.34 / 4.2.1.96 100.00%
Cupriavidus taiwanensis bacteria 1.14.16.1 / 1.5.1.34 / 4.2.1.96 100.00%
Aeromonas salmonicida subsp. salmonicida MAGs 1.14.16.1 / 4.2.1.96 66.67%
Acidovorax sp. JS42 MAGs 1.14.16.1 / 4.2.1.96 66.67%
Bacillus cereus ATCC 14579 MAGs 1.14.16.1 / 4.2.1.96 66.67%
Vibrio cholerae O1 biovar El Tor str. N16961 MAGs 1.14.16.1 / 4.2.1.96 66.67%
Thermus thermophilus HB27 MAGs 1.5.1.34 / 4.2.1.96 66.67%
Trichodesmium erythraeum IMS101 MAGs 1.5.1.34 / 4.2.1.96 66.67%
Caulobacter vibrioides CB15 MAGs 1.14.16.1 / 4.2.1.96 66.67%
Pseudomonas aeruginosa PAO1 MAGs 1.14.16.1 / 4.2.1.96 66.67%