Ornithine Metabolism

Metabolites

2-Oxoglutarate

Formula: C5H6O5 (146.0215226)

CAS ID: 328-50-7

4-(L-gamma-Glutamylamino)butanoate

Formula: C9H16N2O5 (232.1059166)

CAS ID: 5105-96-4

4-Aminobutanoate

Formula: C4H9NO2 (103.0633254)

CAS ID: 56-12-2

4-Aminobutyraldehyde

Formula: C4H9NO (87.0684104)

CAS ID: 4390-05-0

Acetate

Formula: C2H4O2 (60.0211284)

CAS ID: 64-19-7

Acetyl-CoA

Formula: C23H38N7O17P3S (809.1257688000001)

CAS ID: 72-89-9

ADP

Formula: C10H15N5O10P2 (427.02941500000003)

CAS ID: 58-64-0

ATP

Formula: C10H16N5O13P3 (506.9957476)

CAS ID: 56-65-5

CO2

Formula: CO2 (43.98983)

CAS ID: 124-38-9

gamma-L-Glutamylputrescine

Formula: C9H19N3O3 (217.1426344)

CAS ID:

H+

Formula: H (1.0078246)

CAS ID: 12408-02-5

H2O

Formula: H2O (18.0105642)

CAS ID: 7732-18-5

Hydrogen peroxide

Formula: H2O2 (34.0054792)

CAS ID: 7722-84-1

L-Glutamate

Formula: C5H9NO4 (147.0531554)

CAS ID: 56-86-0

L-Ornithine

Formula: C5H12N2O2 (132.0898732)

CAS ID: 70-26-8

N-Acetyl-L-glutamate 5-phosphate

Formula: C7H12NO8P (269.0300522)

CAS ID: 15383-57-0

N-Acetyl-L-glutamate 5-semialdehyde

Formula: C7H11NO4 (173.0688046)

CAS ID: 13074-21-0

N-Acetylornithine

Formula: C7H14N2O3 (174.1004374)

CAS ID: 6205-08-9

NAD+

Formula: C21H28N7O14P2 (664.1169428000001)

CAS ID: 53-84-9

NADH

Formula: C21H29N7O14P2 (665.1247674)

CAS ID: 58-68-4

NADP+

Formula: C21H29N7O17P3 (744.0832754)

CAS ID: 53-59-8

NH4+

Formula: NH4 (18.0343724)

CAS ID: 14798-03-9

Oxygen

Formula: O2 (31.98983)

CAS ID: 7782-44-7

Putrescine

Formula: C4H12N2 (88.1000432)

CAS ID: 110-60-1

Succinate semialdehyde

Formula: C4H6O3 (102.0316926)

CAS ID: 692-29-5

phosphate(3-)

Formula: O4P (94.953423)

CAS ID: 14265-44-2



Enzyme

EC Number name full name note
1.2.1.-
1.2.1.16 succinate-semialdehyde dehydrogenase [NAD(P)+] succinate-semialdehyde:NAD(P)+ oxidoreductase
1.2.1.19 aminobutyraldehyde dehydrogenase 4-aminobutanal:NAD+ 1-oxidoreductase
1.2.1.38 N-acetyl-gamma-glutamyl-phosphate reductase N-acetyl-L-glutamate-5-semialdehyde:NADP+ 5-oxidoreductase (phosphorylating)
1.2.1.5 aldehyde dehydrogenase [NAD(P)+] aldehyde:NAD(P)+ oxidoreductase
1.2.1.79 succinate-semialdehyde dehydrogenase (NADP+) succinate-semialdehyde:NADP+ oxidoreductase
2.6.1.11 acetylornithine transaminase N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase
2.6.1.17 succinyldiaminopimelate transaminase N-succinyl-L-2,6-diaminoheptanedioate:2-oxoglutarate aminotransferase
2.6.1.19 4-aminobutyrate-2-oxoglutarate transaminase 4-aminobutanoate:2-oxoglutarate aminotransferase
2.6.1.29 diamine transaminase diamine:2-oxoglutarate aminotransferase
2.6.1.48 5-aminovalerate transaminase 5-aminopentanoate:2-oxoglutarate aminotransferase
2.6.1.82 putrescine-2-oxoglutarate transaminase putrescine:2-oxoglutarate aminotransferase
2.7.2.8 acetylglutamate kinase ATP:N-acetyl-L-glutamate 5-phosphotransferase
3.5.1.16 acetylornithine deacetylase N2-acetyl-L-ornithine amidohydrolase
3.5.1.94 gamma-glutamyl-gamma-aminobutyrate hydrolase 4-(glutamylamino)butanoate amidohydrolase
4.1.1.17 ornithine decarboxylase L-ornithine carboxy-lyase (putrescine-forming)
6.3.1.11 glutamate-putrescine ligase L-glutamate:putrescine ligase (ADP-forming)


Pathway Source

Organism Taxonomy Group Enzyme List Source Ratio
Escherichia coli K-12 MAGs 1.2.1.- / 1.2.1.16 / 1.2.1.19 / 1.2.1.38 / 1.2.1.5 / 1.2.1.79 / 2.6.1.11 / 2.6.1.17 / 2.6.1.19 / 2.6.1.29 / 2.6.1.48 / 2.6.1.82 / 2.7.2.8 / 3.5.1.16 / 3.5.1.94 / 4.1.1.17 / 6.3.1.11 100.00%
Pseudomonas putida KT2440 MAGs 1.2.1.- / 1.2.1.19 / 1.2.1.38 / 1.2.1.79 / 2.6.1.11 / 2.6.1.17 / 2.6.1.19 / 2.6.1.48 / 2.7.2.8 / 3.5.1.16 / 3.5.1.94 / 4.1.1.17 / 6.3.1.11 76.47%
Enterobacter sp. 638 bacteria 1.2.1.- / 1.2.1.16 / 1.2.1.19 / 1.2.1.38 / 2.6.1.17 / 2.6.1.19 / 2.6.1.29 / 2.6.1.82 / 2.7.2.8 / 3.5.1.16 / 4.1.1.17 64.71%
Paraburkholderia graminis bacteria 1.2.1.- / 1.2.1.16 / 1.2.1.38 / 1.2.1.79 / 2.6.1.11 / 2.6.1.17 / 2.6.1.19 / 2.7.2.8 / 3.5.1.16 / 3.5.1.94 58.82%
Bacillus subtilis subsp. subtilis str. 168 MAGs 1.2.1.- / 1.2.1.16 / 1.2.1.38 / 1.2.1.5 / 1.2.1.79 / 2.6.1.11 / 2.6.1.19 / 2.6.1.48 / 2.7.2.8 / 3.5.1.16 58.82%
Shigella flexneri bacteria 1.2.1.- / 1.2.1.19 / 1.2.1.38 / 2.6.1.11 / 2.6.1.17 / 2.6.1.29 / 2.6.1.82 / 2.7.2.8 / 3.5.1.16 / 3.5.1.94 58.82%
Sinorhizobium meliloti 1021 MAGs 1.2.1.- / 1.2.1.16 / 1.2.1.19 / 1.2.1.38 / 2.6.1.11 / 2.6.1.19 / 2.7.2.8 / 3.5.1.16 / 4.1.1.17 / 6.3.1.11 58.82%
Escherichia coli O157:H7 MAGs 1.2.1.- / 1.2.1.19 / 1.2.1.38 / 2.6.1.11 / 2.6.1.17 / 2.6.1.29 / 2.6.1.82 / 2.7.2.8 / 3.5.1.16 / 3.5.1.94 58.82%
Polaromonas sp. JS666 bacteria 1.2.1.- / 1.2.1.16 / 1.2.1.38 / 2.6.1.11 / 2.6.1.17 / 2.6.1.19 / 2.7.2.8 / 3.5.1.16 / 4.1.1.17 52.94%
Saccharopolyspora erythraea NRRL 2338 MAGs 1.2.1.- / 1.2.1.16 / 1.2.1.38 / 2.6.1.11 / 2.6.1.17 / 2.6.1.19 / 2.7.2.8 / 3.5.1.16 / 4.1.1.17 52.94%
Escherichia coli CFT073 MAGs 1.2.1.- / 1.2.1.19 / 1.2.1.38 / 2.6.1.11 / 2.6.1.17 / 2.6.1.29 / 2.6.1.82 / 2.7.2.8 / 3.5.1.16 52.94%
Aspergillus niger CBS 513.88 MAGs 1.2.1.- / 1.2.1.16 / 1.2.1.38 / 1.2.1.5 / 2.6.1.11 / 2.6.1.19 / 2.7.2.8 / 3.5.1.16 / 4.1.1.17 52.94%
Salmonella enterica subsp. enterica serovar Typhi MAGs 1.2.1.- / 1.2.1.19 / 1.2.1.38 / 2.6.1.11 / 2.6.1.17 / 2.6.1.29 / 2.6.1.82 / 2.7.2.8 / 3.5.1.16 52.94%
Streptomyces albogriseolus bacteria 1.2.1.16 / 1.2.1.38 / 1.2.1.79 / 2.6.1.11 / 2.6.1.17 / 2.6.1.19 / 2.6.1.48 / 2.7.2.8 / 3.5.1.16 52.94%
Cupriavidus taiwanensis bacteria 1.2.1.- / 1.2.1.16 / 1.2.1.38 / 1.2.1.5 / 2.6.1.11 / 2.6.1.17 / 2.6.1.19 / 2.7.2.8 / 3.5.1.16 52.94%
Burkholderia vietnamiensis G4 MAGs 1.2.1.- / 1.2.1.16 / 1.2.1.38 / 2.6.1.11 / 2.6.1.17 / 2.6.1.19 / 2.7.2.8 / 3.5.1.16 / 4.1.1.17 52.94%
Salmonella enterica subsp. enterica serovar Typhimurium str. LT2 MAGs 1.2.1.- / 1.2.1.19 / 1.2.1.38 / 2.6.1.11 / 2.6.1.17 / 2.6.1.29 / 2.6.1.82 / 2.7.2.8 / 3.5.1.16 52.94%
Aeromonas hydrophila subsp. hydrophila ATCC 7966 MAGs 1.2.1.- / 1.2.1.16 / 1.2.1.38 / 2.6.1.11 / 2.6.1.17 / 2.6.1.19 / 2.7.2.8 / 3.5.1.16 / 4.1.1.17 52.94%
Pseudomonas syringae pv. syringae MAGs 1.2.1.- / 1.2.1.38 / 2.6.1.11 / 2.6.1.17 / 2.6.1.19 / 2.7.2.8 / 3.5.1.16 / 3.5.1.94 / 4.1.1.17 52.94%
Bacillus cereus ATCC 14579 MAGs 1.2.1.- / 1.2.1.16 / 1.2.1.38 / 1.2.1.5 / 1.2.1.79 / 2.6.1.11 / 2.6.1.19 / 2.7.2.8 / 3.5.1.16 52.94%