O-linked glycosylation

Moremen KW, Tiemeyer M, Nairn AV. Vertebrate protein glycosylation: diversity, synthesis and function. Nature Reviews Molecular Cell Biology. 2012 Jun 22;13(7):448–62. doi: 10.1038/nrm3383.; Steen PVD, Rudd PM, Dwek RA, Opdenakker G. Concepts and Principles of O-Linked Glycosylation. Critical Reviews in Biochemistry and Molecular Biology. 1998 Jan;33(3):151–208. doi: 10.1080/10409239891204198.

Metabolites

H+

Formula: H (1.0078246)

CAS ID: 12408-02-5

Magnesium cation

Formula: Mg (23.98505)

CAS ID: 22537-22-0

Manganese(2+)

Formula: Mn (54.938046)

CAS ID: 7439-96-5

ATP(4-)

Formula: C10H12N5O13P3 (502.9644492)

CAS ID:

UDPαD-glucose(2-)

Formula: C15H22N2O17P2 (564.0393702)

CAS ID:

UDP-N-acetyl-D-galactosamine(2-)

Formula: C17H25N3O17P2 (605.0659180000001)

CAS ID:

UDP(3-)

Formula: C9H11N2O12P2 (400.9787246)

CAS ID: 86527-70-0

ADP(3-)

Formula: C10H12N5O10P2 (424.0059412)

CAS ID:



Enzyme

EC Number name full name note
2.4.1.-
2.4.1.102 beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase UDP-N-acetyl-alpha-D-glucosamine:O3-[beta-D-galactosyl-(1->3)-N-acetyl-alpha-D-galactosaminyl]-glycoprotein 6-beta-N-acetyl-D-glucosaminyltransferase (configuration-inverting)
2.4.1.109 dolichyl-phosphate-mannose-protein mannosyltransferase dolichyl-phosphate-D-mannose:protein O-D-mannosyltransferase
2.4.1.122 N-acetylgalactosaminide beta-1,3-galactosyltransferase UDP-alpha-D-galactose:N-acetyl-alpha-D-galactosaminyl-R beta-1,3-galactosyltransferase (configuration-inverting)
2.4.1.148 acetylgalactosaminyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase UDP-N-acetyl-D-glucosamine:N-acetyl-beta-D-glucosaminyl-(1->3)-N-acetyl-D-galactosaminyl-R 6-beta-N-acetyl-D-glucosaminyltransferase
2.4.1.150 N-acetyllactosaminide beta-1,6-N-acetylglucosaminyltransferase UDP-N-acetyl-alpha-D-glucosamine:beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminide 6-beta-N-acetylglucosaminyltransferase (configuration-inverting)
2.4.1.221 peptide-O-fucosyltransferase GDP-beta-L-fucose:protein-(L-serine/L-threonine) O-alpha-L-fucosyltransferase (configuration-inverting)
2.4.1.312 protein O-mannose beta-1,4-N-acetylglucosaminyltransferase UDP-N-acetyl-alpha-D-glucosamine:alpha-D-mannosyl-threonyl-[protein] 4-beta-N-acetyl-D-glucosaminyltransferase
2.4.3.1 beta-galactoside alpha-(2,6)-sialyltransferase CMP-N-acetyl-beta-neuraminate:beta-D-galactoside alpha-(2->6)-N-acetylneuraminyltransferase (configuration-inverting)
2.7.1.183 glycoprotein-mannosyl O6-kinase ATP:O3-[N-acetyl-beta-D-galactosaminyl-(1->3)-N-acetyl-beta-D-glucosaminyl-(1->4)-alpha-D-mannosyl]-L-threonyl/L-seryl-[protein] 6-phosphotransferase
2.7.7.40 D-ribitol-5-phosphate cytidylyltransferase CTP:D-ribitol-5-phosphate cytidylyltransferase


Pathway Source

Organism Taxonomy Group Enzyme List Source Ratio
Rattus norvegicus vertebrate_mammalian 2.4.1.- / 2.4.1.102 / 2.4.1.109 / 2.4.1.122 / 2.4.1.148 / 2.4.1.150 / 2.4.1.221 / 2.4.1.312 / 2.4.3.1 / 2.7.1.183 / 2.7.7.40 100.00%
Mus musculus vertebrate_mammalian 2.4.1.- / 2.4.1.102 / 2.4.1.109 / 2.4.1.122 / 2.4.1.148 / 2.4.1.150 / 2.4.1.221 / 2.4.1.312 / 2.4.3.1 / 2.7.1.183 / 2.7.7.40 100.00%
Homo sapiens vertebrate_mammalian 2.4.1.- / 2.4.1.102 / 2.4.1.109 / 2.4.1.122 / 2.4.1.148 / 2.4.1.150 / 2.4.1.221 / 2.4.1.312 / 2.4.3.1 / 2.7.1.183 / 2.7.7.40 100.00%
Diaphorina citri invertebrate 2.4.1.- / 2.4.1.109 / 2.4.1.221 / 2.4.3.1 36.36%
Penicillium vulpinum fungi 2.4.1.- / 2.4.1.109 / 2.4.1.122 27.27%
Phytophthora citrophthora MAGs 2.4.1.- / 2.4.1.109 / 2.4.1.122 27.27%
Aspergillus tubingensis fungi 2.4.1.- / 2.4.1.109 / 2.4.1.122 27.27%
Penicillium brevicompactum fungi 2.4.1.- / 2.4.1.109 / 2.4.1.122 27.27%
Aspergillus niger fungi 2.4.1.- / 2.4.1.109 / 2.4.1.122 27.27%
Aspergillus parasiticus MAGs 2.4.1.- / 2.4.1.109 / 2.4.1.122 27.27%
Penicillium griseofulvum fungi 2.4.1.- / 2.4.1.109 / 2.4.1.122 27.27%
Aspergillus terreus fungi 2.4.1.- / 2.4.1.109 / 2.4.1.122 27.27%
Penicillium canescens fungi 2.4.1.- / 2.4.1.109 / 2.4.1.122 27.27%
Penicillium expansum fungi 2.4.1.- / 2.4.1.109 / 2.4.1.122 27.27%
Penicillium citrinum fungi 2.4.1.- / 2.4.1.109 / 2.4.1.122 27.27%
Aspergillus flavus fungi 2.4.1.- / 2.4.1.109 / 2.4.1.122 27.27%
Exophiala dermatitidis fungi 2.4.1.- / 2.4.1.109 / 2.4.1.122 27.27%
Aspergillus oryzae fungi 2.4.1.- / 2.4.1.109 / 2.4.1.122 27.27%
Penicillium chrysogenum fungi 2.4.1.- / 2.4.1.109 / 2.4.1.122 27.27%
Monascus purpureus MAGs 2.4.1.- / 2.4.1.109 / 2.4.1.122 27.27%