Sphingolipid metabolism: integrated pathway

Mizutani Y, Kihara A, Igarashi Y. Mammalian Lass6 and its related family members regulate synthesis of specific ceramides. Biochem J. 2005 Aug 15;390(Pt 1):263–71. PMID: 15823095; PMCID: PMC1184580.

Metabolites

3-Dehydrosphinganine

Formula: C18H37NO2 (299.2824142)

CAS ID: 16105-69-4

Eicosanoyl-CoA

Formula: C41H74N7O17P3S (1061.4074544)

CAS ID: 15895-27-9

Ethanolamine phosphate

Formula: C2H8NO4P (141.0190938)

CAS ID: 1071-23-4

H2O

Formula: H2O (18.0105642)

CAS ID: 7732-18-5

Hexadecanal

Formula: C16H32O (240.2453022)

CAS ID: 629-80-1

L-Serine

Formula: C3H7NO3 (105.0425912)

CAS ID: 56-45-1

Palmitoyl-CoA

Formula: C37H66N7O17P3S (1005.3448576)

CAS ID: 1763-10-6

Sphinganine

Formula: C18H39NO2 (301.2980634)

CAS ID: 764-22-7

Sphingosine

Formula: C18H37NO2 (299.2824142)

CAS ID: 123-78-4

Stearoyl-CoA

Formula: C39H70N7O17P3S (1033.376156)

CAS ID: 362-66-3

SM(d18:1/18:0)

Formula: C41H83N2O6P (730.5988428)

CAS ID: 58909-84-5

Cer(d18:1/16:0)

Formula: C34H67NO3 (537.5120672)

CAS ID: 24696-26-2

Cer(d18:1/18:0)

Formula: C36H71NO3 (565.5433656)

CAS ID: 2304-81-6

Cer(d18:1/20:0)

Formula: C38H75NO3 (593.574664)

CAS ID: 7344-02-7

Cer(d18:1/22:0)

Formula: C40H79NO3 (621.6059624)

CAS ID: 27888-44-4

Cer(d18:1/24:1(15Z))

Formula: C42H81NO3 (647.6216115999999)

CAS ID: 104404-17-3

Cer(d18:1/26:0)

Formula: C44H87NO3 (677.6685591999999)

CAS ID: 121459-09-4

Cer(d18:1/24:0)

Formula: C42H83NO3 (649.6372607999999)

CAS ID: 34435-05-7

SM(d18:0/16:0)

Formula: C39H81N2O6P (704.5831936)

CAS ID: 60322-02-3

SM(d18:1/16:0)

Formula: C39H79N2O6P (702.5675444000001)

CAS ID: 6254-89-3

SM(d18:1/24:0)

Formula: C47H95N2O6P (814.692738)

CAS ID: 60037-60-7

SM(d18:1/26:0)

Formula: C49H99N2O6P (842.7240363999999)

CAS ID: 221097-57-0

Cer(d18:0/16:0)

Formula: C34H69NO3 (539.5277164)

CAS ID: 5966-29-0

Cer(d18:0/18:0)

Formula: C36H73NO3 (567.5590148)

CAS ID: 2304-80-5

Cer(d18:0/20:0)

Formula: C38H77NO3 (595.5903132)

CAS ID: 121459-06-1

Cer(d18:0/22:0)

Formula: C40H81NO3 (623.6216115999999)

CAS ID: 147492-65-7

Cer(d18:0/24:0)

Formula: C42H85NO3 (651.6529099999999)

CAS ID: 6063-36-1

Cer(d18:0/24:1(15Z))

Formula: C42H83NO3 (649.6372607999999)

CAS ID: 352518-80-0

Cer(d18:0/26:0)

Formula: C44H89NO3 (679.6842084)

CAS ID: 182362-38-5

SM(d18:0/22:0)

Formula: C45H93N2O6P (788.6770888000001)

CAS ID: 221097-58-1

SM(d18:0/24:1(15Z))

Formula: C47H95N2O6P (814.692738)

CAS ID: 945029-65-2

SM(d18:1/20:0)

Formula: C43H87N2O6P (758.6301412)

CAS ID: 121999-68-6

SM(d18:1/22:0)

Formula: C45H91N2O6P (786.6614396)

CAS ID: 94359-12-3

SM(d18:1/24:1(15Z))

Formula: C47H93N2O6P (812.6770888000001)

CAS ID: 94359-13-4

GlcCer(d18:1/24:1(15Z))

Formula: C48H91NO8 (809.6744326)

CAS ID: 887907-50-8

ATP(4-)

Formula: C10H12N5O13P3 (502.9644492)

CAS ID:

ADP(3-)

Formula: C10H12N5O10P2 (424.0059412)

CAS ID:



Enzyme

EC Number name full name note
3.1.3.-
3.1.3.4 phosphatidate phosphatase diacylglycerol-3-phosphate phosphohydrolase


Pathway Source

Organism Taxonomy Group Enzyme List Source Ratio
Neonectria punicea MAGs 3.1.3.- / 3.1.3.4 100.00%
Exophiala dermatitidis fungi 3.1.3.- / 3.1.3.4 100.00%
Phytophthora citrophthora MAGs 3.1.3.- / 3.1.3.4 100.00%
Homo sapiens vertebrate_mammalian 3.1.3.- / 3.1.3.4 100.00%
Knufia fluminis MAGs 3.1.3.- / 3.1.3.4 100.00%
Mus musculus vertebrate_mammalian 3.1.3.- / 3.1.3.4 100.00%
Escherichia coli K-12 MAGs 3.1.3.- / 3.1.3.4 100.00%
Diaphorina citri invertebrate 3.1.3.- / 3.1.3.4 100.00%
Saccharomyces cerevisiae S288C MAGs 3.1.3.- / 3.1.3.4 100.00%
Exophiala sideris MAGs 3.1.3.- / 3.1.3.4 100.00%
Oryza sativa Japonica Group MAGs 3.1.3.- / 3.1.3.4 100.00%
Rattus norvegicus vertebrate_mammalian 3.1.3.- / 3.1.3.4 100.00%
Schizosaccharomyces pombe 972h- MAGs 3.1.3.- / 3.1.3.4 100.00%
Cladophialophora chaetospira MAGs 3.1.3.- / 3.1.3.4 100.00%
Haemophilus influenzae Rd KW20 MAGs 3.1.3.- / 3.1.3.4 100.00%
Shigella flexneri bacteria 3.1.3.- / 3.1.3.4 100.00%
Knufia peltigerae MAGs 3.1.3.- / 3.1.3.4 100.00%
Escherichia coli O157:H7 MAGs 3.1.3.- / 3.1.3.4 100.00%
Enterococcus faecium DO MAGs 3.1.3.- / 3.1.3.4 100.00%
Wickerhamomyces ciferrii NRRL Y-1031 MAGs 3.1.3.- / 3.1.3.4 100.00%