sesquiterpenoid phytoalexins biosynthesis

Takahashi S, Yeo Y, Zhao Y, O'Maille PE, Greenhagen BT, Noel JP, Coates RM, Chappell J. Functional Characterization of Premnaspirodiene Oxygenase, a Cytochrome P450 Catalyzing Regio- and Stereo-specific Hydroxylations of Diverse Sesquiterpene Substrates. Journal of Biological Chemistry. 2007 Oct;282(43):31744–54. doi: 10.1074/jbc.m703378200.

Metabolites

Diphosphate

Formula: H4P2O7 (177.9432294)

CAS ID: 2466-09-3

H2O

Formula: H2O (18.0105642)

CAS ID: 7732-18-5

Lubimin

Formula: C15H24O2 (236.1776204)

CAS ID: 35951-50-9

Oxygen

Formula: O2 (31.98983)

CAS ID: 7782-44-7

Solavetivone

Formula: C15H22O (218.1670562)

CAS ID: 54878-25-0

(2R,5S,10R)-6,10-dimethyl-2-(prop-1-en-2-yl)spiro[4.5]dec-6-en-8-ol

Formula: C15H24O (220.18270539999997)

CAS ID:

(3S,5R,6R)-6,10-dimethyl-3-prop-1-en-2-ylspiro[4.5]dec-9-ene

Formula: C15H24 (204.18779039999998)

CAS ID:



Enzyme

EC Number name full name note
1.14.14.151 premnaspirodiene oxygenase (–)-vetispiradiene,[reduced NADPH-hemoprotein reductase]:oxygen 2alpha-oxidoreductase
4.2.3.21 vetispiradiene synthase trans,trans-farnesyl-diphosphate diphosphate-lyase (cyclizing, vetispiradiene-forming)


Pathway Source

Organism Taxonomy Group Enzyme List Source Ratio