N-acetylneuraminate and N-acetylmannosamine degradation I

Walters DM, Stirewalt VL, Melville SB. Cloning, Sequence, and Transcriptional Regulation of the Operon Encoding a Putative N -Acetylmannosamine-6-Phosphate Epimerase ( nanE ) and Sialic Acid Lyase ( nanA ) in Clostridium perfringens. J Bacteriol. 1999 Aug;181(15):4526–32. doi: 10.1128/jb.181.15.4526-4532.1999.; Plumbridge J, Vimr E. Convergent Pathways for Utilization of the Amino Sugars N -Acetylglucosamine, N -Acetylmannosamine, and N -Acetylneuraminic Acid by Escherichia coli. J Bacteriol. 1999 Jan;181(1):47–54. doi: 10.1128/jb.181.1.47-54.1999.

Metabolites

Copper

Formula: Cu (62.929599)

CAS ID: 7440-50-8

Diethyl pyrocarbonate

Formula: C6H10O5 (162.052821)

CAS ID: 1609-47-8

Fe2+

Formula: Fe (55.934939)

CAS ID: 15438-31-0

Glyceraldehyde

Formula: C3H6O3 (90.0316926)

CAS ID: 367-47-5

Glycerone

Formula: C3H6O3 (90.0316926)

CAS ID: 96-26-4

H+

Formula: H (1.0078246)

CAS ID: 12408-02-5

pyruvate

Formula: C3H3O3 (87.00821880000001)

CAS ID: 57-60-3

3-hydroxypyruvate

Formula: C3H3O4 (103.0031338)

CAS ID:

ATP(4-)

Formula: C10H12N5O13P3 (502.9644492)

CAS ID:

ADP(3-)

Formula: C10H12N5O10P2 (424.0059412)

CAS ID:

N-bromosuccinimide

Formula: C4H4BrNO2 (176.9425384)

CAS ID: 128-08-5

N-acetyl-mannosamine 6-phosphate

Formula: C8H14NO9P-2 (299.04061640000003)

CAS ID:



Enzyme

EC Number name full name note
2.7.1.60 N-acylmannosamine kinase ATP:N-acyl-D-mannosamine 6-phosphotransferase
4.1.3.3 N-acetylneuraminate lyase aceneuramate pyruvate-lyase (N-acetyl-D-mannosamine-forming)
5.1.3.9 N-acylglucosamine-6-phosphate 2-epimerase N-acyl-D-glucosamine-6-phosphate 2-epimerase


Pathway Source

Organism Taxonomy Group Enzyme List Source Ratio
Streptococcus sanguinis SK36 MAGs 2.7.1.60 / 4.1.3.3 / 5.1.3.9 100.00%
Escherichia coli 536 MAGs 2.7.1.60 / 4.1.3.3 / 5.1.3.9 100.00%
Shigella flexneri 5 str. 8401 MAGs 2.7.1.60 / 4.1.3.3 / 5.1.3.9 100.00%
Pasteurella multocida subsp. multocida str. Pm70 MAGs 2.7.1.60 / 4.1.3.3 / 5.1.3.9 100.00%
Salmonella enterica subsp. enterica serovar Typhimurium str. LT2 MAGs 2.7.1.60 / 4.1.3.3 / 5.1.3.9 100.00%
Escherichia coli O139:H28 str. E24377A MAGs 2.7.1.60 / 4.1.3.3 / 5.1.3.9 100.00%
Salmonella enterica subsp. enterica serovar Paratyphi A str. ATCC 9150 MAGs 2.7.1.60 / 4.1.3.3 / 5.1.3.9 100.00%
Salmonella enterica subsp. enterica serovar Typhi MAGs 2.7.1.60 / 4.1.3.3 / 5.1.3.9 100.00%
Escherichia coli O157:H7 MAGs 2.7.1.60 / 4.1.3.3 / 5.1.3.9 100.00%
Escherichia coli K-12 MAGs 2.7.1.60 / 4.1.3.3 / 5.1.3.9 100.00%
Haemophilus influenzae Rd KW20 MAGs 2.7.1.60 / 4.1.3.3 / 5.1.3.9 100.00%
Enterobacter sp. 638 bacteria 2.7.1.60 / 4.1.3.3 / 5.1.3.9 100.00%
Salmonella enterica subsp. arizonae serovar 62:z4,z23:- MAGs 2.7.1.60 / 4.1.3.3 / 5.1.3.9 100.00%
Escherichia coli str. K-12 substr. DH10B MAGs 2.7.1.60 / 4.1.3.3 / 5.1.3.9 100.00%
Escherichia coli HS MAGs 2.7.1.60 / 4.1.3.3 / 5.1.3.9 100.00%
Shigella boydii CDC 3083-94 MAGs 2.7.1.60 / 4.1.3.3 / 5.1.3.9 100.00%
Escherichia coli CFT073 MAGs 2.7.1.60 / 4.1.3.3 / 5.1.3.9 100.00%
Vibrio vulnificus CMCP6 MAGs 2.7.1.60 / 4.1.3.3 / 5.1.3.9 100.00%
Escherichia coli APEC O1 MAGs 2.7.1.60 / 4.1.3.3 / 5.1.3.9 100.00%
Shigella flexneri bacteria 2.7.1.60 / 4.1.3.3 / 5.1.3.9 100.00%